Metoclopramide (BioDeep_00000001547)
Secondary id: BioDeep_00000408588
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
4-Amino-5-chloro-2-methoxy-N-(beta-diethylaminoethyl)benzamide
化学式: C14H22ClN3O2 (299.14)
中文名称: 甲氧氯普胺
谱图信息:
最多检出来源 Homo sapiens(blood) 46.54%
分子结构信息
SMILES: c1(cc(C(=O)NCCN(CC)CC)c(cc1N)OC)Cl
InChI: InChI=1S/C14H22ClN3O2/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3/h8-9H,4-7,16H2,1-3H3,(H,17,19)
描述信息
Metoclopramide is only found in individuals that have used or taken this drug. It is a dopamine D2 antagonist that is used as an antiemetic. [PubChem]Metoclopramide inhibits gastric smooth muscle relaxation produced by dopamine, therefore increasing cholinergic response of the gastrointestinal smooth muscle. It accelerates intestinal transit and gastric emptying by preventing relaxation of gastric body and increasing the phasic activity of antrum. Simultaneously, this action is accompanied by relaxation of the upper small intestine, resulting in an improved coordination between the body and antrum of the stomach and the upper small intestine. Metoclopramide also decreases reflux into the esophagus by increasing the resting pressure of the lower esophageal sphincter and improves acid clearance from the esophagus by increasing amplitude of esophageal peristaltic contractions. Metoclopramides dopamine antagonist action raises the threshold of activity in the chemoreceptor trigger zone and decreases the input from afferent visceral nerves. Studies have also shown that high doses of metoclopramide can antagonize 5-hydroxytryptamine (5-HT) receptors in the peripheral nervous system in animals.
A - Alimentary tract and metabolism > A03 - Drugs for functional gastrointestinal disorders > A03F - Propulsives > A03FA - Propulsives
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
EAWAG_UCHEM_ID 2781; CONFIDENCE standard compound
CONFIDENCE standard compound; EAWAG_UCHEM_ID 2781
D002491 - Central Nervous System Agents
同义名列表
35 个代谢物同义名
4-Amino-5-chloro-2-methoxy-N-(beta-diethylaminoethyl)benzamide; 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide; 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide; 2-Methoxy-4-amino-5-chloro-N,N-(dimethylaminoethyl)benzamide; 4-Amino-5-chloro-2-methoxy-N-(b-diethylaminoethyl)benzamide; 4-Amino-5-chloro-2-methoxy-N-(β-diethylaminoethyl)benzamide; 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-O-anisamide; Metoclopramide monohydrochloride, monohydrate; Temmler brand OF metoclopramide hydrochloride; Berk brand OF metoclopramide hydrochloride; Monohydrochloride, metoclopramide; Metoclopramide monohydrochloride; Dihydrochloride, metoclopramide; Metoclopramide dihydrochloride; 2-Methoxy-5-chloroprocainamide; Hydrochloride, metoclopramide; metoclopramide hydrochloride; Methochlopramide; Metoclopramidum; Methoclopramide; Metochlopramide; Metaclopramide; metoclopramide; Metoclopramida; Metaclopromide; Reliveran; Primperan; Terperan; Maxolon; Rimetin; Elieten; Cerucal; Reglan; Metoclopramide; Metoclopramide
数据库引用编号
31 个数据库交叉引用编号
- ChEBI: CHEBI:107736
- KEGG: C07868
- KEGGdrug: D00726
- PubChem: 4168
- HMDB: HMDB0015363
- Metlin: METLIN1244
- DrugBank: DB01233
- ChEMBL: CHEMBL86
- Wikipedia: Metoclopramide
- MeSH: Metoclopramide
- chemspider: 4024
- CAS: 364-62-5
- MoNA: EA278112
- MoNA: EA278108
- MoNA: EA278105
- MoNA: EA278102
- MoNA: EA278106
- MoNA: EA278114
- MoNA: EA278113
- MoNA: EA278103
- MoNA: EA278109
- MoNA: EA278104
- MoNA: EA278107
- MoNA: EA278110
- MoNA: EA278101
- MoNA: EA278111
- PMhub: MS000000745
- PubChem: 10070
- NIKKAJI: J2.037K
- RefMet: Metoclopramide
- KNApSAcK: 107736
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Juste Baranauskaite, Meryem Aydin, Burcu Uner, Cetin Tas. Formulation of Metoclopramide Hydrochloride-Loaded Lipid Carriers by QbD Approach for Combating Nausea: Safety and Bioavailability Evaluation in New Zealand Rabbit.
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Journal of hypertension.
2016 11; 34(11):2258-65. doi:
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Bioanalysis.
2016 Aug; 8(16):1693-707. doi:
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2016 Mar; 85(?):31-8. doi:
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Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2016 Feb; 57(2):309-14. doi:
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MMW Fortschritte der Medizin.
2015 Dec; 157(21-22):26. doi:
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Neuroscience letters.
2015 Oct; 606(?):60-5. doi:
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American family physician.
2015 Sep; 92(6):516-7. doi:
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Critical care (London, England).
2015 Feb; 19(?):61. doi:
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The Journal of veterinary medical science.
2015 Feb; 77(2):261-3. doi:
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Fundamental & clinical pharmacology.
2015 Feb; 29(1):86-94. doi:
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The Pan African medical journal.
2015; 20(?):264. doi:
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The American surgeon.
2015 Jan; 81(1):E32-3. doi:
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Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2014 Dec; 133(?):597-604. doi:
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MMW Fortschritte der Medizin.
2014 Nov; 156(19):80-1. doi:
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Phytotherapy research : PTR.
2014 Nov; 28(11):1687-91. doi:
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Drug research.
2014 Oct; 64(10):537-40. doi:
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Annals of transplantation.
2014 Aug; 19(?):417-20. doi:
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Journal of medicinal chemistry.
2014 Apr; 57(7):3005-10. doi:
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Headache.
2014 Feb; 54(2):260-8. doi:
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Brazilian journal of anesthesiology (Elsevier).
2014 Jan; 64(1):35-9. doi:
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The Journal of pharmacy and pharmacology.
2013 Nov; 65(11):1607-21. doi:
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Orphanet journal of rare diseases.
2013 Sep; 8(?):142. doi:
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Anatomia, histologia, embryologia.
2013 Aug; 42(4):239-46. doi:
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European review for medical and pharmacological sciences.
2013 Jun; 17(12):1655-7. doi:
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Trials.
2013 May; 14(?):153. doi:
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The Journal of veterinary medical science.
2013 May; 75(4):509-13. doi:
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Journal of pharmacological and toxicological methods.
2013 May; 67(3):129-33. doi:
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Journal of chromatographic science.
2013 Apr; 51(4):383-90. doi:
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Journal of physiology and biochemistry.
2013 Mar; 69(1):133-40. doi:
10.1007/s13105-012-0197-4. [PMID: 22806172] - Federico J Capparelli, Mauricio Abello, L Patricio Maskin, Eugenia Arista, Alejandro Hlavnicka, Maria Fernanda Diaz, Daniel Varela, Nestor A Wainsztein. QTc prolongation after brain surgery.
Neurological research.
2013 Mar; 35(2):159-62. doi:
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African journal of traditional, complementary, and alternative medicines : AJTCAM.
2013; 10(4):24-35. doi:
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Drug metabolism and pharmacokinetics.
2013; 28(6):453-61. doi:
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Kathmandu University medical journal (KUMJ).
2013 Jan; 11(41):9-13. doi:
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Progress in neuro-psychopharmacology & biological psychiatry.
2012 Dec; 39(2):332-8. doi:
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European journal of drug metabolism and pharmacokinetics.
2012 Dec; 37(4):279-88. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2012 Nov; 40(11):2162-73. doi:
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Peptides.
2012 Sep; 37(1):6-12. doi:
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Angiogenesis.
2012 Jun; 15(2):275-86. doi:
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American family physician.
2012 Apr; 85(7):705-10. doi:
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PLoS neglected tropical diseases.
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Archives of toxicology.
2011 Dec; 85(12):1565-73. doi:
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American journal of veterinary research.
2011 Dec; 72(12):1600-6. doi:
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Archives of pharmacal research.
2011 Oct; 34(10):1691-700. doi:
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The Korean journal of pain.
2011 Sep; 24(3):146-53. doi:
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Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2011 Sep; 42(3):518-20. doi:
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The Korean journal of parasitology.
2011 Sep; 49(3):273-5. doi:
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Journal of palliative medicine.
2011 Sep; 14(9):1004-8. doi:
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Analytical and bioanalytical chemistry.
2011 Aug; 401(3):1013-21. doi:
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Clinical pharmacokinetics.
2011 Aug; 50(8):519-30. doi:
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Journal of medicinal chemistry.
2011 Jul; 54(13):4548-58. doi:
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European journal of endocrinology.
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