warfarin (BioDeep_00000015385)

 

Secondary id: BioDeep_00000001524


代谢物信息卡片


(S)-Warfarin

化学式: C19H16O4 (308.1049)
中文名称: S-文拉法辛, 华法林
谱图信息: 最多检出来源 Viridiplantae(plant) 11.33%

分子结构信息

SMILES: CC(=O)CC(C1=CC=CC=C1)C1=C(O)C2=CC=CC=C2OC1=O
InChI: InChI=1S/C19H16O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,15,21H,11H2,1H3

描述信息

A hydroxycoumarin that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.
C78275 - Agent Affecting Blood or Body Fluid > C263 - Anticoagulant Agent
B - Blood and blood forming organs > B01 - Antithrombotic agents > B01A - Antithrombotic agents > B01AA - Vitamin k antagonists
C78275 - Agent Affecting Blood or Body Fluid > C263 - Anticoagulant Agent > C173064 - Vitamin K Antagonist
D006401 - Hematologic Agents > D000925 - Anticoagulants > D015110 - 4-Hydroxycoumarins
D010575 - Pesticides > D012378 - Rodenticides
D016573 - Agrochemicals
Warfarin is a rodenticide used in the home, outdoors, in food service establishments, near fruit trees, in storage buildings, sewers and other places where rodents may be a problem. This white, odorless, tasteless compound, an anti-coagulant, causes bleeding and blood-thinning. [HMDB]
CONFIDENCE standard compound; INTERNAL_ID 1289; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4694; ORIGINAL_PRECURSOR_SCAN_NO 4690
CONFIDENCE standard compound; INTERNAL_ID 1289; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4720; ORIGINAL_PRECURSOR_SCAN_NO 4717
CONFIDENCE standard compound; INTERNAL_ID 1289; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4676; ORIGINAL_PRECURSOR_SCAN_NO 4675
CONFIDENCE standard compound; INTERNAL_ID 1289; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4690; ORIGINAL_PRECURSOR_SCAN_NO 4686
CONFIDENCE standard compound; INTERNAL_ID 1289; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4734; ORIGINAL_PRECURSOR_SCAN_NO 4730
CONFIDENCE standard compound; INTERNAL_ID 1289; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4724; ORIGINAL_PRECURSOR_SCAN_NO 4721
CONFIDENCE standard compound; INTERNAL_ID 1289; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9135; ORIGINAL_PRECURSOR_SCAN_NO 9131
CONFIDENCE standard compound; INTERNAL_ID 1289; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9068; ORIGINAL_PRECURSOR_SCAN_NO 9067
CONFIDENCE standard compound; INTERNAL_ID 1289; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9082; ORIGINAL_PRECURSOR_SCAN_NO 9080
CONFIDENCE standard compound; INTERNAL_ID 1289; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9187; ORIGINAL_PRECURSOR_SCAN_NO 9186
CONFIDENCE standard compound; INTERNAL_ID 1289; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9209; ORIGINAL_PRECURSOR_SCAN_NO 9207
CONFIDENCE standard compound; INTERNAL_ID 1289; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9110; ORIGINAL_PRECURSOR_SCAN_NO 9108
CONFIDENCE standard compound; INTERNAL_ID 377; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4721; ORIGINAL_PRECURSOR_SCAN_NO 4716
CONFIDENCE standard compound; INTERNAL_ID 377; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4720; ORIGINAL_PRECURSOR_SCAN_NO 4719
CONFIDENCE standard compound; INTERNAL_ID 377; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4745; ORIGINAL_PRECURSOR_SCAN_NO 4744
CONFIDENCE standard compound; INTERNAL_ID 377; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4738; ORIGINAL_PRECURSOR_SCAN_NO 4733
CONFIDENCE standard compound; INTERNAL_ID 377; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4832; ORIGINAL_PRECURSOR_SCAN_NO 4831
CONFIDENCE standard compound; INTERNAL_ID 377; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4726; ORIGINAL_PRECURSOR_SCAN_NO 4723
CONFIDENCE standard compound; INTERNAL_ID 377; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9106; ORIGINAL_PRECURSOR_SCAN_NO 9104
CONFIDENCE standard compound; INTERNAL_ID 377; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9133; ORIGINAL_PRECURSOR_SCAN_NO 9130
CONFIDENCE standard compound; INTERNAL_ID 377; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9163; ORIGINAL_PRECURSOR_SCAN_NO 9159
CONFIDENCE standard compound; INTERNAL_ID 377; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9170; ORIGINAL_PRECURSOR_SCAN_NO 9166
CONFIDENCE standard compound; INTERNAL_ID 377; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9145; ORIGINAL_PRECURSOR_SCAN_NO 9142
CONFIDENCE standard compound; INTERNAL_ID 377; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9185; ORIGINAL_PRECURSOR_SCAN_NO 9180
CONFIDENCE standard compound; INTERNAL_ID 2415
CONFIDENCE standard compound; INTERNAL_ID 4042
CONFIDENCE standard compound; INTERNAL_ID 8347
INTERNAL_ID 4042; CONFIDENCE standard compound

同义名列表

3 个代谢物同义名

warfarin; (S)-Warfarin; Warfarin



数据库引用编号

77 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 APOE, BGLAP, CYP2C19, CYP2D6, EGFR, PTGS2
Peripheral membrane protein 1 PTGS2
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 7 CALU, CYP2C19, CYP2D6, EGFR, GGCX, PROS1, PTGS2
Nucleus 2 APOE, EGFR
dendrite 2 APOE, BGLAP
Cell membrane 4 AGTR2, CD79A, EGFR, P2RY12
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 4 AGTR2, ATP4A, GGCX, P2RY12
cell junction 1 EGFR
cell surface 3 EGFR, F3, P2RY12
glutamatergic synapse 2 APOE, EGFR
Golgi apparatus 2 APOE, CALU
Golgi membrane 2 EGFR, PROS1
neuronal cell body 1 APOE
endosome 1 EGFR
plasma membrane 12 AGTR2, APOE, ATP4A, BCHE, CD79A, CYP2C19, EGFR, F2, F3, P2RY12, PROS1, SERPINC1
Membrane 8 APOE, ATP4A, CALU, CYP2D6, EGFR, F3, GGCX, P2RY12
apical plasma membrane 2 ATP4A, EGFR
basolateral plasma membrane 1 EGFR
caveola 1 PTGS2
extracellular exosome 6 APOE, F2, MGP, PROS1, SERPINC1, VWF
endoplasmic reticulum 6 APOE, CALU, CYP2D6, PROS1, PTGS2, VWF
extracellular space 11 APOE, ATP4A, BCHE, BGLAP, CRP, EGFR, F2, F3, PROS1, SERPINC1, VWF
perinuclear region of cytoplasm 1 EGFR
mitochondrion 1 CYP2D6
protein-containing complex 2 EGFR, PTGS2
intracellular membrane-bounded organelle 2 CYP2C19, CYP2D6
Microsome membrane 2 CYP2D6, PTGS2
Single-pass type I membrane protein 3 CD79A, EGFR, F3
Secreted 8 APOE, BCHE, BGLAP, CALU, CRP, F2, PROS1, VWF
extracellular region 9 APOE, BCHE, BGLAP, CALU, CRP, F2, PROS1, SERPINC1, VWF
Single-pass membrane protein 1 CYP2D6
[Isoform 1]: Membrane 1 F3
[Isoform 2]: Secreted 1 F3
nuclear membrane 1 EGFR
external side of plasma membrane 2 CD79A, F3
Endosome, multivesicular body 1 APOE
Extracellular vesicle 1 APOE
Secreted, extracellular space, extracellular matrix 2 APOE, VWF
chylomicron 1 APOE
high-density lipoprotein particle 1 APOE
low-density lipoprotein particle 1 APOE
multivesicular body 2 APOE, CD79A
very-low-density lipoprotein particle 1 APOE
perikaryon 1 BGLAP
Early endosome 1 APOE
vesicle 1 BGLAP
Apical cell membrane 1 ATP4A
Membrane raft 2 CD79A, EGFR
focal adhesion 1 EGFR
extracellular matrix 3 APOE, MGP, VWF
intracellular vesicle 1 EGFR
collagen-containing extracellular matrix 6 APOE, F2, F3, MGP, SERPINC1, VWF
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 1 EGFR
neuron projection 1 PTGS2
Secreted, extracellular space 2 APOE, SERPINC1
blood microparticle 5 APOE, BCHE, F2, PROS1, SERPINC1
Endomembrane system 1 GGCX
Melanosome 2 APOE, CALU
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
platelet alpha granule 1 VWF
Golgi lumen 3 BGLAP, F2, PROS1
endoplasmic reticulum lumen 7 APOE, BCHE, BGLAP, CALU, F2, PTGS2, SERPINC1
platelet alpha granule lumen 2 PROS1, VWF
nuclear envelope lumen 1 BCHE
clathrin-coated endocytic vesicle membrane 2 APOE, EGFR
Sarcoplasmic reticulum lumen 1 CALU
synaptic cleft 1 APOE
discoidal high-density lipoprotein particle 1 APOE
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
endocytic vesicle lumen 1 APOE
IgM B cell receptor complex 1 CD79A
chylomicron remnant 1 APOE
intermediate-density lipoprotein particle 1 APOE
lipoprotein particle 1 APOE
multivesicular body, internal vesicle 1 APOE
Weibel-Palade body 1 VWF
serine-type peptidase complex 1 F3
B cell receptor complex 1 CD79A
cell body membrane 1 P2RY12
cell projection membrane 1 P2RY12
potassium:proton exchanging ATPase complex 1 ATP4A


文献列表

  • Qiang Zhou, Xiang Liu, Zhi-Chun Gu, Xian Yang, Xiao-Hui Huang, Yan-Zi Wu, Ying-Ying Tao, Meng Wei. Short-term antiplatelet versus anticoagulant therapy after left atrial appendage closure: a systematic review and meta-analysis. Journal of thrombosis and thrombolysis. 2024 Feb; 57(2):194-203. doi: 10.1007/s11239-023-02919-2. [PMID: 38180590]
  • Xiaozheng Wu, Wen Li, Zhenliang Luo, Yunzhi Chen. A comprehensive comparison of the safety and efficacy of drugs in the treatment of idiopathic pulmonary fibrosis: a network meta-analysis based on randomized controlled trials. BMC pulmonary medicine. 2024 Jan; 24(1):58. doi: 10.1186/s12890-024-02861-w. [PMID: 38281037]
  • Shenxin Lu, Jie Chen, Rui Zhang, Tiancheng Luo, Lili Ma, Pengju Xu, Hong Ding, Xiaoqing Zeng, Bing Wu, Yihai Shi, Chenghai Liu, Yongping Mu, Shiyao Chen, Jian Wang. Comparative effectiveness of warfarin in cirrhotic patients with non-symptomatic portal vein thrombosis: a multicenter, randomized controlled trial. Expert review of gastroenterology & hepatology. 2024 Jan; 18(1-3):5-12. doi: 10.1080/17474124.2024.2307575. [PMID: 38236640]
  • Xin-Yi Gao, Yue-Ming Liu, Dan-Na Zheng, Yi-Wen Li, Hua Li, Xiao-Ling Xiong, Hong-Yu Chen, Hua Wang, Xiao-Yong Yu, Kai Qu, Juan Jin, Bo Lin, Qiang He. Comparison of the prophylactic antithrombotic effect of indobufen and warfarin in patients with nephrotic syndrome: a randomized controlled trial. Renal failure. 2023 Dec; 45(1):2163505. doi: 10.1080/0886022x.2022.2163505. [PMID: 36636998]
  • Yi-Hsin Chan, Tze-Fan Chao, Shao-Wei Chen, Hsin-Fu Lee, Pei-Ru Li, Yung-Hsin Yeh, Chi-Tai Kuo, Lai-Chu See, Gregory Y H Lip. Clinical Outcomes in Elderly Atrial Fibrillation Patients at Increased Bleeding Risk Treated with Very-Low-Dose versus Regular-Dose Non-Vitamin K Antagonist Oral Anticoagulants: a Nationwide Cohort Study. European heart journal. Cardiovascular pharmacotherapy. 2023 Aug; ?(?):. doi: 10.1093/ehjcvp/pvad058. [PMID: 37580139]
  • Caroline Nb Clezar, Carolina Dq Flumignan, Nicolle Cassola, Luis Cu Nakano, Virginia Fm Trevisani, Ronald Lg Flumignan. Pharmacological interventions for asymptomatic carotid stenosis. The Cochrane database of systematic reviews. 2023 Aug; 8(?):CD013573. doi: 10.1002/14651858.cd013573.pub2. [PMID: 37565307]
  • Jiali Gu, Hongrui Liu, Xiyao Huang, Yanxuan Ma, Liang Zhang. Investigation of the separate and simultaneous bindings of warfarin and fenofibrate to bovine serum albumin. International journal of biological macromolecules. 2023 Mar; 236(?):123978. doi: 10.1016/j.ijbiomac.2023.123978. [PMID: 36906198]
  • Paula M Leite, Ana P N Miranda, Izabella Gomes, Maria L Rodrigues, Layla M Camargos, Juliana M Amorim, Rita C F Duarte, André A G Faraco, Maria G Carvalho, Rachel O Castilho. Antithrombotic potential of Lippia alba: A mechanistic approach. Journal of ethnopharmacology. 2023 Jan; 301(?):115744. doi: 10.1016/j.jep.2022.115744. [PMID: 36181984]
  • Marie Moussouni, Véronique Graff, Franck Couturier, Hugo Herrscher. Drug interactions causing warfarin overdose in a patient with a pancreatic cancer : a case report. Chemotherapy. 2022 Nov; ?(?):. doi: 10.1159/000528063. [PMID: 36446317]
  • Tal Hirschhorn, Brent R Stockwell. Vitamin K: A new guardian against ferroptosis. Molecular cell. 2022 10; 82(20):3760-3762. doi: 10.1016/j.molcel.2022.10.001. [PMID: 36270246]
  • Juan Tamargo, Juan Carlos Kaski, Takeshi Kimura, Jack Charles Barton, Ko Yamamoto, Maki Komiyama, Heinz Drexel, Basil S Lewis, Stefan Agewall, Koji Hasegawa. Racial and ethnic differences in pharmacotherapy to prevent coronary artery disease and thrombotic events. European heart journal. Cardiovascular pharmacotherapy. 2022 Sep; 8(7):738-751. doi: 10.1093/ehjcvp/pvac040. [PMID: 35848895]
  • Zhen Wang, Zhe Wang, Xiaoyu Wang, Xin Lv, Hang Yin, Lili Jiang, Yangliu Xia, Wei Li, Wenli Li, Yong Liu. Potential food-drug interaction risk of thymoquinone with warfarin. Chemico-biological interactions. 2022 Sep; 365(?):110070. doi: 10.1016/j.cbi.2022.110070. [PMID: 35921950]
  • Yan Li, Jing-Ping Ge, Ke Ma, Yuan-Yuan Yin, Juan He, Jian-Ping Gu. The combination of EGCG with warfarin reduces deep vein thrombosis in rabbits through modulating HIF-1α and VEGF via the PI3K/AKT and ERK1/2 signaling pathways. Chinese journal of natural medicines. 2022 Sep; 20(9):679-690. doi: 10.1016/s1875-5364(22)60172-9. [PMID: 36162953]
  • Madison N Irwin, Sarah Adie, Katherine Sandison, Sarah A Alsomairy, Adamo Brancaccio. Warfarin Dose Requirements in Adults Hospitalized With COVID-19 Infection: A Retrospective Case Series. Journal of pharmacy practice. 2022 Aug; 35(4):654-660. doi: 10.1177/08971900211000705. [PMID: 33719699]
  • Eikan Mishima, Junya Ito, Zijun Wu, Toshitaka Nakamura, Adam Wahida, Sebastian Doll, Wulf Tonnus, Palina Nepachalovich, Elke Eggenhofer, Maceler Aldrovandi, Bernhard Henkelmann, Ken-Ichi Yamada, Jonas Wanninger, Omkar Zilka, Emiko Sato, Regina Feederle, Daniela Hass, Adriano Maida, André Santos Dias Mourão, Andreas Linkermann, Edward K Geissler, Kiyotaka Nakagawa, Takaaki Abe, Maria Fedorova, Bettina Proneth, Derek A Pratt, Marcus Conrad. A non-canonical vitamin K cycle is a potent ferroptosis suppressor. Nature. 2022 08; 608(7924):778-783. doi: 10.1038/s41586-022-05022-3. [PMID: 35922516]
  • Shaojun Jiang, Meina Lv, Zhiwei Zeng, Zongwei Fang, Mingrong Chen, Jiafen Qian, Tingting Wu, Wenjun Chen, Jinhua Zhang. Efficacy and safety of app-based remote warfarin management during COVID-19-related lockdown: a retrospective cohort study. Journal of thrombosis and thrombolysis. 2022 Jul; 54(1):20-28. doi: 10.1007/s11239-021-02630-0. [PMID: 35092566]
  • Antoine Pham, Adele Heib, Emily Goodman, Ryan Cotto, Parmida Jafari, Evan Lipsitz, Jeffrey Indes. Warfarin versus direct oral anticoagulants for patients needing distal deep vein thrombosis treatment. Journal of vascular surgery. Venous and lymphatic disorders. 2022 07; 10(4):826-831.e1. doi: 10.1016/j.jvsv.2022.01.006. [PMID: 35124243]
  • Maor Wanounou, Chanan Shaul, Zahi Abu Ghosh, Shoshana Alamia, Yoseph Caraco. The Impact of CYP2C9*11 Allelic Variant on the Pharmacokinetics of Phenytoin and (S)-Warfarin. Clinical pharmacology and therapeutics. 2022 07; 112(1):156-163. doi: 10.1002/cpt.2613. [PMID: 35426132]
  • Tuncay Güzel, Adem Aktan, Raif Kılıç, Bayram Arslan, Baran Arık, Merve Yentür, Halil Yıldız, Lokman Argun, Kamran İldırımlı, Bünyamin Yıldırım, Muhammed Demir, Mehmet Özbek, Faruk Ertaş. Oral Anticoagulant Use and Long-Term Follow-Up Results in Patients with Non-valvular Atrial Fibrillation in Turkey AFTER-2 Study. Anatolian journal of cardiology. 2022 Jul; 26(7):567-576. doi: 10.5152/anatoljcardiol.2022.1597. [PMID: 35791713]
  • M E Bauman, A Hellinger, C Vander Pluym, R Bhat, E Simpson, M Mehegan, P Knox, M P Massicotte. Online KidClot education for patients and families initiating warfarin therapy: The eKITE study. Thrombosis research. 2022 07; 215(?):14-18. doi: 10.1016/j.thromres.2022.05.003. [PMID: 35594736]
  • Sajidah Alkhameys, Ravina Barrett. Impact of the COVID-19 pandemic on England's national prescriptions of oral vitamin K antagonist (VKA) and direct-acting oral anticoagulants (DOACs): an interrupted time series analysis (January 2019-February 2021). Current medical research and opinion. 2022 Jul; 38(7):1081-1092. doi: 10.1080/03007995.2022.2078100. [PMID: 35582854]
  • Alexander T Cohen, Janvi Sah, Amol D Dhamane, Theodore Lee, Lisa Rosenblatt, Patrick Hlavacek, Birol Emir, Rachel Delinger, Huseyin Yuce, Xuemei Luo. Effectiveness and Safety of Apixaban versus Warfarin in Venous Thromboembolism Patients with Chronic Kidney Disease. Thrombosis and haemostasis. 2022 Jun; 122(6):926-938. doi: 10.1055/s-0041-1740254. [PMID: 34963185]
  • Dan Sly, Margaret Husted, Lynn McKeague, Tamara Everington. 'I just didn't want to trust it at all': Atrial fibrillation patient's treatment experience of rivaroxaban and warfarin. Journal of evaluation in clinical practice. 2022 06; 28(3):436-444. doi: 10.1111/jep.13628. [PMID: 34636130]
  • Matthias Hoch, Tirtha Sengupta, Florence Hourcade-Potelleret. Pharmacokinetic drug interactions of asciminib with the sensitive cytochrome P450 probe substrates midazolam, warfarin, and repaglinide in healthy participants. Clinical and translational science. 2022 06; 15(6):1406-1416. doi: 10.1111/cts.13252. [PMID: 35293131]
  • Tatsiana Vaitsiakhovich, Craig I Coleman, Frank Kleinjung, Burcu Vardar, Bernhard Schaefer. Worsening of kidney function in patients with atrial fibrillation and chronic kidney disease: evidence from the real-world CALLIPER study. Current medical research and opinion. 2022 Jun; 38(6):937-945. doi: 10.1080/03007995.2022.2061705. [PMID: 35392744]
  • Alex Handy, Amitava Banerjee, Angela M Wood, Caroline Dale, Cathie L M Sudlow, Christopher Tomlinson, Daniel Bean, Johan H Thygesen, Mehrdad A Mizani, Michail Katsoulis, Rohan Takhar, Sam Hollings, Spiros Denaxas, Venexia Walker, Richard Dobson, Reecha Sofat. Evaluation of antithrombotic use and COVID-19 outcomes in a nationwide atrial fibrillation cohort. Heart (British Cardiac Society). 2022 05; 108(12):923-931. doi: 10.1136/heartjnl-2021-320325. [PMID: 35273122]
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