2-Hydroxyglutarate (BioDeep_00000014772)
Secondary id: BioDeep_00000629081
human metabolite Endogenous blood metabolite Volatile Flavor Compounds
代谢物信息卡片
alpha-Hydroxyglutarate, disodium salt
化学式: C5H8O5 (148.0371718)
中文名称: 羟基戊二酸
谱图信息:
最多检出来源 Viridiplantae(plant) 50%
Reviewed
Last reviewed on 2024-09-13.
Cite this Page
2-Hydroxyglutarate. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/2-hydroxyglutarate (retrieved
2024-11-22) (BioDeep RN: BioDeep_00000014772). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: C(CC(=O)O)C(C(=O)O)O
InChI: InChI=1S/C5H8O5/c6-3(5(9)10)1-2-4(7)8/h3,6H,1-2H2,(H,7,8)(H,9,10)
描述信息
2-Hydroxyglutarate exists in 2 isomers: L-2-hydroxyglutarate acid and D-2-hydroxyglutarate. Both the D and the L stereoisomers of hydroxyglutaric acid (EC 1.1.99.2) are found in body fluids. In humans it is part of butanoate metabolic pathway and can be produced by phosphoglycerate dehydrogenase (PHGDH). More specifically, the enzyme PHGDH catalyzes the NADH-dependent reduction of ?-ketoglutarate (AKG) to D-2-hydroxyglutarate (D-2HG). 2-hydroxyglutarate is also the product of gain-of-function mutations in the cytosolic and mitochondrial isoforms of isocitrate dehydrogenase (IDH). Additionally, 2-hydroxyglutarate can be converted to ?-ketoglutaric acid through the action of 2-hydroxyglutarate dehydrogenase (HGDH). Humans have to variants of this enzyme: D-2-hydroxyglutarate dehydrogenase (D2HGDH) and L-2-hydroxyglutarate dehydrogenase (L2HGDH). A deficiency in either of these two enzymes can lead to a disease known as 2-hydroxyglutaric aciduria. L-2-hydroxyglutaric aciduria (caused by loss of L2HGDH) is chronic, with early symptoms such as hypotonia, tremors, and epilepsy declining into spongiform leukoencephalopathy, muscular choreodystonia, mental retardation, and psychomotor regression. D-2-hydroxyglutaric aciduria (caused by loss of D2HGDH or gain of function of IDH) is rare, with symptoms including cancer, macrocephaly, cardiomyopathy, mental retardation, hypotonia, and cortical blindness. 2-hydroxyglutarate was the first oncometabolite (or cancer-causing metabolite) to be formally named or identified. In cancer it is either produced by overexpression of phosphoglycerate dehydrogenase (PHGDH) or is produced in excess by gain-of-function mutations in the cytosolic and mitochondrial isoforms of isocitrate dehydrogenase (IDH). IDH is part of TCA cycle and is generated in high abundance when IDH is mutated. 2-hydroxyglutarate is sufficiently similar in structure to 2-oxogluratate (2OG) that it is able to inhibit a range of 2OG-dependent dioxygenases, including histone lysine demethylases (KDMs) and members of the ten-eleven translocation (TET) family of 5-methylcytosine (5mC) hydroxylases. This inhibitory effect leads to alterations in the hypoxia induced factor (HIF)-mediated hypoxic response and alterations in gene expression through global epigenetic remodeling. The net effect is that 2-hydroxyglutarate causes a cascading effect that leads genetic perturbations and malignant transformation. Furthermore, 2-hydroxyglutarate is found to be associated with glutaric aciduria II, which is also an inborn error of metabolism. 2-Hydroxyglutarate has also been found to be a metabolite in Aspergillus (PMID: 6057807).
同义名列表
18 个代谢物同义名
alpha-Hydroxyglutarate, disodium salt; alpha-Hydroxyglutarate, (DL)-isomer; alpha-Hydroxyglutarate, (L)-isomer; alpha-Hydroxyglutarate, (D)-isomer; (±)-2-Hydroxyglutaric acid; 2-Hydroxypentanedioic acid; alpha-Hydroxyglutaric acid; DL-2-Hydroxyglutaric acid; 2,3-Dideoxypentaric acid; alpha-Hydroxyglutarate; Α-hydroxyglutaric acid; 2-hydroxyglutaric acid; a-Hydroxyglutaric acid; D-2-Hydroxyglutarate; 2-Hydroxyglutarate; Α-hydroxyglutarate; a-Hydroxyglutarate; 2-Hydroxyglutarate
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:17084
- KEGG: C02630
- PubChem: 43
- HMDB: HMDB0059655
- Metlin: METLIN63268
- ChEMBL: CHEMBL4870693
- Wikipedia: Alpha-Hydroxyglutaric_acid
- MetaCyc: 2-HYDROXYGLUTARIC_ACID
- chemspider: 42
- CAS: 2889-31-8
- PubChem: 5610
- LipidMAPS: LMFA01050483
- 3DMET: B00467
- NIKKAJI: J527.822H
- KNApSAcK: 17084
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
- 3702 - Arabidopsis thaliana: 10.1186/1752-0509-5-1
- 7227 - Drosophila melanogaster: 10.1038/S41467-019-11933-Z
- 9606 - Homo sapiens: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xinting Zhu, Juan Hao, Hong Zhang, Mengyi Chi, Yaxian Wang, Jinlu Huang, Rong Xu, Zhao Xincai, Bo Xin, Xipeng Sun, Jianping Zhang, Shumin Zhou, Dongdong Cheng, Ting Yuan, Jun Ding, Shuier Zheng, Cheng Guo, Quanjun Yang. Oncometabolite D-2-hydroxyglutarate-dependent metabolic reprogramming induces skeletal muscle atrophy during cancer cachexia.
Communications biology.
2023 Sep; 6(1):977. doi:
10.1038/s42003-023-05366-0. [PMID: 37741882] - Daniel Thomas, Manhong Wu, Yusuke Nakauchi, Ming Zheng, Chloe A L Thompson-Peach, Kelly Lim, Niklas Landberg, Thomas Köhnke, Nirmal Robinson, Satinder Kaur, Monika Kutyna, Melissa Stafford, Devendra Hiwase, Andreas Reinisch, Gary Peltz, Ravindra Majeti. Dysregulated Lipid Synthesis by Oncogenic IDH1 Mutation Is a Targetable Synthetic Lethal Vulnerability.
Cancer discovery.
2023 Feb; 13(2):496-515. doi:
10.1158/2159-8290.cd-21-0218. [PMID: 36355448] - Qingwen Zhao. Mutant IDH1 attenuates hepatic lipogenesis through PTEN dependent pathway.
Biochemical and biophysical research communications.
2022 12; 637(?):254-258. doi:
10.1016/j.bbrc.2022.11.041. [PMID: 36410274] - Rafael Teixeira Ribeiro, Andrey Vinícios Soares Carvalho, Rafael Palavro, Luz Elena Durán-Carabali, Ângela Beatris Zemniaçak, Alexandre Umpierrez Amaral, Carlos Alexandre Netto, Moacir Wajner. L-2-Hydroxyglutaric Acid Administration to Neonatal Rats Elicits Marked Neurochemical Alterations and Long-Term Neurobehavioral Disabilities Mediated by Oxidative Stress.
Neurotoxicity research.
2022 Dec; ?(?):. doi:
10.1007/s12640-022-00625-0. [PMID: 36580261] - Gamze Tuna, Nazlı Ecem Dal-Bekar, Ali Akay, Mete Rükşen, Sertaç İşlekel, Gül Hüray İşlekel. Minimally Invasive Detection of IDH1 Mutation With Cell-Free Circulating Tumor DNA and D-2-Hydroxyglutarate, D/L-2-Hydroxyglutarate Ratio in Gliomas.
Journal of neuropathology and experimental neurology.
2022 Jun; 81(7):502-510. doi:
10.1093/jnen/nlac036. [PMID: 35582888] - Quanjun Yang, Juan Hao, Mengyi Chi, Yaxian Wang, Jie Li, Jinlu Huang, Jianping Zhang, Mengqi Zhang, Jin Lu, Shumin Zhou, Ting Yuan, Zan Shen, Shuier Zheng, Cheng Guo. D2HGDH-mediated D2HG catabolism enhances the anti-tumor activities of CAR-T cells in an immunosuppressive microenvironment.
Molecular therapy : the journal of the American Society of Gene Therapy.
2022 03; 30(3):1188-1200. doi:
10.1016/j.ymthe.2022.01.007. [PMID: 35007759] - Bo Wu, Zehua Li, Zepeng Kang, Chunling Ma, Haiyan Song, Fuping Lu, Zhiguang Zhu. An Enzymatic Biosensor for the Detection of D-2-Hydroxyglutaric Acid in Serum and Urine.
Biosensors.
2022 Jan; 12(2):. doi:
10.3390/bios12020066. [PMID: 35200327] - Bernhard Strasser, Nicolas S Arango, Jason P Stockmann, Borjan Gagoski, Bijaya Thapa, Xianqi Li, Wolfgang Bogner, Philipp Moser, Julia Small, Daniel P Cahill, Tracy T Batchelor, Jorg Dietrich, Andre van der Kouwe, Jacob White, Elfar Adalsteinsson, Ovidiu C Andronesi. Improving D-2-hydroxyglutarate MR spectroscopic imaging in mutant isocitrate dehydrogenase glioma patients with multiplexed RF-receive/B0 -shim array coils at 3 T.
NMR in biomedicine.
2022 01; 35(1):e4621. doi:
10.1002/nbm.4621. [PMID: 34609036] - Dan Xiao, Wen Zhang, Xiaoting Guo, Yidong Liu, Chunxia Hu, Shiting Guo, Zhaoqi Kang, Xianzhi Xu, Cuiqing Ma, Chao Gao, Ping Xu. A D-2-hydroxyglutarate biosensor based on specific transcriptional regulator DhdR.
Nature communications.
2021 12; 12(1):7108. doi:
10.1038/s41467-021-27357-7. [PMID: 34876568] - Mònica Bulló, Christopher Papandreou, Jesus García-Gavilán, Miguel Ruiz-Canela, Jun Li, Marta Guasch-Ferré, Estefanía Toledo, Clary Clish, Dolores Corella, Ramon Estruch, Emilio Ros, Montserrat Fitó, Chih-Hao Lee, Kerry Pierce, Cristina Razquin, Fernando Arós, Lluís Serra-Majem, Liming Liang, Miguel A Martínez-González, Frank B Hu, Jordi Salas-Salvadó. Tricarboxylic acid cycle related-metabolites and risk of atrial fibrillation and heart failure.
Metabolism: clinical and experimental.
2021 12; 125(?):154915. doi:
10.1016/j.metabol.2021.154915. [PMID: 34678258] - Pegah Askari, Ivan E Dimitrov, Sandeep K Ganji, Vivek Tiwari, Michael Levy, Toral R Patel, Edward Pan, Bruce E Mickey, Craig R Malloy, Elizabeth A Maher, Changho Choi. Spectral fitting strategy to overcome the overlap between 2-hydroxyglutarate and lipid resonances at 2.25 ppm.
Magnetic resonance in medicine.
2021 10; 86(4):1818-1828. doi:
10.1002/mrm.28829. [PMID: 33977579] - Yue Chen, Nelamangala V Nagaraja, Bin Fan, Luke Utley, Rene M Lemieux, Janeta Popovici-Muller, Lenny Dang, Hyeryun Kim, Liping Yan, Shin-San M Su, Scott A Biller, Hua Yang. Preclinical Drug Metabolism, Pharmacokinetic, and Pharmacodynamic Profiles of Ivosidenib, an Inhibitor of Mutant Isocitrate Dehydrogenase 1 for Treatment of Isocitrate Dehydrogenase 1-Mutant Malignancies.
Drug metabolism and disposition: the biological fate of chemicals.
2021 10; 49(10):870-881. doi:
10.1124/dmd.120.000234. [PMID: 34321251] - Rafael Teixeira Ribeiro, Bianca Seminotti, Ângela Zanatta, Francine Hehn de Oliveira, Alexandre Umpierrez Amaral, Guilhian Leipnitz, Moacir Wajner. Neuronal Death, Glial Reactivity, Microglia Activation, Oxidative Stress and Bioenergetics Impairment Caused by Intracerebroventricular Administration of D-2-hydroxyglutaric Acid to Neonatal Rats.
Neuroscience.
2021 09; 471(?):115-132. doi:
10.1016/j.neuroscience.2021.07.024. [PMID: 34333063] - C J Pirola, M Garaycoechea, D Flichman, G O Castaño, S Sookoian. Liver mitochondrial DNA damage and genetic variability of Cytochrome b - a key component of the respirasome - drive the severity of fatty liver disease.
Journal of internal medicine.
2021 01; 289(1):84-96. doi:
10.1111/joim.13147. [PMID: 32634278] - Garrett Brinkley, Hyeyoung Nam, Eunhee Shim, Richard Kirkman, Anirban Kundu, Suman Karki, Yasaman Heidarian, Jason M Tennessen, Juan Liu, Jason W Locasale, Tao Guo, Shi Wei, Jennifer Gordetsky, Teresa L Johnson-Pais, Devin Absher, Dinesh Rakheja, Anil K Challa, Sunil Sudarshan. Teleological role of L-2-hydroxyglutarate dehydrogenase in the kidney.
Disease models & mechanisms.
2020 11; 13(11):. doi:
10.1242/dmm.045898. [PMID: 32928875] - Martin Kery, Ioanna Papandreou. Emerging strategies to target cancer metabolism and improve radiation therapy outcomes.
The British journal of radiology.
2020 Nov; 93(1115):20200067. doi:
10.1259/bjr.20200067. [PMID: 32462882] - Feng Yin, Yonghua Ling, Jennifer Keller, Dennis Kraus, Rohini Narayanaswamy, Heidi Mangus, Fumin Li, Hua Yang, Guowen Liu. Quantitation of 2-hydroxyglutarate in human plasma via LC-MS/MS using a surrogate analyte approach.
Bioanalysis.
2020 Aug; 12(16):1149-1159. doi:
10.4155/bio-2020-0131. [PMID: 32757862] - Chong Hyun Suh, Ho Sung Kim, Ji Eun Park, Seung Chai Jung, Choong Gon Choi, Dong-Cheol Woo, Ho Beom Lee, Sang Joon Kim. Comparative Value of 2-Hydroxyglutarate-to-Lipid and Lactate Ratio versus 2-Hydroxyglutarate Concentration on MR Spectroscopic Images for Predicting Isocitrate Dehydrogenase Mutation Status in Gliomas.
Radiology. Imaging cancer.
2020 07; 2(4):e190083. doi:
10.1148/rycan.2020190083. [PMID: 33778723] - Nanxiang Xiong, Xiaofei Gao, Hongyang Zhao, Feng Cai, Fang-Cheng Zhang, Ye Yuan, Weichao Liu, Fangping He, Lauren G Zacharias, Hong Lin, Hieu S Vu, Chao Xing, Dong-Xiao Yao, Fei Chen, Benyan Luo, Wenzhi Sun, Ralph J DeBerardinis, Hao Xu, Woo-Ping Ge. Using arterial-venous analysis to characterize cancer metabolic consumption in patients.
Nature communications.
2020 06; 11(1):3169. doi:
10.1038/s41467-020-16810-8. [PMID: 32576825] - Tong Liu, Xiang Gu, Li-Xiang Li, Ming Li, Bing Li, Xiao Cui, Xiu-Li Zuo. Microbial and metabolomic profiles in correlation with depression and anxiety co-morbidities in diarrhoea-predominant IBS patients.
BMC microbiology.
2020 06; 20(1):168. doi:
10.1186/s12866-020-01841-4. [PMID: 32552668] - Bin Fan, Ingo K Mellinghoff, Patrick Y Wen, Maeve A Lowery, Lipika Goyal, William D Tap, Shuchi S Pandya, Erika Manyak, Liewen Jiang, Guowen Liu, Tara Nimkar, Camelia Gliser, Molly Prahl Judge, Sam Agresta, Hua Yang, David Dai. Clinical pharmacokinetics and pharmacodynamics of ivosidenib, an oral, targeted inhibitor of mutant IDH1, in patients with advanced solid tumors.
Investigational new drugs.
2020 04; 38(2):433-444. doi:
10.1007/s10637-019-00771-x. [PMID: 31028664] - Valeria Cuccarini, Luigi Antelmi, Bianca Pollo, Rosina Paterra, Chiara Calatozzolo, Anna Nigri, Francesco DiMeco, Marica Eoli, Gaetano Finocchiaro, Greta Brenna, Irene Tramacere, Maria Grazia Bruzzone, Elena Anghileri. In vivo 2-hydroxyglutarate-proton magnetic resonance spectroscopy (3 T, PRESS technique) in treatment-naïve suspect lower-grade gliomas: feasibility and accuracy in a clinical setting.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology.
2020 Feb; 41(2):347-355. doi:
10.1007/s10072-019-04087-9. [PMID: 31650436] - Tian-Xiang Wang, Jun-Yun Liang, Cheng Zhang, Yue Xiong, Kun-Liang Guan, Hai-Xin Yuan. The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis.
Cell death & disease.
2019 10; 10(10):755. doi:
10.1038/s41419-019-1984-4. [PMID: 31591388] - Shinji K Strain, Morris D Groves, Mark R Emmett. Differentiation of 2-hydroxyglutarate enantiomers and its lactones by gas chromatography/electron ionization tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2019 Sep; 33(17):1401-1409. doi:
10.1002/rcm.8485. [PMID: 31148247] - Hao-Wen Sim, Romina Nejad, Wenjiang Zhang, Farshad Nassiri, Warren Mason, Kenneth D Aldape, Gelareh Zadeh, Eric X Chen. Tissue 2-Hydroxyglutarate as a Biomarker for Isocitrate Dehydrogenase Mutations in Gliomas.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2019 06; 25(11):3366-3373. doi:
10.1158/1078-0432.ccr-18-3205. [PMID: 30777876] - Phuong-Nhi Bories, Samir Nakib, Luc Cynober, Anne-Sophie Alary, Marie-Magdelaine Coude, Florian Chevillon, Jérôme Tamburini, Rudy Birsen, Olivier Kosmider, Didier Bouscary. Establishing assay-specific 97.5th percentile upper reference limit for serum D-2-hydroxyglutarate for the management of patients with acute myeloid leukemia.
Clinical chemistry and laboratory medicine.
2019 03; 57(4):e57-e59. doi:
10.1515/cclm-2018-0427. [PMID: 30267623] - Andrew M Brunner, Donna S Neuberg, Seth A Wander, Hossein Sadrzadeh, Karen K Ballen, Philip C Amrein, Eyal Attar, Gabriela S Hobbs, Yi-Bin Chen, Ashley Perry, Christine Connolly, Christelle Joseph, Meghan Burke, Aura Ramos, Ilene Galinsky, Katharine Yen, Hua Yang, Kimberly Straley, Sam Agresta, Sophia Adamia, Darrell R Borger, Anthony Iafrate, Timothy A Graubert, Richard M Stone, Amir T Fathi. Isocitrate dehydrogenase 1 and 2 mutations, 2-hydroxyglutarate levels, and response to standard chemotherapy for patients with newly diagnosed acute myeloid leukemia.
Cancer.
2019 02; 125(4):541-549. doi:
10.1002/cncr.31729. [PMID: 30422308] - Sandeep Shelar, Eun-Hee Shim, Garrett J Brinkley, Anirban Kundu, Francesca Carobbio, Tyler Poston, Jubilee Tan, Vishwas Parekh, Daniel Benson, David K Crossman, Phillip J Buckhaults, Dinesh Rakheja, Richard Kirkman, Yusuke Sato, Seishi Ogawa, Shilpa Dutta, Sadanandan E Velu, Ethan Emberley, Alison Pan, Jason Chen, Tony Huang, Devin Absher, Anja Becker, Conrad Kunick, Sunil Sudarshan. Biochemical and Epigenetic Insights into L-2-Hydroxyglutarate, a Potential Therapeutic Target in Renal Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2018 12; 24(24):6433-6446. doi:
10.1158/1078-0432.ccr-18-1727. [PMID: 30108105] - Conor A Bradley. Oncometabolite mechanism unravelled.
Nature reviews. Urology.
2018 11; 15(11):656-657. doi:
10.1038/s41585-018-0086-x. [PMID: 30185913] - Lucille Stuani, Fabien Riols, Pierre Millard, Marie Sabatier, Aurélie Batut, Estelle Saland, Fanny Viars, Laure Tonini, Sonia Zaghdoudi, Laetitia K Linares, Jean-Charles Portais, Jean-Emmanuel Sarry, Justine Bertrand-Michel. Stable Isotope Labeling Highlights Enhanced Fatty Acid and Lipid Metabolism in Human Acute Myeloid Leukemia.
International journal of molecular sciences.
2018 Oct; 19(11):. doi:
10.3390/ijms19113325. [PMID: 30366412] - Mehmet G Badur, Thangaselvam Muthusamy, Seth J Parker, Shenghong Ma, Samuel K McBrayer, Thekla Cordes, Jose H Magana, Kun-Liang Guan, Christian M Metallo. Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Sells.
Cell reports.
2018 10; 25(4):1018-1026.e4. doi:
10.1016/j.celrep.2018.09.074. [PMID: 30355481] - Garfield A Simon, Andrea Wierenga. Quantitation of plasma and urine 3-hydroxyglutaric acid, after separation from 2-hydroxyglutaric acid and other compounds of similar ion transition, by liquid chromatography-tandem mass spectrometry for the confirmation of glutaric aciduria type 1.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Oct; 1097-1098(?):101-110. doi:
10.1016/j.jchromb.2018.09.007. [PMID: 30218917] - Yuanfeng Zhang, Chunmei Wang, Kunfang Yang, Simei Wang, Guoli Tian, Yucai Chen. A novel compound heterozygous mutation of the L2HGDH gene in a Chinese boy with L-2-hydroxyglutaric aciduria: case report and literature review.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology.
2018 Oct; 39(10):1697-1703. doi:
10.1007/s10072-018-3483-2. [PMID: 29980873] - Christophe Willekens, Aline Renneville, Sophie Broutin, Véronique Saada, Jean-Baptiste Micol, Julia Delahousse, Vianney Poinsignon, Claire Bories, Céline Berthon, Raphael Itzykson, Nicolas Boissel, Cyril Quivoron, Marie Terroir-Cassou-Mounat, Jacques Bosq, Claude Preudhomme, Angelo Paci, Virginie Penard-Lacronique, Stéphane De Botton. Mutational profiling of isolated myeloid sarcomas and utility of serum 2HG as biomarker of IDH1/2 mutations.
Leukemia.
2018 09; 32(9):2008-2081. doi:
10.1038/s41375-018-0056-6. [PMID: 29479068] - Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics.
Scientific reports.
2018 07; 8(1):10056. doi:
10.1038/s41598-018-28477-9. [PMID: 29968805] - Peipei Lin, Yingwan Luo, Shuanghong Zhu, Dominic Maggio, Haiyang Yang, Chao Hu, Jinghan Wang, Hua Zhang, Yanling Ren, Xinping Zhou, Chen Mei, Liya Ma, Weilai Xu, Li Ye, Zhengping Zhuang, Jie Jin, Hongyan Tong. Isocitrate dehydrogenase 2 mutations correlate with leukemic transformation and are predicted by 2-hydroxyglutarate in myelodysplastic syndromes.
Journal of cancer research and clinical oncology.
2018 Jun; 144(6):1037-1047. doi:
10.1007/s00432-018-2627-3. [PMID: 29549529] - Xuemei Ding, Shuhai Lin, Hongbo Weng, Jianying Liang. Separation and determination of the enantiomers of lactic acid and 2-hydroxyglutaric acid by chiral derivatization combined with gas chromatography and mass spectrometry.
Journal of separation science.
2018 Jun; 41(12):2576-2584. doi:
10.1002/jssc.201701555. [PMID: 29603663] - Tie Li, Christopher D Cox, Byram H Ozer, Nhung T Nguyen, HuyTram N Nguyen, Thomas J Lai, Sichen Li, Fei Liu, Harley I Kornblum, Linda M Liau, Phioanh L Nghiemphu, Timothy F Cloughesy, Albert Lai. D-2-Hydroxyglutarate Is Necessary and Sufficient for Isocitrate Dehydrogenase 1 Mutant-Induced MIR148A Promoter Methylation.
Molecular cancer research : MCR.
2018 06; 16(6):947-960. doi:
10.1158/1541-7786.mcr-17-0367. [PMID: 29545476] - Feng Peng, Yingzi Liu, Chenjie He, Yi Kong, Qianying Ouyang, Xiaonv Xie, Tong Liu, Zhaoqian Liu, Jingbo Peng. Prediction of platinum-based chemotherapy efficacy in lung cancer based on LC-MS metabolomics approach.
Journal of pharmaceutical and biomedical analysis.
2018 May; 154(?):95-101. doi:
10.1016/j.jpba.2018.02.051. [PMID: 29544107] - Manman Zhang, Chao Gao, Xiaoting Guo, Shiting Guo, Zhaoqi Kang, Dan Xiao, Jinxin Yan, Fei Tao, Wen Zhang, Wenyue Dong, Pan Liu, Chen Yang, Cuiqing Ma, Ping Xu. Increased glutarate production by blocking the glutaryl-CoA dehydrogenation pathway and a catabolic pathway involving L-2-hydroxyglutarate.
Nature communications.
2018 05; 9(1):2114. doi:
10.1038/s41467-018-04513-0. [PMID: 29844506] - Esther Fernández-Galán, Núria Massana, Marina Parra-Robert, Susana Hidalgo, Gregori Casals, Jordi Esteve, Wladimiro Jiménez. Validation of a routine gas chromatography mass spectrometry method for 2-hydroxyglutarate quantification in human serum as a screening tool for detection of idh mutations.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Apr; 1083(?):28-34. doi:
10.1016/j.jchromb.2018.02.038. [PMID: 29522955] - Rafael Teixeira Ribeiro, Ângela Zanatta, Alexandre Umpierrez Amaral, Guilhian Leipnitz, Francine Hehn de Oliveira, Bianca Seminotti, Moacir Wajner. Experimental Evidence that In Vivo Intracerebral Administration of L-2-Hydroxyglutaric Acid to Neonatal Rats Provokes Disruption of Redox Status and Histopathological Abnormalities in the Brain.
Neurotoxicity research.
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Proceedings of the National Academy of Sciences of the United States of America.
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JCI insight.
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Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
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Molecular cell.
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The oncologist.
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PloS one.
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The oncologist.
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