O-Acetylserine (BioDeep_00000001397)

 

Secondary id: BioDeep_00000400287

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


(2S)-3-(acetyloxy)-2-aminopropanoic acid

化学式: C5H9NO4 (147.0532)
中文名称: O-乙酰-L-丝氨酸
谱图信息: 最多检出来源 Homo sapiens(lipidsearch) 14.96%

Reviewed

Last reviewed on 2024-09-27.

Cite this Page

O-Acetylserine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/o-acetylserine (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000001397). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC(=O)OCC(C(=O)O)N
InChI: InChI=1S/C5H9NO4/c1-3(7)10-2-4(6)5(8)9/h4H,2,6H2,1H3,(H,8,9)/t4-/m0/s1

描述信息

O-Acetylserine is an α-amino acid with the chemical formula HO2CCH(NH2)CH2OC(O)CH3. It is an intermediate in the biosynthesis of the common amino acid cysteine in bacteria and plants. O-Acetylserine is biosynthesized by acetylation of the serine by the enzyme serine transacetylase. The enzyme O-acetylserine (thiol)-lyase, using sulfide sources, converts this ester into cysteine, releasing acetate. O-Acetylserine belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom. O-Acetylserine (OASS) is an acylated amino acid derivative. O-Acetylserine exists in all living species, ranging from bacteria to humans. Outside of the human body, O-Acetylserine has been detected, but not quantified in several different foods, such as okra, vaccinium (blueberry, cranberry, huckleberry), rapes, sparkleberries, and lingonberries. This could make O-acetylserine a potential biomarker for the consumption of these foods.
O-acetyl-l-serine, also known as L-serine, acetate (ester) or (2s)-3-acetyloxy-2-aminopropanoate, is a member of the class of compounds known as L-alpha-amino acids. L-alpha-amino acids are alpha amino acids which have the L-configuration of the alpha-carbon atom. O-acetyl-l-serine is soluble (in water) and a moderately acidic compound (based on its pKa). O-acetyl-l-serine can be found in a number of food items such as sorrel, summer savory, purslane, and cherimoya, which makes O-acetyl-l-serine a potential biomarker for the consumption of these food products. O-acetyl-l-serine can be found primarily in blood and urine, as well as in human prostate tissue. O-acetyl-l-serine exists in all living species, ranging from bacteria to humans.
Acquisition and generation of the data is financially supported in part by CREST/JST.
O-Acetylserine (O-Acetyl-L-serine) is an intermediate in the biosynthesis of the amino acid cysteine in bacteria and plants.

同义名列表

13 个代谢物同义名

(2S)-3-(acetyloxy)-2-aminopropanoic acid; O-Acetylserine hydrobromide, (D)-isomer; O-acetyl-L-serine hydrochloride; L-Serine, acetic acid (ester); O-Acetylserine, (L)-isomer; L-Serine, acetate (ester); Serine acetate ester; O3-Acetyl-L-serine; O-Acetyl-L-serine; O-Acetyl-serine; O-Acetylserine; O-Acetyl-L-serine; O-acetyl-L-serine



数据库引用编号

29 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(3)

BioCyc(0)

PlantCyc(0)

代谢反应

333 个相关的代谢反应过程信息。

Reactome(4)

BioCyc(1)

WikiPathways(0)

Plant Reactome(328)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

40 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 CARS1, CAT, CBS, CTH, MPST, TXN
Nucleus 3 CBS, FIRRM, TXN
cytosol 11 CARS1, CAT, CBS, CTH, CYS1, FIRRM, GCLM, GSR, PHGDH, TDO2, TXN
nucleoplasm 2 FIRRM, TXN
Cell membrane 1 SLC26A2
Lipid-anchor 1 CYS1
Multi-pass membrane protein 1 SLC26A2
Golgi apparatus membrane 1 ST3GAL4
Synapse 1 MPST
Golgi apparatus 1 ST3GAL4
Golgi membrane 1 ST3GAL4
plasma membrane 2 CTH, SLC26A2
Membrane 4 CAT, CTH, SLC26A2, ST3GAL4
apical plasma membrane 1 SLC26A2
extracellular exosome 7 CAT, CTH, GSR, MPST, PHGDH, SLC26A2, TXN
extracellular space 1 TST
mitochondrion 4 CAT, GSR, MPST, TST
protein-containing complex 1 CAT
intracellular membrane-bounded organelle 1 CAT
Single-pass type I membrane protein 1 CTH
Secreted 1 TXN
extracellular region 3 CAT, ST3GAL4, TXN
Mitochondrion matrix 1 TST
mitochondrial matrix 4 CAT, GSR, MPST, TST
ciliary membrane 1 CYS1
external side of plasma membrane 1 GSR
midbody 1 FIRRM
spindle midzone 1 FIRRM
Single-pass type II membrane protein 1 ST3GAL4
Apical cell membrane 1 SLC26A2
Cytoplasm, cytoskeleton, spindle 1 FIRRM
focal adhesion 1 CAT
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
neuron projection 1 MPST
cilium 1 CYS1
cytoskeleton 1 CYS1
Cytoplasm, cytoskeleton, cilium axoneme 1 CYS1
microvillus membrane 1 SLC26A2
Chromosome, centromere 1 FIRRM
Chromosome, centromere, kinetochore 1 FIRRM
Golgi cisterna membrane 1 ST3GAL4
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
kinetochore 1 FIRRM
chromosome, centromeric region 1 FIRRM
Synapse, synaptosome 1 MPST
Cell projection, cilium membrane 1 CYS1
catalase complex 1 CAT
glutamate-cysteine ligase complex 1 GCLM


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