Adipic acid (BioDeep_00000001438)

 

Secondary id: BioDeep_00000405274

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


1,4-Butanedicarboxylic acid

化学式: C6H10O4 (146.0579)
中文名称: 己二酸
谱图信息: 最多检出来源 Homo sapiens(feces) 20.48%

Reviewed

Last reviewed on 2024-07-16.

Cite this Page

Adipic acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/adipic_acid (retrieved 2024-12-26) (BioDeep RN: BioDeep_00000001438). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(CCC(=O)O)CC(=O)O
InChI: InChI=1S/C6H10O4/c7-5(8)3-1-2-4-6(9)10/h1-4H2,(H,7,8)(H,9,10)

描述信息

Adipic acid is an important inudstrial dicarboxylic acid with about 2.5 billion kilograms produced per year. It is used mainly in the production of nylon. It occurs relatively rarely in nature. It has a tart taste and is also used as an additive and gelling agent in jello or gelatins. It is also used in some calcium carbonate antacids to make them tart. Adipic acid has also been incorporated into controlled-release formulation matrix tablets to obtain pH-independent release for both weakly basic and weakly acidic drugs. Adipic acid in the urine and in the blood is typically exogenous in origin and is a good biomarker of jello consumption. In fact, a condition known as adipic aciduria is actually an artifact of jello consumption (PMID: 1779643). However, certain disorders (such as diabetes and glutaric aciduria type I.) can lead to elevated levels of adipic acid snd other dicarboxcylic acids (such as suberic acid) in urine (PMID: 17520433; PMID: 6778884). Moreover, adipic acid is also found to be associated with 3-hydroxy-3-methylglutaryl-CoA lyase deficiency, carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, and medium Chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism. Adipic acid is also microbial metabolite found in Escherichia.
Constituent of beet juice, pork fat, guava fruit (Psidium guajava), papaya (Carica papaya) and raspberry (Rubus idaeus). Food acidulant

Adipic acid. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=124-04-9 (retrieved 2024-07-16) (CAS RN: 124-04-9). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Adipic acid is found to be associated with HMG-CoA lyase deficiency, carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, and medium Chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism.

同义名列表

43 个代谢物同义名

Adipic acid, cu(+2) salt (1:1); Adipic acid, monoammonium salt; Adipic acid, diammonium salt; 1,4-Butanedicarboxylic acid; Adipic acid, potassium salt; Hexan-1,6-dicarboxylic acid; Adipic acid, MG salt (1:1); Adipic acid, disodium salt; Adipic acid, calcium salt; Adipic acid, nickel salt; Adipic acid, cu(+2) salt; Adipic acid, sodium salt; Hexan-1,6-dicarboxylate; 1,4-Butanedicarboxylate; Adipic acid, cu salt; 1,6-Hexanedioic acid; Diammonium adipate; Molten adipic acid; Magnesium adipate; 1,6-Hexanedioate; hexanedioic acid; Ammonium adipate; Kyselina adipova; Sodium adipate; Molten adipate; Adipinic acid; Adilactetten; Hexanedioate; Adipinsaeure; INS no. 355; adipic acid; Acifloctin; Acinetten; Adipinate; FA 6:1;O2; Adi-pure; Adipate; e 355; e-355; e355; Adipic acid; Adipate; Adipic acid



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

57 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 ACADM, CA8, CAT, HADH, PTGS2
Peripheral membrane protein 3 CYP1B1, HSD17B6, PTGS2
Endoplasmic reticulum membrane 2 CYP1B1, PTGS2
Nucleus 3 ACADM, CUX1, PPARA
cytosol 4 ACOX1, CAT, CUX1, LIPE
mitochondrial membrane 1 ACADM
nucleoplasm 4 CD2, CUX1, HADH, PPARA
Cell membrane 3 CD2, LIPE, TNFRSF1A
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 4 ABCC3, SLC22A6, SLC22A8, SLC25A16
Golgi apparatus membrane 2 CUX1, TNFRSF1A
cell surface 2 CD2, TNFRSF1A
Golgi apparatus 2 CD2, CUX1
Golgi membrane 3 CUX1, INS, TNFRSF1A
mitochondrial inner membrane 2 HADH, SLC25A16
Cytoplasm, cytosol 1 LIPE
plasma membrane 5 ABCC3, CD2, SLC22A6, SLC22A8, TNFRSF1A
Membrane 8 ABCC3, ACOX1, CAT, CYP1B1, LIPE, SLC22A6, SLC25A16, TNFRSF1A
apical plasma membrane 1 SLC22A8
axon 1 ACADM
basolateral plasma membrane 3 ABCC3, SLC22A6, SLC22A8
caveola 3 LIPE, PTGS2, SLC22A6
extracellular exosome 3 CAT, SLC22A6, SLC22A8
Lumenal side 1 HSD17B6
endoplasmic reticulum 2 HSD17B6, PTGS2
extracellular space 2 INS, TNFRSF1A
mitochondrion 6 ACADM, CAT, CYP1B1, HADH, LIPF, SLC25A16
protein-containing complex 4 CAT, CD2, PTGS2, SLC22A6
intracellular membrane-bounded organelle 5 CAT, CUX1, CYP1B1, HSD17B6, LIPF
Microsome membrane 3 CYP1B1, HSD17B6, PTGS2
Single-pass type I membrane protein 2 CD2, TNFRSF1A
Secreted 3 INS, LIPF, TNFRSF1A
extracellular region 5 CAT, CD2, INS, LIPF, TNFRSF1A
cytoplasmic side of plasma membrane 1 CD2
Mitochondrion matrix 2 ACADM, HADH
mitochondrial matrix 3 ACADM, CAT, HADH
external side of plasma membrane 1 CD2
cell-cell junction 1 CD2
Mitochondrion inner membrane 2 HADH, SLC25A16
Membrane raft 1 TNFRSF1A
focal adhesion 1 CAT
mitochondrial nucleoid 1 HADH
Peroxisome 2 ACOX1, CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 2 ACOX1, CAT
peroxisomal membrane 2 ACOX1, CAT
lateral plasma membrane 1 SLC22A8
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 1 TNFRSF1A
neuron projection 1 PTGS2
chromatin 2 CUX1, PPARA
Basolateral cell membrane 3 ABCC3, SLC22A6, SLC22A8
endosome lumen 1 INS
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
basal plasma membrane 2 ABCC3, SLC22A6
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 INS, PTGS2
transport vesicle 1 INS
mitochondrial fatty acid beta-oxidation multienzyme complex 1 HADH
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Single-pass type IV membrane protein 1 CUX1
Basal cell membrane 2 ABCC3, SLC22A6
catalase complex 1 CAT
tumor necrosis factor receptor superfamily complex 1 TNFRSF1A


文献列表

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