5-Fluorouridine monophosphate (BioDeep_00000011320)

 

Secondary id: BioDeep_00001872461

human metabolite Endogenous blood metabolite Chemicals and Drugs


代谢物信息卡片


{[(2R,3S,4R,5R)-5-(5-fluoro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid

化学式: C9H12FN2O9P (342.0264)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 26.29%

分子结构信息

SMILES: C1=C(C(=O)NC(=O)N1C2C(C(C(O2)COP(=O)(O)O)O)O)F
InChI: InChI=1S/C9H12FN2O9P/c10-3-1-12(9(16)11-7(3)15)8-6(14)5(13)4(21-8)2-20-22(17,18)19/h1,4-6,8,13-14H,2H2,(H,11,15,16)(H2,17,18,19)/t4-,5-,6-,8-/m1/s1

描述信息

5-Fluorouridine monophosphate is a metabolite of fluorouracil. Fluorouracil (5-FU or f5U) (sold under the brand names Adrucil, Carac, Efudix, Efudex and Fluoroplex) is a drug that is a pyrimidine analog which is used in the treatment of cancer. It is a suicide inhibitor and works through irreversible inhibition of thymidylate synthase. It belongs to the family of drugs called antimetabolites. It is typically administered with leucovorin. (Wikipedia)

同义名列表

17 个代谢物同义名

{[(2R,3S,4R,5R)-5-(5-fluoro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid; [(2R,3S,4R,5R)-5-(5-fluoro-2,4-dioxo-3H-pyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxyphosphonic acid; 5-Fluorouridine 5-phosphate, disodium salt; 5-Fluorouridine 5-phosphate, calcium salt; 5-Fluorouridine 5-phosphate, 18F-labeled; 5-Fluorouridine 5-monophosphoric acid; 5-Fluorouridine monophosphoric acid; 5-Fluorouridine monophosphate; 5-Fluorouridine 5-phosphate; 5-Fluorouridylic acid; 5-Fluorouridylate; Fosfluoridine; 5-fluoro-UMP; 5-F-UMP; 5-FUMP; Fump-5; 5-Fluorouridine monophosphate



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 CAPN2, CAST, CMPK2, DHFR, DPYD, PNP, SMAD4, TP53, TYMS, UPRT
Nucleus 7 CAPN2, OMP, SMAD4, TP53, TYMS, UGDH, UPRT
cytosol 14 CAPN2, CAST, DHFR, DPYD, NGFR, OMP, PNP, PPAT, SMAD4, TP53, TYMP, TYMS, UGDH, UPP1
dendrite 1 CAPN2
centrosome 2 SMAD4, TP53
nucleoplasm 8 CAST, CMPK2, NGFR, SMAD4, TP53, UGDH, UPP1, UPRT
RNA polymerase II transcription regulator complex 1 SMAD4
Cell membrane 1 NGFR
Cell projection, growth cone 1 NGFR
Synapse 1 OMP
cell surface 1 NGFR
Golgi apparatus 1 CAPN2
Golgi membrane 1 INS
growth cone 1 NGFR
mitochondrial inner membrane 1 TYMS
neuromuscular junction 1 NGFR
neuronal cell body 2 CAPN2, OMP
postsynapse 1 CAPN2
Lysosome 1 CAPN2
Presynapse 2 CAPN2, NGFR
endosome 1 NGFR
plasma membrane 3 CAPN2, IFNLR1, NGFR
Membrane 4 CAST, IFNLR1, NGFR, TP53
axon 1 OMP
extracellular exosome 3 CAPN2, PNP, UGDH
endoplasmic reticulum 3 CAPN2, CAST, TP53
extracellular space 3 IL2, INS, PNP
mitochondrion 5 CAST, CMPK2, DHFR, TP53, TYMS
protein-containing complex 1 TP53
intracellular membrane-bounded organelle 1 UPRT
postsynaptic density 1 NGFR
Single-pass type I membrane protein 2 IFNLR1, NGFR
Secreted 3 IL2, INS, PNP
extracellular region 4 IL2, INS, NGFR, PNP
Mitochondrion matrix 2 TP53, TYMS
mitochondrial matrix 2 TP53, TYMS
transcription regulator complex 2 SMAD4, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
external side of plasma membrane 1 CAPN2
dendritic spine 1 NGFR
perikaryon 1 NGFR
nucleolus 2 CAST, TP53
cell-cell junction 1 NGFR
Mitochondrion inner membrane 1 TYMS
Membrane raft 1 CAPN2
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 1 CAPN2
Cell projection, dendritic spine 1 NGFR
Nucleus, PML body 1 TP53
PML body 1 TP53
chromatin 3 CAPN2, SMAD4, TP53
Chromosome 1 CAST
Nucleus, nucleolus 1 CAST
site of double-strand break 1 TP53
fibrillar center 1 CAST
endosome lumen 1 INS
germ cell nucleus 1 TP53
replication fork 1 TP53
pseudopodium 1 CAPN2
ficolin-1-rich granule lumen 1 PNP
secretory granule lumen 2 INS, PNP
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
cortical actin cytoskeleton 1 CAPN2
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
perinuclear endoplasmic reticulum 1 CAPN2
[Isoform 1]: Nucleus 1 TP53
heteromeric SMAD protein complex 1 SMAD4
RNA polymerase I complex 1 CAST
SMAD protein complex 1 SMAD4
RNA polymerase I transcription regulator complex 1 CAST
activin responsive factor complex 1 SMAD4
calpain complex 1 CAPN2
interleukin-28 receptor complex 1 IFNLR1


文献列表

  • Chen-Hsi Hsieh, Yen-Ju Hsieh, Chia-Yuan Liu, Hung-Chi Tai, Yu-Chuen Huang, Pei-Wei Shueng, Le-Jung Wu, Li-Ying Wang, Tung-Hu Tsai, Yu-Jen Chen. Abdominal irradiation modulates 5-Fluorouracil pharmacokinetics. Journal of translational medicine. 2010 Mar; 8(?):29. doi: 10.1186/1479-5876-8-29. [PMID: 20338060]
  • S B Howell. Clinical applications of a novel sustained-release injectable drug delivery system: DepoFoam technology. Cancer journal (Sudbury, Mass.). 2001 May; 7(3):219-27. doi: . [PMID: 11419030]
  • P M Schwartz, R D Moir, C M Hyde, P J Turek, R E Handschumacher. Role of uridine phosphorylase in the anabolism of 5-fluorouracil. Biochemical pharmacology. 1985 Oct; 34(19):3585-9. doi: 10.1016/0006-2952(85)90737-3. [PMID: 2996553]