Flonicamid (BioDeep_00000001541)

   

natural product


代谢物信息卡片


Pesticide4_Flonicamid_C9H6F3N3O_N-(Cyanomethyl)-4-(trifluoromethyl)nicotinamide

化学式: C9H6F3N3O (229.0463)
中文名称: 氟啶虫酰胺
谱图信息: 最多检出来源 Viridiplantae(plant) 25.08%

分子结构信息

SMILES: C1=CN=CC(=C1C(F)(F)F)C(=O)NCC#N
InChI: InChI=1S/C9H6F3N3O/c10-9(11,12)7-1-3-14-5-6(7)8(16)15-4-2-13/h1,3,5H,4H2,(H,15,16)

描述信息

D010575 - Pesticides > D007306 - Insecticides
D016573 - Agrochemicals
CONFIDENCE standard compound; EAWAG_UCHEM_ID 2943
EAWAG_UCHEM_ID 2943; CONFIDENCE standard compound

同义名列表

3 个代谢物同义名

Flonicamid; Pesticide4_Flonicamid_C9H6F3N3O_N-(Cyanomethyl)-4-(trifluoromethyl)nicotinamide; Flonicamid



数据库引用编号

31 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 ANXA5, ARHGAP45, CYP2D6, PPM1G
Peripheral membrane protein 1 ANXA5
Endosome membrane 1 SORT1
Endoplasmic reticulum membrane 2 CYP2D6, SORT1
Nucleus 2 KDR, PPM1G
cytosol 4 ANXA5, ARHGAP45, KCNA6, SORT1
nucleoplasm 1 PPM1G
Cell membrane 4 KCNA6, KCNE1, KDR, TRPV4
Lipid-anchor 1 PPM1G
lamellipodium 1 TRPV4
ruffle membrane 2 ARHGAP45, TRPV4
Multi-pass membrane protein 3 KCNA3, KCNA6, TRPV4
cell junction 1 KDR
cell surface 3 KCNE1, SORT1, TRPV4
glutamatergic synapse 1 KCNA3
Golgi apparatus 2 KDR, SORT1
growth cone 1 TRPV4
lysosomal membrane 1 SORT1
presynaptic membrane 1 KCNA3
sarcolemma 1 ANXA5
Lysosome 2 KCNE1, SORT1
endosome 1 KDR
plasma membrane 7 ARHGAP45, KCNA3, KCNA6, KCNE1, KDR, SORT1, TRPV4
Membrane 8 ANXA5, ARHGAP45, CYP2D6, KCNA3, KCNA6, PPM1G, SORT1, TRPV4
apical plasma membrane 2 KCNE1, TRPV4
axon 1 KCNA3
extracellular exosome 1 ANXA5
Lysosome membrane 1 SORT1
endoplasmic reticulum 3 CYP2D6, KDR, TRPV4
perinuclear region of cytoplasm 2 KCNA3, SORT1
adherens junction 1 TRPV4
mitochondrion 1 CYP2D6
intracellular membrane-bounded organelle 2 CYP2D6, KCNA6
Microsome membrane 1 CYP2D6
filopodium 1 TRPV4
Single-pass type I membrane protein 2 KCNE1, SORT1
extracellular region 3 ANXA5, ARHGAP45, KDR
Single-pass membrane protein 1 CYP2D6
[Isoform 2]: Secreted 1 KDR
anchoring junction 1 KDR
Cell projection, cilium 1 TRPV4
Nucleus membrane 1 SORT1
nuclear membrane 1 SORT1
external side of plasma membrane 2 ANXA5, KDR
Z disc 1 KCNE1
cytoplasmic vesicle 1 SORT1
Early endosome 2 KDR, SORT1
clathrin-coated pit 1 SORT1
postsynaptic membrane 1 KCNA3
Apical cell membrane 2 KCNE1, TRPV4
Cell projection, ruffle membrane 1 ARHGAP45
Membrane raft 3 KCNA3, KCNE1, KDR
focal adhesion 2 ANXA5, TRPV4
Cell junction, adherens junction 1 TRPV4
collagen-containing extracellular matrix 1 ANXA5
receptor complex 1 KDR
Zymogen granule membrane 1 ANXA5
cilium 1 TRPV4
[Isoform 2]: Cell membrane 1 KCNA3
sorting endosome 1 KDR
Golgi cisterna membrane 1 SORT1
clathrin-coated vesicle 1 SORT1
potassium channel complex 1 KCNA6
voltage-gated potassium channel complex 3 KCNA3, KCNA6, KCNE1
trans-Golgi network transport vesicle 1 SORT1
secretory granule lumen 1 ARHGAP45
cortical actin cytoskeleton 1 TRPV4
axon terminus 1 KCNA6
azurophil granule lumen 1 ARHGAP45
Golgi apparatus, Golgi stack membrane 1 SORT1
calyx of Held 1 KCNA3
vesicle membrane 1 ANXA5
cytoplasmic microtubule 1 TRPV4
[Isoform 1]: Cell membrane 2 KCNA3, TRPV4
cerebellar climbing fiber to Purkinje cell synapse 1 SORT1
[Isoform 2]: Endoplasmic reticulum 1 TRPV4
endothelial microparticle 1 ANXA5
[Isoform 5]: Cell membrane 1 TRPV4
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3
[Isoform 4]: Endoplasmic reticulum 1 TRPV4
[Isoform 6]: Endoplasmic reticulum 1 TRPV4


文献列表

  • Xue-Xiu Yu, Ke-Xin Chen, Pan-Pan Yuan, Yu-He Wang, Hua-Xiao Li, Yun-Xiu Zhao, Yi-Jun Dai. Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit-like amidase mediates the degradation of insecticide flonicamid by Variovorax boronicumulans CGMCC 4969. The Science of the total environment. 2024 Jun; 928(?):172479. doi: 10.1016/j.scitotenv.2024.172479. [PMID: 38621543]
  • Konstantinos Samaras, Maria L Pappas, Alberto Pozzebon, George D Broufas. Pollen provisioning attenuates pesticide side-effects on a phytoseiid predator. Pest management science. 2024 Jan; ?(?):. doi: 10.1002/ps.7969. [PMID: 38294174]
  • Hina Gul, Ihsan Ul Haq, Farman Ullah, Shanza Khan, Aqsa Yaseen, Said Hussain Shah, Kaleem Tariq, Ali Güncan, Nicolas Desneux, Xiaoxia Liu. Impact of sublethal concentrations of flonicamid on key demographic parameters and feeding behavior of Schizaphis graminum. Ecotoxicology (London, England). 2023 Jul; ?(?):. doi: 10.1007/s10646-023-02682-3. [PMID: 37462788]
  • Huadong Tan, Licheng Wang, Ling Mo, Chunyuan Wu, Qiao Xing, Xiaoying Zhang, Xiao Deng, Yi Li, Qinfen Li. Occurrence and ecological risks of flonicamid and its metabolites in multiple substrates from intensive rice-vegetable rotations in tropical China. The Science of the total environment. 2023 Jul; 899(?):165571. doi: 10.1016/j.scitotenv.2023.165571. [PMID: 37459992]
  • Huoyong Jiang, Nengdang Jiang, Li Wang, Jingjing Guo, Kexin Chen, Yijun Dai. Characterization of nitrilases from Variovorax boronicumulans that functions in insecticide flonicamid degradation and β-cyano-L-alanine detoxification. Journal of applied microbiology. 2022 Aug; 133(2):311-322. doi: 10.1111/jam.15561. [PMID: 35365856]
  • Farag Malhat, Mona Bakery, Chris Anagnostopoulos, Mohamed Youssef, Walaa Abd El-Ghany, Amira Abdallah, Shokr Abd El-Salam. Investigation of the dissipation behaviour and exposure of spitotetramat, flonicamid, imidacloprid and pymetrozine in open field strawberries in Egypt. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2021 Dec; 38(12):2128-2136. doi: 10.1080/19440049.2021.1973113. [PMID: 34525319]
  • Naeem Abbas, Muhammad Abubakar, Muhammad Waqar Hassan, Sarfraz Ali Shad, Abdulwahab M Hafez. Risk Assessment of Flonicamid Resistance in Musca domestica (Diptera: Muscidae): Resistance Monitoring, Inheritance, and Cross-Resistance Potential. Journal of medical entomology. 2021 07; 58(4):1779-1787. doi: 10.1093/jme/tjab036. [PMID: 33758935]
  • Inam Ullah, Shabana Wazir, Naeem Abbas, Muhammad Naeem, Khalid Abdullah, Zahid Mahmood, Mamoon-Ur Rashid, Abdulwahab M Hafez. Monitoring of field-evolved resistance to flonicamid, neonicotinoid, and conventional insecticides in the Oxycarenus hyalinipennis costa. Environmental monitoring and assessment. 2021 Jun; 193(7):382. doi: 10.1007/s10661-021-09158-z. [PMID: 34089115]
  • Xiangkun Meng, Zhaolu Wu, Xuemei Yang, Kun Qian, Nan Zhang, Heng Jiang, Xingcan Yin, Daojie Guan, Yang Zheng, Jianjun Wang. Flonicamid and knockdown of inward rectifier potassium channel gene CsKir2B adversely affect the feeding and development of Chilo suppressalis. Pest management science. 2021 Apr; 77(4):2045-2053. doi: 10.1002/ps.6232. [PMID: 33342029]
  • Saqib Rahman, Zhenzhen Zhao, Muhammad Umair Sial, Yanning Zhang, Hongyun Jiang. Case Study Using Recommended Reference Genes Actin and 18S for Reverse-Transcription Quantitative Real-Time PCR Analysis in Myzus persicae. PloS one. 2021; 16(10):e0258201. doi: 10.1371/journal.pone.0258201. [PMID: 34669698]
  • Hui Jiang, Yongqing Tian, Jianjun Chen, Zhixiang Zhang, Hanhong Xu. Enhanced uptake of drip-applied flonicamid by arbuscular mycorrhizal fungi and improved control of cotton aphid. Pest management science. 2020 Dec; 76(12):4222-4230. doi: 10.1002/ps.5979. [PMID: 32594648]
  • Ali Taheri Mirghaed, Melika Baes, Seyyed Morteza Hoseini. Humoral immune responses and gill antioxidant-related gene expression of common carp (Cyprinus carpio) exposed to lufenuron and flonicamide. Fish physiology and biochemistry. 2020 Apr; 46(2):739-746. doi: 10.1007/s10695-019-00747-x. [PMID: 31848827]
  • Peter M Piermarini, Edna Alfaro Inocente, Nuris Acosta, Corey R Hopkins, Jerod S Denton, Andrew P Michel. Inward rectifier potassium (Kir) channels in the soybean aphid Aphis glycines: Functional characterization, pharmacology, and toxicology. Journal of insect physiology. 2018 10; 110(?):57-65. doi: 10.1016/j.jinsphys.2018.09.001. [PMID: 30196125]
  • Quan Zhang, Ximing Wang, Zhe Li, Hangbiao Jin, Zhengbiao Lu, Chang Yu, Yu-Fang Huang, Meirong Zhao. Simultaneous determination of nine neonicotinoids in human urine using isotope-dilution ultra-performance liquid chromatography-tandem mass spectrometry. Environmental pollution (Barking, Essex : 1987). 2018 Sep; 240(?):647-652. doi: 10.1016/j.envpol.2018.04.144. [PMID: 29772515]
  • Miaomiao Ren, Jianguo Niu, Bo Hu, Qi Wei, Cheng Zheng, Xiangrui Tian, Congfen Gao, Bingjun He, Ke Dong, Jianya Su. Block of Kir channels by flonicamid disrupts salivary and renal excretion of insect pests. Insect biochemistry and molecular biology. 2018 08; 99(?):17-26. doi: 10.1016/j.ibmb.2018.05.007. [PMID: 29842935]
  • Jiaxin Li, Yujie Wang, Jian Xue, Pengsi Wang, Shangmei Shi. Dietary Exposure Risk Assessment of Flonicamid and Its Effect on Constituents after Application in Lonicerae Japonicae Flos. Chemical & pharmaceutical bulletin. 2018 Jun; 66(6):608-611. doi: 10.1248/cpb.c17-00985. [PMID: 29540625]
  • Shao-Yan Hou, Yu-Jie Wang, Jian Xue, Jia-Xin Li, Peng-Si Wang. [Research on control effect of sulfoxaflor and flonicamid on Lonicera japonica]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2018 Jan; 43(2):306-308. doi: 10.19540/j.cnki.cjcmm.20171030.007. [PMID: 29552848]
  • Kaleem Tariq, Mah Noor, Elaine A Backus, Adil Hussain, Asad Ali, Wei Peng, Hongyu Zhang. The toxicity of flonicamid to cotton leafhopper, Amrasca biguttula (Ishida), is by disruption of ingestion: an electropenetrography study. Pest management science. 2017 Aug; 73(8):1661-1669. doi: 10.1002/ps.4508. [PMID: 27990759]
  • Ramani Kandasamy, Damian London, Lynn Stam, Wolfgang von Deyn, Xilong Zhao, Vincent L Salgado, Alexandre Nesterov. Afidopyropen: New and potent modulator of insect transient receptor potential channels. Insect biochemistry and molecular biology. 2017 05; 84(?):32-39. doi: 10.1016/j.ibmb.2017.03.005. [PMID: 28347703]
  • Yujie Wang, Jian Xue, Hongyu Jin, Shuangcheng Ma. Dissipation of Flonicamid in Honeysuckle and Its Transfer during Brewing Process. Chemical & pharmaceutical bulletin. 2017 May; 65(5):492-497. doi: 10.1248/cpb.c16-01015. [PMID: 28320974]
  • Kurt Put, Tim Bollens, Felix Wäckers, Apostolos Pekas. Non-target effects of commonly used plant protection products in roses on the predatory mite Euseius gallicus Kreiter & Tixier (Acari: Phytoseidae). Pest management science. 2016 Jul; 72(7):1373-80. doi: 10.1002/ps.4162. [PMID: 26434923]
  • Ralf Nauen, Katharina Wölfel, Bettina Lueke, Antonis Myridakis, Dimitra Tsakireli, Emmanouil Roditakis, Anastasia Tsagkarakou, Euripides Stephanou, John Vontas. Development of a lateral flow test to detect metabolic resistance in Bemisia tabaci mediated by CYP6CM1, a cytochrome P450 with broad spectrum catalytic efficiency. Pesticide biochemistry and physiology. 2015 Jun; 121(?):3-11. doi: 10.1016/j.pestbp.2014.12.023. [PMID: 26047106]
  • Emmanouil Roditakis, Natasa Fytrou, Marianna Staurakaki, John Vontas, Anastasia Tsagkarakou. Activity of flonicamid on the sweet potato whitely Bemisia tabaci (Homoptera: Aleyrodidae) and its natural enemies. Pest management science. 2014 Oct; 70(10):1460-7. doi: 10.1002/ps.3723. [PMID: 24408346]
  • Peter Asiimwe, Steven E Naranjo, Peter C Ellsworth. Effects of irrigation levels on interactions among Lygus hesperus (Hemiptera: Miridae), insecticides, and predators in cotton. Environmental entomology. 2014 Apr; 43(2):263-73. doi: 10.1603/en12328. [PMID: 24533912]
  • Raymond A Cloyd, Nicholas R Timmons, Jessica M Goebel, Kenneth E Kemp. Effect of pesticides on adult rove beetle Atheta coriaria (Coleoptera: Staphylinidae) survival in growing medium. Journal of economic entomology. 2009 Oct; 102(5):1750-8. doi: 10.1603/029.102.0504. [PMID: 19886438]
  • Angela Fanigliulo, Vittorio Filì, Rosa Pacella, Soccorsa Comes, Aniello Crescenzi. Teppeki, selective insecticide about Bombus terrestris. Communications in agricultural and applied biological sciences. 2009; 74(2):407-10. doi: . [PMID: 20222598]
  • Masayuki Morita, Tsuyoshi Ueda, Tetsuo Yoneda, Tohru Koyanagi, Takahiro Haga. Flonicamid, a novel insecticide with a rapid inhibitory effect on aphid feeding. Pest management science. 2007 Oct; 63(10):969-73. doi: 10.1002/ps.1423. [PMID: 17659536]