Roxithromycin (BioDeep_00000001563)
human metabolite blood metabolite
代谢物信息卡片
(3R,4S,5S,6R,7R,9R,11S,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,7,9,11,13-hexamethyl-10-(2,4,7-trioxa-1-azaoctan-1-ylidene)-1-oxacyclotetradecan-2-one
化学式: C41H76N2O15 (836.5245)
中文名称: 罗红霉素
谱图信息:
最多检出来源 Homo sapiens(blood) 58.33%
分子结构信息
SMILES: CCC1C(C(C(C(=NOCOCCOC)C(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)O)(C)O
InChI: InChI=1S/C41H76N2O15/c1-15-29-41(10,49)34(45)24(4)31(42-53-21-52-17-16-50-13)22(2)19-39(8,48)36(58-38-32(44)28(43(11)12)18-23(3)54-38)25(5)33(26(6)37(47)56-29)57-30-20-40(9,51-14)35(46)27(7)55-30/h22-30,32-36,38,44-46,48-49H,15-21H2,1-14H3/t22-,23-,24+,25+,26-,27+,28+,29-,30+,32-,33+,34-,35+,36-,38+,39-,40-,41-/m1/s1
描述信息
Roxithromycin is a semi-synthetic macrolide antibiotic. It is very similar in composition, chemical structure and mechanism of action to erythromycin, azithromycin, or clarithromycin. Roxithromycin prevents bacteria from growing, by interfering with their protein synthesis. Roxithromycin binds to the subunit 50S of the bacterial ribosome, and thus inhibits the translocation of peptides. Roxithromycin has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila. It can treat respiratory tract, urinary and soft tissue infections.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01F - Macrolides, lincosamides and streptogramins > J01FA - Macrolides
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C784 - Protein Synthesis Inhibitor > C261 - Macrolide Antibiotic
C254 - Anti-Infective Agent > C258 - Antibiotic
同义名列表
53 个代谢物同义名
(3R,4S,5S,6R,7R,9R,11S,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,7,9,11,13-hexamethyl-10-(2,4,7-trioxa-1-azaoctan-1-ylidene)-1-oxacyclotetradecan-2-one; 9-[O-(2-methoxyethoxymethyl)-oxime] of erythromycin; CT-Arzneimittel brand OF roxithromycin; Infectopharm brand OF roxithromycin; Lichtenstein brand OF roxithromycin; Grünenthal brand OF roxithromycin; Merck dura brand OF roxithromycin; Betapharm brand OF roxithromycin; Alpharma brand OF roxithromycin; Hoechst brand OF roxithromycin; Aventis brand OF roxithromycin; Medeva brand OF roxithromycin; Pfizer brand OF roxithromycin; Basics brand OF roxithromycin; Wörwag brand OF roxithromycin; Knoll brand OF roxithromycin; Wolff brand OF roxithromycin; Hexal brand OF roxithromycin; Sigma brand OF roxithromycin; Faes brand OF roxithromycin; Juta brand OF roxithromycin; MTW Brand OF roxithromycin; MIP brand OF roxithromycin; TAD brand OF roxithromycin; Roxithromycin hexal brand; 1a Brand OF roxithromycin; Roxi-paed 1A Pharma; MTW-Roxithromycin; Roxi 1A Pharma; Roxithromycin; Roxithro-Lich; Infectoroxit; Roxi Basics; roxi von ct; Roxi-Wolff; Roxi-Puren; Roxi-saar; Roxigamma; Roxihexal; Rotramin; Roxigrün; Roxibeta; Macrosil; Roxi TAD; roxidura; Claramid; Rotesan; Biaxsig; Rulide; Roxi-Q; roxiβ; Rulid; Roxithromycin
数据库引用编号
20 个数据库交叉引用编号
- ChEBI: CHEBI:48844
- ChEBI: CHEBI:48935
- KEGG: C13173
- PubChem: 6915744
- PubChem: 5106
- HMDB: HMDB0014916
- Metlin: METLIN44347
- DrugBank: DB00778
- ChEMBL: CHEMBL1214185
- Wikipedia: Roxithromycin
- MeSH: Roxithromycin
- chemspider: 5291557
- CAS: 80214-83-1
- PMhub: MS000000774
- ChEBI: CHEBI:32109
- PubChem: 585237
- PDB-CCD: ROX
- NIKKAJI: J227.543K
- RefMet: Roxithromycin
- KNApSAcK: 32109
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jiahua Guo, Yi Bai, Zhi Chen, Jiezhang Mo, Qi Li, Haotian Sun, Qiang Zhang. Transcriptomic analysis suggests the inhibition of DNA damage repair in green alga Raphidocelis subcapitata exposed to roxithromycin.
Ecotoxicology and environmental safety.
2020 Sep; 201(?):110737. doi:
10.1016/j.ecoenv.2020.110737. [PMID: 32505758] - Abdelghani Mahmoudi, Mihaela Tertiş, Laura-Mihaela Simon, Ann Van Schepdael, Silvia De Francia, Lia-Monica Junie, Robert Săndulescu. Correlated quantification using microbiological and electrochemical assays for roxithromycin determination in biological and pharmaceutical samples.
Talanta.
2020 May; 211(?):120703. doi:
10.1016/j.talanta.2019.120703. [PMID: 32070606] - Xiang Liu, Chen Chen, Xiaoying Zhang. Drug-drug interaction of acetaminophen and roxithromycin with the cocktail of cytochrome P450 and hepatotoxicity in rats.
International journal of medical sciences.
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Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases.
2019 Nov; 42(11):845-851. doi:
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Zhonghua yi xue za zhi.
2019 Aug; 99(32):2542-2546. doi:
10.3760/cma.j.issn.0376-2491.2019.32.015. [PMID: 31484284] - Syed Faheem Askari Rizvi, Saleha Tariq, Muhammad Mehdi, Ahmad Junaid Hassan. Synthesis of 99m Tc-roxithromycin: A novel diagnostic agent to discriminate between septic and aseptic inflammation.
Chemical biology & drug design.
2019 06; 93(6):1166-1174. doi:
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Materials science & engineering. C, Materials for biological applications.
2019 Jun; 99(?):159-170. doi:
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Clinical therapeutics.
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Bioorganic & medicinal chemistry.
2008 Aug; 16(16):7691-7. doi:
10.1016/j.bmc.2008.07.009. [PMID: 18650096] - Jingwu Wang, Zhiming Yang, Xiaoxia Wang, Nianjun Yang. Capillary electrophoresis with gold nanoparticles enhanced electrochemiluminescence for the detection of roxithromycin.
Talanta.
2008 Jun; 76(1):85-90. doi:
10.1016/j.talanta.2008.02.006. [PMID: 18585245] - S A P Condé, F M Aarestrup, B J Vieira, M G Bastos. Roxithromycin reduces cyclosporine-induced gingival hyperplasia in renal transplant patients.
Transplantation proceedings.
2008 Jun; 40(5):1435-8. doi:
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Biomedical chromatography : BMC.
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2007 Dec; 7(12):1544-51. doi:
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Clinica chimica acta; international journal of clinical chemistry.
2007 Jul; 382(1-2):20-4. doi:
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Antimicrobial agents and chemotherapy.
2007 May; 51(5):1741-52. doi:
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Inflammatory bowel diseases.
2007 May; 13(5):547-56. doi:
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The Journal of rheumatology.
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Atherosclerosis.
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Analytical and bioanalytical chemistry.
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