methyl farnesoate (BioDeep_00000011226)

 

Secondary id: BioDeep_00000864882

natural product


代谢物信息卡片


(2E,6E)-METHYL 3,7,11-TRIMETHYLDODECA-2,6,10-TRIENOATE

化学式: C16H26O2 (250.1933)
中文名称: 反式,反式-法尼基酸甲酯, 法尼酸甲酯
谱图信息: 最多检出来源 Viridiplantae(plant) 13.61%

分子结构信息

SMILES: CC(=CCCC(=CCCC(=CC(=O)OC)C)C)C
InChI: InChI=1S/C16H26O2/c1-13(2)8-6-9-14(3)10-7-11-15(4)12-16(17)18-5/h8,10,12H,6-7,9,11H2,1-5H3/b14-10+,15-12+

描述信息

A member of the juvenile hormone family of compounds that is the methyl ester of farnesoic acid. Found in several species of crustaceans.

同义名列表

8 个代谢物同义名

(2E,6E)-METHYL 3,7,11-TRIMETHYLDODECA-2,6,10-TRIENOATE; Methyl (2E,6E)-farnesoate; methyl farnesoate; (E,E)-METHYL FARNESOATE; Methyl farnesoate; Methyl farnesoate; Methyl farnesoate; Methyl farnesoate



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(1)

代谢反应

3 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(1)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ARNT, CDC123, FDPS, MTR, MVD, MVK, ZMYND8
Peripheral membrane protein 2 CTSL, CYP1B1
Endoplasmic reticulum membrane 3 ACAT1, CYP1B1, HMGCR
Nucleus 4 ARNT, BHMT, CTSL, ZMYND8
cytosol 8 BHMT, FDPS, MAT1A, MTR, MVD, MVK, PMVK, PRKCQ
nuclear body 1 ARNT
nucleoplasm 3 ARNT, FDPS, ZMYND8
RNA polymerase II transcription regulator complex 1 ARNT
Multi-pass membrane protein 2 ACAT1, HMGCR
cell surface 1 LBP
dendritic shaft 1 ZMYND8
Golgi apparatus 1 CTSL
Golgi membrane 1 INS
Cytoplasm, cytosol 2 BHMT, PMVK
Lysosome 1 CTSL
plasma membrane 2 CTSL, PRKCQ
Membrane 6 ACAT1, CYP1B1, FDPS, HMGCR, LBP, PMVK
apical plasma membrane 1 CTSL
extracellular exosome 6 A2M, ACAT1, BHMT, CTSL, LBP, PMVK
endoplasmic reticulum 2 ACAT1, HMGCR
extracellular space 5 A2M, CTSL, INS, LBP, MSTN
lysosomal lumen 1 CTSL
mitochondrion 2 ACAT1, CYP1B1
intracellular membrane-bounded organelle 3 CTSL, CYP1B1, MVK
Microsome membrane 1 CYP1B1
Secreted 5 A2M, CTSL, INS, LBP, MSTN
extracellular region 4 A2M, CTSL, INS, LBP
mitochondrial matrix 2 ACAT1, FDPS
Extracellular side 1 CTSL
transcription regulator complex 1 ARNT
centriolar satellite 1 PRKCQ
multivesicular body 1 CTSL
dendritic spine 1 ZMYND8
nucleolus 1 ZMYND8
Apical cell membrane 1 CTSL
Peroxisome 3 FDPS, MVK, PMVK
peroxisomal membrane 1 HMGCR
collagen-containing extracellular matrix 2 A2M, CTSL
chromatin 2 ARNT, ZMYND8
Chromosome 1 ZMYND8
Secreted, extracellular space 1 CTSL
blood microparticle 1 A2M
endosome lumen 1 INS
aryl hydrocarbon receptor complex 1 ARNT
Peroxisome membrane 1 HMGCR
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
platelet alpha granule lumen 1 A2M
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
[Isoform 2]: Nucleus 1 CTSL
site of DNA damage 1 ZMYND8
endocytic vesicle lumen 1 CTSL
Cytoplasmic vesicle, secretory vesicle, chromaffin granule 1 CTSL
chromaffin granule 1 CTSL
endolysosome lumen 1 CTSL
Cytoplasmic granule membrane 1 LBP
nuclear aryl hydrocarbon receptor complex 1 ARNT
methionine adenosyltransferase complex 1 MAT1A


文献列表

  • Marcela Nouzova, Marten J Edwards, Veronika Michalkova, Cesar E Ramirez, Marnie Ruiz, Maria Areiza, Matthew DeGennaro, Francisco Fernandez-Lima, René Feyereisen, Marek Jindra, Fernando G Noriega. Epoxidation of juvenile hormone was a key innovation improving insect reproductive fitness. Proceedings of the National Academy of Sciences of the United States of America. 2021 11; 118(45):. doi: 10.1073/pnas.2109381118. [PMID: 34697248]
  • Dov Borovsky, Robert G Hancock, Pierre Rougé, Charles A Powell, Robert G Shatters. Juvenile hormone affects the splicing of Culex quinquefasciatus early trypsin messenger RNA. Archives of insect biochemistry and physiology. 2018 Nov; 99(3):e21506. doi: 10.1002/arch.21506. [PMID: 30176073]
  • Inmaculada Fuertes, Rita Jordão, Josefina Casas, Carlos Barata. Allocation of glycerolipids and glycerophospholipids from adults to eggs in Daphnia magna: Perturbations by compounds that enhance lipid droplet accumulation. Environmental pollution (Barking, Essex : 1987). 2018 Nov; 242(Pt B):1702-1710. doi: 10.1016/j.envpol.2018.07.102. [PMID: 30064873]
  • Rita Jordão, Elba Garreta, Bruno Campos, Marco F L Lemos, Amadeu M V M Soares, Romà Tauler, Carlos Barata. Compounds altering fat storage in Daphnia magna. The Science of the total environment. 2016 Mar; 545-546(?):127-36. doi: 10.1016/j.scitotenv.2015.12.097. [PMID: 26747981]
  • Di Wen, Crisalejandra Rivera-Perez, Mohamed Abdou, Qiangqiang Jia, Qianyu He, Xi Liu, Ola Zyaan, Jingjing Xu, William G Bendena, Stephen S Tobe, Fernando G Noriega, Subba R Palli, Jian Wang, Sheng Li. Methyl farnesoate plays a dual role in regulating Drosophila metamorphosis. PLoS genetics. 2015 Mar; 11(3):e1005038. doi: 10.1371/journal.pgen.1005038. [PMID: 25774983]
  • Danny W-K Ng, Changqing Zhang, Marisa Miller, Gregory Palmer, Marvin Whiteley, Dorothea Tholl, Z Jeffrey Chen. cis- and trans-Regulation of miR163 and target genes confers natural variation of secondary metabolites in two Arabidopsis species and their allopolyploids. The Plant cell. 2011 May; 23(5):1729-40. doi: 10.1105/tpc.111.083915. [PMID: 21602291]
  • Anna V Kuballa, Timothy A Holton, Brian Paterson, Abigail Elizur. Moult cycle specific differential gene expression profiling of the crab Portunus pelagicus. BMC genomics. 2011 Mar; 12(?):147. doi: 10.1186/1471-2164-12-147. [PMID: 21396120]
  • Arti T Navare, Jaime G Mayoral, Marcela Nouzova, Fernando G Noriega, Facundo M Fernández. Rapid direct analysis in real time (DART) mass spectrometric detection of juvenile hormone III and its terpene precursors. Analytical and bioanalytical chemistry. 2010 Dec; 398(7-8):3005-13. doi: 10.1007/s00216-010-4269-4. [PMID: 20936260]
  • Shuhua Liu, Chengwei Zhang, Baojun Yang, Jianhua Gu, Zewen Liu. Cloning and characterization of a putative farnesoic acid O-methyltransferase gene from the brown planthopper, Nilaparvata lugens. Journal of insect science (Online). 2010; 10(?):103. doi: 10.1673/031.010.10301. [PMID: 20874390]
  • Susanna Roeder, Katharina Dreschler, Markus Wirtz, Simona M Cristescu, Frans J M van Harren, Rüdiger Hell, Birgit Piechulla. SAM levels, gene expression of SAM synthetase, methionine synthase and ACC oxidase, and ethylene emission from N. suaveolens flowers. Plant molecular biology. 2009 Jul; 70(5):535-46. doi: 10.1007/s11103-009-9490-1. [PMID: 19396585]
  • Y I N Silva Gunawardene, S S Tobe, W G Bendena, B K C Chow, K J Yagi, S-M Chan. Function and cellular localization of farnesoic acid O-methyltransferase (FAMeT) in the shrimp, Metapenaeus ensis. European journal of biochemistry. 2002 Jul; 269(14):3587-95. doi: 10.1046/j.1432-1033.2002.03048.x. [PMID: 12135499]
  • Y Soroka, A Sagi, I Khalaila, U Abdu, Y Milner. Changes in protein kinase C during vitellogenesis in the crayfish Cherax quadricarinatus--possible activation by methyl farnesoate. General and comparative endocrinology. 2000 May; 118(2):200-8. doi: 10.1006/gcen.2000.7471. [PMID: 10890562]
  • E Homola, E S Chang. Distribution and regulation of esterases that hydrolyze methyl farnesoate in Homarus americanus and other crustaceans. General and comparative endocrinology. 1997 Apr; 106(1):62-72. doi: 10.1006/gcen.1996.6850. [PMID: 9126466]
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