3beta-Hydroxypregn-5-en-20-one sulfate (BioDeep_00000012045)

Main id: BioDeep_00000019615

 

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


[(1S,2R,5S,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-7-en-5-yl]oxidanesulfonic acid

化学式: C21H32O5S (396.197)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OS(=O)(=O)O)C)C
InChI: InChI=1S/C21H32O5S/c1-13(22)17-6-7-18-16-5-4-14-12-15(26-27(23,24)25)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19H,5-12H2,1-3H3,(H,23,24,25)/t15-,16-,17+,18-,19-,20-,21+/m0/s1

描述信息

3beta-Hydroxypregn-5-en-20-one sulfate is a metabolite of pregnenolone. Pregnenolone, also known as 3α,5β-tetrahydroprogesterone (3α,5β-THP), is an endogenous steroid hormone involved in the steroidogenesis of progestogens, mineralocorticoids, glucocorticoids, androgens, and estrogens, as well as the neuroactive steroids. As such it is a prohormone, though it also has biological effects of its own, behaving namely as a neuroactive steroid in its own right with potent anxiolytic effects. (Wikipedia)
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate can protect the brain from cannabis intoxication[1][2]. Pregnenolone monosulfate is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].
Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate can protect the brain from cannabis intoxication[1][2]. Pregnenolone monosulfate is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].

同义名列表

42 个代谢物同义名

[(1S,2R,5S,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-7-en-5-yl]oxidanesulfonic acid; Pregnenolone sulfate, sodium salt, (3beta)-isomer; 3beta-Hydroxypregn-5-en-20-one sulphuric acid; 3beta-Hydroxypregn-5-en-20-one sulfuric acid; 3b-Hydroxypregn-5-en-20-one sulphuric acid; 3Β-hydroxypregn-5-en-20-one sulphuric acid; 3Β-hydroxypregn-5-en-20-one sulfuric acid; 3b-Hydroxypregn-5-en-20-one sulfuric acid; 5-Pregnen-3beta-ol-20-one sulphuric acid; 5-Pregnen-3beta-ol-20-one sulfuric acid; 3beta-Hydroxypregn-5-en-20-one sulphate; 3beta-Hydroxypregn-5-en-20-one sulfate; (3beta)-3-(Sulphooxy)pregn-5-en-20-one; 5-Pregnen-3β-ol-20-one sulphuric acid; (3beta)-3-(sulfooxy)pregn-5-en-20-one; 5-Pregnen-3b-ol-20-one sulphuric acid; Pregnenolone sulfate, (3alpha)-isomer; 3b-Hydroxypregn-5-en-20-one sulphate; 3Β-hydroxypregn-5-en-20-one sulphate; 5-Pregnen-3b-ol-20-one sulfuric acid; 5-Pregnen-3β-ol-20-one sulfuric acid; 3Β-hydroxypregn-5-en-20-one sulfate; (3Β)-3-(sulphooxy)pregn-5-en-20-one; (3b)-3-(Sulphooxy)pregn-5-en-20-one; 3b-Hydroxypregn-5-en-20-one sulfate; 5-Pregnen-3beta-ol-20-one sulphate; (3b)-3-(Sulfooxy)pregn-5-en-20-one; (3Β)-3-(sulfooxy)pregn-5-en-20-one; 5-Pregnen-3 beta-ol-20-one sulfate; 20-oxopregn-5-en-3beta-yl sulfate; 5-pregnen-3beta-ol-20-one sulfate; 5-Pregnen-3b-ol-20-one sulphate; 5-Pregnen-3β-ol-20-one sulphate; 5-Pregnen-3b-ol-20-one sulfate; 5-Pregnen-3β-ol-20-one sulfate; Pregnenolone sulphuric acid; Pregnenolone sulfuric acid; Pregnenolone sulphate; pregnenolone sulfate; 3β-Hydroxy-5-pregnen-20-one monosulfate; Pregnenolone monosulfate; 3beta-Hydroxypregn-5-en-20-one sulfate



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(0)

PlantCyc(0)

代谢反应

44 个相关的代谢反应过程信息。

Reactome(44)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 CA1, GRIN1, GRIN2B, MAPK1
Peripheral membrane protein 1 CYP11A1
Endoplasmic reticulum membrane 7 CYP17A1, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, STS
Mitochondrion membrane 1 CYP11A1
Nucleus 2 JUND, MAPK1
cytosol 3 CA1, MAPK1, PRKCQ
dendrite 2 GRIN1, OPRM1
centrosome 1 MAPK1
nucleoplasm 2 JUND, MAPK1
RNA polymerase II transcription regulator complex 1 JUND
Cell membrane 9 GRID1, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, OPRM1, TRPM3, TRPV1
Cell projection, axon 1 OPRM1
Multi-pass membrane protein 10 CACNA1I, CATSPER3, GRID1, GRIN1, GRIN2A, GRIN2B, GRIN2C, OPRM1, TRPM3, TRPV1
Synapse 4 GRIN1, GRIN2A, MAPK1, OPRM1
cell surface 3 GRIN1, GRIN2A, GRIN2B
glutamatergic synapse 4 GRID1, GRIN2A, GRIN2C, GRIN2D
Golgi apparatus 3 MAPK1, OPRM1, STS
Golgi membrane 1 INS
mitochondrial inner membrane 1 CYP11A1
neuronal cell body 2 CYP17A1, TRPV1
presynaptic membrane 1 GRIN2A
synaptic vesicle 2 GRIN1, GRIN2A
Lysosome 2 GRIN2B, STS
acrosomal vesicle 1 CATSPER3
endosome 2 OPRM1, STS
plasma membrane 14 CACNA1I, CATSPER3, GRID1, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, MAPK1, OPRM1, PRKCQ, STS, TRPM3, TRPV1
terminal bouton 1 GRIN1
Membrane 10 CACNA1I, CYP11A1, GRIN1, GRIN2A, GRIN2B, GRIN2C, OPRM1, STS, TRPM3, TRPV1
axon 2 CYP17A1, OPRM1
caveola 1 MAPK1
extracellular exosome 2 CA1, GRID1
endoplasmic reticulum 5 CATSPER3, CYP17A1, GRIN2A, OPRM1, STS
extracellular space 2 GNRH1, INS
mitochondrion 2 CYP11A1, MAPK1
intracellular membrane-bounded organelle 1 STS
Microsome membrane 1 CYP17A1
postsynaptic density 3 GRIN1, GRIN2A, GRIN2B
Secreted 1 INS
extracellular region 3 GNRH1, INS, MAPK1
excitatory synapse 1 GRIN1
hippocampal mossy fiber to CA3 synapse 1 GRIN2D
mitochondrial matrix 1 CYP11A1
transcription regulator complex 1 JUND
centriolar satellite 1 PRKCQ
motile cilium 1 CATSPER3
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 MAPK1
external side of plasma membrane 1 TRPV1
dendritic spine 2 GRIN1, GRIN2A
perikaryon 1 OPRM1
Early endosome 1 MAPK1
postsynaptic membrane 7 GRID1, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, TRPV1
presynaptic active zone membrane 1 GRIN2D
Mitochondrion inner membrane 1 CYP11A1
Cell junction, focal adhesion 1 MAPK1
Cytoplasm, cytoskeleton 1 GRIN2B
Cytoplasm, cytoskeleton, spindle 1 MAPK1
focal adhesion 1 MAPK1
spindle 1 MAPK1
GABA-ergic synapse 2 GRID1, TRPV1
Cell projection, dendritic spine 1 GRIN2A
Postsynaptic cell membrane 6 GRID1, GRIN1, GRIN2A, GRIN2B, GRIN2C, TRPV1
Late endosome 2 GRIN2B, MAPK1
Cell projection, neuron projection 1 TRPV1
neuron projection 4 GRIN1, GRIN2A, GRIN2B, OPRM1
chromatin 1 JUND
mitotic spindle 1 MAPK1
cytoskeleton 2 GRIN2B, MAPK1
endosome lumen 1 INS
Membrane, caveola 1 MAPK1
Cell projection, cilium, flagellum membrane 1 CATSPER3
Cytoplasmic vesicle membrane 1 GRIN2A
Cell projection, dendrite 2 GRIN2B, OPRM1
pseudopodium 1 MAPK1
Synaptic cell membrane 1 GRIN1
synaptic membrane 3 GRIN1, GRIN2A, GRIN2B
ficolin-1-rich granule lumen 1 MAPK1
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 INS, MAPK1, STS
transcription repressor complex 1 JUND
voltage-gated calcium channel complex 1 CACNA1I
transport vesicle 1 INS
azurophil granule lumen 1 MAPK1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
postsynaptic density membrane 6 GRID1, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
synaptic cleft 1 GRIN1
NMDA selective glutamate receptor complex 5 GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D
Cell projection, dendritic spine membrane 1 TRPV1
dendritic spine membrane 1 TRPV1
transcription factor AP-1 complex 1 JUND
Cytoplasmic vesicle, secretory vesicle, microneme membrane 1 STS
microneme membrane 1 STS
[Isoform 12]: Cytoplasm 1 OPRM1
CatSper complex 1 CATSPER3


文献列表

  • Ádám Horváth, Anita Steib, Andrea Nehr-Majoros, Boglárka Kántás, Ágnes Király, Márk Racskó, Balázs István Tóth, Eszter Szánti-Pintér, Eva Kudová, Rita Skoda-Földes, Zsuzsanna Helyes, Éva Szőke. Anti-Nociceptive Effects of Sphingomyelinase and Methyl-Beta-Cyclodextrin in the Icilin-Induced Mouse Pain Model. International journal of molecular sciences. 2024 Apr; 25(9):. doi: 10.3390/ijms25094637. [PMID: 38731855]
  • Alexander Becker, Claudia Götz, Mathias Montenarh, Stephan E Philipp. Control of TRPM3 Ion Channels by Protein Kinase CK2-Mediated Phosphorylation in Pancreatic β-Cells of the Line INS-1. International journal of molecular sciences. 2021 Dec; 22(23):. doi: 10.3390/ijms222313133. [PMID: 34884938]
  • Cecilia Rustichelli, Elisa Bellei, Stefania Bergamini, Emanuela Monari, Flavia Lo Castro, Carlo Baraldi, Aldo Tomasi, Anna Ferrari. Comparison of pregnenolone sulfate, pregnanolone and estradiol levels between patients with menstrually-related migraine and controls: an exploratory study. The journal of headache and pain. 2021 Mar; 22(1):13. doi: 10.1186/s10194-021-01231-9. [PMID: 33757421]
  • Jude Prah, Ali Winters, Kiran Chaudhari, Jessica Hersh, Ran Liu, Shao-Hua Yang. Cholesterol sulfate alters astrocyte metabolism and provides protection against oxidative stress. Brain research. 2019 11; 1723(?):146378. doi: 10.1016/j.brainres.2019.146378. [PMID: 31425677]
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