Spergualin (BioDeep_00000011378)

   


代谢物信息卡片


Spergualin

化学式: C17H37N7O4 (403.2907)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(CCN=C(N)N)CC(CC(=O)NC(C(=O)NCCCCNCCCN)O)O
InChI: InChI=1S/C17H37N7O4/c18-7-5-9-21-8-3-4-10-22-15(27)16(28)24-14(26)12-13(25)6-1-2-11-23-17(19)20/h13,16,21,25,28H,1-12,18H2,(H,22,27)(H,24,26)(H4,19,20,23)/t13-,16-/m0/s1

描述信息

D000970 - Antineoplastic Agents

同义名列表

2 个代谢物同义名

Spergualin; Spergualin



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 ANG, AOC3, ISG20, NFKB1
Endoplasmic reticulum membrane 1 TRPM8
Nucleus 3 ANG, ISG20, NFKB1
cytosol 2 ANG, NFKB1
nucleoplasm 2 ISG20, NFKB1
Cell membrane 10 AOC3, CD80, CD86, CD8A, ITGAM, ITGB2, TNF, TRPA1, TRPM8, TRPV1
Multi-pass membrane protein 3 TRPA1, TRPM8, TRPV1
cell surface 9 AOC3, CD40, CD80, CD86, ICAM1, ITGAM, ITGB2, PLG, TNF
glutamatergic synapse 1 PLG
Golgi apparatus 1 AOC3
growth cone 1 ANG
neuronal cell body 4 ANG, CD40, TNF, TRPV1
plasma membrane 14 AOC3, CD40, CD80, CD86, CD8A, ICAM1, ITGAM, ITGB2, PLG, RNPEP, TNF, TRPA1, TRPM8, TRPV1
Membrane 10 AOC3, CD40, CD80, CD86, ICAM1, ITGAM, ITGB2, TRPA1, TRPM8, TRPV1
extracellular exosome 8 CD40, CD86, CPVL, ICAM1, ITGAM, ITGB2, PLG, RNPEP
endoplasmic reticulum 1 AOC3
extracellular space 9 ANG, CD40, ICAM1, IL2, IL4, ITGAM, PLG, RNPEP, TNF
Schaffer collateral - CA1 synapse 1 PLG
mitochondrion 1 NFKB1
intracellular membrane-bounded organelle 1 CD40
Single-pass type I membrane protein 7 CD40, CD80, CD86, CD8A, ICAM1, ITGAM, ITGB2
Secreted 5 ANG, IL2, IL4, PLG, RNPEP
extracellular region 8 ANG, CD8A, IL2, IL4, NFKB1, PLG, RNPEP, TNF
[Isoform 2]: Secreted 1 CD8A
transcription regulator complex 1 NFKB1
centriolar satellite 1 CD86
CD40 receptor complex 1 CD40
external side of plasma membrane 11 CD40, CD80, CD86, CD8A, ICAM1, ITGAM, ITGB2, PLG, TNF, TRPM8, TRPV1
varicosity 1 CD40
Extracellular vesicle 1 ITGB2
actin cytoskeleton 1 ANG
nucleolus 2 ANG, ISG20
Cytoplasm, P-body 1 ISG20
P-body 1 ISG20
Early endosome 1 AOC3
recycling endosome 1 TNF
Single-pass type II membrane protein 2 AOC3, TNF
postsynaptic membrane 1 TRPV1
Membrane raft 5 ICAM1, ITGAM, ITGB2, TNF, TRPM8
focal adhesion 2 ICAM1, ITGB2
GABA-ergic synapse 1 TRPV1
basement membrane 1 ANG
PML body 1 ISG20
collagen-containing extracellular matrix 2 ICAM1, PLG
Postsynaptic cell membrane 1 TRPV1
receptor complex 2 CD8A, ITGB2
Cell projection, neuron projection 1 TRPV1
chromatin 1 NFKB1
stereocilium bundle 1 TRPA1
phagocytic cup 1 TNF
Chromosome 1 ANG
Nucleus, nucleolus 2 ANG, ISG20
blood microparticle 1 PLG
microvillus 1 AOC3
specific granule membrane 2 ITGAM, ITGB2
tertiary granule membrane 2 ITGAM, ITGB2
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
plasma membrane raft 4 CD8A, ITGAM, ITGB2, TRPM8
secretory granule lumen 1 NFKB1
platelet alpha granule lumen 1 PLG
specific granule lumen 1 NFKB1
endocytic vesicle 1 ANG
immunological synapse 1 ICAM1
Cajal body 1 ISG20
ficolin-1-rich granule membrane 1 ITGB2
[Isoform 1]: Cell membrane 1 CD8A
Nucleus, Cajal body 1 ISG20
integrin complex 2 ITGAM, ITGB2
Cell projection, dendritic spine membrane 1 TRPV1
dendritic spine membrane 1 TRPV1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 1 CD8A
angiogenin-PRI complex 1 ANG
integrin alphaL-beta2 complex 1 ITGB2
integrin alphaM-beta2 complex 2 ITGAM, ITGB2
integrin alphaX-beta2 complex 1 ITGB2
protein complex involved in cell adhesion 1 CD80
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Xu Yang, Ahmed E Yousef. Antimicrobial peptides produced by Brevibacillus spp.: structure, classification and bioactivity: a mini review. World journal of microbiology & biotechnology. 2018 Mar; 34(4):57. doi: 10.1007/s11274-018-2437-4. [PMID: 29594558]
  • S Kunimoto, T Takeuchi. Kinetic studies of the interaction between spergualin or 15-deoxyspergualin and amine oxidase from bovine plasma. The Journal of antibiotics. 1994 Oct; 47(10):1130-5. doi: 10.7164/antibiotics.47.1130. [PMID: 7961163]
  • S Kunimoto, C Nosaka, C Z Xu, T Takeuchi. Serum effect on cellular uptake of spermidine, spergualin, 15-deoxyspergualin, and their metabolites by L5178Y cells. The Journal of antibiotics. 1989 Jan; 42(1):116-22. doi: 10.7164/antibiotics.42.116. [PMID: 2921216]
  • M Okubo, K Inoue, N Umetani, N Sato, K Kamata, Y Masaki, T Uchiyama, X J Yan, T Aoyagi, T Shirai. Lupus nephropathy in New Zealand F1 hybrid mice treated by (-)15-deoxyspergualin. Kidney international. 1988 Oct; 34(4):467-73. doi: 10.1038/ki.1988.204. [PMID: 3199666]
  • H Kuramochi, M Hiratsuka, S Nagamine, K Takahashi, T Nakamura, T Takeuchi, H Umezawa. The antiproliferative action of deoxyspergualin is different from that induced by amine oxidase. The Journal of antibiotics. 1988 Feb; 41(2):234-8. doi: 10.7164/antibiotics.41.234. [PMID: 3356611]
  • T Takeuchi. [Spergualin, a new antitumor antibiotic]. Gan to kagaku ryoho. Cancer & chemotherapy. 1987 Mar; 14(3 Pt 2):845-9. doi: . [PMID: 3566295]
  • K Umezawa, T Takeuchi. Spergualin: a new antitumour antibiotic. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 1987; 41(5):227-32. doi: . [PMID: 3499181]
  • S Kunimoto, K Miura, H Iinuma, T Takeuchi, H Umezawa. Cytotoxicity of spergualin and amine oxidase activity in medium. The Journal of antibiotics. 1985 Jul; 38(7):899-903. doi: 10.7164/antibiotics.38.899. [PMID: 4030503]