Pipecolic acid (BioDeep_00000001407)

 

Secondary id: BioDeep_00000027635, BioDeep_00000229634, BioDeep_00000399925, BioDeep_00000400367, BioDeep_00000405194, BioDeep_00000412684

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019 Volatile Flavor Compounds


代谢物信息卡片


Pipecolic acid, 14C-labeled CPD, (+,-)-isomer

化学式: C6H11NO2 (129.0789746)
中文名称: S-2-哌啶甲酸盐酸盐, L-2-哌啶酸, DL-哌啶甲酸, 哌啶酸, 2-哌啶甲酸, 哌啶甲酸, 胡椒酸, L-高脯氨酸
谱图信息: 最多检出来源 Homo sapiens(blood) 0.33%

Reviewed

Last reviewed on 2024-09-13.

Cite this Page

Pipecolic acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/pipecolic_acid (retrieved 2024-11-21) (BioDeep RN: BioDeep_00000001407). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1CCNC(C1)C(=O)O
InChI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)

描述信息

Pipecolic acid is a metabolite of lysine found in human physiological fluids such as urine, plasma and CSF. However, it is uncertain if pipecolic acid originates directly from food intake or from mammalian or intestinal bacterial enzyme metabolism. Recent studies suggest that plasma pipecolic acid, particularly the D-isomer, originates mainly from the catabolism of dietary lysine by intestinal bacteria rather than by direct food intake. In classic Zellweger syndrome (a cerebro-hepato-renal genetic disorder, OMIM 214100) pipecolic acid accumulate in the plasma of the patients. It is known that plasma pipecolic acid levels are also elevated in patients with chronic liver diseases. Pipecolic acid is moderately elevated in patients with pyridoxine-dependent seizures and might therefore be a possible biochemical marker for selecting candidates for pyridoxine therapy (Plecko et al 2000). Pipecolic acid was also elevated in CSF in these vitamin B6-responsive patients (PMID 12705501). Pipecolic acid is found to be associated with adrenoleukodystrophy, infantile Refsum disease, and peroxisomal biogenesis defect, which are also inborn errors of metabolism. Pipecolic acid is a biomarker for the consumption of dried and cooked beans.
Pipecolic acid is a metabolite of lysine found in human physiological fluids such as urine, plasma and CSF. However, it is uncertain if pipecolic acid originates directly from food intake or from mammalian or intestinal bacterial enzyme metabolism. Recent studies suggest that plasma pipecolic acid, particularly the D-isomer, originates mainly from the catabolism of dietary lysine by intestinal bacteria rather than by direct food intake. In classic Zellweger syndrome (a cerebro-hepato-renal genetic disorder, OMIM 214100) pipecolic acid accumulate in the plasma of the patients. It is known that plasma pipecolic acid levels are also elevated in patients with chronic liver diseases. Pipecolic acid is moderately elevated in patients with pyridoxine-dependent seizures and might therefore be a possible biochemical marker for selecting candidates for pyridoxine therapy (Plecko et al 2000). Pipecolic acid was also elevated in CSF in these vitamin B6-responsive patients. (PMID 12705501) [HMDB]. Pipecolic acid is a biomarker for the consumption of dried and cooked beans.
Acquisition and generation of the data is financially supported in part by CREST/JST.
KEIO_ID P048
L-Pipecolic acid (H-HoPro-OH) is a breakdown product of lysine, accumulates in body fluids of infants with generalized genetic peroxisomal disorders, such as Zellweger syndrome, neonatal adrenoleukodystrophy.
L-Pipecolic acid (H-HoPro-OH) is a breakdown product of lysine, accumulates in body fluids of infants with generalized genetic peroxisomal disorders, such as Zellweger syndrome, neonatal adrenoleukodystrophy.
Pipecolic acid, a metabolite of Lysine, is an important precursor of many useful microbial secondary metabolites. Pipecolic acid can be used as a diagnostic marker of Pyridoxine-dependent epilepsy[1][2].
Pipecolic acid, a metabolite of Lysine, is an important precursor of many useful microbial secondary metabolites. Pipecolic acid can be used as a diagnostic marker of Pyridoxine-dependent epilepsy[1][2].

同义名列表

63 个代谢物同义名

Pipecolic acid, 14C-labeled CPD, (+,-)-isomer; Pipecolic acid hydrochloride, (+-)-isomer; Pipecolic acid, ion(1-), (+,-)-isomer; Pipecolic acid, ion(1-), (S)-isomer; (.+/-.)-2-piperidinecarboxylic acid; (S)-(-)-2-Piperidinecarboxylic acid; Pipecolic acid, monopotassium salt; (+/-)-2-piperidinecarboxylic acid; (RS)-2-Piperidinecarboxylic acid; Acide piperidine-carboxylique-2; ()-Piperidine-2-carboxylic acid; DL-2-Piperidinecarboxylic acid; (+/-)-2-piperidinecarboxylate; 2-Piperidinylcarboxylic acid; (RS)-2-Piperidinecarboxylate; Pipecolic acid, (+,-)-isomer; piperidine-2-carboxylic acid; 2-Piperidinecarboxylic acid; DL-2-Piperidinecarboxylate; hexahydro-2-Picolinic acid; Pipecolic acid, (R)-isomer; Pipecolic acid, (S)-isomer; Pipecolic acid, ion (1-); Pipecolic acid free base; .alpha.-pipecolinic acid; Piperidine-2-carboxylate; 2-Piperidinecarboxylate; Hexahydropicolinic acid; hexahydro-2-Picolinate; (+/-)-pipecolinic acid; alpha-Pipecolinic acid; L(-)-Pipecolinic acid; (+,-)-pipecolic acid; (+/-)-pipecolic acid; Hexahydropicolinate; 2-Carboxypiperidine; DL-Pipecolinic acid; Homopipecolic acid; a-Pipecolinic acid; 2-Pipecolinic acid; alpha-Pipecolinate; (+/-)-pipecolinate; DL-Pipecolic acid; Acide pipecolique; Piperolinic acid; (+/-)-pipecolate; Pipecolinic acid; L-Pipecolic acid; Dihydrobaikiane; L-Pipecolicacid; DL-Pipecolinate; DL-Homoproline; a-Pipecolinate; Pipecolic acid; DL-Pipecolate; L-Homoproline; Pipecolinate; Piperolinate; Homoproline; Pipecolate; Pipecolic acid; Pipecolic acid; H-HoPro-OH



数据库引用编号

46 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(1)

BioCyc(0)

PlantCyc(0)

代谢反应

49 个相关的代谢反应过程信息。

Reactome(26)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(22)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Liying Luo, Yuying Cai, Yanyun Jiang, Yingying Gong, Chunyang Cai, Dongwei Lai, Xiao Jin, Zhiqiang Guan, Qinghua Qiu. Pipecolic acid mitigates ferroptosis in diabetic retinopathy by regulating GPX4-YAP signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Dec; 169(?):115895. doi: 10.1016/j.biopha.2023.115895. [PMID: 37984309]
  • Alessandro Brambilla, Miriam Lenk, Andrea Ghirardo, Laura Eccleston, Claudia Knappe, Baris Weber, Birgit Lange, Jafargholi Imani, Anton R Schäffner, Jörg-Peter Schnitzler, A Corina Vlot. Pipecolic acid synthesis is required for systemic acquired resistance and plant-to-plant-induced immunity in barley. Journal of experimental botany. 2023 Mar; ?(?):. doi: 10.1093/jxb/erad095. [PMID: 36905226]
  • Lennart Mohnike, Weijie Huang, Brigitte Worbs, Kirstin Feussner, Yuelin Zhang, Ivo Feussner. N-Hydroxy pipecolic acid methyl ester is involved in Arabidopsis immunity. Journal of experimental botany. 2023 01; 74(1):458-471. doi: 10.1093/jxb/erac422. [PMID: 36260503]
  • Feifei Luo, Guirong Tang, Song Hong, Tianyu Gong, Xiu-Fang Xin, Chengshu Wang. Promotion of Arabidopsis immune responses by a rhizosphere fungus via supply of pipecolic acid to plants and selective augment of phytoalexins. Science China. Life sciences. 2022 Nov; ?(?):. doi: 10.1007/s11427-022-2238-8. [PMID: 36449213]
  • Lei Liu, Jia Wu, Minxin Shi, Fengying Wang, Haimin Lu, Jibing Liu, Weiqin Chen, Guanzhen Yu, Dan Liu, Jing Yang, Qin Luo, Yan Ni, Xing Jin, Xiaoxia Jin, Wen-Lian Chen. New Metabolic Alterations and A Predictive Marker Pipecolic Acid in Sera for Esophageal Squamous Cell Carcinoma. Genomics, proteomics & bioinformatics. 2022 Aug; 20(4):670-687. doi: 10.1016/j.gpb.2021.08.016. [PMID: 35351627]
  • Tarun Keswani, Aisha Obeidallah, Edward Nieves, Simone Sidoli, Melissa Fazzari, Terrie Taylor, Karl Seydel, Johanna P Daily. Pipecolic Acid, a Putative Mediator of the Encephalopathy of Cerebral Malaria and the Experimental Model of Cerebral Malaria. The Journal of infectious diseases. 2022 02; 225(4):705-714. doi: 10.1093/infdis/jiab615. [PMID: 34932816]
  • Tamara Treleaven, Madeleine L M Hardy, Michelle Guttman-Jones, Michael B Morris, Margot L Day. In Vitro Fertilisation of Mouse Oocytes in L-Proline and L-Pipecolic Acid Improves Subsequent Development. Cells. 2021 05; 10(6):. doi: 10.3390/cells10061352. [PMID: 34072568]
  • Eric C Holmes, Yun-Chu Chen, Mary Beth Mudgett, Elizabeth S Sattely. Arabidopsis UGT76B1 glycosylates N-hydroxy-pipecolic acid and inactivates systemic acquired resistance in tomato. The Plant cell. 2021 05; 33(3):750-765. doi: 10.1093/plcell/koaa052. [PMID: 33955491]
  • Lennart Mohnike, Dmitrij Rekhter, Weijie Huang, Kirstin Feussner, Hainan Tian, Cornelia Herrfurth, Yuelin Zhang, Ivo Feussner. The glycosyltransferase UGT76B1 modulates N-hydroxy-pipecolic acid homeostasis and plant immunity. The Plant cell. 2021 05; 33(3):735-749. doi: 10.1093/plcell/koaa045. [PMID: 33955489]
  • Hanna Hõrak. How to achieve immune balance and harmony: glycosyltransferase UGT76B1 inactivates N-hydroxy-pipecolic acid to suppress defense responses. The Plant cell. 2021 05; 33(3):453-454. doi: 10.1093/plcell/koaa053. [PMID: 35234939]
  • S Pazarlar, U Sanver, N Cetinkaya. Exogenous pipecolic acid modulates plant defence responses against Podosphaera xanthii and Pseudomonas syringae pv. lachrymans in cucumber (Cucumis sativus L.). Plant biology (Stuttgart, Germany). 2021 May; 23(3):473-484. doi: 10.1111/plb.13243. [PMID: 33547740]
  • Marta Pastorczyk-Szlenkier, Paweł Bednarek. UGT76B1 controls the growth-immunity trade-off during systemic acquired resistance. Molecular plant. 2021 04; 14(4):544-546. doi: 10.1016/j.molp.2021.03.012. [PMID: 33753308]
  • A Corina Vlot. A quest for long-distance signals: the epidermis as central regulator of pipecolic acid-associated systemic acquired resistance. Journal of experimental botany. 2021 03; 72(7):2266-2268. doi: 10.1093/jxb/eraa606. [PMID: 33779751]
  • Jianghua Cai, Adam Jozwiak, Lara Holoidovsky, Michael M Meijler, Sagit Meir, Ilana Rogachev, Asaph Aharoni. Glycosylation of N-hydroxy-pipecolic acid equilibrates between systemic acquired resistance response and plant growth. Molecular plant. 2021 03; 14(3):440-455. doi: 10.1016/j.molp.2020.12.018. [PMID: 33387676]
  • Sandeep Sharma, Babita Choudhary, Sonam Yadav, Avinash Mishra, Vinod K Mishra, Ramesh Chand, Chen Chen, Shree P Pandey. Metabolite profiling identified pipecolic acid as an important component of peanut seed resistance against Aspergillus flavus infection. Journal of hazardous materials. 2021 02; 404(Pt A):124155. doi: 10.1016/j.jhazmat.2020.124155. [PMID: 33049626]
  • Tomiko Kuhara, Tomoyuki Akiyama, Morimasa Ohse, Takayoshi Koike, Jun Shibasaki, Katsumi Imai, ArthurJ L Cooper. Identification of new biomarkers of pyridoxine-dependent epilepsy by GC/MS-based urine metabolomics. Analytical biochemistry. 2020 09; 604(?):113739. doi: 10.1016/j.ab.2020.113739. [PMID: 32339489]
  • Déborah Mathis, Karin Beese, Carmen Rüegg, Barbara Plecko, Martin Hersberger. LC-MS/MS method for the differential diagnosis of treatable early onset inherited metabolic epilepsies. Journal of inherited metabolic disease. 2020 09; 43(5):1102-1111. doi: 10.1002/jimd.12244. [PMID: 32319100]
  • Mar Garcia-Aloy, Marynka Ulaszewska, Pietro Franceschi, Sheila Estruel-Amades, Christoph H Weinert, Alba Tor-Roca, Mireia Urpi-Sarda, Fulvio Mattivi, Cristina Andres-Lacueva. Discovery of Intake Biomarkers of Lentils, Chickpeas, and White Beans by Untargeted LC-MS Metabolomics in Serum and Urine. Molecular nutrition & food research. 2020 07; 64(13):e1901137. doi: 10.1002/mnfr.201901137. [PMID: 32420683]
  • Dan Li, Ruiying Liu, Deepjyoti Singh, Xinyu Yuan, Pradeep Kachroo, Ramesh Raina. JMJ14 encoded H3K4 demethylase modulates immune responses by regulating defence gene expression and pipecolic acid levels. The New phytologist. 2020 03; 225(5):2108-2121. doi: 10.1111/nph.16270. [PMID: 31622519]
  • Denis S Willett, Camila C Filgueiras, Nicole D Benda, Jing Zhang, Kevin E Kenworthy. Sting nematodes modify metabolomic profiles of host plants. Scientific reports. 2020 02; 10(1):2212. doi: 10.1038/s41598-020-59062-8. [PMID: 32042018]
  • Yongsig Kim, Sarah J Gilmour, Lumen Chao, Sunchung Park, Michael F Thomashow. Arabidopsis CAMTA Transcription Factors Regulate Pipecolic Acid Biosynthesis and Priming of Immunity Genes. Molecular plant. 2020 01; 13(1):157-168. doi: 10.1016/j.molp.2019.11.001. [PMID: 31733370]
  • Tiziana Guerra, Silke Schilling, Katharina Hake, Karin Gorzolka, Fabian-Philipp Sylvester, Benjamin Conrads, Bernhard Westermann, Tina Romeis. Calcium-dependent protein kinase 5 links calcium signaling with N-hydroxy-l-pipecolic acid- and SARD1-dependent immune memory in systemic acquired resistance. The New phytologist. 2020 01; 225(1):310-325. doi: 10.1111/nph.16147. [PMID: 31469917]
  • Francisco Oiram Filho, Ebenézer de Oliveira Silva, Mônica Maria de Almeida Lopes, Paulo Riceli Vasconselos Ribeiro, Andréia Hansen Oster, Jhonyson Arruda Carvalho Guedes, Dávila de Souza Zampieri, Patrícia do Nascimento Bordallo, Guilherme Julião Zocolo. Effect of pulsed light on postharvest disease control-related metabolomic variation in melon (Cucumis melo) artificially inoculated with Fusarium pallidoroseum. PloS one. 2020; 15(4):e0220097. doi: 10.1371/journal.pone.0220097. [PMID: 32310943]
  • Cristina Razquin, Miguel Ruiz-Canela, Clary B Clish, Jun Li, Estefania Toledo, Courtney Dennis, Liming Liang, Albert Salas-Huetos, Kerry A Pierce, Marta Guasch-Ferré, Dolores Corella, Emilio Ros, Ramon Estruch, Enrique Gómez-Gracia, Montse Fitó, Jose Lapetra, Dora Romaguera, Angel Alonso-Gómez, Lluis Serra-Majem, Jordi Salas-Salvadó, Frank B Hu, Miguel A Martínez-González. Lysine pathway metabolites and the risk of type 2 diabetes and cardiovascular disease in the PREDIMED study: results from two case-cohort studies. Cardiovascular diabetology. 2019 11; 18(1):151. doi: 10.1186/s12933-019-0958-2. [PMID: 31722714]
  • Marjo Tuomainen, Olli Kärkkäinen, Jukka Leppänen, Seppo Auriola, Marko Lehtonen, Markku J Savolainen, Kjeld Hermansen, Ulf Risérus, Björn Åkesson, Inga Thorsdottir, Marjukka Kolehmainen, Matti Uusitupa, Kaisa Poutanen, Ursula Schwab, Kati Hanhineva. Quantitative assessment of betainized compounds and associations with dietary and metabolic biomarkers in the randomized study of the healthy Nordic diet (SYSDIET). The American journal of clinical nutrition. 2019 11; 110(5):1108-1118. doi: 10.1093/ajcn/nqz179. [PMID: 31504116]
  • Marion Wenig, Andrea Ghirardo, Jennifer H Sales, Elisabeth S Pabst, Heiko H Breitenbach, Felix Antritter, Baris Weber, Birgit Lange, Miriam Lenk, Robin K Cameron, Joerg-Peter Schnitzler, A Corina Vlot. Systemic acquired resistance networks amplify airborne defense cues. Nature communications. 2019 08; 10(1):3813. doi: 10.1038/s41467-019-11798-2. [PMID: 31444353]
  • Jiao Xue, Junjuan Wang, Pan Gong, Minhang Wu, Wenshuang Yang, Shiju Jiang, Ye Wu, Yuwu Jiang, Yuehua Zhang, Tatiana Yuzyuk, Hong Li, Zhixian Yang. Simultaneous quantification of alpha-aminoadipic semialdehyde, piperideine-6-carboxylate, pipecolic acid and alpha-aminoadipic acid in pyridoxine-dependent epilepsy. Scientific reports. 2019 08; 9(1):11371. doi: 10.1038/s41598-019-47882-2. [PMID: 31388081]
  • Christian Dutton, Hanna Hõrak, Christopher Hepworth, Alice Mitchell, Jurriaan Ton, Lee Hunt, Julie E Gray. Bacterial infection systemically suppresses stomatal density. Plant, cell & environment. 2019 08; 42(8):2411-2421. doi: 10.1111/pce.13570. [PMID: 31042812]
  • Min-Zhi Peng, Yan-Na Cai, Yong-Xian Shao, Lu Zhao, Min-Yan Jiang, Yun-Ting Lin, Xi Yin, Hui-Ying Sheng, Li Liu. Simultaneous quantification of 48 plasma amino acids by liquid chromatography-tandem mass spectrometry to investigate urea cycle disorders. Clinica chimica acta; international journal of clinical chemistry. 2019 Aug; 495(?):406-416. doi: 10.1016/j.cca.2019.05.011. [PMID: 31095934]
  • Shu Wang, Kelei Han, Jiejun Peng, Jinping Zhao, Liangliang Jiang, Yuwen Lu, Hongying Zheng, Lin Lin, Jianping Chen, Fei Yan. NbALD1 mediates resistance to turnip mosaic virus by regulating the accumulation of salicylic acid and the ethylene pathway in Nicotiana benthamiana. Molecular plant pathology. 2019 07; 20(7):990-1004. doi: 10.1111/mpp.12808. [PMID: 31012537]
  • Christina Krönauer, Joachim Kilian, Tina Strauß, Mark Stahl, Thomas Lahaye. Cell Death Triggered by the YUCCA-like Bs3 Protein Coincides with Accumulation of Salicylic Acid and Pipecolic Acid But Not of Indole-3-Acetic Acid. Plant physiology. 2019 07; 180(3):1647-1659. doi: 10.1104/pp.18.01576. [PMID: 31068387]
  • Olli Kärkkäinen, Maria A Lankinen, Marilena Vitale, Jenna Jokkala, Jukka Leppänen, Ville Koistinen, Marko Lehtonen, Rosalba Giacco, Natalia Rosa-Sibakov, Valérie Micard, Angela A A Rivellese, Ursula Schwab, Hannu Mykkänen, Matti Uusitupa, Marjukka Kolehmainen, Gabriele Riccardi, Kaisa Poutanen, Seppo Auriola, Kati Hanhineva. Diets rich in whole grains increase betainized compounds associated with glucose metabolism. The American journal of clinical nutrition. 2018 11; 108(5):971-979. doi: 10.1093/ajcn/nqy169. [PMID: 30256894]
  • Yiming Wang, Stefan Schuck, Jingni Wu, Ping Yang, Anne-Christin Döring, Jürgen Zeier, Kenichi Tsuda. A MPK3/6-WRKY33-ALD1-Pipecolic Acid Regulatory Loop Contributes to Systemic Acquired Resistance. The Plant cell. 2018 10; 30(10):2480-2494. doi: 10.1105/tpc.18.00547. [PMID: 30228125]
  • Veronika Boczonadi, Martin S King, Anthony C Smith, Monika Olahova, Boglarka Bansagi, Andreas Roos, Filmon Eyassu, Christoph Borchers, Venkateswaran Ramesh, Hanns Lochmüller, Tuomo Polvikoski, Roger G Whittaker, Angela Pyle, Helen Griffin, Robert W Taylor, Patrick F Chinnery, Alan J Robinson, Edmund R S Kunji, Rita Horvath. Mitochondrial oxodicarboxylate carrier deficiency is associated with mitochondrial DNA depletion and spinal muscular atrophy-like disease. Genetics in medicine : official journal of the American College of Medical Genetics. 2018 10; 20(10):1224-1235. doi: 10.1038/gim.2017.251. [PMID: 29517768]
  • Nóra Gampe, András Darcsi, László Kursinszki, Szabolcs Béni. Separation and characterization of homopipecolic acid isoflavonoid ester derivatives isolated from Ononis spinosa L. root. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2018 Aug; 1091(?):21-28. doi: 10.1016/j.jchromb.2018.05.023. [PMID: 29803686]
  • Shachi Joglekar, Mohamed Suliman, Michael Bartsch, Vivek Halder, Jens Maintz, Jaqueline Bautor, Jürgen Zeier, Jane E Parker, Erich Kombrink. Chemical Activation of EDS1/PAD4 Signaling Leading to Pathogen Resistance in Arabidopsis. Plant & cell physiology. 2018 Aug; 59(8):1592-1607. doi: 10.1093/pcp/pcy106. [PMID: 29931201]
  • Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics. Scientific reports. 2018 07; 8(1):10056. doi: 10.1038/s41598-018-28477-9. [PMID: 29968805]
  • Yuan Yuan, Xuenan Li, Huangyou Liu, Yating Qu, Wantong Zhang, Huilin Yu, Jiaojiao Zhang, Hong Zhuang. Carnitine, A New Precursor in the Formation of the Plant Growth Regulator Mepiquat. Journal of agricultural and food chemistry. 2018 Jun; 66(23):5907-5912. doi: 10.1021/acs.jafc.8b01084. [PMID: 29783845]
  • Tongjun Sun, Lucas Busta, Qian Zhang, Pingtao Ding, Reinhard Jetter, Yuelin Zhang. TGACG-BINDING FACTOR 1 (TGA1) and TGA4 regulate salicylic acid and pipecolic acid biosynthesis by modulating the expression of SYSTEMIC ACQUIRED RESISTANCE DEFICIENT 1 (SARD1) and CALMODULIN-BINDING PROTEIN 60g (CBP60g). The New phytologist. 2018 Jan; 217(1):344-354. doi: 10.1111/nph.14780. [PMID: 28898429]
  • D Garcia-Seco, M Chiapello, M Bracale, C Pesce, P Bagnaresi, E Dubois, L Moulin, C Vannini, R Koebnik. Transcriptome and proteome analysis reveal new insight into proximal and distal responses of wheat to foliar infection by Xanthomonas translucens. Scientific reports. 2017 08; 7(1):10157. doi: 10.1038/s41598-017-10568-8. [PMID: 28860643]
  • Yuan Yuan, Adrienne Tarres, Thomas Bessaire, Wilhelm Rademacher, Richard H Stadler, Thierry Delatour. Heat-induced formation of mepiquat by decarboxylation of pipecolic acid and its betaine derivative. Part 2: Natural formation in cooked vegetables and selected food products. Food chemistry. 2017 Aug; 228(?):99-105. doi: 10.1016/j.foodchem.2017.01.122. [PMID: 28317783]
  • Teresa Donze-Reiner, Nathan A Palmer, Erin D Scully, Travis J Prochaska, Kyle G Koch, Tiffany Heng-Moss, Jeffrey D Bradshaw, Paul Twigg, Keenan Amundsen, Scott E Sattler, Gautam Sarath. Transcriptional analysis of defense mechanisms in upland tetraploid switchgrass to greenbugs. BMC plant biology. 2017 02; 17(1):46. doi: 10.1186/s12870-017-0998-2. [PMID: 28209137]
  • Frederic Tort, Olatz Ugarteburu, Maria Angeles Torres, Judit García-Villoria, Marisa Girós, Angeles Ruiz, Antonia Ribes. Lysine Restriction and Pyridoxal Phosphate Administration in a NADK2 Patient. Pediatrics. 2016 11; 138(5):. doi: 10.1542/peds.2015-4534. [PMID: 27940755]
  • J Xue, Z X Yang, H Li, P Qian, Y Wu, Y W Jiang, X Y Liu. [Clinical and genetic characteristics and detection of urinary pipecolic acid in pyridoxine dependent epilepsy]. Zhonghua er ke za zhi = Chinese journal of pediatrics. 2016 Aug; 54(8):592-6. doi: 10.3760/cma.j.issn.0578-1310.2016.08.007. [PMID: 27510871]
  • Eva-Maria Reimer-Michalski, Uwe Conrath. Innate immune memory in plants. Seminars in immunology. 2016 08; 28(4):319-27. doi: 10.1016/j.smim.2016.05.006. [PMID: 27264335]
  • Tatiana Yuzyuk, Amanda Thomas, Krista Viau, Aiping Liu, Irene De Biase, Lorenzo D Botto, Marzia Pasquali, Nicola Longo. Effect of dietary lysine restriction and arginine supplementation in two patients with pyridoxine-dependent epilepsy. Molecular genetics and metabolism. 2016 07; 118(3):167-172. doi: 10.1016/j.ymgme.2016.04.015. [PMID: 27324284]
  • Arthur Sorlin, Gilbert Briand, David Cheillan, Arnaud Wiedemann, Bettina Montaut-Verient, Emmanuelle Schmitt, François Feillet. Effect of l-Arginine in One Patient with Peroxisome Biogenesis Disorder due to PEX12 Deficiency. Neuropediatrics. 2016 Jun; 47(3):179-81. doi: 10.1055/s-0036-1578798. [PMID: 26947510]
  • Alejandro Leganés-Ramos, Elena Alba Álvaro-Alonso, Ana María Martín de Rosales-Cabrera, Montserrat Pérez-Encinas. Oral formulation of pyridoxine for the treatment of pyridoxinedependent epilepsy in a paediatric patient. Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria. 2016 Mar; 40(2):131-3. doi: 10.7399/fh.2016.40.2.9233. [PMID: 26980171]
  • Nilwala S Abeysekara, Sivakumar Swaminathan, Nalini Desai, Lining Guo, Madan K Bhattacharyya. The plant immunity inducer pipecolic acid accumulates in the xylem sap and leaves of soybean seedlings following Fusarium virguliforme infection. Plant science : an international journal of experimental plant biology. 2016 Feb; 243(?):105-14. doi: 10.1016/j.plantsci.2015.11.008. [PMID: 26795155]
  • Friederike Bernsdorff, Anne-Christin Döring, Katrin Gruner, Stefan Schuck, Andrea Bräutigam, Jürgen Zeier. Pipecolic Acid Orchestrates Plant Systemic Acquired Resistance and Defense Priming via Salicylic Acid-Dependent and -Independent Pathways. The Plant cell. 2016 Jan; 28(1):102-29. doi: 10.1105/tpc.15.00496. [PMID: 26672068]
  • Thushanthi Perera, Matthew R Young, Zhiying Zhang, Gwen Murphy, Nancy H Colburn, Elaine Lanza, Terryl J Hartman, Amanda J Cross, Gerd Bobe. Identification and monitoring of metabolite markers of dry bean consumption in parallel human and mouse studies. Molecular nutrition & food research. 2015 Apr; 59(4):795-806. doi: 10.1002/mnfr.201400847. [PMID: 25641932]
  • Genya Watanabe, Hiroyuki Kobayashi, Masahiro Shibata, Masatoshi Kubota, Motoni Kadowaki, Shinobu Fujimura. Regulation of free glutamate content in meat by dietary lysine in broilers. Animal science journal = Nihon chikusan Gakkaiho. 2015 Apr; 86(4):435-42. doi: 10.1111/asj.12321. [PMID: 25491790]
  • Nicolás M Cecchini, Ho Won Jung, Nancy L Engle, Timothy J Tschaplinski, Jean T Greenberg. ALD1 Regulates Basal Immune Components and Early Inducible Defense Responses in Arabidopsis. Molecular plant-microbe interactions : MPMI. 2015 Apr; 28(4):455-66. doi: 10.1094/mpmi-06-14-0187-r. [PMID: 25372120]
  • Michela Semeraro, Maurizio Muraca, Giulio Catesini, Rita Inglese, Francesca Iacovone, Gloria Maria Barraco, Melania Manco, Sara Boenzi, Carlo Dionisi-Vici, Cristiano Rizzo. Determination of plasma pipecolic acid by an easy and rapid liquid chromatography-tandem mass spectrometry method. Clinica chimica acta; international journal of clinical chemistry. 2015 Feb; 440(?):108-12. doi: 10.1016/j.cca.2014.11.014. [PMID: 25447702]
  • Olivier Hilfiker, Raphaël Groux, Friederike Bruessow, Karin Kiefer, Jürgen Zeier, Philippe Reymond. Insect eggs induce a systemic acquired resistance in Arabidopsis. The Plant journal : for cell and molecular biology. 2014 Dec; 80(6):1085-94. doi: 10.1111/tpj.12707. [PMID: 25329965]
  • Eduard A Struys, Erwin E W Jansen, Gajja S Salomons. Human pyrroline-5-carboxylate reductase (PYCR1) acts on Δ(1)-piperideine-6-carboxylate generating L-pipecolic acid. Journal of inherited metabolic disease. 2014 May; 37(3):327-32. doi: 10.1007/s10545-013-9673-4. [PMID: 24431009]
  • Giovana Reche Dalazen, Melaine Terra, Carlos Eduardo Diaz Jacques, Juliana G Coelho, Raylane Freitas, Priscila Nicolao Mazzola, Carlos Severo Dutra-Filho. Pipecolic acid induces oxidative stress in vitro in cerebral cortex of young rats and the protective role of lipoic acid. Metabolic brain disease. 2014 Mar; 29(1):175-83. doi: 10.1007/s11011-013-9466-3. [PMID: 24338030]
  • Huaiyu Yang, Uwe Ludewig. Lysine catabolism, amino acid transport, and systemic acquired resistance: what is the link?. Plant signaling & behavior. 2014; 9(7):e28933. doi: 10.4161/psb.28933. [PMID: 25763483]
  • Valerie Vranova, Lea Lojkova, Klement Rejsek, Pavel Formanek. Significance of the natural occurrence of L- versus D-pipecolic acid: a review. Chirality. 2013 Dec; 25(12):823-31. doi: 10.1002/chir.22237. [PMID: 24114978]
  • Drissia Vogel-Adghough, Elia Stahl, Hana Návarová, Juergen Zeier. Pipecolic acid enhances resistance to bacterial infection and primes salicylic acid and nicotine accumulation in tobacco. Plant signaling & behavior. 2013 Nov; 8(11):e26366. doi: 10.4161/psb.26366. [PMID: 24025239]
  • Saadet Mercimek-Mahmutoglu, Elizabeth J Donner, Komudi Siriwardena. Normal plasma pipecolic acid level in pyridoxine dependent epilepsy due to ALDH7A1 mutations. Molecular genetics and metabolism. 2013 Sep; 110(1-2):197. doi: 10.1016/j.ymgme.2013.04.018. [PMID: 23683770]
  • Raluca-Ioana Stefan-van Staden, Iuliana Moldoveanu, Daniel-Florin Sava, Constantina Kapnissi-Christodoulou, Jacobus Frederick van Staden. Enantioanalysis of pipecolic acid with stochastic and potentiometric microsensors. Chirality. 2013 Feb; 25(2):114-8. doi: 10.1002/chir.22119. [PMID: 23180678]
  • Hana Návarová, Friederike Bernsdorff, Anne-Christin Döring, Jürgen Zeier. Pipecolic acid, an endogenous mediator of defense amplification and priming, is a critical regulator of inducible plant immunity. The Plant cell. 2012 Dec; 24(12):5123-41. doi: 10.1105/tpc.112.103564. [PMID: 23221596]
  • Clara D M van Karnebeek, Hans Hartmann, Sravan Jaggumantri, Levinus A Bok, Barb Cheng, Mary Connolly, Curtis R Coughlin, Anibh M Das, Sidney M Gospe, Cornelis Jakobs, Johanna H van der Lee, Saadet Mercimek-Mahmutoglu, Uta Meyer, Eduard Struys, Graham Sinclair, Johan Van Hove, Jean-Paul Collet, Barbara R Plecko, Sylvia Stockler. Lysine restricted diet for pyridoxine-dependent epilepsy: first evidence and future trials. Molecular genetics and metabolism. 2012 Nov; 107(3):335-44. doi: 10.1016/j.ymgme.2012.09.006. [PMID: 23022070]
  • Kristopher R Koch, Chen-Ou Zhang, Piotr Kaczmarek, Joseph Barchi, Li Guo, Hanief M Shahjee, Susan Keay. The effect of a novel frizzled 8-related antiproliferative factor on in vitro carcinoma and melanoma cell proliferation and invasion. Investigational new drugs. 2012 Oct; 30(5):1849-64. doi: 10.1007/s10637-011-9746-x. [PMID: 21931970]
  • Bradley L Baumgarner, Bruce R Cooper. Evaluation of a tandem gas chromatography/time-of-flight mass spectrometry metabolomics platform as a single method to investigate the effect of starvation on whole-animal metabolism in rainbow trout (Oncorhynchus mykiss). The Journal of experimental biology. 2012 May; 215(Pt 10):1627-32. doi: 10.1242/jeb.059873. [PMID: 22539729]
  • Luigi Servillo, Alfonso Giovane, Maria Luisa Balestrieri, Giovanna Ferrari, Domenico Cautela, Domenico Castaldo. Occurrence of pipecolic acid and pipecolic acid betaine (homostachydrine) in Citrus genus plants. Journal of agricultural and food chemistry. 2012 Jan; 60(1):315-21. doi: 10.1021/jf204286r. [PMID: 22208890]
  • Hervé Colinet, David Renault, Blandine Charoy-Guével, Emmanuelle Com. Metabolic and proteomic profiling of diapause in the aphid parasitoid Praon volucre. PloS one. 2012; 7(2):e32606. doi: 10.1371/journal.pone.0032606. [PMID: 22389713]
  • Arjun Sengupta, Soumita Ghosh, Angika Basant, Suhas Malusare, Parul Johri, Sulabha Pathak, Shobhona Sharma, Haripalsingh M Sonawat. Global host metabolic response to Plasmodium vivax infection: a 1H NMR based urinary metabonomic study. Malaria journal. 2011 Dec; 10(?):384. doi: 10.1186/1475-2875-10-384. [PMID: 22196439]
  • Charles R Warren, Ismael Aranda, F Javier Cano. Responses to water stress of gas exchange and metabolites in Eucalyptus and Acacia spp. Plant, cell & environment. 2011 Oct; 34(10):1609-29. doi: 10.1111/j.1365-3040.2011.02357.x. [PMID: 21692813]
  • Sylvia Stockler, Barbara Plecko, Sidney M Gospe, Marion Coulter-Mackie, Mary Connolly, Clara van Karnebeek, Saadet Mercimek-Mahmutoglu, Hans Hartmann, Gunter Scharer, Eduard Struijs, Ingrid Tein, Cornelis Jakobs, Peter Clayton, Johan L K Van Hove. Pyridoxine dependent epilepsy and antiquitin deficiency: clinical and molecular characteristics and recommendations for diagnosis, treatment and follow-up. Molecular genetics and metabolism. 2011 Sep; 104(1-2):48-60. doi: 10.1016/j.ymgme.2011.05.014. [PMID: 21704546]
  • Edgar P Moraes, Francisco Javier Rupérez, Merichel Plaza, Miguel Herrero, Coral Barbas. Metabolomic assessment with CE-MS of the nutraceutical effect of Cystoseira spp extracts in an animal model. Electrophoresis. 2011 Aug; 32(15):2055-62. doi: 10.1002/elps.201000546. [PMID: 21792987]
  • Andrew D Patterson, Jessica A Bonzo, Fei Li, Kristopher W Krausz, Gabriel S Eichler, Sadaf Aslam, Xenia Tigno, John N Weinstein, Barbara C Hansen, Jeffrey R Idle, Frank J Gonzalez. Metabolomics reveals attenuation of the SLC6A20 kidney transporter in nonhuman primate and mouse models of type 2 diabetes mellitus. The Journal of biological chemistry. 2011 Jun; 286(22):19511-22. doi: 10.1074/jbc.m111.221739. [PMID: 21487016]
  • Zhenhua Du, Lei Zhang, Shuye Liu. [Application of liquid chromatography-mass spectrometry in the study of metabolic profiling of cirrhosis in different grades]. Se pu = Chinese journal of chromatography. 2011 Apr; 29(4):314-9. doi: 10.3724/sp.j.1123.2011.00314. [PMID: 21770240]
  • Eric B Segal, Zachary M Grinspan, Arthur M Mandel, Sidney M Gospe. Biomarkers aiding diagnosis of atypical presentation of pyridoxine-dependent epilepsy. Pediatric neurology. 2011 Apr; 44(4):289-91. doi: 10.1016/j.pediatrneurol.2010.11.012. [PMID: 21397171]
  • Hyun-Jin Kim, Jin Hee Kim, Siwon Noh, Haeng Jeon Hur, Mi Jeong Sung, Jin-Taek Hwang, Jae Ho Park, Hye Jeong Yang, Myung-Sunny Kim, Dae Young Kwon, Suk Hoo Yoon. Metabolomic analysis of livers and serum from high-fat diet induced obese mice. Journal of proteome research. 2011 Feb; 10(2):722-31. doi: 10.1021/pr100892r. [PMID: 21047143]
  • Sven W Sauer, Silvana Opp, Georg F Hoffmann, David M Koeller, Jürgen G Okun, Stefan Kölker. Therapeutic modulation of cerebral L-lysine metabolism in a mouse model for glutaric aciduria type I. Brain : a journal of neurology. 2011 Jan; 134(Pt 1):157-70. doi: 10.1093/brain/awq269. [PMID: 20923787]
  • Jia V Li, Jasmina Saric, Yulan Wang, Jürg Utzinger, Elaine Holmes, Oliver Balmer. Metabonomic investigation of single and multiple strain Trypanosoma brucei brucei infections. The American journal of tropical medicine and hygiene. 2011 Jan; 84(1):91-8. doi: 10.4269/ajtmh.2011.10-0402. [PMID: 21212208]
  • Navneet Kaur, Jianping Hu. Defining the plant peroxisomal proteome: from Arabidopsis to rice. Frontiers in plant science. 2011; 2(?):103. doi: 10.3389/fpls.2011.00103. [PMID: 22645559]
  • Atsushi Fukushima, Miyako Kusano, Henning Redestig, Masanori Arita, Kazuki Saito. Metabolomic correlation-network modules in Arabidopsis based on a graph-clustering approach. BMC systems biology. 2011 Jan; 5(?):1. doi: 10.1186/1752-0509-5-1. [PMID: 21194489]
  • Wayne Chadwick, Randall Brenneman, Bronwen Martin, Stuart Maudsley. Complex and multidimensional lipid raft alterations in a murine model of Alzheimer's disease. International journal of Alzheimer's disease. 2010 Dec; 2010(?):604792. doi: 10.4061/2010/604792. [PMID: 21151659]
  • Jiye A, Sixuan Qian, Guangji Wang, Bei Yan, Sujiang Zhang, Qing Huang, Lingna Ni, Weibin Zha, Linsheng Liu, Bei Cao, Ming Hong, Hanxin Wu, Hua Lu, Jian Shi, Mengjie Li, Jianyong Li. Chronic myeloid leukemia patients sensitive and resistant to imatinib treatment show different metabolic responses. PloS one. 2010 Oct; 5(10):e13186. doi: 10.1371/journal.pone.0013186. [PMID: 20949032]
  • Philippa B Mills, Emma J Footitt, Kevin A Mills, Karin Tuschl, Sarah Aylett, Sophia Varadkar, Cheryl Hemingway, Neil Marlow, Janet Rennie, Peter Baxter, Olivier Dulac, Rima Nabbout, William J Craigen, Bernhard Schmitt, François Feillet, Ernst Christensen, Pascale De Lonlay, Mike G Pike, M Imelda Hughes, Eduard A Struys, Cornelis Jakobs, Sameer M Zuberi, Peter T Clayton. Genotypic and phenotypic spectrum of pyridoxine-dependent epilepsy (ALDH7A1 deficiency). Brain : a journal of neurology. 2010 Jul; 133(Pt 7):2148-59. doi: 10.1093/brain/awq143. [PMID: 20554659]
  • Anna A Dobritsa, Zhentian Lei, Shuh-Ichi Nishikawa, Ewa Urbanczyk-Wochniak, David V Huhman, Daphne Preuss, Lloyd W Sumner. LAP5 and LAP6 encode anther-specific proteins with similarity to chalcone synthase essential for pollen exine development in Arabidopsis. Plant physiology. 2010 Jul; 153(3):937-55. doi: 10.1104/pp.110.157446. [PMID: 20442277]
  • Jasmina Saric, Jia V Li, Jonathan R Swann, Jürg Utzinger, Gail Calvert, Jeremy K Nicholson, Stephan Dirnhofer, Maggie J Dallman, Magda Bictash, Elaine Holmes. Integrated cytokine and metabolic analysis of pathological responses to parasite exposure in rodents. Journal of proteome research. 2010 May; 9(5):2255-64. doi: 10.1021/pr901019z. [PMID: 20092362]
  • Wagner L Araújo, Kimitsune Ishizaki, Adriano Nunes-Nesi, Tony R Larson, Takayuki Tohge, Ina Krahnert, Sandra Witt, Toshihiro Obata, Nicolas Schauer, Ian A Graham, Christopher J Leaver, Alisdair R Fernie. Identification of the 2-hydroxyglutarate and isovaleryl-CoA dehydrogenases as alternative electron donors linking lysine catabolism to the electron transport chain of Arabidopsis mitochondria. The Plant cell. 2010 May; 22(5):1549-63. doi: 10.1105/tpc.110.075630. [PMID: 20501910]
  • Angika Basant, Mayuri Rege, Shobhona Sharma, Haripalsingh M Sonawat. Alterations in urine, serum and brain metabolomic profiles exhibit sexual dimorphism during malaria disease progression. Malaria journal. 2010 Apr; 9(?):110. doi: 10.1186/1475-2875-9-110. [PMID: 20412601]
  • Hye-Ran Yoon, Yong-Wun An. Determination of pipecolic acid following trimethylsilyl and trifluoroacyl derivatisation on plasma filter paper by stable isotope GC-MS for peroxisomal disorders. Archives of pharmacal research. 2010 Feb; 33(2):317-23. doi: 10.1007/s12272-010-0218-1. [PMID: 20195834]
  • Katerina Sadilkova, Sidney M Gospe, Si Houn Hahn. Simultaneous determination of alpha-aminoadipic semialdehyde, piperideine-6-carboxylate and pipecolic acid by LC-MS/MS for pyridoxine-dependent seizures and folinic acid-responsive seizures. Journal of neuroscience methods. 2009 Oct; 184(1):136-41. doi: 10.1016/j.jneumeth.2009.07.019. [PMID: 19631689]
  • Banzragch Battur, Damdinsuren Boldbaatar, Rika Umemiya-Shirafuji, Min Liao, Badgar Battsetseg, DeMar Taylor, Badarch Baymbaa, Kozo Fujisaki. LKR/SDH plays important roles throughout the tick life cycle including a long starvation period. PloS one. 2009 Sep; 4(9):e7136. doi: 10.1371/journal.pone.0007136. [PMID: 19774086]
  • Renata C Gallagher, Johan L K Van Hove, Gunter Scharer, Keith Hyland, Barbara Plecko, Paula J Waters, Saadet Mercimek-Mahmutoglu, Sylvia Stockler-Ipsiroglu, Gajja S Salomons, Efraim H Rosenberg, Eduard A Struys, Cornelis Jakobs. Folinic acid-responsive seizures are identical to pyridoxine-dependent epilepsy. Annals of neurology. 2009 May; 65(5):550-6. doi: 10.1002/ana.21568. [PMID: 19142996]
  • Craig L Bennett, Yingzhang Chen, Sihoun Hahn, Ian A Glass, Sidney M Gospe. Prevalence of ALDH7A1 mutations in 18 North American pyridoxine-dependent seizure (PDS) patients. Epilepsia. 2009 May; 50(5):1167-75. doi: 10.1111/j.1528-1167.2008.01816.x. [PMID: 19128417]
  • S J Steinberg, A Snowden, N E Braverman, L Chen, P A Watkins, P T Clayton, K D R Setchell, J E Heubi, G V Raymond, A B Moser, H W Moser. A PEX10 defect in a patient with no detectable defect in peroxisome assembly or metabolism in cultured fibroblasts. Journal of inherited metabolic disease. 2009 Feb; 32(1):109-19. doi: 10.1007/s10545-008-0969-8. [PMID: 19127411]
  • Griet Van Zeebroeck, Beatriz Monge Bonini, Matthias Versele, Johan M Thevelein. Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor. Nature chemical biology. 2009 Jan; 5(1):45-52. doi: 10.1038/nchembio.132. [PMID: 19060912]
  • Man-Jeong Paik, Jinwoo Lee, Kyoung-Rae Kim. N-ethoxycarbonylation combined with (S)-1-phenylethylamidation for enantioseparation of amino acids by achiral gas chromatography and gas chromatography-mass spectrometry. Journal of chromatography. A. 2008 Dec; 1214(1-2):151-6. doi: 10.1016/j.chroma.2008.10.068. [PMID: 18995862]
  • Xi-Qiang Cui, Xing-Cui Li, Lei Wang, Ruo-Yun Chen. [Chemical constituents from Faeces bombycis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2008 Nov; 33(21):2493-6. doi: ". [PMID: 19149256]
  • G Kluger, R Blank, K Paul, E Paschke, E Jansen, C Jakobs, H Wörle, B Plecko. Pyridoxine-dependent epilepsy: normal outcome in a patient with late diagnosis after prolonged status epilepticus causing cortical blindness. Neuropediatrics. 2008 Oct; 39(5):276-9. doi: 10.1055/s-0029-1202833. [PMID: 19294602]
  • Stephen Hanessian, Luciana Auzzas. The practice of ring constraint in peptidomimetics using bicyclic and polycyclic amino acids. Accounts of chemical research. 2008 Oct; 41(10):1241-51. doi: 10.1021/ar8000052. [PMID: 18646869]
  • Jia V Li, Yulan Wang, Jasmina Saric, Jeremy K Nicholson, Stephan Dirnhofer, Burton H Singer, Marcel Tanner, Sergio Wittlin, Elaine Holmes, Jürg Utzinger. Global metabolic responses of NMRI mice to an experimental Plasmodium berghei infection. Journal of proteome research. 2008 Sep; 7(9):3948-56. doi: 10.1021/pr800209d. [PMID: 18646786]