L-2,4-diaminobutyric acid (BioDeep_00000001361)
Main id: BioDeep_00000017817
Secondary id: BioDeep_00000875166
human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite
代谢物信息卡片
化学式: C4H10N2O2 (118.0742)
中文名称: L-2,4-二氨基丁酸氢溴酸盐
谱图信息:
最多检出来源 Homo sapiens(blood) 13.49%
分子结构信息
SMILES: C(CN)C(C(=O)O)N
InChI: InChI=1S/C4H10N2O2/c5-2-1-3(6)4(7)8/h3H,1-2,5-6H2,(H,7,8)/t3-/m0/s1
描述信息
L-3-Amino-isobutanoic acid is a component of branched-chain amino acid biosynthesis and metabolism. It can also be used in pyrimidine metabolism. L-3-Amino-isobutanoic acid is produced from S-methylmalonate semialdehyde by the enzyme 4-aminobutyrate aminotransferase.
KEIO_ID D038
L-DABA (L-2,4-Diaminobutyric acid) is a week GABA transaminase inhibitor with an IC50 of larger than 500 μM; exhibits antitumor activity in vivo and in vitro.
L-DABA (L-2,4-Diaminobutyric acid) is a week GABA transaminase inhibitor with an IC50 of larger than 500 μM; exhibits antitumor activity in vivo and in vitro.
同义名列表
37 个代谢物同义名
2,4-Diaminobutyric acid monohydrochloride, (+-)-isomer; 2,4-Diaminobutyric acid monohydrochloride, (S)-isomer; 2,4-Diaminobutyric acid dihydrochloride, (+-)-isomer; 2,4-Diaminobutyric acid dihydrochloride, (S)-isomer; 2,4-Diaminobutyric acid, (+-)-isomer; 2,4-Diaminobutyric acid, (+)-isomer; 2,4-Diaminobutyric acid, (R)-isomer; 2,4-Diaminobutyric acid, (S)-isomer; L-alpha,gamma-Diaminobutyric acid; alpha,gamma-Diaminobutyric acid; α,γ-Diaminobutyrate; (S)-2,4-diamino-Butanoic acid; (2S)-2,4-diaminobutanoic acid; (S)-2,4-Diaminobutanoic acid; L-2,4-diamino-N-Butyric acid; alpha,gamma-Diaminobutyrate; (S)-2,4-Diaminobutyric acid; L-2,4-Diaminobutanoic acid; L-2,4-diamino-Butyric acid; L-2,4-Diaminobutyric acid; (S)-2,4-diamino-Butanoate; (S)-2,4-Diaminobutanoate; Α,γ-diaminobutyric acid; 2,4-Diaminobutyric acid; a,g-Diaminobutyric acid; L-2,4-Diaminobutanoate; L-2,4-Diaminobutyrate; L-Diaminobutyric acid; Α,γ-diaminobutyrate; a,g-Diaminobutyrate; 2,4-Diaminobutyrate; L-Diaminobutyrate; H-Dab.HBr; L-DABA; L-Dbu; DBU; L-2,4-Diaminobutanoate
数据库引用编号
24 个数据库交叉引用编号
- ChEBI: CHEBI:48950
- KEGG: C03283
- PubChem: 134490
- HMDB: HMDB0006284
- Metlin: METLIN58381
- DrugBank: DB03817
- ChEMBL: CHEMBL321357
- MetaCyc: CPD-470
- KNApSAcK: C00001353
- foodb: FDB012588
- chemspider: 118548
- CAS: 1358-80-1
- CAS: 1758-80-1
- MoNA: KO002675
- MoNA: KO002673
- MoNA: KO002676
- MoNA: KO002674
- MoNA: KO002672
- PubChem: 6142
- PDB-CCD: DAB
- 3DMET: B00574
- NIKKAJI: J80.310C
- medchemexpress: HY-101414
- KNApSAcK: 48950
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
5 个相关的物种来源信息
- 3039 - Euglena gracilis: 10.3389/FBIOE.2021.662655
- 9606 - Homo sapiens: -
- 154494 - Lathyrus latifolius: 10.1016/S0031-9422(96)00425-6
- 1886 - Streptomyces albidoflavus: 10.1128/AEM.01992-09
- 1902 - Streptomyces coelicolor: 10.1128/AEM.01992-09
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sea-Yong Kim, Per Hedberg, Monika Winder, Sara Rydberg. Evidence of 2,4-diaminobutyric acid (DAB) production as a defense mechanism in diatom Thalassiosira pseudonana.
Aquatic toxicology (Amsterdam, Netherlands).
2022 Aug; 249(?):106210. doi:
10.1016/j.aquatox.2022.106210. [PMID: 35665646] - Kate Samardzic, Joel R Steele, Jake P Violi, Anne Colville, Simon M Mitrovic, Kenneth J Rodgers. Toxicity and bioaccumulation of two non-protein amino acids synthesised by cyanobacteria, β-N-Methylamino-L-alanine (BMAA) and 2,4-diaminobutyric acid (DAB), on a crop plant.
Ecotoxicology and environmental safety.
2021 Jan; 208(?):111515. doi:
10.1016/j.ecoenv.2020.111515. [PMID: 33099142] - Le-Ni Sun, Dan-Dan Pan, Xiang-Wei Wu, En-Dong Yang, Ri-Mao Hua, Qing X Li. Leucobacter triazinivorans sp. nov., a s-triazine herbicide prometryn-degrading bacterium isolated from sludge.
International journal of systematic and evolutionary microbiology.
2018 Jan; 68(1):204-210. doi:
10.1099/ijsem.0.002483. [PMID: 29139349] - Peter B Nunn, Geoffrey A Codd. Metabolic solutions to the biosynthesis of some diaminomonocarboxylic acids in nature: Formation in cyanobacteria of the neurotoxins 3-N-methyl-2,3-diaminopropanoic acid (BMAA) and 2,4-diaminobutanoic acid (2,4-DAB).
Phytochemistry.
2017 Dec; 144(?):253-270. doi:
10.1016/j.phytochem.2017.09.015. [PMID: 29059579] - Yong Li, Wei Fang, Shou-Jiang Xie, Xuqi Yang, Lai-Fa Wang. Leucobacter corticis sp. nov., isolated from symptomatic bark of Populus × euramericana canker.
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2017 Jul; 67(7):2248-2252. doi:
10.1099/ijsem.0.001934. [PMID: 28699860] - Wei Fang, Xia Li, Xiu-Mei Tan, Lai-Fa Wang, Chun-Gen Piao, Yong Li. Leucobacter populi sp. nov. isolated from a symptomatic bark of Populus × euramericana canker.
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10.1099/ijsem.0.000640. [PMID: 26420495] - Juan Du, Hina Singh, Jung-Eun Yang, Chang Shik Yin, MooChang Kook, Hongshan Yu, Tae-Hoo Yi. Pseudoclavibacter terrae sp. nov. isolated from rhizosphere soil of Ophiopogon japonicus.
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10.1007/s00216-014-7872-y. [PMID: 24858470] - Maitham Ahmed Al-Sammak, Kyle D Hoagland, David Cassada, Daniel D Snow. Co-occurrence of the cyanotoxins BMAA, DABA and anatoxin-a in Nebraska reservoirs, fish, and aquatic plants.
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