2-Methylhistamine (BioDeep_00000011967)

 

Secondary id: BioDeep_00001869497

human metabolite blood metabolite


代谢物信息卡片


2-(2-methyl-1H-imidazol-5-yl)ethan-1-amine

化学式: C6H11N3 (125.0953)
中文名称: 2-甲基组胺
谱图信息: 最多检出来源 Mus musculus(blood) 100%

分子结构信息

SMILES: CC1=NC=C(CCN)N1
InChI: InChI=1S/C6H11N3/c1-5-8-4-6(9-5)2-3-7/h4H,2-3,7H2,1H3,(H,8,9)



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ARG1, AXIN2, HDC, HNMT, IL11, IL1A, ITPR3, POMC
Peripheral membrane protein 2 ACHE, AOC1
Endoplasmic reticulum membrane 1 ITPR3
Nucleus 5 ACHE, ARG1, AXIN2, HDC, IL1A
cytosol 6 ARG1, AVP, AXIN2, HDC, HNMT, IL1A
dendrite 1 AVP
centrosome 2 AXIN2, HNMT
nucleoplasm 3 CD2, HNMT, ITPR3
Cell membrane 4 ACHE, AOC1, CD2, TRPC7
Cytoplasmic granule 1 ARG1
Multi-pass membrane protein 2 ITPR3, TRPC7
Synapse 2 ACHE, TAC1
cell surface 3 ACHE, CD2, IL1A
Golgi apparatus 2 ACHE, CD2
lysosomal membrane 1 TRPC7
neuromuscular junction 1 ACHE
neuronal cell body 2 ITPR3, TAC1
Lysosome 1 TRPC7
plasma membrane 10 ACHE, AOC1, AXIN2, BCHE, CD160, CD2, ITPR3, KNG1, REN, TRPC7
Membrane 5 ACHE, HDC, ITPR3, REN, TRPC7
axon 1 TAC1
brush border 1 ITPR3
extracellular exosome 3 AOC1, HNMT, KNG1
endoplasmic reticulum 1 ITPR3
extracellular space 13 ACHE, AOC1, ARG1, AVP, BCHE, GAST, IL11, IL1A, IL2, KNG1, POMC, REN, TAC1
perinuclear region of cytoplasm 2 ACHE, TRPC7
bicellular tight junction 1 AOC1
protein-containing complex 1 CD2
Single-pass type I membrane protein 1 CD2
Secreted 9 ACHE, AVP, BCHE, GAST, IL11, IL1A, IL2, POMC, REN
extracellular region 15 ACHE, AOC1, ARG1, AVP, BCHE, CD160, CD2, GAST, IL11, IL1A, IL2, KNG1, POMC, REN, TAC1
cytoplasmic side of plasma membrane 1 CD2
Extracellular side 2 ACHE, AOC1
external side of plasma membrane 1 CD2
perikaryon 1 TRPC7
beta-catenin destruction complex 1 AXIN2
cytoplasmic vesicle 1 TRPC7
nucleolus 1 ITPR3
apical part of cell 2 ITPR3, REN
cell-cell junction 1 CD2
Peroxisome 1 AOC1
basement membrane 1 ACHE
sarcoplasmic reticulum 1 ITPR3
collagen-containing extracellular matrix 1 KNG1
secretory granule 2 AVP, POMC
nuclear outer membrane 1 ITPR3
receptor complex 1 ITPR3
cell projection 1 TRPC7
Secreted, extracellular space 2 AOC1, KNG1
blood microparticle 2 BCHE, KNG1
Lipid-anchor, GPI-anchor 2 ACHE, CD160
[Isoform 2]: Cell membrane 1 TRPC7
nuclear envelope 1 TRPC7
Nucleus envelope 1 TRPC7
Cytoplasmic vesicle membrane 1 TRPC7
specific granule membrane 1 TRPC7
tertiary granule membrane 1 TRPC7
side of membrane 2 ACHE, CD160
secretory granule lumen 1 POMC
secretory granule membrane 1 ITPR3
endoplasmic reticulum lumen 2 BCHE, KNG1
platelet alpha granule lumen 1 KNG1
specific granule lumen 2 AOC1, ARG1
azurophil granule lumen 1 ARG1
neuronal dense core vesicle 1 AVP
nuclear envelope lumen 1 BCHE
clathrin-coated endocytic vesicle membrane 1 AVP
platelet dense tubular network membrane 1 ITPR3
synaptic cleft 1 ACHE
ficolin-1-rich granule membrane 1 TRPC7
[Isoform 1]: Cell membrane 1 TRPC7
Cytoplasmic vesicle, secretory vesicle membrane 1 ITPR3
[Isoform 3]: Cell membrane 1 TRPC7
[CD160 antigen]: Cell membrane 1 CD160
transport vesicle membrane 1 ITPR3
cytoplasmic side of endoplasmic reticulum membrane 1 ITPR3
[Isoform H]: Cell membrane 1 ACHE
cation channel complex 1 TRPC7


文献列表

  • G Kanny, T Bauza, S Frémont, F Guillemin, A Blaise, F Daumas, J C Cabanis, J P Nicolas, D A Moneret-Vautrin. Histamine content does not influence the tolerance of wine in normal subjects. Allergie et immunologie. 1999 Feb; 31(2):45-8. doi: NULL. [PMID: 10219426]
  • A Sabbah, S Hassoun, M Drouet, M G Lauret, M Loiry, M el Founini, M Guittot, J Sainte-Laudy. [Allergic immunobiology and anesthesiology]. Allergie et immunologie. 1998 Jun; 30(6):173-6. doi: NULL. [PMID: 9684038]
  • S Tsujimoto, C Kamei, T Yoshida, K Tasaka. Changes in plasma adrenocorticotropic hormone and cortisol levels induced by intracerebroventricular injection of histamine and its related compounds in dogs. Pharmacology. 1993 Aug; 47(2):73-83. doi: 10.1159/000139081. [PMID: 8102804]
  • Y Akiyama, T Mukai, C Kamei, K Tasaka. Histamine lipolysis I: changes in the free fatty acid levels of dog plasma after intravenous infusion of histamine. Methods and findings in experimental and clinical pharmacology. 1990 Jun; 12(5):315-24. doi: NULL. [PMID: 1977972]
  • G Schmidt, P Kannisto, C Owman, N O Sjöberg. Alteration by histamine of the sympathetic nerve-mediated contractions in the bovine ovarian follicle wall in vitro. European journal of pharmacology. 1987 Mar; 135(1):11-22. doi: 10.1016/0014-2999(87)90752-7. [PMID: 3569422]
  • R O Banks, E D Jacobson. Renal vasodilation with ureteral occlusion and prostaglandins: attenuation by histamine H1 antagonists. The American journal of physiology. 1985 Dec; 249(6 Pt 2):F851-7. doi: 10.1152/ajprenal.1985.249.6.f851. [PMID: 2866716]
  • R J Harvima, E O Kajander, I T Harvima, J E Fraki. Purification and partial characterization of rat kidney histamine-N-methyltransferase. Biochimica et biophysica acta. 1985 Jul; 841(1):42-9. doi: 10.1016/0304-4165(85)90272-7. [PMID: 4016144]
  • A O Donoso, M B Zárate, A Seltzer. Histamine-induced prolactin release: pharmacological characterization of receptors in male rats. Neuroendocrinology. 1983 Jun; 36(6):436-42. doi: 10.1159/000123495. [PMID: 6308490]
  • A P Baker, L W Chakrin, D A Holden, W J Smith, C P Sung. Effect of histamine agonists and antagonists on the production of murine reaginic antibodies. International journal of immunopharmacology. 1981; 3(4):349-56. doi: 10.1016/0192-0561(81)90030-8. [PMID: 6460705]