Ketoprofen (BioDeep_00000001483)

 

Secondary id: BioDeep_00000398576

human metabolite blood metabolite Chemicals and Drugs natural product Volatile Flavor Compounds


代谢物信息卡片


3-benzoyl-α-methyl-benzeneacetic acid

化学式: C16H14O3 (254.0942894)
中文名称: 酮洛芬
谱图信息: 最多检出来源 Homo sapiens(urine) 5.07%

分子结构信息

SMILES: CC(C(=O)O)c1cccc(C(=O)c2ccccc2)c1
InChI: InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)

描述信息

Ketoprofen is only found in individuals that have used or taken this drug. It is a propionic acid derivative and is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. The anti-inflammatory effects of ketoprofen are believed to be due to inhibition cylooxygenase-2 (COX-2), an enzyme involved in prostaglandin synthesis via the arachidonic acid pathway. This results in decreased levels of prostaglandins that mediate pain, fever and inflammation. Ketoprofen is a non-specific cyclooxygenase inhibitor and inhibition of COX-1 is thought to confer some of its side effects, such as GI upset and ulceration. Ketoprofen is thought to have anti-bradykinin activity, as well as lysosomal membrane-stabilizing action. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation.
M - Musculo-skeletal system > M02 - Topical products for joint and muscular pain > M02A - Topical products for joint and muscular pain > M02AA - Antiinflammatory preparations, non-steroids for topical use
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AE - Propionic acid derivatives
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
CONFIDENCE standard compound; EAWAG_UCHEM_ID 205
CONFIDENCE standard compound; INTERNAL_ID 1150
CONFIDENCE standard compound; INTERNAL_ID 4086
CONFIDENCE standard compound; INTERNAL_ID 8562
D000893 - Anti-Inflammatory Agents
D004791 - Enzyme Inhibitors

同义名列表

22 个代谢物同义名

3-benzoyl-α-methyl-benzeneacetic acid; 3-Benzoyl-alpha-methylbenzeneacetic acid; Lacide (benzoyl-3-phenyl)-2-propionique; 3-Benzoyl-alpha-methylbenzeneacetate; 3-Benzoyl-α-methylbenzeneacetic acid; 3-Benzoyl-a-methylbenzeneacetic acid; 2-(3-benzoylphenyl)propanoic acid; 2-(3-Benzoylphenyl)propionic acid; 3-Benzoyl-α-methylbenzeneacetate; 3-Benzoyl-a-methylbenzeneacetate; 2-(3-Benzoylphenyl)propionate; 3-Benzoylhydratropic acid; m-Benzoylhydratropic acid; Benzoylhydratropic acid; m-Benzoylhydratropate; 3-Benzoylhydratropate; ketoprofen; Alrheumum; Alrheumat; Profenid; Orudis; Ketoprofen



数据库引用编号

59 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Huan Wang, Zhiheng Li, Luoqin Shen, Ping Zhang, Yanyao Lin, Xinting Huang, Shaoting Du, Huijun Liu. Ketoprofen exposure perturbs nitrogen assimilation and ATP synthesis in rice roots: An integrated metabolome and microbiome analysis. Environmental pollution (Barking, Essex : 1987). 2023 Aug; 336(?):122485. doi: 10.1016/j.envpol.2023.122485. [PMID: 37659631]
  • Jianwen Liao, Mingchao Zhang, Zichuan Shi, Hao Lu, Lichen Wang, Weijia Fan, Xiaoguang Tong, Hua Yan. Improving the Function of Meningeal Lymphatic Vessels to Promote Brain Edema Absorption after Traumatic Brain Injury. Journal of neurotrauma. 2023 02; 40(3-4):383-394. doi: 10.1089/neu.2022.0150. [PMID: 36106596]
  • Halley Gora Ravuri, Pawel Sadowski, Zainab Noor, Nana Satake, Paul C Mills. Plasma proteomic changes in response to surgical trauma and a novel transdermal analgesic treatment in dogs. Journal of proteomics. 2022 08; 265(?):104648. doi: 10.1016/j.jprot.2022.104648. [PMID: 35691609]
  • Didier Ramírez-Morales, Daniela Fajardo-Romero, Carlos E Rodríguez-Rodríguez, Nina Cedergreen. Single and mixture toxicity of selected pharmaceuticals to the aquatic macrophyte Lemna minor. Ecotoxicology (London, England). 2022 Jul; 31(5):714-724. doi: 10.1007/s10646-022-02537-3. [PMID: 35348978]
  • Rubina Novelli, Andrea Aramini, Serena Boccella, Michela Bagnasco, Franca Cattani, Mauro Paolo Ferrari, Giovanni Goisis, Enrico Maria Minnella, Marcello Allegretti, Virgilio Pace. Ketoprofen lysine salt has a better gastrointestinal and renal tolerability than ketoprofen acid: A comparative tolerability study in the Beagle dog. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 153(?):113336. doi: 10.1016/j.biopha.2022.113336. [PMID: 35772374]
  • Bianca-Maria Ţuchiu, Raluca-Ioana Stefan-van Staden, Marius Bădulescu, Jacobus Frederick van Staden. Disposable stochastic sensors for fast analysis of ibuprofen, ketoprofen, and flurbiprofen in their topical pharmaceutical formulations. Journal of pharmaceutical and biomedical analysis. 2022 Jun; 215(?):114758. doi: 10.1016/j.jpba.2022.114758. [PMID: 35421777]
  • Ersin Koksal, Yasemin Burcu Ustun, Sezgin Bilgin, Abdurrahman Aksoy, Yavuz Kursad Das, Murat Yarim, Fatih Ozkan, Cengiz Kaya, Burhan Dost. The effects of dexketoprofen on renal ischemia-reperfusion injury: an experimental study. Brazilian journal of anesthesiology (Elsevier). 2022 May; 72(3):365-371. doi: 10.1016/j.bjane.2021.07.033. [PMID: 34411625]
  • Wataru Kashihara, Mio Shinoda, Kiyoka Tsuchiya, Tasuku Isozaki, Batsaikhan Mijiddorj, Kazuyoshi Ueda, Tadashi Suzuki. Photochemical Reaction of Ketoprofen with Proteinogenic Amino Acids. The journal of physical chemistry. B. 2022 03; 126(10):2098-2107. doi: 10.1021/acs.jpcb.1c10108. [PMID: 35142495]
  • G Cetin, O Corum, D D Corum, O Atik, F Altan, E Turk, I O Tekeli, H E Faki, K Uney. Pharmacokinetics of intravenous meloxicam, ketoprofen and tolfenamic acid in chukar partridge (Alectoris chukar). British poultry science. 2022 Feb; 63(1):14-20. doi: 10.1080/00071668.2021.1990211. [PMID: 34633873]
  • Orhan Corum, Kamil Uney, Duygu Durna Corum, Orkun Atik, Devran Coskun, Aidai Zhunushova, Muammer Elmas. Effect of ketoprofen on intravenous pharmacokinetics of ganciclovir in chukar partridges (Alectoris chukar). Journal of veterinary pharmacology and therapeutics. 2022 Jan; 45(1):126-132. doi: 10.1111/jvp.13027. [PMID: 34719792]
  • Isadora A Preigschadt, Raíssa C Bevilacqua, Matias S Netto, Jordana Georgin, Dison S P Franco, Evandro S Mallmann, Diana Pinto, Edson L Foletto, Guilherme L Dotto. Optimization of ketoprofen adsorption from aqueous solutions and simulated effluents using H2SO4 activated Campomanesia guazumifolia bark. Environmental science and pollution research international. 2022 Jan; 29(2):2122-2135. doi: 10.1007/s11356-021-15668-7. [PMID: 34363168]
  • Pooja Prasanthan, Nand Kishore. Unusual human serum albumin fibrillation inhibition by ketoprofen and fenoprofen: Mechanistic insights. Journal of molecular recognition : JMR. 2021 12; 34(12):e2937. doi: 10.1002/jmr.2937. [PMID: 34505308]
  • Gul Cetin, Duygu Durna Corum, Orhan Corum, Orkun Atik, Devran Coskun, Kamil Uney. Effect of ketoprofen and tolfenamic acid on intravenous pharmacokinetics of ceftriaxone in sheep. Journal of veterinary pharmacology and therapeutics. 2021 Nov; 44(6):945-951. doi: 10.1111/jvp.13001. [PMID: 34312894]
  • Kristen J Reynolds, Ron Johnson, Robert M Friendship, Jennifer Brown, Saad Enouri, Ronette Gehring, Terri L O'Sullivan. Pharmacokinetics and bioavailability of ketoprofen when compounded with iron dextran for use in nursing piglets. The Canadian veterinary journal = La revue veterinaire canadienne. 2021 11; 62(11):1211-1218. doi: NULL. [PMID: 34728849]
  • Sunkyung Jeong, Joseph E Valdez, Natalia Miękus, Joon Yub Kwon, Wooyong Kwon, Tomasz Bączek, Doo Soo Chung. Facile and highly efficient three-phase single drop microextraction in-line coupled with capillary electrophoresis. Journal of chromatography. A. 2021 Oct; 1655(?):462520. doi: 10.1016/j.chroma.2021.462520. [PMID: 34517164]
  • Darya A Kuznetsova, Leysan A Vasileva, Gulnara A Gaynanova, Elmira A Vasilieva, Oksana A Lenina, Irek R Nizameev, Marsil K Kadirov, Konstantin A Petrov, Lucia Ya Zakharova, Oleg G Sinyashin. Cationic liposomes mediated transdermal delivery of meloxicam and ketoprofen: Optimization of the composition, in vitro and in vivo assessment of efficiency. International journal of pharmaceutics. 2021 Aug; 605(?):120803. doi: 10.1016/j.ijpharm.2021.120803. [PMID: 34144135]
  • Shan Chen, Shu Zhou, Jinli Fu, Sisi Tang, Xiaodan Wu, Pengfei Zhao, Zhaohui Zhang. A near infrared fluorescence imprinted sensor based on zinc oxide nanorods for rapid determination of ketoprofen. Analytical methods : advancing methods and applications. 2021 07; 13(25):2836-2846. doi: 10.1039/d1ay00555c. [PMID: 34080589]
  • Yuting Wang, Liyan He, Guoyan Dang, Hui Li, Xiaoli Li. Polypyrrole-functionalized magnetic Bi2MoO6 nanocomposites as a fast, efficient and reusable adsorbent for removal of ketoprofen and indomethacin from aqueous solution. Journal of colloid and interface science. 2021 Jun; 592(?):51-65. doi: 10.1016/j.jcis.2021.02.033. [PMID: 33639538]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Craig A Harms, Laura K Ruterbories, Nicole I Stacy, Emily F Christiansen, Mark G Papich, Alex M Lynch, Ashley Barratclough, Maria E Serrano. SAFETY OF MULTIPLE-DOSE INTRAMUSCULAR KETOPROFEN TREATMENT IN LOGGERHEAD TURTLES (CARETTA CARETTA). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 2021 Apr; 52(1):126-132. doi: 10.1638/2020-0159. [PMID: 33827169]
  • Caroline Belló, Ana Paula Prestes, Josiane Aparecida Schemberger, Ana Carolina Mendes Hacke, Romaiana Picada Pereira, Francine Alessandra Manente, Iracilda Zeppone Carlos, Cleverton Roberto de Andrade, Daniel Fernandes, Ivana Beatrice Manica da Cruz, Taís Cristina Unfer, José Carlos Rebuglio Vellosa. Aqueous extract of Paullinia cupana attenuates renal and hematological effects associated with ketoprofen. Journal of food biochemistry. 2021 01; 45(1):e13560. doi: 10.1111/jfbc.13560. [PMID: 33270240]
  • Angélica F M Streit, Gabriela C Collazzo, Susanne P Druzian, Rodrigo S Verdi, Edson L Foletto, Luis F S Oliveira, Guilherme L Dotto. Adsorption of ibuprofen, ketoprofen, and paracetamol onto activated carbon prepared from effluent treatment plant sludge of the beverage industry. Chemosphere. 2021 Jan; 262(?):128322. doi: 10.1016/j.chemosphere.2020.128322. [PMID: 32962838]
  • Fátima Tous-Romero, Pablo L Ortiz Romero, Javier Ortiz de Frutos. Usefulness of Patch Testing With Patient's Own Products in the Diagnosis of Allergic Contact Dermatitis. Dermatitis : contact, atopic, occupational, drug. 2021 Jan; 32(1):38-41. doi: 10.1097/der.0000000000000654. [PMID: 33449479]
  • Shoko Okazaki, Ayako Hirata, Yusuke Shogomori, Megumi Takemoto, Takuro Nagata, Eriko Hayashida, Keizo Takeshita. Radical reactions induced by ketoprofen in phospholipid membranes under ultraviolet light irradiation. Journal of photochemistry and photobiology. B, Biology. 2021 Jan; 214(?):112090. doi: 10.1016/j.jphotobiol.2020.112090. [PMID: 33302245]
  • Steven X Hu, Kelsey Ernst, Charles P Benner, Kenneth L Feenstra. Stability of Ketoprofen Methylester in Plasma of Different Species. Current drug metabolism. 2021; 22(3):215-223. doi: 10.2174/1389200221666201217141025. [PMID: 33334282]
  • Emma Nixon, Alexandra R Carlson, Patricia A Routh, Liliana Hernandez, Glen W Almond, Ronald E Baynes, Kristen M Messenger. Comparative effects of nonsteroidal anti-inflammatory drugs at castration and tail-docking in neonatal piglets. PloS one. 2021; 16(11):e0254409. doi: 10.1371/journal.pone.0254409. [PMID: 34847143]
  • Hany H Arab, Muhammed A Saad, Ayman E El-Sahar, Muhammad Y Al-Shorbagy. Mechanistic perspective of morin protection against ketoprofen-induced gastric mucosal injury: Targeting HMGB1/RAGE/NF-κB, DJ-1/Nrf2/HO-1 and PI3K/mTOR pathways. Archives of biochemistry and biophysics. 2020 10; 693(?):108552. doi: 10.1016/j.abb.2020.108552. [PMID: 32860758]
  • J C López-Doval, A Serra-Compte, S Rodríguez-Mozaz, D Barceló, S Sabater. Diet quality and NSAIDs promote changes in formation of prostaglandins by an aquatic invertebrate. Chemosphere. 2020 Oct; 257(?):126892. doi: 10.1016/j.chemosphere.2020.126892. [PMID: 32480082]
  • T S Tschoner, Y Zablotski, G Knubben-Schweizer, M Feist. Effect of xylazine administration before laparoscopic abomasopexy to correct left displaced abomasum on markers of stress in dairy cows. Journal of dairy science. 2020 Oct; 103(10):9318-9331. doi: 10.3168/jds.2020-18523. [PMID: 32747093]
  • Ibrahim Ozan Tekeli, Erdinc Turk, Duygu Durna Corum, Orhan Corum, Fatma Ceren Kirgiz, Fatih Sakin, Kamil Uney. Effect of ketoprofen co-administration on pharmacokinetics of cefquinome following repeated administration in goats. Journal of veterinary pharmacology and therapeutics. 2020 Sep; 43(5):440-447. doi: 10.1111/jvp.12904. [PMID: 32815194]
  • Keigo Nakayama, Hidetaka Kamimura, Hiroshi Suemizu, Nao Yoneda, Megumi Nishiwaki, Kazuhiko Iwamoto, Mari Mizunaga, Tamotsu Negoro, Soichiro Ito, Hiroshi Yamazaki, Yukihiro Nomura. Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data. Drug metabolism and pharmacokinetics. 2020 Aug; 35(4):389-396. doi: 10.1016/j.dmpk.2020.05.004. [PMID: 32690433]
  • Shukai Ding, Bilal Mustafa, Nicolas Anton, Christophe A Serra, Delphine Chan-Seng, Thierry F Vandamme. Production of lipophilic nanogels by spontaneous emulsification. International journal of pharmaceutics. 2020 Jul; 585(?):119481. doi: 10.1016/j.ijpharm.2020.119481. [PMID: 32473375]
  • Joanna Porażka, Edyta Szałek, Wojciech Żółtaszek, Tomasz Grabowski, Anna Wolc, Edmund Grześkowiak. Influence of obesity on pharmacokinetics and analgesic effect of ketoprofen administered intravenously to patients after laparoscopic cholecystectomy. Pharmacological reports : PR. 2020 Jun; 72(3):763-768. doi: 10.1007/s43440-019-00042-9. [PMID: 32048255]
  • Zhongyan Wang, Chuanrui Ma, Yuna Shang, Lijun Yang, Jing Zhang, Cuihong Yang, Chunhua Ren, Jinjian Liu, Guanwei Fan, Jianfeng Liu. Simultaneous co-assembly of fenofibrate and ketoprofen peptide for the dual-targeted treatment of nonalcoholic fatty liver disease (NAFLD). Chemical communications (Cambridge, England). 2020 May; 56(36):4922-4925. doi: 10.1039/d0cc00513d. [PMID: 32239031]
  • Nam Hyeon Kang, Sulagna Mukherjee, Myeong Hwan Jang, Huong Giang Pham, MinJi Choi, Jong Won Yun. Ketoprofen alleviates diet-induced obesity and promotes white fat browning in mice via the activation of COX-2 through mTORC1-p38 signaling pathway. Pflugers Archiv : European journal of physiology. 2020 05; 472(5):583-596. doi: 10.1007/s00424-020-02380-7. [PMID: 32358780]
  • Marta Ziegler-Borowska, Kinga Mylkie, Pawel Nowak, Patryk Rybczynski, Adam Sikora, Dorota Chelminiak-Dudkiewicz, Anna Kaczmarek-Kedziera. Testing for Ketoprofen Binding to HSA Coated Magnetic Nanoparticles under Normal Conditions and after Oxidative Stress. Molecules (Basel, Switzerland). 2020 Apr; 25(8):. doi: 10.3390/molecules25081945. [PMID: 32331398]
  • M Locatelli, A Tartaglia, F D'Ambrosio, P Ramundo, H I Ulusoy, K G Furton, A Kabir. Biofluid sampler: A new gateway for mail-in-analysis of whole blood samples. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Apr; 1143(?):122055. doi: 10.1016/j.jchromb.2020.122055. [PMID: 32172173]
  • Marcio Antonio Rodrigues Araujo. Ketoprofen hypersensibility and idiosyncratic response - a case report. Immunopharmacology and immunotoxicology. 2020 Apr; 42(2):174-177. doi: 10.1080/08923973.2020.1728764. [PMID: 32079429]
  • Silvia Bua, Laura Lucarini, Laura Micheli, Marta Menicatti, Gianluca Bartolucci, Silvia Selleri, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Emanuela Masini, Fabrizio Carta, Paola Gratteri, Alessio Nocentini, Claudiu T Supuran. Bioisosteric Development of Multitarget Nonsteroidal Anti-Inflammatory Drug-Carbonic Anhydrases Inhibitor Hybrids for the Management of Rheumatoid Arthritis. Journal of medicinal chemistry. 2020 03; 63(5):2325-2342. doi: 10.1021/acs.jmedchem.9b01130. [PMID: 31689108]
  • Kamil Zielinski, Bartosz Sekula, Anna Bujacz, Izabela Szymczak. Structural investigations of stereoselective profen binding by equine and leporine serum albumins. Chirality. 2020 03; 32(3):334-344. doi: 10.1002/chir.23162. [PMID: 31905261]
  • Natalia Pettinelli, Saddys Rodríguez-Llamazares, Yousof Farrag, Rebeca Bouza, Luis Barral, Sandra Feijoo-Bandín, Francisca Lago. Poly(hydroxybutyrate-co-hydroxyvalerate) microparticles embedded in κ-carrageenan/locust bean gum hydrogel as a dual drug delivery carrier. International journal of biological macromolecules. 2020 Mar; 146(?):110-118. doi: 10.1016/j.ijbiomac.2019.12.193. [PMID: 31881300]
  • Ahmed Jasim Twayej, Hussein Kadhem Al-Hakeim, Arafat Hussein Al-Dujaili, Michael Maes. Lowered zinc and copper levels in drug-naïve patients with major depression: Effects of antidepressants, ketoprofen and immune activation. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. 2020 02; 21(2):127-138. doi: 10.1080/15622975.2019.1612090. [PMID: 31062629]
  • Małgorzata Maciążek-Jurczyk, Kamil Janas, Jadwiga Pożycka, Agnieszka Szkudlarek, Wojciech Rogóż, Aleksandra Owczarzy, Karolina Kulig. Human Serum Albumin Aggregation/Fibrillation and its Abilities to Drugs Binding. Molecules (Basel, Switzerland). 2020 Jan; 25(3):. doi: 10.3390/molecules25030618. [PMID: 32023900]
  • Wenqian Wu, Feng Lin, Xiaohan Yang, Bin Wang, Xin Lu, Qiuxia Chen, Fanggui Ye, Shulin Zhao. Facile synthesis of magnetic carbon nanotubes derived from ZIF-67 and application to magnetic solid-phase extraction of profens from human serum. Talanta. 2020 Jan; 207(?):120284. doi: 10.1016/j.talanta.2019.120284. [PMID: 31594616]
  • Hussein Kadhem Al-Hakeim, Ahmed Jasim Twayej, Arafat Hussein Al-Dujaili, Michael Maes. Plasma Indoleamine-2,3-Dioxygenase (IDO) is Increased in Drug-Naï ve Major Depressed Patients and Treatment with Sertraline and Ketoprofen Normalizes IDO in Association with Pro-Inflammatory and Immune- Regulatory Cytokines. CNS & neurological disorders drug targets. 2020; 19(1):44-54. doi: 10.2174/1871527319666200102100307. [PMID: 31894751]
  • Paula Ossowicz, Proletina Kardaleva, Maya Guncheva, Joanna Klebeko, Ewelina Świątek, Ewa Janus, Denitsa Yancheva, Ivan Angelov. Ketoprofen-Based Ionic Liquids: Synthesis and Interactions with Bovine Serum Albumin. Molecules (Basel, Switzerland). 2019 Dec; 25(1):. doi: 10.3390/molecules25010090. [PMID: 31881750]
  • Li-Na Yin, Ya-Wen Zhang, Wen-Hai Huang, Sheng-Hao Wang, Gao-Li Zheng. Stereoselectivity evaluation of chiral chitosan microspheres delivery system containing rac-KET in vitro and in vivo. Drug delivery. 2019 Dec; 26(1):63-69. doi: 10.1080/10717544.2018.1556360. [PMID: 30744429]
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  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Xiaofei Han, Jia Chen, Zhan Li, Hongdeng Qiu. Combustion fabrication of magnetic porous carbon as a novel magnetic solid-phase extraction adsorbent for the determination of non-steroidal anti-inflammatory drugs. Analytica chimica acta. 2019 Oct; 1078(?):78-89. doi: 10.1016/j.aca.2019.06.022. [PMID: 31358231]
  • Jiajie Hu, Hengjiang Liu, Pu Xu, Yazhuo Shang, Honglai Liu. Investigation of Drug for Pulmonary Administration-Model Pulmonary Surfactant Monolayer Interactions Using Langmuir-Blodgett Monolayer and Molecular Dynamics Simulation: A Case Study of Ketoprofen. Langmuir : the ACS journal of surfaces and colloids. 2019 10; 35(41):13452-13460. doi: 10.1021/acs.langmuir.9b02412. [PMID: 31524404]
  • Arafat Hussein Al-Dujaili, Hussein Kadhem Al-Hakeim, Ahmed Jasim Twayej, Michael Maes. Total and ionized calcium and magnesium are significantly lowered in drug-naïve depressed patients: effects of antidepressants and associations with immune activation. Metabolic brain disease. 2019 10; 34(5):1493-1503. doi: 10.1007/s11011-019-00458-5. [PMID: 31292851]
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