Carisoprodol (BioDeep_00000001446)

 

Secondary id: BioDeep_00000397854

human metabolite blood metabolite Volatile Flavor Compounds


代谢物信息卡片


(1-Methylethyl)carbamic acid 2-(((aminocarbonyl)oxy)methyl)-2-methylpentyl ester

化学式: C12H24N2O4 (260.1735984)
中文名称: 卡立普多
谱图信息: 最多检出来源 Homo sapiens(blood) 62.69%

分子结构信息

SMILES: CCCC(C)(COC(=N)O)COC(O)=NC(C)C
InChI: InChI=1S/C12H24N2O4/c1-5-6-12(4,7-17-10(13)15)8-18-11(16)14-9(2)3/h9H,5-8H2,1-4H3,(H2,13,15)(H,14,16)

描述信息

A centrally acting skeletal muscle relaxant whose mechanism of action is not completely understood but may be related to its sedative actions. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1202)
M - Musculo-skeletal system > M03 - Muscle relaxants > M03B - Muscle relaxants, centrally acting agents > M03BA - Carbamic acid esters
D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents
C78281 - Agent Affecting Musculoskeletal System > C29696 - Muscle Relaxant
D002491 - Central Nervous System Agents

同义名列表

40 个代谢物同义名

(1-Methylethyl)carbamic acid 2-(((aminocarbonyl)oxy)methyl)-2-methylpentyl ester; (1-Methylethyl)carbamate 2-(((aminocarbonyl)oxy)methyl)-2-methylpentyl ester; (+-)-2-Methyl-2-propyl-1,3-propanediol carbamic acid isopropylcarbamic acid; 2-Methyl-2-propyl-1,3-propanediol carbamic acid isopropylcarbamic acid; (+-)-2-Methyl-2-propyl-1,3-propanediol carbamate isopropylcarbamate; 2-Methyl-2-propyltrimethylene carbamic acid isopropylcarbamic acid; Carbamic acid 2-isopropylcarbamoyloxymethyl-2-methyl-pentyl ester; 2-[(carbamoyloxy)methyl]-2-methylpentyl N-(propan-2-yl)carbamate; 2-Methyl-2-propyl-1,3-propanediol carbamate isopropylcarbamate; Carbamate 2-isopropylcarbamoyloxymethyl-2-methyl-pentyl ester; N-Isopropy-2-methyl-2-propyl-1,3-propanediol dicarbamic acid; 2-Methyl-2-propyltrimethylene carbamate isopropylcarbamate; N-Isopropy-2-methyl-2-propyl-1,3-propanediol dicarbamate; GM Pharmaceuticals brand OF carisoprodol; Carter horner brand OF carisoprodol; Wallace brand 1 OF carisoprodol; Wallace brand 2 OF carisoprodol; Wallace brand 3 OF carisoprodol; Belmac brand OF carisoprodol; Schein brand OF carisoprodol; Forest brand OF carisoprodol; Isopropyl meprobamic acid; Isopropyl meprobamate; Isopropylmeprobamate; Carisoprodolum; Carisoprodatum; Isomeprobamate; Carisoprodate; carisoprodol; Isoprothane; Isoprotane; Mio relax; Isobamate; Somalgit; Carisoma; Soprodol; Vanadom; Soma; Carisoprodol; Carisoprodol



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Manoj Kumar, Manish Kumar, John M Freund, Glenn H Dillon. A Single Amino Acid Residue at Transmembrane Domain 4 of the α Subunit Influences Carisoprodol Direct Gating Efficacy at GABAA Receptors. The Journal of pharmacology and experimental therapeutics. 2017 09; 362(3):395-404. doi: 10.1124/jpet.117.242156. [PMID: 28642232]
  • Matthew H Slawson, Kamisha L Johnson-Davis. Quantitation of Carisoprodol and Meprobamate in Urine and Plasma Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS). Methods in molecular biology (Clifton, N.J.). 2016; 1383(?):105-14. doi: 10.1007/978-1-4939-3252-8_12. [PMID: 26660179]
  • Jessica L Knittel, Shawn P Vorce, Barry Levine, Rhome L Hughes, Thomas Z Bosy. Multidrug toxicity involving sumatriptan. Journal of analytical toxicology. 2015 Jan; 39(1):75-9. doi: 10.1093/jat/bku120. [PMID: 25324526]
  • Stephanie A Tse, Rabia S Atayee, Joseph D Ma, Brookie M Best. Factors affecting carisoprodol metabolism in pain patients using urinary excretion data. Journal of analytical toxicology. 2014 Apr; 38(3):122-8. doi: 10.1093/jat/bku002. [PMID: 24488112]
  • Vudagandla Sreenivasulu, Mullangi Ramesh, Inamadugu Jaswanth Kumar, Ravi Vasu Babu, Nageswara Rao Pilli, Abburi Krishnaiah. Simultaneous determination of carisoprodol and aspirin in human plasma using liquid chromatography-tandem mass spectrometry in polarity switch mode: application to a human pharmacokinetic study. Biomedical chromatography : BMC. 2013 Feb; 27(2):179-85. doi: 10.1002/bmc.2766. [PMID: 22674769]
  • Gudrun Høiseth, Umair Majid, Jørg Mørland, Jørgen G Bramness, Espen Molden. CYP2C19 genetics in fatal carisoprodol intoxications. European journal of clinical pharmacology. 2012 Nov; 68(11):1561-5. doi: 10.1007/s00228-012-1278-6. [PMID: 22527345]
  • Kristian Linnet. Postmortem drug concentration intervals for the non-intoxicated state - A review. Journal of forensic and legal medicine. 2012 Jul; 19(5):245-9. doi: 10.1016/j.jflm.2012.02.010. [PMID: 22687764]
  • Stephanie A Tse, Rabia S Atayee, Brookie M Best, Amadeo J Pesce. Evaluating the relationship between carisoprodol concentrations and meprobamate formation and inter-subject and intra-subject variability in urinary excretion data of pain patients. Journal of analytical toxicology. 2012 May; 36(4):221-31. doi: 10.1093/jat/bks018. [PMID: 22511696]
  • Jean-Claude Alvarez, Charlotte Duverneuil, Khémais Zouaoui, Emuri Abe, Philippe Charlier, Geoffroy Lorin de la Grandmaison, Stanislas Grassin-Delyle. Evaluation of the first immunoassay for the semi-quantitative measurement of meprobamate in human whole blood or plasma using biochip array technology. Clinica chimica acta; international journal of clinical chemistry. 2012 Jan; 413(1-2):273-7. doi: 10.1016/j.cca.2011.10.025. [PMID: 22057036]
  • Rebecca Heltsley, Anne DePriest, David L Black, Tim Robert, Lucas Marshall, Viola M Meadors, Yale H Caplan, Edward J Cone. Oral fluid drug testing of chronic pain patients. I. Positive prevalence rates of licit and illicit drugs. Journal of analytical toxicology. 2011 Oct; 35(8):529-40. doi: 10.1093/anatox/35.8.529. [PMID: 22004671]
  • Guohong Wang, Kim Huynh, Rekha Barhate, Warren Rodrigues, Christine Moore, Cynthia Coulter, Michael Vincent, James Soares. Validation of a new homogeneous immunoassay for the detection of carisoprodol in urine. Journal of analytical toxicology. 2011 Mar; 35(2):108-12. doi: 10.1093/anatox/35.2.108. [PMID: 21396230]
  • Amadeo Pesce, Cameron West, Robert West, Bridgit Crews, Charles Mikel, Murray Rosenthal, Perla Almazon, Sergey Latyshev. Determination of medication cutoff values in a pain patient population. Journal of opioid management. 2011 Mar; 7(2):117-22. doi: 10.5055/jom.2011.0054. [PMID: 21561035]
  • Raffaele Longhi, Silvia Corbioli, Stefano Fontana, Federicia Vinco, Simone Braggio, Lydia Helmdach, Jürgen Schiller, Hinnerk Boriss. Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method. Drug metabolism and disposition: the biological fate of chemicals. 2011 Feb; 39(2):312-21. doi: 10.1124/dmd.110.036095. [PMID: 21071520]
  • Ryan J Hansen, Bradley J Samber, Daniel L Gustafson. Rapid and sensitive LC-MS/MS method for determination of felbamate in mouse plasma and tissues and human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Dec; 878(32):3432-6. doi: 10.1016/j.jchromb.2010.10.006. [PMID: 21081288]
  • Patrick J Phillips, Steven G Smith, D W Kolpin, Steven D Zaugg, Herbert T Buxton, Edward T Furlong, Kathleen Esposito, Beverley Stinson. Pharmaceutical formulation facilities as sources of opioids and other pharmaceuticals to wastewater treatment plant effluents. Environmental science & technology. 2010 Jul; 44(13):4910-6. doi: 10.1021/es100356f. [PMID: 20521847]
  • Robert West, Amadeo Pesce, Cameron West, Bridgit Crews, Charles Mikel, Murray Rosenthal, Perla Almazan, Sergey Latyshev. Observations of medication compliance by measurement of urinary drug concentrations in a pain management population. Journal of opioid management. 2010 Jul; 6(4):253-7. doi: 10.5055/jom.2010.0023. [PMID: 20862905]
  • Kevin J Bisceglia, Jim T Yu, Mehmet Coelhan, Edward J Bouwer, A Lynn Roberts. Trace determination of pharmaceuticals and other wastewater-derived micropollutants by solid phase extraction and gas chromatography/mass spectrometry. Journal of chromatography. A. 2010 Jan; 1217(4):558-64. doi: 10.1016/j.chroma.2009.11.062. [PMID: 20015510]
  • Hong Wan, Madeleine Ahman, Anders G Holmén. Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry. 2009 Mar; 52(6):1693-700. doi: 10.1021/jm801441s. [PMID: 19256501]
  • Brianne E Akins, Estuardo Miranda, J Matthew Lacy, Barry K Logan. A multi-drug intoxication fatality involving Xyrem (GHB). Journal of forensic sciences. 2009 Mar; 54(2):495-6. doi: 10.1111/j.1556-4029.2008.00965.x. [PMID: 19187456]
  • Edward J Cone, Yale H Caplan, David L Black, Timothy Robert, Frank Moser. Urine drug testing of chronic pain patients: licit and illicit drug patterns. Journal of analytical toxicology. 2008 Oct; 32(8):530-43. doi: 10.1093/jat/32.8.530. [PMID: 19007501]
  • S Hegstad, H Z Khiabani, L Kristoffersen, N Kunøe, P P Lobmaier, A S Christophersen. Drug screening of hair by liquid chromatography-tandem mass spectrometry. Journal of analytical toxicology. 2008 Jun; 32(5):364-72. doi: 10.1093/jat/32.5.364. [PMID: 18544222]
  • Arne Helland, Ketil Arne Espnes, Arne Reimers, Trond Aamo, Kolbjørn Zahlsen, Tarjei Rygnestad, Olav Spigset. [Toxicological screening of medicines and drugs of abuse in emergency cases]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke. 2008 Jan; 128(1):42-5. doi: NULL. [PMID: 18183057]
  • Eugene W Schwilke, Maria Isabel Sampaio dos Santos, Barry K Logan. Changing patterns of drug and alcohol use in fatally injured drivers in Washington State. Journal of forensic sciences. 2006 Sep; 51(5):1191-8. doi: 10.1111/j.1556-4029.2006.00239.x. [PMID: 17018108]
  • Sandrine Daval, Damien Richard, Bertrand Souweine, Alain Eschalier, François Coudore. A one-step and sensitive GC-MS assay for meprobamate determination in emergency situations. Journal of analytical toxicology. 2006 Jun; 30(5):302-5. doi: 10.1093/jat/30.5.302. [PMID: 16839465]
  • Heesun Chung. Role of drug testing as an early warning programme: the experience of the Republic of Korea. Bulletin on narcotics. 2005; 57(1-2):231-48. doi: NULL. [PMID: 21338024]
  • Magne Arve Flaten, Terje Simonsen, Kolbjørn Zahlsen, Trond Aamo, Georg Sager, Harald Olsen. Stimulant and relaxant drugs combined with stimulant and relaxant information: a study of active placebo. Psychopharmacology. 2004 Nov; 176(3-4):426-34. doi: 10.1007/s00213-004-1886-7. [PMID: 15549277]
  • Teemu Gunnar, Sirpa Mykkänen, Kari Ariniemi, Pirjo Lillsunde. Validated semiquantitative/quantitative screening of 51 drugs in whole blood as silylated derivatives by gas chromatography-selected ion monitoring mass spectrometry and gas chromatography electron capture detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2004 Jul; 806(2):205-19. doi: 10.1016/j.jchromb.2004.04.005. [PMID: 15171931]
  • Irina Rudik Miksa, Robert H Poppenga. Direct and rapid determination of baclofen (Lioresal) and carisoprodol (Soma) in bovine serum by liquid chromatography-mass spectrometry. Journal of analytical toxicology. 2003 Jul; 27(5):275-83. doi: 10.1093/jat/27.5.275. [PMID: 12908940]
  • Tomohiro Matsumoto, Toshiyuki Sano, Toshiyasu Matsuoka, Minoru Aoki, Yoshitaka Maeno, Masataka Nagao. Simultaneous determination of carisoprodol and acetaminophen in an attempted suicide by liquid chromatography-mass spectrometry with positive electrospray ionization. Journal of analytical toxicology. 2003 Mar; 27(2):118-22. doi: 10.1093/jat/27.2.118. [PMID: 12670008]
  • David N Bailey, John R Briggs. Carisoprodol: an unrecognized drug of abuse. American journal of clinical pathology. 2002 Mar; 117(3):396-400. doi: 10.1309/4ktm-cy6n-572p-7erd. [PMID: 11888078]
  • P C Chan. NTP toxicity studies of carisoprodol (CAS No. 78-44-4) administered by Gavage to F344/N rats and B6C3F1 mice. Toxicity report series. 2000 Aug; ?(56):1-G14. doi: NULL. [PMID: 11986679]
  • M A Flaten, T Simonsen, H Olsen. Drug-related information generates placebo and nocebo responses that modify the drug response. Psychosomatic medicine. 1999 Mar; 61(2):250-5. doi: 10.1097/00006842-199903000-00018. [PMID: 10204979]
  • P Dalén, G Alvan, M Wakelkamp, H Olsen. Formation of meprobamate from carisoprodol is catalysed by CYP2C19. Pharmacogenetics. 1996 Oct; 6(5):387-94. doi: 10.1097/00008571-199610000-00002. [PMID: 8946470]
  • H Olsen, E Koppang, G Alvan, J Mørland. Carisoprodol elimination in humans. Therapeutic drug monitoring. 1994 Aug; 16(4):337-40. doi: 10.1097/00007691-199408000-00001. [PMID: 7974621]
  • R C Backer, R Zumwalt, P McFeeley, S Veasey, N Wohlenberg. Carisoprodol concentrations from different anatomical sites: three overdose cases. Journal of analytical toxicology. 1990 Sep; 14(5):332-4. doi: 10.1093/jat/14.5.332. [PMID: 2263072]
  • P Kintz, P Mangin, A A Lugnier, A J Chaumont. A rapid and sensitive gas chromatographic analysis of meprobamate or carisoprodol in urine and plasma. Journal of analytical toxicology. 1988 Mar; 12(2):73-4. doi: 10.1093/jat/12.2.73. [PMID: 3379924]
  • N Kucharczyk, F H Segelman, E Kelton, J Summers, R D Sofia, H Mahrous, R Heath. Gas chromatographic determination of carisoprodol in human plasma. Journal of chromatography. 1986 Apr; 377(?):384-90. doi: 10.1016/s0378-4347(00)80798-7. [PMID: 3711232]
  • E Cayanis, E D Gomperts, D Balinsky, P Disler, A Myers. G6PD hillbrow: a new variant of glucose-6-phosphate dehydrogenase associated with drug-induced haemolytic anaemia. British journal of haematology. 1975 Jul; 30(3):343-50. doi: 10.1111/j.1365-2141.1975.tb00550.x. [PMID: 1201217]
  • H R Adams, T Kerzee, C D Morehead. Carisoprodol-related death in a child. Journal of forensic sciences. 1975 Jan; 20(1):200-2. doi: NULL. [PMID: 1117271]
  • A Baïsset, J Cotonat, P Montastruc. [Effect of some antidiuretic agents on the polyuria-polydipsia provoked by alcohol]. Comptes rendus des seances de la Societe de biologie et de ses filiales. 1975; 169(2):444-8. doi: NULL. [PMID: 126784]
  • R Maes, R Bouche, L Laruelle. [Quantitative determination of meprobamate and carisoprodol by gas chromatography in different cases of poisoning]. European journal of toxicology. 1970 Mar; 3(2):140-3. doi: NULL. [PMID: 5520468]
  • J Jacob. [Side effects of drugs]. Il Farmaco; edizione pratica. 1970 Jan; 25(1):3-23. doi: NULL. [PMID: 4905301]
  • D Goldberg. Carisoprodol toxicity. Military medicine. 1969 Aug; 134(8):597-601. doi: 10.1093/milmed/134.8.597. [PMID: 4979454]
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  • R Maes, N Hodnett, H Landesman, G Kananen, B Finkle, I Sunshine. The gas chromatographic determination of selected sedatives (ethchlorvynol, paraldehyde, meprobamate, and Carisoprodol) in biological material. Journal of forensic sciences. 1969 Apr; 14(2):235-54. doi: . [PMID: 5782014]
  • J F Douglas, N B Smith, J A Stockage. Gas chromatographic determination of mebutamate, carisoprodol, and tybamate in plasma and urine. Journal of pharmaceutical sciences. 1969 Jan; 58(1):145-6. doi: 10.1002/jps.2600580139. [PMID: 5765828]
  • R Kato, A Takanaka. Effect of starvation on the in vivo metabolism and effect of drugs in female and male rats. Japanese journal of pharmacology. 1967 Jun; 17(2):208-17. doi: 10.1254/jjp.17.208. [PMID: 4295244]
  • J F DOUGLAS, W H BRADSHAW, B J LUDWIG, D POWERS. INTERACTION OF PLASMA PROTEIN WITH RELATED 1,3-PROPANEDIOL DICARBAMATES. Biochemical pharmacology. 1964 Mar; 13(?):537-9. doi: 10.1016/0006-2952(64)90177-7. [PMID: 14157619]
  • H DOBETA. [CLINICAL AND EXPERIMENTAL STUDIES ON SOME ASPECTS OF THE INTERRELATION BETWEEN PSYCHE AND SOMA]. Fukuoka igaku zasshi = Hukuoka acta medica. 1963 Mar; 54(?):330-58. doi: NULL. [PMID: 14049487]
  • S J MYBURGH. The supplementary effect between the proteins of a heat-treated soybean meal (soma meal) and a South African strain of yellow maize seed (eksteen). The Onderstepoort journal of veterinary science and animal industry. 1947 Mar; 21(2):301-4. doi: ". [PMID: 20247523]