Creatinine (BioDeep_00000001124)

 

Secondary id: BioDeep_00000229617, BioDeep_00000399890, BioDeep_00000864760

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


2-imino-1-methylimidazolidin-4-one

化学式: C4H7N3O (113.0589)
中文名称: 肌酐, 肌酸酐
谱图信息: 最多检出来源 Homo sapiens(blood) 16.77%

Reviewed

Last reviewed on 2024-07-01.

Cite this Page

Creatinine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/creatinine (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000001124). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CN1CC(=O)N=C1N
InChI: InChI=1S/C4H7N3O/c1-7-2-3(8)6-4(7)5/h2H2,1H3,(H2,5,6,8)

描述信息

Creatinine or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of water molecule from creatine results in the formation of creatinine. Creatinine is transferred to the kidneys by blood plasma, whereupon it is eliminated from the body by glomerular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate by the body. Measuring serum creatinine is a simple test and it is the most commonly used indicator of renal function. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. The typical reference range for women is considered about 45-90 umol/l, for men 60-110 umol/l. Creatine and creatinine are metabolized in the kidneys, muscle, liver and pancreas. [HMDB]. Creatinine is a biomarker for the consumption of meat. Creatinine is found in many foods, some of which are canada blueberry, other bread, french plantain, and grape.
Creatinine, or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of a water molecule from creatine results in the formation of creatinine. Creatinine is transferred to the kidneys by blood plasma, whereupon it is eliminated from the body by glomerular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate by the body. Measuring serum creatinine is a simple test and it is the most commonly used indicator of renal function. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons. Therefore, this test is not suitable for detecting early kidney disease. The typical reference range for women is considered about 45-90 µmol/L; for men 60-110 µmol/L. Creatine and creatinine are metabolized in the kidneys, muscle, liver, and pancreas.

Creatinine. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=60-27-5 (retrieved 2024-07-01) (CAS RN: 60-27-5). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Creatinine (NSC13123) is a breakdown product of creatine phosphate in muscles.
Creatinine (NSC13123) is a breakdown product of creatine phosphate in muscles.

同义名列表

20 个代谢物同义名

2-Amino-1,5-dihydro-1-methyl-4H-imidazol-4-one; 2-Amino-1-methyl-1,5-dihydroimidazol-4-one; 2-imino-1-methylimidazolidin-4-one; 2-Amino-1-methylimidazolin-4-one; 1-Methylhydantoin-2-imide; Salt, creatinine sulfate; Sulfate salt, creatinine; Creatinine sulfate salt; 1-Methylglycocyamidine; Creatinine,anhydrous; creatinine tautomer; Creatine anhydride; Creatinine; Creatinina; Krebiozen; Kreatinin; Creatinine; Creatinine; Creatinine; NSC13123



数据库引用编号

46 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(2)

BioCyc(3)

PlantCyc(0)

代谢反应

20 个相关的代谢反应过程信息。

Reactome(3)

BioCyc(15)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(1)

PathBank(0)

PharmGKB(0)

8 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 ACE, BGLAP, FABP1, IL18
Nucleus 1 FABP1
cytosol 4 FABP1, IL18, LIPE, MB
dendrite 1 BGLAP
nucleoplasm 1 FABP1
Cell membrane 6 ACE, AGTR2, GGT1, HAVCR1, LIPE, TNF
Multi-pass membrane protein 2 AGTR2, CACNA1I
cell surface 3 HAVCR1, TNF, UMOD
neuronal cell body 1 TNF
Cytoplasm, cytosol 2 IL18, LIPE
Lysosome 1 ACE
endosome 1 ACE
plasma membrane 7 ACE, AGTR2, CACNA1I, GGT1, HAVCR1, REN, TNF
Membrane 6 ACE, CACNA1I, GGT1, LIPE, REN, UMOD
apical plasma membrane 1 UMOD
basolateral plasma membrane 1 UMOD
caveola 1 LIPE
extracellular exosome 6 ACE, FABP1, GGT1, IGFBP7, MB, UMOD
endoplasmic reticulum 1 UMOD
extracellular space 14 ACE, BGLAP, CCL2, CXCL8, GGT1, IGFBP7, IL10, IL18, IL6, LPA, PTH, REN, TNF, UMOD
protein-containing complex 1 FABP1
Single-pass type I membrane protein 2 ACE, HAVCR1
Secreted 9 ACE, BGLAP, CCL2, CXCL8, IL10, IL18, IL6, REN, UMOD
extracellular region 12 ACE, BGLAP, CCL2, CXCL8, IGFBP7, IL10, IL18, IL6, LPA, PTH, REN, TNF
ciliary membrane 1 UMOD
motile cilium 1 HAVCR1
external side of plasma membrane 2 ACE, TNF
perikaryon 1 BGLAP
sarcoplasm 1 MB
apical part of cell 1 REN
recycling endosome 1 TNF
Single-pass type II membrane protein 2 GGT1, TNF
vesicle 1 BGLAP
Apical cell membrane 1 UMOD
Membrane raft 1 TNF
peroxisomal matrix 1 FABP1
collagen-containing extracellular matrix 1 IGFBP7
cilium 1 UMOD
phagocytic cup 1 TNF
brush border membrane 1 ACE
spindle pole 1 UMOD
sperm midpiece 1 ACE
Basolateral cell membrane 1 UMOD
Lipid-anchor, GPI-anchor 1 UMOD
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
side of membrane 1 UMOD
basal plasma membrane 1 ACE
Golgi lumen 2 BGLAP, UMOD
endoplasmic reticulum lumen 3 BGLAP, IGFBP7, IL6
voltage-gated calcium channel complex 1 CACNA1I
extrinsic component of membrane 1 UMOD
Cell projection, cilium membrane 1 UMOD
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
Cytoplasm, sarcoplasm 1 MB
interleukin-6 receptor complex 1 IL6
apical cortex 1 FABP1
[Uromodulin, secreted form]: Secreted 1 UMOD
plasma lipoprotein particle 1 LPA
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

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  • Ruixue Tian, Shuqin Tang, Jingyu Zhao, Yajie Hao, Limei Zhao, Xiutao Han, Xingru Wang, Lijun Zhang, Rongshan Li, Xiaoshuang Zhou. β-Hydroxybutyrate Protects Against Cisplatin-Induced Renal Damage via Regulating Ferroptosis. Renal failure. 2024 Dec; 46(1):2354918. doi: 10.1080/0886022x.2024.2354918. [PMID: 38757723]
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  • Yizeng Xu, Fang Lu, Meng Wang, Lingchen Wang, Chaoyang Ye, Shuohui Yang, Chen Wang. Shen Shuai II recipe improves renal hypoxia to attenuate renal injury in 5/6 renal ablation/infarction rats and effect evaluation using blood oxygenation level-dependent functional magnetic resonance imaging. Renal failure. 2024 Dec; 46(1):2338565. doi: 10.1080/0886022x.2024.2338565. [PMID: 38622926]
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  • Ying-Ling Zhang, Si-Min Chen, Yi-Jie Song, Md Ariful Islam, Pei-Li Rao, Meng-Jie Zhu, Wen-Yi Gu, Yu Xu, Hong-Xi Xu. Red ginseng ameliorates lipotoxicity-induced renal fibrosis in hyperuricemia mice. Journal of ethnopharmacology. 2024 Jun; 327(?):118014. doi: 10.1016/j.jep.2024.118014. [PMID: 38460576]
  • Mahdi Babamir Satehi, Mahdi Karimi, Zohreh Farrokhian, Fateme Pakbaz. The effect of aqueous extract of Iranian oak (Quercus brantii) on antioxidant capacity and oxidative stress in beta-thalassemia patients: Randomized controlled trial. Clinical nutrition ESPEN. 2024 Jun; 61(?):230-236. doi: 10.1016/j.clnesp.2024.03.037. [PMID: 38777439]
  • Wen-Wen Liu, Hong-Jing Dong, Zhe Zhang, Xin-Hui Ma, Shuang Liu, Wei Huang, Xiao Wang. Analyzing chemical composition of Sargentodoxae caulis water extract and their hypouricemia effect in hyperuricemic mice. Fitoterapia. 2024 Jun; 175(?):105926. doi: 10.1016/j.fitote.2024.105926. [PMID: 38537887]
  • ChaoQiong Zhou, QianRong Xie, HuaLi Wang, Feng Wu, DaHai He, Ying Huang, Ying He, ShiRong Dai, Jie Chen, LiRui Kong, Yan Zhang. Biological variation in the estimated glomerular filtration rate of healthy individuals within 24 h calculated using 2021CKD-EPI equations. Irish journal of medical science. 2024 Jun; 193(3):1613-1620. doi: 10.1007/s11845-024-03621-9. [PMID: 38308766]
  • Divya Bisht, Deena Prakash, Ramesh Kumar, Arvind Kumar Shakya, Sadhana Shrivastava. Phytochemical profiling and nephroprotective potential of ethanolic leaf extract of Polyalthia longifolia against cisplatin-induced oxidative stress in rat model. Journal of ethnopharmacology. 2024 May; 326(?):117922. doi: 10.1016/j.jep.2024.117922. [PMID: 38403004]
  • Xiayan Yu, Wenjing Qiang, Kexin Gong, Yidan Cao, Shuangqin Yan, Guopeng Gao, Fangbiao Tao, Beibei Zhu. No role of the third-trimester inflammatory factors in the association of gestational diabetes mellitus with postpartum cardiometabolic indicators. BMC pregnancy and childbirth. 2024 May; 24(1):361. doi: 10.1186/s12884-024-06563-3. [PMID: 38750471]
  • Jia-Jia Wu, Tian-Yi Zhang, Ying-Hui Qi, Min-Yan Zhu, Yan Fang, Chao-Jun Qi, Li-Ou Cao, Ji-Fang Lu, Bo-Han Lu, Lu-Min Tang, Jian-Xiao Shen, Shan Mou. Efficacy and safety of Yiqi Peiyuan granules for improving the short-term prognosis of patients with acute kidney injury: A multicenter, double-blind, placebo-controlled, randomized trial. Journal of integrative medicine. 2024 May; 22(3):279-285. doi: 10.1016/j.joim.2024.04.004. [PMID: 38688809]
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  • Bo Zou, Qiaoqiao Yuan, Hongyu Luo, Munan Wang, Xin Chen, Zuling Gao, Jianwei Wang, Yongbo Peng, Haijun Yang, Feng Dai, Xuekuan Huang. Combination of Fushengong decoction with Western medicine on patients with chronic renal failure: An observational study. Medicine. 2024 Apr; 103(15):e37473. doi: 10.1097/md.0000000000037473. [PMID: 38608120]
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  • Jiayou Luo, Miyang Luo, Atipatsa C Kaminga, Jia Wei, Wen Dai, Yunlong Peng, Kunyan Zhao, Yamei Duan, Xiang Xiao, SiSi Ouyang, Zhenzhen Yao, Yixu Liu, Xiongfeng Pan. Integrative metabolomics highlights gut microbiota metabolites as novel NAFLD-related candidate biomarkers in children. Microbiology spectrum. 2024 Apr; 12(4):e0523022. doi: 10.1128/spectrum.05230-22. [PMID: 38445874]
  • Thaise Boeing, Alana Bittencourt F Lima, Maria Eduarda Busana, Luísa Nathália Bolda Mariano, Luisa Mota da Silva, Rita de Cássia Vilhena da Silva, Priscila de Souza. Characterization of Diclofenac-induced Renal Damage in Normotensive and Hypertensive Rats: A Comparative Analysis. Drug research. 2024 Apr; 74(4):171-179. doi: 10.1055/a-2277-8458. [PMID: 38503307]
  • Jen-Hsuan Wu, Kuo-Jen Lin, Ying-Hao Hsu, Yang-Jen Chiang, Sheng-Hsien Chu, Chih-Te Lin, Pai-Yen Pan, Sy-Yuan Chen, Jui-Yen Wang, Hsu-Han Wang. Festivity: The Effects of Traditional Holidays on the Graft Function Among Stable Kidney Recipients. Transplantation proceedings. 2024 Apr; 56(3):546-549. doi: 10.1016/j.transproceed.2024.02.018. [PMID: 38523012]
  • Farah Aziz, Mohammad Fareed Khan, Amna Moiz. Gestational diabetes mellitus, hypertension, and dyslipidemia as the risk factors of preeclampsia. Scientific reports. 2024 03; 14(1):6182. doi: 10.1038/s41598-024-56790-z. [PMID: 38486097]
  • Rhulani Makhuvele, Kenn Foubert, Nina Hermans, Luc Pieters, Luc Verschaeve, Esameldin Elgorashi. Hepatoprotective effects of leaf extract of Annona senegalensis against aflatoxin B1 toxicity in rats. The Onderstepoort journal of veterinary research. 2024 Mar; 91(1):e1-e6. doi: 10.4102/ojvr.v91i1.2133. [PMID: 38572889]
  • Abdullah B Yıldız, Sezan Vehbi, Sidar Copur, Bengi Gurses, Dimitrie Siriopol, Bahar Afak Durur Karakaya, Nuri B Hasbal, Bahar Tekin, Murat Akyıldız, Daniel H van Raalte, Mario Cozzolino, Mehmet Kanbay. Kidney and liver fat accumulation: from imaging to clinical consequences. Journal of nephrology. 2024 Mar; 37(2):483-490. doi: 10.1007/s40620-023-01824-4. [PMID: 38133740]
  • Ji Huang, Cong Cheng, Kangxin Li, Chunping Zhu, Youshun Liu. Effectiveness and Safety of Tenofovir Alafenamide Fumarate in the Prevention of Perinatal Hepatitis B Transmission: A Meta-Analysis. Digestive diseases and sciences. 2024 Mar; 69(3):978-988. doi: 10.1007/s10620-023-08258-9. [PMID: 38341392]
  • Meng-Ke Bai, Xiao-Qing Yang, Xiao-Feng Mei, Jin-Gang Li, Yue-Li Yang, Yan-Jie Huang. [Urinary protein and renal pathological features in children with immunoglobulin A vasculitis with nephritis and hypercoagulability]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. 2024 Feb; 26(2):164-168. doi: 10.7499/j.issn.1008-8830.2309033. [PMID: 38436314]
  • Sumei Li, Shouping Yuan, Jintian Zhang, Feipeng Xu, Feng Zhu. The effect of periodic resistance training on obese patients with type 2 diabetic nephropathy. Scientific reports. 2024 02; 14(1):2761. doi: 10.1038/s41598-024-53333-4. [PMID: 38307949]
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  • Hend A Essa, Salwa M El Shebini, Maha I A Moaty, Nihad H Ahmed, Ahmed M S Hussein, Magda S Mohamed. Efficacy of parsley seed-supplemented bread in improving serum osteopontin level and renal health in obese women: A nutritional intervention study. Clinical nutrition ESPEN. 2024 02; 59(?):287-295. doi: 10.1016/j.clnesp.2023.12.022. [PMID: 38220388]
  • Chloe Orkin, Jean-Michel Molina, Pedro Cahn, Johannes Lombaard, Khuanchai Supparatpinyo, Sushma Kumar, Havilland Campbell, Hong Wan, Valerie Teal, Zhi Jin Xu, Ernest Asante-Appiah, Peter Sklar, Hedy Teppler, Rima Lahoulou. Safety and efficacy of doravirine as first-line therapy in adults with HIV-1: week 192 results from the open-label extensions of the DRIVE-FORWARD and DRIVE-AHEAD phase 3 trials. The lancet. HIV. 2024 Feb; 11(2):e75-e85. doi: 10.1016/s2352-3018(23)00258-8. [PMID: 38141637]
  • Fatemeh Mohammadi, Amirhossein Yadegar, Soghra Rabizadeh, Aryan Ayati, Seyed Arsalan Seyedi, Seyed Ali Nabipoorashrafi, Alireza Esteghamati, Manouchehr Nakhjavani. Correlates of normal and decreased HDL cholesterol levels in type 2 diabetes: a cohort-based cross-sectional study. Lipids in health and disease. 2024 Jan; 23(1):18. doi: 10.1186/s12944-024-02010-6. [PMID: 38243302]
  • Özge Kendirlinan, Yurdun Kuyucu, Bilge Güzelel, Ebru Dündar Yenilmez, Abdullah Tuli, Gülşah Seydaoğlu, Ufuk Özgü Mete. Investigation the effects of 2-aminoethoxydiphenyl borate (2-APB) on aminoglycoside nephrotoxicity. Ultrastructural pathology. 2024 Jan; 48(1):29-41. doi: 10.1080/01913123.2023.2278629. [PMID: 37970647]
  • Jinshu Chen, Pihou Chen, Yijin Song, Jiaxin Wei, Fan Wu, Jing Sun, Zhiquan Xu. STING upregulation mediates ferroptosis and inflammatory response in lupus nephritis by upregulating TBK1 and activating NF-κB signal pathway. Journal of biosciences. 2024; 49(?):. doi: . [PMID: 38186000]
  • Jianhua Wang, Yang Wang, Jie Yin, Lei Xia. Efficacy of Flexible Ureteroscopy Lithotripsy and Percutaneous Nephrolithotomy in the Treatment of Patients with Kidney Stones and Their Impact on Inflammatory Response and Renal Function. Annali italiani di chirurgia. 2024; 95(2):220-226. doi: 10.62713/aic.3175. [PMID: 38684501]
  • Dan Chen, Leying Wang, Xiaoyan Guo, Zijun Zhang, Xizhan Xu, Zi-Bing Jin, Qingfeng Liang. Evaluation of Limbal Stem Cells in Patients With Type 2 Diabetes: An In Vivo Confocal Microscopy Study. Cornea. 2024 Jan; 43(1):67-75. doi: 10.1097/ico.0000000000003334. [PMID: 37399570]
  • Ahmed I Abd El Maksoud, Ahmed A Al-Karmalawy, Dalia ElEbeedy, Aml Ghanem, Yasmin Rasheed, Ibrahim A Ibrahim, Reem A Elghaish, Amany Belal, Mona A Raslan, Rehab F Taher. Symbiotic Antidiabetic Effect of Lactobacillus casei and the Bioactive Extract of Cleome droserifolia (Forssk.) Del. on Mice with Type 2 Diabetes Induced by Alloxan. Chemistry & biodiversity. 2024 Jan; 21(1):e202301397. doi: 10.1002/cbdv.202301397. [PMID: 38078801]
  • Carlo Palizzotto, Felippo Ferri, Carolina Callegari, Francesco Rossi, Marcello Manfredi, Laura Carcangiu, Gabriele Gerardi, Silvia Ferro, Laura Cavicchioli, Elizabeth Müller, Marco Weiss, Anne-Catherine Vogt, Francesca Lavatelli, Stefano Ricagno, Karyl Hurley, Eric Zini. Renal amyloid-A amyloidosis in cats: Characterization of proteinuria and biomarker discovery, and associations with kidney histology. Journal of veterinary internal medicine. 2024 Jan; 38(1):205-215. doi: 10.1111/jvim.16920. [PMID: 37991136]
  • Soroush Masrouri, Seyed Saeed Tamehri Zadeh, Mehdi Pishgahi, Fereidoun Azizi, Michael D Shapiro, Farzad Hadaegh. Kidney function decline is associated with mortality events: over a decade of follow-up from Tehran Lipid and Glucose Study. Journal of nephrology. 2024 01; 37(1):107-118. doi: 10.1007/s40620-023-01756-z. [PMID: 37665526]
  • Fatma Ben Mansour, Habib Ayadi, Jos van Pelt, Abdelfattah Elfeki, Khaled Bellassoued. Antioxidant and Protective Effect of Ocimum basilicum Seeds Extract on Renal Toxicity Induced by Carbon Tetrachloride in Rats. Journal of medicinal food. 2024 Jan; 27(1):60-71. doi: 10.1089/jmf.2023.0184. [PMID: 38150214]
  • Yun Xie, Qin Guo, Bo Yang, Pan Xie, Jingxiao Zhang, Wei Lu, Claudio Ronco, Gengru Jiang. Tissue Inhibitor Metalloproteinase-2·IGF-Binding Protein 7 for the Prediction of Acute Kidney Injury following Cardiac Surgery. Cardiorenal medicine. 2024; 14(1):251-260. doi: 10.1159/000538031. [PMID: 38588650]
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  • Jacob Lessard-Lord, Serge Auger, Sarah Demers, Pier-Luc Plante, Pierre Picard, Yves Desjardins. Automated High-Throughput Quantification of Phenyl-γ-valerolactones and Creatinine in Urine by Laser Diode Thermal Desorption. Journal of agricultural and food chemistry. 2023 Nov; 71(44):16787-16796. doi: 10.1021/acs.jafc.3c03888. [PMID: 37890868]
  • H A Al-Amer, N S Al-Sowayan, H A Alfheeaid, S A Althwab, S A Alrobaish, E M Hamad, K H Musa, H M Mousa. Oral administration of naringenin and a mixture of coconut water and Arabic gum attenuate oxidative stress and lipid peroxidation in gentamicin-induced nephrotoxicity in rats. European review for medical and pharmacological sciences. 2023 Nov; 27(21):10427-10437. doi: 10.26355/eurrev_202311_34317. [PMID: 37975366]
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  • Réka Szentimrei, Hajnalka Lőrincz, Anita Szentpéteri, Viktória Evelin Varga, Ildikó Seres, Éva Varga, Balázs Nemes, Mariann Harangi, György Paragh. Assessment of amino-terminal C-type natriuretic peptide serum level and its correlation with high-density lipoprotein structure and function in patients with end stage renal disease before and after kidney transplantation. Chemico-biological interactions. 2023 Nov; 385(?):110749. doi: 10.1016/j.cbi.2023.110749. [PMID: 37802408]
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