Metoclopramide (BioDeep_00000001547)

 

Secondary id: BioDeep_00000408588

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


4-Amino-5-chloro-2-methoxy-N-(beta-diethylaminoethyl)benzamide

化学式: C14H22ClN3O2 (299.1400462)
中文名称: 甲氧氯普胺
谱图信息: 最多检出来源 Homo sapiens(blood) 7%

分子结构信息

SMILES: c1(cc(C(=O)NCCN(CC)CC)c(cc1N)OC)Cl
InChI: InChI=1S/C14H22ClN3O2/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3/h8-9H,4-7,16H2,1-3H3,(H,17,19)

描述信息

Metoclopramide is only found in individuals that have used or taken this drug. It is a dopamine D2 antagonist that is used as an antiemetic. [PubChem]Metoclopramide inhibits gastric smooth muscle relaxation produced by dopamine, therefore increasing cholinergic response of the gastrointestinal smooth muscle. It accelerates intestinal transit and gastric emptying by preventing relaxation of gastric body and increasing the phasic activity of antrum. Simultaneously, this action is accompanied by relaxation of the upper small intestine, resulting in an improved coordination between the body and antrum of the stomach and the upper small intestine. Metoclopramide also decreases reflux into the esophagus by increasing the resting pressure of the lower esophageal sphincter and improves acid clearance from the esophagus by increasing amplitude of esophageal peristaltic contractions. Metoclopramides dopamine antagonist action raises the threshold of activity in the chemoreceptor trigger zone and decreases the input from afferent visceral nerves. Studies have also shown that high doses of metoclopramide can antagonize 5-hydroxytryptamine (5-HT) receptors in the peripheral nervous system in animals.
A - Alimentary tract and metabolism > A03 - Drugs for functional gastrointestinal disorders > A03F - Propulsives > A03FA - Propulsives
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
EAWAG_UCHEM_ID 2781; CONFIDENCE standard compound
CONFIDENCE standard compound; EAWAG_UCHEM_ID 2781
D002491 - Central Nervous System Agents

同义名列表

33 个代谢物同义名

4-Amino-5-chloro-2-methoxy-N-(beta-diethylaminoethyl)benzamide; 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide; 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide; 2-Methoxy-4-amino-5-chloro-N,N-(dimethylaminoethyl)benzamide; 4-Amino-5-chloro-2-methoxy-N-(b-diethylaminoethyl)benzamide; 4-Amino-5-chloro-2-methoxy-N-(β-diethylaminoethyl)benzamide; 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-O-anisamide; Metoclopramide monohydrochloride, monohydrate; Temmler brand OF metoclopramide hydrochloride; Berk brand OF metoclopramide hydrochloride; Monohydrochloride, metoclopramide; Metoclopramide monohydrochloride; Dihydrochloride, metoclopramide; Metoclopramide dihydrochloride; 2-Methoxy-5-chloroprocainamide; Hydrochloride, metoclopramide; metoclopramide hydrochloride; Methochlopramide; Metoclopramidum; Methoclopramide; Metochlopramide; Metaclopramide; metoclopramide; Metoclopramida; Metaclopromide; Reliveran; Primperan; Terperan; Maxolon; Rimetin; Elieten; Cerucal; Reglan



数据库引用编号

30 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Juste Baranauskaite, Meryem Aydin, Burcu Uner, Cetin Tas. Formulation of Metoclopramide Hydrochloride-Loaded Lipid Carriers by QbD Approach for Combating Nausea: Safety and Bioavailability Evaluation in New Zealand Rabbit. AAPS PharmSciTech. 2024 Apr; 25(4):73. doi: 10.1208/s12249-024-02791-0. [PMID: 38575825]
  • Hyun-Ku Lee, Chul Jin, Seungwon Kwon, Bo-Hyoung Jang, Jin Pyeong Jeon, Ye-Seul Lee, Seung-Bo Yang, Woo-Sang Jung, Sang-Kwan Moon, Ki-Ho Cho. Treatment of nausea and vomiting associated with cerebellar infarction using the traditional herbal medicines banhabaekchulcheonma-tang and oryeong-san: Two case reports (CARE-complaint). Explore (New York, N.Y.). 2023 Jan; 19(1):141-146. doi: 10.1016/j.explore.2021.11.011. [PMID: 34911662]
  • Die Wang, Changyan Zi, Baocheng Zhang, Baojia Wang, Tao Chen, Long Wang, Yongxiang Gao. Effectiveness and safety of metoclopramide in treatment of intractable hiccup: a protocol of systematic review and meta-analysis. BMJ open. 2022 10; 12(10):e059887. doi: 10.1136/bmjopen-2021-059887. [PMID: 36202584]
  • A A Sher, A Iqbal, M Adil, S Ullah, S Bawazeer, M K Binmahri, L Z Zamil, M Irfan. GC-MS analysis of organic fractions of Chrozophora tinctoria (L.) A.Juss. and their prokinetic propensity in animal models. Brazilian journal of biology = Revista brasleira de biologia. 2022; 84(?):e260566. doi: 10.1590/1519-6984.260566. [PMID: 35613215]
  • Flavia Storelli, Olena Anoshchenko, Jashvant D Unadkat. Successful Prediction of Human Steady-State Unbound Brain-to-Plasma Concentration Ratio of P-gp Substrates Using the Proteomics-Informed Relative Expression Factor Approach. Clinical pharmacology and therapeutics. 2021 08; 110(2):432-442. doi: 10.1002/cpt.2227. [PMID: 33675056]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Yifan Chen, Min Zhang, Xinghao Ji, Jinjin Zhao, Shuang Qin, Yinghua Ji, Ruijuan Fan, Yanting Liu, Ping Lu. The anti-cancer effect of metoclopramide on triple-negative breast cancer cells. Die Pharmazie. 2021 04; 76(4):172-174. doi: 10.1691/ph.2021.0977. [PMID: 33849703]
  • Akbar Dorgalaleh, Ali Dabbagh, Shadi Tabibian, Mehran Bahraini, Hassan Rafieemehr. Persistent hiccups in a patient with mild congenital factor V deficiency and COVID-19; clinical and laboratory finding of a rare bleeding disorder. International journal of laboratory hematology. 2021 04; 43(2):e87-e88. doi: 10.1111/ijlh.13385. [PMID: 33174336]
  • Martin Bauer, Sandra Barna, Matthias Blaickner, Konstantin Prosenz, Karsten Bamminger, Verena Pichler, Nicolas Tournier, Marcus Hacker, Markus Zeitlinger, Georgios Karanikas, Oliver Langer. Human Biodistribution and Radiation Dosimetry of the P-Glycoprotein Radiotracer [11C]Metoclopramide. Molecular imaging and biology. 2021 04; 23(2):180-185. doi: 10.1007/s11307-021-01582-4. [PMID: 33481175]
  • Martin Bauer, Karsten Bamminger, Verena Pichler, Maria Weber, Simon Binder, Alexandra Maier-Salamon, Ammar Tahir, Walter Jäger, Helmuth Haslacher, Nicolas Tournier, Marcus Hacker, Markus Zeitlinger, Oliver Langer. Impaired Clearance From the Brain Increases the Brain Exposure to Metoclopramide in Elderly Subjects. Clinical pharmacology and therapeutics. 2021 03; 109(3):754-761. doi: 10.1002/cpt.2052. [PMID: 32966590]
  • Kun-Siang Huang, Bo-Lin Pan, Wei-An Lai, Pin-Jie Bin, Yao-Hsu Yang, Chia-Pei Chou. Could prokinetic agents protect long-term nasogastric tube-dependent patients from being hospitalized for pneumonia? A nationwide population-based case-crossover study. PloS one. 2021; 16(4):e0249645. doi: 10.1371/journal.pone.0249645. [PMID: 33819293]
  • Irene Hernández-Lozano, Severin Mairinger, Michael Sauberer, Johann Stanek, Thomas Filip, Thomas Wanek, Giuliano Ciarimboli, Nicolas Tournier, Oliver Langer. Influence of Cation Transporters (OCTs and MATEs) on the Renal and Hepatobiliary Disposition of [11C]Metoclopramide in Mice. Pharmaceutical research. 2021 Jan; 38(1):127-140. doi: 10.1007/s11095-021-03002-2. [PMID: 33559045]
  • Shufan Ge, Susan R Mendley, Jacqueline G Gerhart, Chiara Melloni, Christoph P Hornik, Janice E Sullivan, Andrew Atz, Paula Delmore, Adriana Tremoulet, Barrie Harper, Elizabeth Payne, Susan Lin, Jinson Erinjeri, Michael Cohen-Wolkowiez, Daniel Gonzalez. Population Pharmacokinetics of Metoclopramide in Infants, Children, and Adolescents. Clinical and translational science. 2020 11; 13(6):1189-1198. doi: 10.1111/cts.12803. [PMID: 32324313]
  • Jung-Woo Bae, Kyung-Yul Oh, So-Jung Yoon, Hyo-Bin Shin, Eui Hyun Jung, Chang-Keun Cho, Chang Woo Lim, Pureum Kang, Chang-Ik Choi, Choon-Gon Jang, Seok-Yong Lee, Yun Jeong Lee. Effects of CYP2D6 genetic polymorphism on the pharmacokinetics of metoclopramide. Archives of pharmacal research. 2020 Nov; 43(11):1207-1213. doi: 10.1007/s12272-020-01293-4. [PMID: 33247397]
  • Iram Kaukab, Syed Nisar Hussain Shah, Zelal Jaber Kharaba, Manal Ali Buabeid, Yaseen Abd Alfoteih, Ghulam Murtaza. Effect of clarithromycin pre-treatment on the pharmacokinetics of metoclopramide after their simultaneous oral intake. Expert opinion on drug metabolism & toxicology. 2020 Aug; 16(8):735-740. doi: 10.1080/17425255.2020.1779699. [PMID: 32524862]
  • Viktoria Zoufal, Severin Mairinger, Mirjam Brackhan, Markus Krohn, Thomas Filip, Michael Sauberer, Johann Stanek, Thomas Wanek, Nicolas Tournier, Martin Bauer, Jens Pahnke, Oliver Langer. Imaging P-Glycoprotein Induction at the Blood-Brain Barrier of a β-Amyloidosis Mouse Model with 11C-Metoclopramide PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2020 07; 61(7):1050-1057. doi: 10.2967/jnumed.119.237198. [PMID: 31806767]
  • Julien Wils, Céline Duparc, Anne-Françoise Cailleux, Antoine-Guy Lopez, Caroline Guiheneuf, Isabelle Boutelet, Hadrien-Gaël Boyer, Christophe Dubessy, Saloua Cherifi, Bruno Cauliez, Françoise Gobet, Guillaume Defortescu, Jean-François Ménard, Estelle Louiset, Hervé Lefebvre. The neuropeptide substance P regulates aldosterone secretion in human adrenals. Nature communications. 2020 05; 11(1):2673. doi: 10.1038/s41467-020-16470-8. [PMID: 32471973]
  • Siew Cheng Foong, May Loong Tan, Wai Cheng Foong, Lisa A Marasco, Jacqueline J Ho, Joo Howe Ong. Oral galactagogues (natural therapies or drugs) for increasing breast milk production in mothers of non-hospitalised term infants. The Cochrane database of systematic reviews. 2020 05; 5(?):CD011505. doi: 10.1002/14651858.cd011505.pub2. [PMID: 32421208]
  • Amir Reza Naemi, Vahid Kashanitabar, Alireza Kamali, Ashkan Shiva. Comparison of the Effects of Haloperidol, Metoclopramide, Dexmedetomidine and Ginger on Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy. Journal of medicine and life. 2020 Apr; 13(2):206-210. doi: 10.25122/jml-2019-0070. [PMID: 32742515]
  • Beata Irena Cejko, Sławomir Krejszeff, Sylwia Judycka, Katarzyna Targońska, Dariusz Kucharczyk. Effect of different treatment agents and post-treatment latency times on spermiation stimulation of northern pike (Esox lucius) under controlled conditions. Theriogenology. 2020 Jan; 142(?):260-267. doi: 10.1016/j.theriogenology.2019.10.035. [PMID: 31711700]
  • Cecilia Nwadiuto Amadi, Wisdom Izuchukwu Nwachukwu. The effects of oral administration of Cola nitida on the pharmacokinetic profile of metoclopramide in rabbits. BMC pharmacology & toxicology. 2020 01; 21(1):4. doi: 10.1186/s40360-019-0379-6. [PMID: 31907041]
  • Iram Kaukab, Syed Nisar Hussain Shah, Muhammad Asad Abrar, Naveed Anwer, Ghulam Murtaza. Influence of Rifampicin Pre-treatment on the In vivo Pharmacokinetics of Metoclopramide in Pakistani Healthy Volunteers Following Concurrent Oral Administration. Current drug metabolism. 2020; 21(4):301-306. doi: 10.2174/1389200221666200514132654. [PMID: 32407272]
  • Yusuke Marikawa, Hong-Ru Chen, Mark Menor, Youping Deng, Vernadeth B Alarcon. Exposure-based assessment of chemical teratogenicity using morphogenetic aggregates of human embryonic stem cells. Reproductive toxicology (Elmsford, N.Y.). 2020 01; 91(?):74-91. doi: 10.1016/j.reprotox.2019.10.004. [PMID: 31711903]
  • Mustafa Bilici, M Utku Badak, Adem Zengin, Zekiye Suludere, Nahit Aktas. Synthesis of magnetic halloysite nanotube-based molecularly imprinted polymers for sensitive spectrophotometric detection of metoclopramide in urine samples. Materials science & engineering. C, Materials for biological applications. 2020 Jan; 106(?):110223. doi: 10.1016/j.msec.2019.110223. [PMID: 31753383]
  • Ahmad Al-Saffar, Hans Lennernäs, Per M Hellström. Gastroparesis, metoclopramide, and tardive dyskinesia: Risk revisited. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 2019 11; 31(11):e13617. doi: 10.1111/nmo.13617. [PMID: 31050085]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Selen Gur-Ozmen, Ruhan Karahan-Ozcan. Factors Associated with Insulin Resistance in Women with Migraine: A Cross-Sectional Study. Pain medicine (Malden, Mass.). 2019 10; 20(10):2043-2050. doi: 10.1093/pm/pnz055. [PMID: 30938814]
  • Chao Jiang, Ting Wang, Zheng-Guo Qiu, Bo Chen, Bang-Jiang Fang. Efficacy of metoclopramide for the treatment of acute migraine. Medicine. 2019 Sep; 98(37):e17065. doi: 10.1097/md.0000000000017065. [PMID: 31517828]
  • Nicolas Tournier, Martin Bauer, Verena Pichler, Lukas Nics, Eva-Maria Klebermass, Karsten Bamminger, Peter Matzneller, Maria Weber, Rudolf Karch, Fabien Caillé, Sylvain Auvity, Solène Marie, Walter Jäger, Wolfgang Wadsak, Marcus Hacker, Markus Zeitlinger, Oliver Langer. Impact of P-Glycoprotein Function on the Brain Kinetics of the Weak Substrate 11C-Metoclopramide Assessed with PET Imaging in Humans. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2019 07; 60(7):985-991. doi: 10.2967/jnumed.118.219972. [PMID: 30630940]
  • Shirin Osouli Tabrizi, Mojgan Mirghafourvand, Abdollah Jannat Dost, Sakineh Mohammad-Alizadeh-Charandabi, Yousef Javadzadeh, Robabe Seyedi. Effect of metoclopramide administration to mothers on neonatal bilirubin and maternal prolactin: a randomized, controlled, clinical trial. World journal of pediatrics : WJP. 2019 Apr; 15(2):135-142. doi: 10.1007/s12519-018-0217-8. [PMID: 30519818]
  • Iram Kaukab, Syed Nisar Hussain Shah, Zelal Kharaba, Ghulam Murtaza, Abubaker Ali Saad, Shakeel Ahmad. Evaluation of Pharmacokinetic Interaction of Cilostazol with Metoclopramide after Oral Administration in Human. Current drug metabolism. 2019; 20(11):924-928. doi: 10.2174/1389200220666191105115805. [PMID: 31702486]
  • Noura H Abd Ellah, Esraa A Ahmed, Rasha B Abd-Ellatief, Marwa F Ali, Asmaa M Zahran, Helal F Hetta. Metoclopramide nanoparticles modulate immune response in a diabetic rat model: association with regulatory T cells and proinflammatory cytokines. International journal of nanomedicine. 2019; 14(?):2383-2395. doi: 10.2147/ijn.s196842. [PMID: 31040663]
  • Joanna Sikora, Piotr Niezgoda, Malwina Barańska, Katarzyna Buszko, Natalia Skibińska, Wiktor Sroka, Krzysztof Pstrągowski, Jolanta Siller-Matula, Jilma Bernd, Diana Gorog, Eliano Pio Navarese, Michał Piotr Marszałł, Jacek Kubica. METoclopramide Administration as a Strategy to Overcome MORPHine-ticagrelOr Interaction in PatientS with Unstable Angina PectorIS-The METAMORPHOSIS Trial. Thrombosis and haemostasis. 2018 Dec; 118(12):2126-2133. doi: 10.1055/s-0038-1675605. [PMID: 30453344]
  • Bei Hu, Xin Ouyang, Liming Lei, Cheng Sun, Ruibin Chi, Jian Guo, Wenlong Guo, Yanlin Zhang, Yong Li, Daoyong Huang, Huafeng Sun, Zhiqiang Nie, Jieyang Yu, Yuan Zhou, Hao Wang, Jinhe Zhang, Chunbo Chen. Erythromycin versus metoclopramide for post-pyloric spiral nasoenteric tube placement: a randomized non-inferiority trial. Intensive care medicine. 2018 Dec; 44(12):2174-2182. doi: 10.1007/s00134-018-5466-4. [PMID: 30465070]
  • Laura J Henze, Brendan T Griffin, Martin Christiansen, Christoffer Bundgaard, Peter Langguth, René Holm. Exploring gastric emptying rate in minipigs: Effect of food type and pre-dosing of metoclopramide. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2018 Jun; 118(?):183-190. doi: 10.1016/j.ejps.2018.03.017. [PMID: 29559403]
  • James B Leonard, Kashif M Munir, Hong K Kim. Metoclopramide induced pheochromocytoma crisis. The American journal of emergency medicine. 2018 Jun; 36(6):1124.e1-1124.e2. doi: 10.1016/j.ajem.2018.03.009. [PMID: 29534916]
  • Gina Della Togna, Brian Gratwicke, Matthew Evans, Lauren Augustine, Han Chia, Ed Bronikowski, James B Murphy, Pierre Comizzoli. Influence of extracellular environment on the motility and structural properties of spermatozoa collected from hormonally stimulated Panamanian Golden Frog (Atelopus zeteki). Theriogenology. 2018 Mar; 108(?):153-160. doi: 10.1016/j.theriogenology.2017.11.032. [PMID: 29216539]
  • Ying Li, Xianpeng Fan, Wanqing Li, Peng Yang, Hui Zhang, Daoquan Tang, Xiaoxin Yin, Jianxu Sun, Aiping Zheng. Metoclopramide nasal spray in vitro evaluation and in vivo pharmacokinetic studies in dogs. Pharmaceutical development and technology. 2018 Mar; 23(3):275-281. doi: 10.1080/10837450.2017.1316734. [PMID: 28379057]
  • S K Zhang, W B Gao, Y Liu, H He. [Therapeutic effect of cervical Jiaji electroacupuncture on postoperative intractable hiccup of liver neoplasms]. Zhonghua zhong liu za zhi [Chinese journal of oncology]. 2018 Feb; 40(2):138-140. doi: 10.3760/cma.j.issn.0253-3766.2018.02.011. [PMID: 29502375]
  • Stefanie R Keller, Zsolt Abonyi-Tóth, Norbert Sprenger, Sean C Austin, Brigitta A C Wichert, Annette Liesegang, Christine H Y Oei, Orsolya Balogh, Iris M Reichler. Effect of metoclopramide treatment of bitches during the first week of lactation on serum prolactin concentration, milk composition, and milk yield and on weight gain of their puppies. American journal of veterinary research. 2018 Feb; 79(2):233-241. doi: 10.2460/ajvr.79.2.233. [PMID: 29359978]
  • Fabien Caillé, Sébastien Goutal, Solène Marie, Sylvain Auvity, Salvatore Cisternino, Bertrand Kuhnast, Géraldine Pottier, Nicolas Tournier. Positron Emission Tomography Imaging Reveals an Importance of Saturable Liver Uptake Transport for the Pharmacokinetics of Metoclopramide. Contrast media & molecular imaging. 2018; 2018(?):7310146. doi: 10.1155/2018/7310146. [PMID: 29853808]
  • Suxian Luan, Meiling Mu, Liangzhi Sun. The mechanism of selfheal extract in treating hyperprolactinemia. Cancer biomarkers : section A of Disease markers. 2017 Dec; 20(4):575-580. doi: 10.3233/cbm-170454. [PMID: 28946556]
  • Hannah Kenward, Jonathan Elliott, Terry Lee, Ludovic Pelligand. Anti-nausea effects and pharmacokinetics of ondansetron, maropitant and metoclopramide in a low-dose cisplatin model of nausea and vomiting in the dog: a blinded crossover study. BMC veterinary research. 2017 Aug; 13(1):244. doi: 10.1186/s12917-017-1156-7. [PMID: 28814338]
  • Yuanyi Wei, Lei La, Lili Wang, Robert Batey, Chunxia Wang, Yuhao Li. Paeoniflorin and liquiritin, two major constituents in Chinese herbal formulas used to treat hyperprolactinemia-associated disorders, inhibits prolactin secretion in prolactinoma cells by different mechanisms. Journal of ethnopharmacology. 2017 May; 204(?):36-44. doi: 10.1016/j.jep.2017.03.054. [PMID: 28396166]
  • Ahmed Madisch, Bettina R Vinson, Heba Abdel-Aziz, Olaf Kelber, Karen Nieber, Karin Kraft, Martin Storr. Modulation of gastrointestinal motility beyond metoclopramide and domperidone : Pharmacological and clinical evidence for phytotherapy in functional gastrointestinal disorders. Wiener medizinische Wochenschrift (1946). 2017 May; 167(7-8):160-168. doi: 10.1007/s10354-017-0557-3. [PMID: 28424994]
  • Emilie Zingler, Angélica Amorim Amato, Alysson Zanatta, Maria de Fátima Brito Vogt, Miriam da Silva Wanderley, Coríntio Mariani Neto, Alberto Moreno Zaconeta. Lactation Induction in a Commissioned Mother by Surrogacy: Effects on Prolactin Levels, Milk Secretion and Mother Satisfaction. Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia. 2017 Feb; 39(2):86-89. doi: 10.1055/s-0037-1598641. [PMID: 28257588]
  • Carsten Stoetzer, Marc Voelker, Thorben Doll, Joerg Heineke, Florian Wegner, Andreas Leffler. Cardiotoxic Antiemetics Metoclopramide and Domperidone Block Cardiac Voltage-Gated Na+ Channels. Anesthesia and analgesia. 2017 01; 124(1):52-60. doi: 10.1213/ane.0000000000001673. [PMID: 27861438]
  • Ahmad Khan, Jallat Khan, Muhammad Irfan, Syed Baqir Shyum Naqvi, Gul Majid Khan, Muhammad Harris Shoaib, Rabia Ismail Yousaf, Amjad Khan. Validation and application of high performance liquid chromatographic method for the estimation of metoclopramide hydrochloride in plasma. Pakistan journal of pharmaceutical sciences. 2017 Jan; 30(1):143-147. doi: NULL. [PMID: 28603124]
  • Giacomo Rossitto, Diego Miotto, Michele Battistel, Giulio Barbiero, Giuseppe Maiolino, Valeria Bisogni, Viola Sanga, Gian Paolo Rossi. Metoclopramide unmasks potentially misleading contralateral suppression in patients undergoing adrenal vein sampling for primary aldosteronism. Journal of hypertension. 2016 11; 34(11):2258-65. doi: 10.1097/hjh.0000000000001082. [PMID: 27512976]
  • Venkateswaran Shekar, Abhi Shah, Mohammad Shadid, Jing-Tao Wu, Jayaprakasam Bolleddula, Swapan Chowdhury. An accelerated background subtraction algorithm for processing high-resolution MS data and its application to metabolite identification. Bioanalysis. 2016 Aug; 8(16):1693-707. doi: 10.4155/bio-2016-0101. [PMID: 27460980]
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