Ketoprofen (BioDeep_00000001483)

 

Secondary id: BioDeep_00000398576

human metabolite blood metabolite Chemicals and Drugs natural product


代谢物信息卡片


3-benzoyl-α-methyl-benzeneacetic acid

化学式: C16H14O3 (254.0942894)
中文名称: 酮洛芬
谱图信息: 最多检出来源 Homo sapiens(urine) 5.07%

分子结构信息

SMILES: CC(C(=O)O)c1cccc(C(=O)c2ccccc2)c1
InChI: InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)

描述信息

Ketoprofen is only found in individuals that have used or taken this drug. It is a propionic acid derivative and is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. The anti-inflammatory effects of ketoprofen are believed to be due to inhibition cylooxygenase-2 (COX-2), an enzyme involved in prostaglandin synthesis via the arachidonic acid pathway. This results in decreased levels of prostaglandins that mediate pain, fever and inflammation. Ketoprofen is a non-specific cyclooxygenase inhibitor and inhibition of COX-1 is thought to confer some of its side effects, such as GI upset and ulceration. Ketoprofen is thought to have anti-bradykinin activity, as well as lysosomal membrane-stabilizing action. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation.
M - Musculo-skeletal system > M02 - Topical products for joint and muscular pain > M02A - Topical products for joint and muscular pain > M02AA - Antiinflammatory preparations, non-steroids for topical use
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AE - Propionic acid derivatives
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
CONFIDENCE standard compound; EAWAG_UCHEM_ID 205
CONFIDENCE standard compound; INTERNAL_ID 1150
CONFIDENCE standard compound; INTERNAL_ID 4086
CONFIDENCE standard compound; INTERNAL_ID 8562
D000893 - Anti-Inflammatory Agents
D004791 - Enzyme Inhibitors

同义名列表

21 个代谢物同义名

3-benzoyl-α-methyl-benzeneacetic acid; 3-Benzoyl-alpha-methylbenzeneacetic acid; Lacide (benzoyl-3-phenyl)-2-propionique; 3-Benzoyl-alpha-methylbenzeneacetate; 3-Benzoyl-α-methylbenzeneacetic acid; 3-Benzoyl-a-methylbenzeneacetic acid; 2-(3-benzoylphenyl)propanoic acid; 2-(3-Benzoylphenyl)propionic acid; 3-Benzoyl-α-methylbenzeneacetate; 3-Benzoyl-a-methylbenzeneacetate; 2-(3-Benzoylphenyl)propionate; 3-Benzoylhydratropic acid; m-Benzoylhydratropic acid; Benzoylhydratropic acid; m-Benzoylhydratropate; 3-Benzoylhydratropate; ketoprofen; Alrheumum; Alrheumat; Profenid; Orudis



数据库引用编号

58 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Huan Wang, Zhiheng Li, Luoqin Shen, Ping Zhang, Yanyao Lin, Xinting Huang, Shaoting Du, Huijun Liu. Ketoprofen exposure perturbs nitrogen assimilation and ATP synthesis in rice roots: An integrated metabolome and microbiome analysis. Environmental pollution (Barking, Essex : 1987). 2023 Aug; 336(?):122485. doi: 10.1016/j.envpol.2023.122485. [PMID: 37659631]
  • Jianwen Liao, Mingchao Zhang, Zichuan Shi, Hao Lu, Lichen Wang, Weijia Fan, Xiaoguang Tong, Hua Yan. Improving the Function of Meningeal Lymphatic Vessels to Promote Brain Edema Absorption after Traumatic Brain Injury. Journal of neurotrauma. 2023 02; 40(3-4):383-394. doi: 10.1089/neu.2022.0150. [PMID: 36106596]
  • Halley Gora Ravuri, Pawel Sadowski, Zainab Noor, Nana Satake, Paul C Mills. Plasma proteomic changes in response to surgical trauma and a novel transdermal analgesic treatment in dogs. Journal of proteomics. 2022 08; 265(?):104648. doi: 10.1016/j.jprot.2022.104648. [PMID: 35691609]
  • Didier Ramírez-Morales, Daniela Fajardo-Romero, Carlos E Rodríguez-Rodríguez, Nina Cedergreen. Single and mixture toxicity of selected pharmaceuticals to the aquatic macrophyte Lemna minor. Ecotoxicology (London, England). 2022 Jul; 31(5):714-724. doi: 10.1007/s10646-022-02537-3. [PMID: 35348978]
  • Rubina Novelli, Andrea Aramini, Serena Boccella, Michela Bagnasco, Franca Cattani, Mauro Paolo Ferrari, Giovanni Goisis, Enrico Maria Minnella, Marcello Allegretti, Virgilio Pace. Ketoprofen lysine salt has a better gastrointestinal and renal tolerability than ketoprofen acid: A comparative tolerability study in the Beagle dog. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 153(?):113336. doi: 10.1016/j.biopha.2022.113336. [PMID: 35772374]
  • Bianca-Maria Ţuchiu, Raluca-Ioana Stefan-van Staden, Marius Bădulescu, Jacobus Frederick van Staden. Disposable stochastic sensors for fast analysis of ibuprofen, ketoprofen, and flurbiprofen in their topical pharmaceutical formulations. Journal of pharmaceutical and biomedical analysis. 2022 Jun; 215(?):114758. doi: 10.1016/j.jpba.2022.114758. [PMID: 35421777]
  • Ersin Koksal, Yasemin Burcu Ustun, Sezgin Bilgin, Abdurrahman Aksoy, Yavuz Kursad Das, Murat Yarim, Fatih Ozkan, Cengiz Kaya, Burhan Dost. The effects of dexketoprofen on renal ischemia-reperfusion injury: an experimental study. Brazilian journal of anesthesiology (Elsevier). 2022 May; 72(3):365-371. doi: 10.1016/j.bjane.2021.07.033. [PMID: 34411625]
  • Wataru Kashihara, Mio Shinoda, Kiyoka Tsuchiya, Tasuku Isozaki, Batsaikhan Mijiddorj, Kazuyoshi Ueda, Tadashi Suzuki. Photochemical Reaction of Ketoprofen with Proteinogenic Amino Acids. The journal of physical chemistry. B. 2022 03; 126(10):2098-2107. doi: 10.1021/acs.jpcb.1c10108. [PMID: 35142495]
  • G Cetin, O Corum, D D Corum, O Atik, F Altan, E Turk, I O Tekeli, H E Faki, K Uney. Pharmacokinetics of intravenous meloxicam, ketoprofen and tolfenamic acid in chukar partridge (Alectoris chukar). British poultry science. 2022 Feb; 63(1):14-20. doi: 10.1080/00071668.2021.1990211. [PMID: 34633873]
  • Orhan Corum, Kamil Uney, Duygu Durna Corum, Orkun Atik, Devran Coskun, Aidai Zhunushova, Muammer Elmas. Effect of ketoprofen on intravenous pharmacokinetics of ganciclovir in chukar partridges (Alectoris chukar). Journal of veterinary pharmacology and therapeutics. 2022 Jan; 45(1):126-132. doi: 10.1111/jvp.13027. [PMID: 34719792]
  • Isadora A Preigschadt, Raíssa C Bevilacqua, Matias S Netto, Jordana Georgin, Dison S P Franco, Evandro S Mallmann, Diana Pinto, Edson L Foletto, Guilherme L Dotto. Optimization of ketoprofen adsorption from aqueous solutions and simulated effluents using H2SO4 activated Campomanesia guazumifolia bark. Environmental science and pollution research international. 2022 Jan; 29(2):2122-2135. doi: 10.1007/s11356-021-15668-7. [PMID: 34363168]
  • Pooja Prasanthan, Nand Kishore. Unusual human serum albumin fibrillation inhibition by ketoprofen and fenoprofen: Mechanistic insights. Journal of molecular recognition : JMR. 2021 12; 34(12):e2937. doi: 10.1002/jmr.2937. [PMID: 34505308]
  • Gul Cetin, Duygu Durna Corum, Orhan Corum, Orkun Atik, Devran Coskun, Kamil Uney. Effect of ketoprofen and tolfenamic acid on intravenous pharmacokinetics of ceftriaxone in sheep. Journal of veterinary pharmacology and therapeutics. 2021 Nov; 44(6):945-951. doi: 10.1111/jvp.13001. [PMID: 34312894]
  • Kristen J Reynolds, Ron Johnson, Robert M Friendship, Jennifer Brown, Saad Enouri, Ronette Gehring, Terri L O'Sullivan. Pharmacokinetics and bioavailability of ketoprofen when compounded with iron dextran for use in nursing piglets. The Canadian veterinary journal = La revue veterinaire canadienne. 2021 11; 62(11):1211-1218. doi: NULL. [PMID: 34728849]
  • Sunkyung Jeong, Joseph E Valdez, Natalia Miękus, Joon Yub Kwon, Wooyong Kwon, Tomasz Bączek, Doo Soo Chung. Facile and highly efficient three-phase single drop microextraction in-line coupled with capillary electrophoresis. Journal of chromatography. A. 2021 Oct; 1655(?):462520. doi: 10.1016/j.chroma.2021.462520. [PMID: 34517164]
  • Darya A Kuznetsova, Leysan A Vasileva, Gulnara A Gaynanova, Elmira A Vasilieva, Oksana A Lenina, Irek R Nizameev, Marsil K Kadirov, Konstantin A Petrov, Lucia Ya Zakharova, Oleg G Sinyashin. Cationic liposomes mediated transdermal delivery of meloxicam and ketoprofen: Optimization of the composition, in vitro and in vivo assessment of efficiency. International journal of pharmaceutics. 2021 Aug; 605(?):120803. doi: 10.1016/j.ijpharm.2021.120803. [PMID: 34144135]
  • Shan Chen, Shu Zhou, Jinli Fu, Sisi Tang, Xiaodan Wu, Pengfei Zhao, Zhaohui Zhang. A near infrared fluorescence imprinted sensor based on zinc oxide nanorods for rapid determination of ketoprofen. Analytical methods : advancing methods and applications. 2021 07; 13(25):2836-2846. doi: 10.1039/d1ay00555c. [PMID: 34080589]
  • Yuting Wang, Liyan He, Guoyan Dang, Hui Li, Xiaoli Li. Polypyrrole-functionalized magnetic Bi2MoO6 nanocomposites as a fast, efficient and reusable adsorbent for removal of ketoprofen and indomethacin from aqueous solution. Journal of colloid and interface science. 2021 Jun; 592(?):51-65. doi: 10.1016/j.jcis.2021.02.033. [PMID: 33639538]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Craig A Harms, Laura K Ruterbories, Nicole I Stacy, Emily F Christiansen, Mark G Papich, Alex M Lynch, Ashley Barratclough, Maria E Serrano. SAFETY OF MULTIPLE-DOSE INTRAMUSCULAR KETOPROFEN TREATMENT IN LOGGERHEAD TURTLES (CARETTA CARETTA). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 2021 Apr; 52(1):126-132. doi: 10.1638/2020-0159. [PMID: 33827169]
  • Caroline Belló, Ana Paula Prestes, Josiane Aparecida Schemberger, Ana Carolina Mendes Hacke, Romaiana Picada Pereira, Francine Alessandra Manente, Iracilda Zeppone Carlos, Cleverton Roberto de Andrade, Daniel Fernandes, Ivana Beatrice Manica da Cruz, Taís Cristina Unfer, José Carlos Rebuglio Vellosa. Aqueous extract of Paullinia cupana attenuates renal and hematological effects associated with ketoprofen. Journal of food biochemistry. 2021 01; 45(1):e13560. doi: 10.1111/jfbc.13560. [PMID: 33270240]
  • Angélica F M Streit, Gabriela C Collazzo, Susanne P Druzian, Rodrigo S Verdi, Edson L Foletto, Luis F S Oliveira, Guilherme L Dotto. Adsorption of ibuprofen, ketoprofen, and paracetamol onto activated carbon prepared from effluent treatment plant sludge of the beverage industry. Chemosphere. 2021 Jan; 262(?):128322. doi: 10.1016/j.chemosphere.2020.128322. [PMID: 32962838]
  • Fátima Tous-Romero, Pablo L Ortiz Romero, Javier Ortiz de Frutos. Usefulness of Patch Testing With Patient's Own Products in the Diagnosis of Allergic Contact Dermatitis. Dermatitis : contact, atopic, occupational, drug. 2021 Jan; 32(1):38-41. doi: 10.1097/der.0000000000000654. [PMID: 33449479]
  • Shoko Okazaki, Ayako Hirata, Yusuke Shogomori, Megumi Takemoto, Takuro Nagata, Eriko Hayashida, Keizo Takeshita. Radical reactions induced by ketoprofen in phospholipid membranes under ultraviolet light irradiation. Journal of photochemistry and photobiology. B, Biology. 2021 Jan; 214(?):112090. doi: 10.1016/j.jphotobiol.2020.112090. [PMID: 33302245]
  • Steven X Hu, Kelsey Ernst, Charles P Benner, Kenneth L Feenstra. Stability of Ketoprofen Methylester in Plasma of Different Species. Current drug metabolism. 2021; 22(3):215-223. doi: 10.2174/1389200221666201217141025. [PMID: 33334282]
  • Emma Nixon, Alexandra R Carlson, Patricia A Routh, Liliana Hernandez, Glen W Almond, Ronald E Baynes, Kristen M Messenger. Comparative effects of nonsteroidal anti-inflammatory drugs at castration and tail-docking in neonatal piglets. PloS one. 2021; 16(11):e0254409. doi: 10.1371/journal.pone.0254409. [PMID: 34847143]
  • Hany H Arab, Muhammed A Saad, Ayman E El-Sahar, Muhammad Y Al-Shorbagy. Mechanistic perspective of morin protection against ketoprofen-induced gastric mucosal injury: Targeting HMGB1/RAGE/NF-κB, DJ-1/Nrf2/HO-1 and PI3K/mTOR pathways. Archives of biochemistry and biophysics. 2020 10; 693(?):108552. doi: 10.1016/j.abb.2020.108552. [PMID: 32860758]
  • J C López-Doval, A Serra-Compte, S Rodríguez-Mozaz, D Barceló, S Sabater. Diet quality and NSAIDs promote changes in formation of prostaglandins by an aquatic invertebrate. Chemosphere. 2020 Oct; 257(?):126892. doi: 10.1016/j.chemosphere.2020.126892. [PMID: 32480082]
  • T S Tschoner, Y Zablotski, G Knubben-Schweizer, M Feist. Effect of xylazine administration before laparoscopic abomasopexy to correct left displaced abomasum on markers of stress in dairy cows. Journal of dairy science. 2020 Oct; 103(10):9318-9331. doi: 10.3168/jds.2020-18523. [PMID: 32747093]
  • Ibrahim Ozan Tekeli, Erdinc Turk, Duygu Durna Corum, Orhan Corum, Fatma Ceren Kirgiz, Fatih Sakin, Kamil Uney. Effect of ketoprofen co-administration on pharmacokinetics of cefquinome following repeated administration in goats. Journal of veterinary pharmacology and therapeutics. 2020 Sep; 43(5):440-447. doi: 10.1111/jvp.12904. [PMID: 32815194]
  • Keigo Nakayama, Hidetaka Kamimura, Hiroshi Suemizu, Nao Yoneda, Megumi Nishiwaki, Kazuhiko Iwamoto, Mari Mizunaga, Tamotsu Negoro, Soichiro Ito, Hiroshi Yamazaki, Yukihiro Nomura. Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data. Drug metabolism and pharmacokinetics. 2020 Aug; 35(4):389-396. doi: 10.1016/j.dmpk.2020.05.004. [PMID: 32690433]
  • Shukai Ding, Bilal Mustafa, Nicolas Anton, Christophe A Serra, Delphine Chan-Seng, Thierry F Vandamme. Production of lipophilic nanogels by spontaneous emulsification. International journal of pharmaceutics. 2020 Jul; 585(?):119481. doi: 10.1016/j.ijpharm.2020.119481. [PMID: 32473375]
  • Joanna Porażka, Edyta Szałek, Wojciech Żółtaszek, Tomasz Grabowski, Anna Wolc, Edmund Grześkowiak. Influence of obesity on pharmacokinetics and analgesic effect of ketoprofen administered intravenously to patients after laparoscopic cholecystectomy. Pharmacological reports : PR. 2020 Jun; 72(3):763-768. doi: 10.1007/s43440-019-00042-9. [PMID: 32048255]
  • Zhongyan Wang, Chuanrui Ma, Yuna Shang, Lijun Yang, Jing Zhang, Cuihong Yang, Chunhua Ren, Jinjian Liu, Guanwei Fan, Jianfeng Liu. Simultaneous co-assembly of fenofibrate and ketoprofen peptide for the dual-targeted treatment of nonalcoholic fatty liver disease (NAFLD). Chemical communications (Cambridge, England). 2020 May; 56(36):4922-4925. doi: 10.1039/d0cc00513d. [PMID: 32239031]
  • Nam Hyeon Kang, Sulagna Mukherjee, Myeong Hwan Jang, Huong Giang Pham, MinJi Choi, Jong Won Yun. Ketoprofen alleviates diet-induced obesity and promotes white fat browning in mice via the activation of COX-2 through mTORC1-p38 signaling pathway. Pflugers Archiv : European journal of physiology. 2020 05; 472(5):583-596. doi: 10.1007/s00424-020-02380-7. [PMID: 32358780]
  • Marta Ziegler-Borowska, Kinga Mylkie, Pawel Nowak, Patryk Rybczynski, Adam Sikora, Dorota Chelminiak-Dudkiewicz, Anna Kaczmarek-Kedziera. Testing for Ketoprofen Binding to HSA Coated Magnetic Nanoparticles under Normal Conditions and after Oxidative Stress. Molecules (Basel, Switzerland). 2020 Apr; 25(8):. doi: 10.3390/molecules25081945. [PMID: 32331398]
  • M Locatelli, A Tartaglia, F D'Ambrosio, P Ramundo, H I Ulusoy, K G Furton, A Kabir. Biofluid sampler: A new gateway for mail-in-analysis of whole blood samples. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Apr; 1143(?):122055. doi: 10.1016/j.jchromb.2020.122055. [PMID: 32172173]
  • Marcio Antonio Rodrigues Araujo. Ketoprofen hypersensibility and idiosyncratic response - a case report. Immunopharmacology and immunotoxicology. 2020 Apr; 42(2):174-177. doi: 10.1080/08923973.2020.1728764. [PMID: 32079429]
  • Silvia Bua, Laura Lucarini, Laura Micheli, Marta Menicatti, Gianluca Bartolucci, Silvia Selleri, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Emanuela Masini, Fabrizio Carta, Paola Gratteri, Alessio Nocentini, Claudiu T Supuran. Bioisosteric Development of Multitarget Nonsteroidal Anti-Inflammatory Drug-Carbonic Anhydrases Inhibitor Hybrids for the Management of Rheumatoid Arthritis. Journal of medicinal chemistry. 2020 03; 63(5):2325-2342. doi: 10.1021/acs.jmedchem.9b01130. [PMID: 31689108]
  • Kamil Zielinski, Bartosz Sekula, Anna Bujacz, Izabela Szymczak. Structural investigations of stereoselective profen binding by equine and leporine serum albumins. Chirality. 2020 03; 32(3):334-344. doi: 10.1002/chir.23162. [PMID: 31905261]
  • Natalia Pettinelli, Saddys Rodríguez-Llamazares, Yousof Farrag, Rebeca Bouza, Luis Barral, Sandra Feijoo-Bandín, Francisca Lago. Poly(hydroxybutyrate-co-hydroxyvalerate) microparticles embedded in κ-carrageenan/locust bean gum hydrogel as a dual drug delivery carrier. International journal of biological macromolecules. 2020 Mar; 146(?):110-118. doi: 10.1016/j.ijbiomac.2019.12.193. [PMID: 31881300]
  • Ahmed Jasim Twayej, Hussein Kadhem Al-Hakeim, Arafat Hussein Al-Dujaili, Michael Maes. Lowered zinc and copper levels in drug-naïve patients with major depression: Effects of antidepressants, ketoprofen and immune activation. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. 2020 02; 21(2):127-138. doi: 10.1080/15622975.2019.1612090. [PMID: 31062629]
  • Małgorzata Maciążek-Jurczyk, Kamil Janas, Jadwiga Pożycka, Agnieszka Szkudlarek, Wojciech Rogóż, Aleksandra Owczarzy, Karolina Kulig. Human Serum Albumin Aggregation/Fibrillation and its Abilities to Drugs Binding. Molecules (Basel, Switzerland). 2020 Jan; 25(3):. doi: 10.3390/molecules25030618. [PMID: 32023900]
  • Wenqian Wu, Feng Lin, Xiaohan Yang, Bin Wang, Xin Lu, Qiuxia Chen, Fanggui Ye, Shulin Zhao. Facile synthesis of magnetic carbon nanotubes derived from ZIF-67 and application to magnetic solid-phase extraction of profens from human serum. Talanta. 2020 Jan; 207(?):120284. doi: 10.1016/j.talanta.2019.120284. [PMID: 31594616]
  • Hussein Kadhem Al-Hakeim, Ahmed Jasim Twayej, Arafat Hussein Al-Dujaili, Michael Maes. Plasma Indoleamine-2,3-Dioxygenase (IDO) is Increased in Drug-Naï ve Major Depressed Patients and Treatment with Sertraline and Ketoprofen Normalizes IDO in Association with Pro-Inflammatory and Immune- Regulatory Cytokines. CNS & neurological disorders drug targets. 2020; 19(1):44-54. doi: 10.2174/1871527319666200102100307. [PMID: 31894751]
  • Paula Ossowicz, Proletina Kardaleva, Maya Guncheva, Joanna Klebeko, Ewelina Świątek, Ewa Janus, Denitsa Yancheva, Ivan Angelov. Ketoprofen-Based Ionic Liquids: Synthesis and Interactions with Bovine Serum Albumin. Molecules (Basel, Switzerland). 2019 Dec; 25(1):. doi: 10.3390/molecules25010090. [PMID: 31881750]
  • Li-Na Yin, Ya-Wen Zhang, Wen-Hai Huang, Sheng-Hao Wang, Gao-Li Zheng. Stereoselectivity evaluation of chiral chitosan microspheres delivery system containing rac-KET in vitro and in vivo. Drug delivery. 2019 Dec; 26(1):63-69. doi: 10.1080/10717544.2018.1556360. [PMID: 30744429]
  • Senar Aydin, Mehmet Emin Aydin, Arzu Ulvi. Monitoring the release of anti-inflammatory and analgesic pharmaceuticals in the receiving environment. Environmental science and pollution research international. 2019 Dec; 26(36):36887-36902. doi: 10.1007/s11356-019-06821-4. [PMID: 31745804]
  • Myrthe Giesbers, Enrique Javier Carrasco-Correa, Ernesto F Simó-Alfonso, José Manuel Herrero-Martínez. Hybrid monoliths with metal-organic frameworks in spin columns for extraction of non-steroidal drugs prior to their quantitation by reversed-phase HPLC. Mikrochimica acta. 2019 11; 186(12):759. doi: 10.1007/s00604-019-3923-6. [PMID: 31712934]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Xiaofei Han, Jia Chen, Zhan Li, Hongdeng Qiu. Combustion fabrication of magnetic porous carbon as a novel magnetic solid-phase extraction adsorbent for the determination of non-steroidal anti-inflammatory drugs. Analytica chimica acta. 2019 Oct; 1078(?):78-89. doi: 10.1016/j.aca.2019.06.022. [PMID: 31358231]
  • Jiajie Hu, Hengjiang Liu, Pu Xu, Yazhuo Shang, Honglai Liu. Investigation of Drug for Pulmonary Administration-Model Pulmonary Surfactant Monolayer Interactions Using Langmuir-Blodgett Monolayer and Molecular Dynamics Simulation: A Case Study of Ketoprofen. Langmuir : the ACS journal of surfaces and colloids. 2019 10; 35(41):13452-13460. doi: 10.1021/acs.langmuir.9b02412. [PMID: 31524404]
  • Arafat Hussein Al-Dujaili, Hussein Kadhem Al-Hakeim, Ahmed Jasim Twayej, Michael Maes. Total and ionized calcium and magnesium are significantly lowered in drug-naïve depressed patients: effects of antidepressants and associations with immune activation. Metabolic brain disease. 2019 10; 34(5):1493-1503. doi: 10.1007/s11011-019-00458-5. [PMID: 31292851]
  • P T Ramos, N S Pedra, M S P Soares, E F da Silveira, P S Oliveira, F B Grecco, L M C da Silva, L M Ferreira, D A Ribas, M Gehrcke, A O C Felix, F M Stefanello, R M Spanevello, L Cruz, E Braganhol. Ketoprofen-loaded rose hip oil nanocapsules attenuate chronic inflammatory response in a pre-clinical trial in mice. Materials science & engineering. C, Materials for biological applications. 2019 Oct; 103(?):109742. doi: 10.1016/j.msec.2019.109742. [PMID: 31349429]
  • Malek Hassan, Usama Alshana. Switchable-hydrophilicity solvent liquid-liquid microextraction of non-steroidal anti-inflammatory drugs from biological fluids prior to HPLC-DAD determination. Journal of pharmaceutical and biomedical analysis. 2019 Sep; 174(?):509-517. doi: 10.1016/j.jpba.2019.06.023. [PMID: 31238298]
  • Katarína Želonková, Samuel Havadej, Valéria Verebová, Beáta Holečková, Jozef Uličný, Jana Staničová. Fungicide Tebuconazole Influences the Structure of Human Serum Albumin Molecule. Molecules (Basel, Switzerland). 2019 Sep; 24(17):. doi: 10.3390/molecules24173190. [PMID: 31480789]
  • Z Kovacevic, D Stojanovic, M Cincovic, B Belic, I Davidov, N Stojanac, A Galfi. Effect of postpartum administration of ketoprofen on proinflammatory cytokine concentration and their correlation with lipogenesis and ketogenesis in Holstein dairy cows. Polish journal of veterinary sciences. 2019 Sep; 22(3):609-615. doi: 10.24425/pjvs.2019.129970. [PMID: 31560476]
  • Elias Makhoul, Joe El Mir, Marc Harb. Does rectal ketoprofen prevent post ERCP pancreatitis?. Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology. 2019 Sep; 20(3):141-144. doi: 10.1016/j.ajg.2019.09.004. [PMID: 31582291]
  • Rashmi Boppana, Sushil Yadaorao Raut, G Krishna Mohan, Biswanath Sa, Srinivas Mutalik, Kakarla Raghava Reddy, Kusal K Das, Mallanagouda S Biradar, Raghavendra V Kulkarni. Novel pH-sensitive interpenetrated network polyspheres of polyacrylamide-g-locust bean gum and sodium alginate for intestinal targeting of ketoprofen: In vitro and in vivo evaluation. Colloids and surfaces. B, Biointerfaces. 2019 Aug; 180(?):362-370. doi: 10.1016/j.colsurfb.2019.04.060. [PMID: 31077864]
  • Elena Puris, Mikko Gynther, Elizabeth C M de Lange, Seppo Auriola, Margareta Hammarlund-Udenaes, Kristiina M Huttunen, Irena Loryan. Mechanistic Study on the Use of the l-Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets. Molecular pharmaceutics. 2019 07; 16(7):3261-3274. doi: 10.1021/acs.molpharmaceut.9b00502. [PMID: 31180686]
  • Cristina Román-Hidalgo, Germán López-Pérez, María Jesús Martín-Valero, Miguel Ángel Bello-López. Chitosan tailor-made membranes as biopolymeric support for electromembrane extraction. Talanta. 2019 Jul; 199(?):290-295. doi: 10.1016/j.talanta.2019.02.079. [PMID: 30952260]
  • Shikha Sehajpal, Deo Nandan Prasad, Rajesh K Singh. Novel ketoprofen-antioxidants mutual codrugs as safer nonsteroidal anti-inflammatory drugs: Synthesis, kinetic and pharmacological evaluation. Archiv der Pharmazie. 2019 Jul; 352(7):e1800339. doi: 10.1002/ardp.201800339. [PMID: 31231875]
  • Satoshi Endo, Namiki Miyagi, Toshiyuki Matsunaga, Akira Ikari. Rabbit dehydrogenase/reductase SDR family member 11 (DHRS11): Its identity with acetohexamide reductase with broad substrate specificity and inhibitor sensitivity, different from human DHRS11. Chemico-biological interactions. 2019 May; 305(?):12-20. doi: 10.1016/j.cbi.2019.03.026. [PMID: 30926317]
  • M Siepsiak-Połom, E Szałek, J Porażka, A Karbownik, T Grabowski, M Mziray, K Adrych, E Grześkowiak. Ketoprofen and tramadol pharmacokinetics in patients with chronic pancreatitis. European review for medical and pharmacological sciences. 2019 May; 23(9):4044-4051. doi: 10.26355/eurrev_201905_17835. [PMID: 31115034]
  • Marie-Pier Thibault, Éric Tremblay, John L Wallace, Jean-François Beaulieu. Effect of Ketoprofen and ATB-352 on the Immature Human Intestine: Identification of Responders and Non-responders. Journal of pediatric gastroenterology and nutrition. 2019 05; 68(5):623-629. doi: 10.1097/mpg.0000000000002308. [PMID: 31022092]
  • Laís Bhering Martins, Ana Maria Dos Santos Rodrigues, Débora Fernandes Rodrigues, Luana Caroline Dos Santos, Antônio Lúcio Teixeira, Adaliene Versiani Matos Ferreira. Double-blind placebo-controlled randomized clinical trial of ginger ( Zingiber officinale Rosc.) addition in migraine acute treatment. Cephalalgia : an international journal of headache. 2019 Jan; 39(1):68-76. doi: 10.1177/0333102418776016. [PMID: 29768938]
  • Kheireddine Mrad Daly, Kays Chaker, Sami Ben Rhouma, Mohamed Ali Ben Chehida, Yassine Ouanes, Ahmed Sellami, Yassine Nouira. [Evaluation of protocols on the use of analgesics for pain management in patients with extracorporeal shock wave lithotripsy (ESWL)]. The Pan African medical journal. 2019; 32(?):109. doi: 10.11604/pamj.2019.32.109.17690. [PMID: 31223399]
  • Denisa Dan, Rupert M Bruckmaier, Olga Wellnitz. Ketoprofen affects the mammary immune response in dairy cows in vivo and in vitro. Journal of dairy science. 2018 Dec; 101(12):11321-11329. doi: 10.3168/jds.2018-15034. [PMID: 30243628]
  • K M Huttunen. Identification of human, rat and mouse hydrolyzing enzymes bioconverting amino acid ester prodrug of ketoprofen. Bioorganic chemistry. 2018 12; 81(?):494-503. doi: 10.1016/j.bioorg.2018.09.018. [PMID: 30243240]
  • Basuvannan Rangasamy, Devan Hemalatha, Chellappan Shobana, Bojan Nataraj, Mathan Ramesh. Developmental toxicity and biological responses of zebrafish (Danio rerio) exposed to anti-inflammatory drug ketoprofen. Chemosphere. 2018 Dec; 213(?):423-433. doi: 10.1016/j.chemosphere.2018.09.013. [PMID: 30243208]
  • Álvaro J Gutiérrez-Bautista, Juan Morgaz, María Del Mar Granados, Rafael J Gómez-Villamandos, Juan M Dominguez, José A Fernandez-Sarmiento, Daniel Aguilar-García, Rocío Navarrete-Calvo. Evaluation and comparison of postoperative analgesic effects of dexketoprofen and methadone in dogs. Veterinary anaesthesia and analgesia. 2018 Nov; 45(6):820-830. doi: 10.1016/j.vaa.2018.06.016. [PMID: 30316696]
  • Stanley G Rockson, Wen Tian, Xinguo Jiang, Tatiana Kuznetsova, Francois Haddad, Jamie Zampell, Babak Mehrara, Joshua P Sampson, Leslie Roche, Jinah Kim, Mark R Nicolls. Pilot studies demonstrate the potential benefits of antiinflammatory therapy in human lymphedema. JCI insight. 2018 10; 3(20):. doi: 10.1172/jci.insight.123775. [PMID: 30333315]
  • Nicola Gladden, Dorothy McKeegan, Lorenzo Viora, Kathryn Amanda Ellis. Postpartum ketoprofen treatment does not alter stress biomarkers in cows and calves experiencing assisted and unassisted parturition: a randomised controlled trial. The Veterinary record. 2018 Oct; 183(13):414. doi: 10.1136/vr.104913. [PMID: 29960984]
  • Laura Escuder-Gilabert, Yolanda Martín-Biosca, Mireia Perez-Baeza, Salvador Sagrado, María José Medina-Hernández. Direct chromatographic study of the enantioselective biodegradation of ibuprofen and ketoprofen by an activated sludge. Journal of chromatography. A. 2018 Sep; 1568(?):140-148. doi: 10.1016/j.chroma.2018.07.034. [PMID: 30001901]
  • H Hajizadeh, A Asghari, G Abedi, S Hesaraki. Comparative Evaluation of the Biochemical Effects of Ketamine plus Ketoprofen and Midazolam in the Premedication of Pigeons. Archives of Razi Institute. 2018 09; 73(3):223-227. doi: 10.22092/ari.2017.109066.1099. [PMID: 30280842]
  • François Noverraz, Elisa Montanari, Joël Pimenta, Luca Szabó, Daniel Ortiz, Carmen Gonelle-Gispert, Léo H Bühler, Sandrine Gerber-Lemaire. Antifibrotic Effect of Ketoprofen-Grafted Alginate Microcapsules in the Transplantation of Insulin Producing Cells. Bioconjugate chemistry. 2018 06; 29(6):1932-1941. doi: 10.1021/acs.bioconjchem.8b00190. [PMID: 29787238]
  • M Mezzelani, S Gorbi, D Fattorini, G d'Errico, G Consolandi, M Milan, L Bargelloni, F Regoli. Long-term exposure of Mytilus galloprovincialis to diclofenac, Ibuprofen and Ketoprofen: Insights into bioavailability, biomarkers and transcriptomic changes. Chemosphere. 2018 May; 198(?):238-248. doi: 10.1016/j.chemosphere.2018.01.148. [PMID: 29421735]
  • Jeroen Van Renterghem, Heleen Dhondt, Glenn Verstraete, Michiel De Bruyne, Chris Vervaet, Thomas De Beer. The impact of the injection mold temperature upon polymer crystallization and resulting drug release from immediate and sustained release tablets. International journal of pharmaceutics. 2018 Apr; 541(1-2):108-116. doi: 10.1016/j.ijpharm.2018.01.053. [PMID: 29409747]
  • K A Thompson, M G Papich, B Higgins, J Flanagan, E F Christiansen, C A Harms. Ketoprofen pharmacokinetics of R- and S-isomers in juvenile loggerhead sea turtles (Caretta caretta) after single intravenous and single- and multidose intramuscular administration. Journal of veterinary pharmacology and therapeutics. 2018 Apr; 41(2):340-348. doi: 10.1111/jvp.12460. [PMID: 29057479]
  • Jun Wang, Shu-Qi Zhao, Meng-Ya Zhang, Bing-Shu He. Targeted eco-pharmacovigilance for ketoprofen in the environment: Need, strategy and challenge. Chemosphere. 2018 Mar; 194(?):450-462. doi: 10.1016/j.chemosphere.2017.12.020. [PMID: 29227893]
  • Román-Hidalgo Cristina, Martín-Valero María Jesús, Fernández-Torres Rut, Bello-López Miguel Ángel. Use of Polymer Inclusion Membranes (PIMs) as support for electromembrane extraction of non-steroidal anti-inflammatory drugs and highly polar acidic drugs. Talanta. 2018 Mar; 179(?):601-607. doi: 10.1016/j.talanta.2017.11.066. [PMID: 29310282]
  • Angela Carolina Finato, Thais Fernanda Fraga-Silva, Amanda Uliana Carvalho Prati, Amauri Alves de Souza Júnior, Bruna Fonseca Mazzeu, Lidiane Gaspareto Felippe, Rute Alves Pinto, Marjorie de Assis Golim, Maria Sueli Parreira Arruda, Maysa Furlan, James Venturini. Crude leaf extracts of Piperaceae species downmodulate inflammatory responses by human monocytes. PloS one. 2018; 13(6):e0198682. doi: 10.1371/journal.pone.0198682. [PMID: 29924840]
  • Tigran Makunts, Isaac V Cohen, Kelly C Lee, Ruben Abagyan. Population scale retrospective analysis reveals distinctive antidepressant and anxiolytic effects of diclofenac, ketoprofen and naproxen in patients with pain. PloS one. 2018; 13(4):e0195521. doi: 10.1371/journal.pone.0195521. [PMID: 29668764]
  • Raj Kumar, Ashutosh Singh, Neha Garg, Prem Felix Siril. Solid lipid nanoparticles for the controlled delivery of poorly water soluble non-steroidal anti-inflammatory drugs. Ultrasonics sonochemistry. 2018 Jan; 40(Pt A):686-696. doi: 10.1016/j.ultsonch.2017.08.018. [PMID: 28946474]
  • Shingo Tanaka, Takeshi Kanagawa, Kazuo Momma, Satoko Hori, Hiroki Satoh, Takeshi Nagamatsu, Tomoyuki Fujii, Tadashi Kimura, Yasufumi Sawada. Prediction of sustained fetal toxicity induced by ketoprofen based on PK/PD analysis using human placental perfusion and rat toxicity data. British journal of clinical pharmacology. 2017 Nov; 83(11):2503-2516. doi: 10.1111/bcp.13352. [PMID: 28635050]
  • B Feragalli, E Ippolito, M Dugall, M Cacchio, G Belcaro, M R Cesarone, M Abdel-Tawab, A Riva, S Togni, R Eggenhoffner, L Giacomelli. Effectiveness of a novel boswellic acids delivery form (Casperome®) in the management of grade II ankle sprains due to sport trauma - a registry study. European review for medical and pharmacological sciences. 2017 Oct; 21(20):4726-4732. doi: NULL. [PMID: 29131239]
  • Elena Puris, Mikko Gynther, Johanna Huttunen, Aleksanteri Petsalo, Kristiina M Huttunen. L-type amino acid transporter 1 utilizing prodrugs: How to achieve effective brain delivery and low systemic exposure of drugs. Journal of controlled release : official journal of the Controlled Release Society. 2017 09; 261(?):93-104. doi: 10.1016/j.jconrel.2017.06.023. [PMID: 28662899]
  • Alexey V Osipov, Tatiana I Terpinskaya, Tatiana E Kuznetsova, Elena L Ryzhkovskaya, Vladimir S Lukashevich, Julia A Rudnichenko, Vladimir S Ulashchyk, Vladislav G Starkov, Yuri N Utkin. Cobra Venom Factor and Ketoprofen Abolish the Antitumor Effect of Nerve Growth Factor from Cobra Venom. Toxins. 2017 09; 9(9):. doi: 10.3390/toxins9090274. [PMID: 28878143]
  • Menglin Wang, Longwei Li, Junxia Xie, Yinghua Sun, Guixia Ling, Zhonggui He. Transdermal Adhesive Patches Loaded with Ketoprofen Evaluated by Dynamic Detection of Percutaneous Absorption. AAPS PharmSciTech. 2017 Aug; 18(6):2141-2148. doi: 10.1208/s12249-016-0695-8. [PMID: 28035612]
  • Farya Zafar, Muhammad Harris Shoaib, Rabia Ismail Yousuf, Huma Ali, Rabia Bushra. Pharmacokinetic and bioequivalence studies of fast dispersible ketoprofen tablets in healthy volunteers. Pakistan journal of pharmaceutical sciences. 2017 Jul; 30(4):1239-1244. doi: NULL. [PMID: 29039320]
  • Sibel Ilbasmis-Tamer, Fatmanur Tugcu-Demiroz, Ismail Tuncer Degim. Carbon nanotube membranes to predict skin permeability of compounds. Pharmaceutical development and technology. 2017 Jun; 22(4):606-616. doi: 10.1080/10837450.2016.1221430. [PMID: 27491272]
  • Y Zhang, G W Price, R Jamieson, D Burton, K Khosravi. Sorption and desorption of selected non-steroidal anti-inflammatory drugs in an agricultural loam-textured soil. Chemosphere. 2017 May; 174(?):628-637. doi: 10.1016/j.chemosphere.2017.02.027. [PMID: 28199939]
  • Jyothsna Manikkath, Aswathi R Hegde, Guruprasad Kalthur, Harendra S Parekh, Srinivas Mutalik. Influence of peptide dendrimers and sonophoresis on the transdermal delivery of ketoprofen. International journal of pharmaceutics. 2017 Apr; 521(1-2):110-119. doi: 10.1016/j.ijpharm.2017.02.002. [PMID: 28163223]
  • Joanna Porażka, Agnieszka Karbownik, Dawid Murawa, Arkadiusz Spychała, Magdalena Firlej, Tomasz Grabowski, Paweł Murawa, Edmund Grześkowiak, Edyta Szałek. The pharmacokinetics of oral ketoprofen in patients after gastric resection. Pharmacological reports : PR. 2017 Apr; 69(2):296-299. doi: 10.1016/j.pharep.2016.11.010. [PMID: 28178590]
  • Chung-Ping Yu, Douglas H Sweet, Yu-Hsuan Peng, Yow-Wen Hsieh, Pei-Dawn Lee Chao, Yu-Chi Hou, Shiuan-Pey Lin. Effects of nonsteroidal anti-inflammatory drugs on the renal excretion of indoxyl sulfate, a nephro-cardiovascular toxin, in rats. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2017 Apr; 101(?):66-70. doi: 10.1016/j.ejps.2017.02.007. [PMID: 28185988]
  • Mian Wu, Huili Ye, Faqiong Zhao, Baizhao Zeng. High-Quality Metal-Organic Framework ZIF-8 Membrane Supported on Electrodeposited ZnO/2-methylimidazole Nanocomposite: Efficient Adsorbent for the Enrichment of Acidic Drugs. Scientific reports. 2017 01; 7(?):39778. doi: 10.1038/srep39778. [PMID: 28051129]
  • Stephane Junot, Stephanie Keroak, Jerome R E Del Castillo, Jean-Yves Ayoub, Christian Paquet, Jeanne-Marie Bonnet-Garin, Eric Troncy. Inhaled nitric oxide prevents NSAID-induced renal impairment in pseudo-normovolaemic piglets. PloS one. 2017; 12(6):e0179475. doi: 10.1371/journal.pone.0179475. [PMID: 28658254]
  • Sadaharu Matsushita, Koji Nishi, Yasunori Iwao, Yu Ishima, Hiroshi Watanabe, Kazuaki Taguchi, Keishi Yamasaki, Toru Maruyama, Masaki Otagiri. Recombinant Human Serum Albumin Containing 3 Copies of Domain I, Has Significant in Vitro Antioxidative Capacity Compared to the Wild-Type. Biological & pharmaceutical bulletin. 2017; 40(10):1813-1817. doi: 10.1248/bpb.b17-00528. [PMID: 28966257]
  • Zhipeng Chen, Lei Xing, Qin Fan, Andrew G Cheetham, Ran Lin, Barbara Holt, Liwen Chen, Yanyu Xiao, Honggang Cui. Drug-Bearing Supramolecular Filament Hydrogels as Anti-Inflammatory Agents. Theranostics. 2017; 7(7):2003-2014. doi: 10.7150/thno.19404. [PMID: 28656057]