cdiGMP (BioDeep_00000011196)
代谢物信息卡片
9,9-[(2r,3r,3as,5s,7ar,9r,10r,10as,12s,14ar)-3,5,10,12-Tetrahydroxy-5,12-Dioxidooctahydro-2h,7h-Difuro[3,2-D:3,2-J][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-Diyl]bis(2-Amino-1,9-Dihydro-6h-Purin-6-One)
化学式: C20H24N10O14P2 (690.0948664)
中文名称:
谱图信息:
最多检出来源 Viridiplantae(plant) 2.65%
分子结构信息
SMILES: C1C2C(C(C(O2)N3C=NC4=C3N=C(NC4=O)N)O)OP(=O)(OCC5C(C(C(O5)N6C=NC7=C6N=C(NC7=O)N)O)OP(=O)(O1)O)O
InChI: InChI=1S/C20H24N10O14P2/c21-19-25-13-7(15(33)27-19)23-3-29(13)17-9(31)11-5(41-17)1-39-45(35,36)44-12-6(2-40-46(37,38)43-11)42-18(10(12)32)30-4-24-8-14(30)26-20(22)28-16(8)34/h3-6,9-12,17-18,31-32H,1-2H2,(H,35,36)(H,37,38)(H3,21,25,27,33)(H3,22,26,28,34)
描述信息
同义名列表
8 个代谢物同义名
9,9-[(2r,3r,3as,5s,7ar,9r,10r,10as,12s,14ar)-3,5,10,12-Tetrahydroxy-5,12-Dioxidooctahydro-2h,7h-Difuro[3,2-D:3,2-J][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-Diyl]bis(2-Amino-1,9-Dihydro-6h-Purin-6-One); 3,5-Cyclic diguanylic acid; Cyclic di-3,5-guanylate; Bis-(3,5)-cyclic diGMP; 3,5-Cyclic diGMP; cdiGMP; Bis(3,5)-cyclic diguanylic acid; Cyclic-di-GMP(c-di-GMP)
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:49537
- KEGG: C16463
- PubChem: 135440063
- PubChem: 137221491
- Metlin: METLIN71205
- ChEMBL: CHEMBL1231573
- CAS: 61093-23-0
- PMhub: MS000025158
- PubChem: 47205759
- PDB-CCD: C2E
- NIKKAJI: J687.951I
分类词条
相关代谢途径
BioCyc(0)
PlantCyc(0)
代谢反应
40 个相关的代谢反应过程信息。
Reactome(40)
- Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
Cl- + H+ + H2O2 ⟶ H2O + HOCl - Cytosolic sensors of pathogen-associated DNA:
STING:STING + c-di-GMP ⟶ STING:c-di-GMP - STING mediated induction of host immune responses:
STING:STING + c-di-GMP ⟶ STING:c-di-GMP - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
TLR4:TLR6 + oxLDL:CD36 ⟶ TLR4:TLR6:CD36:oxLDL - Cytosolic sensors of pathogen-associated DNA:
STING:STING + c-di-GMP ⟶ STING:c-di-GMP - STING mediated induction of host immune responses:
STING:STING + c-di-GMP ⟶ STING:c-di-GMP - Immune System:
Epac + cAMP ⟶ RAPGEF3:cAMP complex - Innate Immune System:
Cl- + H+ + H2O2 ⟶ H2O + HOCl - Cytosolic sensors of pathogen-associated DNA:
STING:STING + c-di-GMP ⟶ STING:c-di-GMP - STING mediated induction of host immune responses:
STING:STING + c-di-GMP ⟶ STING:c-di-GMP - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
Cl- + H+ + H2O2 ⟶ H2O + HOCl - Cytosolic sensors of pathogen-associated DNA:
STING:STING + c-di-GMP ⟶ STING:c-di-GMP - STING mediated induction of host immune responses:
STING:STING + c-di-GMP ⟶ STING:c-di-GMP - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
TLR4:TLR6 + oxLDL:CD36 ⟶ TLR4:TLR6:CD36:oxLDL - Cytosolic sensors of pathogen-associated DNA:
Mg2+ + TREX1 dimer + viral DNA with 3' sticky ends ⟶ TREX1:viral DNA - STING mediated induction of host immune responses:
STING:STING + c-di-GMP ⟶ STING:c-di-GMP - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
TLR4:TLR6 + oxLDL:CD36 ⟶ TLR4:TLR6:CD36:oxLDL - Cytosolic sensors of pathogen-associated DNA:
STING:STING + c-di-GMP ⟶ STING:c-di-GMP - STING mediated induction of host immune responses:
STING:STING + c-di-GMP ⟶ STING:c-di-GMP - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
TLR4:TLR6 + oxLDL:CD36 ⟶ TLR4:TLR6:CD36:oxLDL - Cytosolic sensors of pathogen-associated DNA:
STING:STING + c-di-GMP ⟶ STING:c-di-GMP - STING mediated induction of host immune responses:
STING:STING + c-di-GMP ⟶ STING:c-di-GMP - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
TLR4:TLR6 + oxLDL:CD36 ⟶ TLR4:TLR6:CD36:oxLDL - Cytosolic sensors of pathogen-associated DNA:
STING:STING + c-di-GMP ⟶ STING:c-di-GMP - STING mediated induction of host immune responses:
STING:STING + c-di-GMP ⟶ STING:c-di-GMP - Immune System:
ATP + Ag-substrate:E3:E2:Ub ⟶ AMP + E3:Ub:substrate + PPi - Innate Immune System:
ATP + DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 oligomer + UBE2N:UBE2V1 ⟶ AMP + DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 + PPi + UBE2N:UBE2V1 - Cytosolic sensors of pathogen-associated DNA:
ATP + STING:TBK1:STAT6 ⟶ ADP + STING:p-S172-TBK1:STAT6 - STING mediated induction of host immune responses:
ATP + STING:TBK1:STAT6 ⟶ ADP + STING:p-S172-TBK1:STAT6 - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Innate Immune System:
Cl- + H+ + H2O2 ⟶ H2O + HOCl - Cytosolic sensors of pathogen-associated DNA:
STING:STING + c-di-GMP ⟶ STING:c-di-GMP - STING mediated induction of host immune responses:
STING:STING + c-di-GMP ⟶ STING:c-di-GMP
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Haofei Liu, Gaoge Xu, Baodian Guo, Fengquan Liu. Old role with new feature: T2SS ATPase as a cyclic-di-GMP receptor to regulate antibiotic production.
Applied and environmental microbiology.
2024 May; 90(5):e0041824. doi:
10.1128/aem.00418-24. [PMID: 38624198] - Xiaocui Ling, Xiao Liu, Kun Wang, Minhao Guo, Yanzhe Ou, Danting Li, Yulin Xiang, Jiachen Zheng, Lihua Hu, Hongyun Zhang, Weihui Li. Lsr2 acts as a cyclic di-GMP receptor that promotes keto-mycolic acid synthesis and biofilm formation in mycobacteria.
Nature communications.
2024 Jan; 15(1):695. doi:
10.1038/s41467-024-44774-6. [PMID: 38267428] - Raj Kumar Verma, Parimala Gondu, Tirthankar Saha, Subhadeep Chatterjee. The global transcription regulator XooClp governs Type IV pili system mediated bacterial virulence by directly binding to their promoters to coordinate virulence associated functions.
Molecular plant-microbe interactions : MPMI.
2023 Dec; ?(?):. doi:
10.1094/mpmi-07-23-0100-r. [PMID: 38105438] - Biswarup Banerjee, Xiaochen Yuan, Ching-Hong Yang. Dissecting the molecular dance: c-di-GMP, cAMP-CRP, and VfmH collaboration in pectate lyase regulation for Dickeya dadantii-unveiling the soft rot pathogen's strategy.
Microbiology spectrum.
2023 Oct; ?(?):e0153723. doi:
10.1128/spectrum.01537-23. [PMID: 37811940] - Tingting Wang, Canfeng Hua, Xin Deng. c-di-GMP signaling in Pseudomonas syringae complex.
Microbiological research.
2023 Oct; 275(?):127445. doi:
10.1016/j.micres.2023.127445. [PMID: 37450986] - Kangwen Xu, Limin Wang, Dan Xiong, Hongjun Chen, Xinru Tong, Xiaolong Shao, Tao Li, Guoliang Qian. The Wsp chemosensory system modulates c-di-GMP-dependent biofilm formation by integrating DSF quorum sensing through the WspR-RpfG complex in Lysobacter.
NPJ biofilms and microbiomes.
2022 12; 8(1):97. doi:
10.1038/s41522-022-00365-1. [PMID: 36526637] - Roshni R Kharadi, George W Sundin. CsrD regulates amylovoran biosynthesis and virulence in Erwinia amylovora in a novel cyclic-di-GMP dependent manner.
Molecular plant pathology.
2022 08; 23(8):1154-1169. doi:
10.1111/mpp.13217. [PMID: 35396793] - Daqing Jiang, Quan Zeng, Biswarup Banerjee, Haiping Lin, John Srok, Manda Yu, Ching-Hong Yang. The phytopathogen Dickeya dadantii 3937 cpxR locus gene participates in the regulation of virulence and the global c-di-GMP network.
Molecular plant pathology.
2022 08; 23(8):1187-1199. doi:
10.1111/mpp.13219. [PMID: 35460168] - Roshni R Kharadi, Kayla Selbmann, George W Sundin. A complete twelve-gene deletion null mutant reveals that cyclic di-GMP is a global regulator of phase-transition and host colonization in Erwinia amylovora.
PLoS pathogens.
2022 08; 18(8):e1010737. doi:
10.1371/journal.ppat.1010737. [PMID: 35914003] - Esther Blanco-Romero, Daniel Garrido-Sanz, David Durán, Rafael Rivilla, Miguel Redondo-Nieto, Marta Martín. Regulation of extracellular matrix components by AmrZ is mediated by c-di-GMP in Pseudomonas ogarae F113.
Scientific reports.
2022 07; 12(1):11914. doi:
10.1038/s41598-022-16162-x. [PMID: 35831472] - Yufan Chen, Mingfa Lv, Zhibin Liang, Zhiqing Liu, Jianuan Zhou, Lian-Hui Zhang. Cyclic di-GMP modulates sessile-motile phenotypes and virulence in Dickeya oryzae via two PilZ domain receptors.
Molecular plant pathology.
2022 06; 23(6):870-884. doi:
10.1111/mpp.13200. [PMID: 35254732] - Meng-Lun Hsieh, Niklas Kiel, Lisa M Miller Jenkins, Wai-Leung Ng, Leslie Knipling, Christopher M Waters, Deborah M Hinton. The Vibrio cholerae master regulator for the activation of biofilm biogenesis genes, VpsR, senses both cyclic di-GMP and phosphate.
Nucleic acids research.
2022 05; 50(8):4484-4499. doi:
10.1093/nar/gkac253. [PMID: 35438787] - Biswarup Banerjee, Quan Zeng, Manda Yu, Brian Y Hsueh, Christopher M Waters, Ching-Hong Yang. Quorum-Sensing Master Regulator VfmE Is a c-di-GMP Effector That Controls Pectate Lyase Production in the Phytopathogen Dickeya dadantii.
Microbiology spectrum.
2022 04; 10(2):e0180521. doi:
10.1128/spectrum.01805-21. [PMID: 35352959] - Laura Barrientos-Moreno, María Antonia Molina-Henares, María Isabel Ramos-González, Manuel Espinosa-Urgel. Role of the Transcriptional Regulator ArgR in the Connection between Arginine Metabolism and c-di-GMP Signaling in Pseudomonas putida.
Applied and environmental microbiology.
2022 04; 88(7):e0006422. doi:
10.1128/aem.00064-22. [PMID: 35254100] - Xiaotong Yu, Jing Yu, Hong Dai, Chenyun Deng, Xudong Sun, Sijie Long, Zhujun Jiang, Hongyan Jin, Zhu Guan, Zhenjun Yang. Novel formulation of c-di-GMP with cytidinyl/cationic lipid reverses T cell exhaustion and activates stronger anti-tumor immunity.
Theranostics.
2022; 12(15):6723-6739. doi:
10.7150/thno.71010. [PMID: 36185614] - Liting Hou, Xiaoming Yu, Yuanyuan Zhang, Luping Du, Yuanpeng Zhang, Haiwei Cheng, Qisheng Zheng, Jin Chen, Jibo Hou. Enhanced Immune Responses in Mice Induced by the c-di-GMP Adjuvanted Inactivated Vaccine for Pseudorabies Virus.
Frontiers in immunology.
2022; 13(?):845680. doi:
10.3389/fimmu.2022.845680. [PMID: 35432301] - Ying Wen, Ying Wang, Shouwen Chen, Xiangshan Zhou, Yuanxing Zhang, Dahai Yang, Gabriel Núñez, Qin Liu. Dysregulation of Cytosolic c-di-GMP in Edwardsiella piscicida Promotes Cellular Non-Canonical Ferroptosis.
Frontiers in cellular and infection microbiology.
2022; 12(?):825824. doi:
10.3389/fcimb.2022.825824. [PMID: 35186798] - Kaihuai Li, Gaoge Xu, Bo Wang, Guichun Wu, Rongxian Hou, Fengquan Liu. The predatory soil bacterium Lysobacter reprograms quorum sensing system to regulate antifungal antibiotic production in a cyclic-di-GMP-independent manner.
Communications biology.
2021 09; 4(1):1131. doi:
10.1038/s42003-021-02660-7. [PMID: 34561536] - Akanksha Kakkar, Raj Kumar Verma, Biswajit Samal, Subhadeep Chatterjee. Interplay between the cyclic di-GMP network and the cell-cell signalling components coordinates virulence-associated functions in Xanthomonas oryzae pv. oryzae.
Environmental microbiology.
2021 09; 23(9):5433-5462. doi:
10.1111/1462-2920.15664. [PMID: 34240791] - Kangwen Xu, Danyu Shen, Nianda Yang, Shan-Ho Chou, Mark Gomelsky, Guoliang Qian. Coordinated control of the type IV pili and c-di-GMP-dependent antifungal antibiotic production in Lysobacter by the response regulator PilR.
Molecular plant pathology.
2021 05; 22(5):602-617. doi:
10.1111/mpp.13046. [PMID: 33709522] - Pedro Dorado-Morales, Igor Martínez, Virginia Rivero-Buceta, Eduardo Díaz, Heike Bähre, Iñigo Lasa, Cristina Solano. Elevated c-di-GMP levels promote biofilm formation and biodesulfurization capacity of Rhodococcus erythropolis.
Microbial biotechnology.
2021 05; 14(3):923-937. doi:
10.1111/1751-7915.13689. [PMID: 33128507] - Henrik Almblad, Trevor E Randall, Fanny Liu, Katherine Leblanc, Ryan A Groves, Weerayuth Kittichotirat, Geoffrey L Winsor, Nicolas Fournier, Emily Au, Julie Groizeleau, Jacquelyn D Rich, Yuefei Lou, Elise Granton, Laura K Jennings, Larissa A Singletary, Tara M L Winstone, Nathan M Good, Roger E Bumgarner, Michael F Hynes, Manu Singh, Maria Silvina Stietz, Fiona S L Brinkman, Ayush Kumar, Ann Karen Cornelia Brassinga, Matthew R Parsek, Boo Shan Tseng, Ian A Lewis, Bryan G Yipp, Justin L MacCallum, Joe Jonathan Harrison. Bacterial cyclic diguanylate signaling networks sense temperature.
Nature communications.
2021 03; 12(1):1986. doi:
10.1038/s41467-021-22176-2. [PMID: 33790266] - Yi-Ping Chen, Li Xu, Tao-Wei Tang, Cheuh-Hsuan Chen, Quan-Hong Zheng, Tsang-Pai Liu, Chung-Yuan Mou, Cheng-Hsun Wu, Si-Han Wu. STING Activator c-di-GMP-Loaded Mesoporous Silica Nanoparticles Enhance Immunotherapy Against Breast Cancer.
ACS applied materials & interfaces.
2020 Dec; 12(51):56741-56752. doi:
10.1021/acsami.0c16728. [PMID: 33305564] - Yufan Chen, Jianuan Zhou, Mingfa Lv, Zhibin Liang, Matthew R Parsek, Lian-Hui Zhang. Systematic Analysis of c-di-GMP Signaling Mechanisms and Biological Functions in Dickeya zeae EC1.
mBio.
2020 12; 11(6):. doi:
10.1128/mbio.02993-20. [PMID: 33262261] - Fei Liang, Bo Zhang, Qingqing Yang, Yang Zhang, Dehong Zheng, Li-Qun Zhang, Qing Yan, Xiaogang Wu. Cyclic-di-GMP Regulates the Quorum-Sensing System and Biocontrol Activity of Pseudomonas fluorescens 2P24 through the RsmA and RsmE Proteins.
Applied and environmental microbiology.
2020 11; 86(24):. doi:
10.1128/aem.02016-20. [PMID: 33036989] - Muhammad Umar Shahbaz, Shanshan Qian, Fei Yun, Jie Zhang, Chao Yu, Fang Tian, Fenghuan Yang, Huamin Chen. Identification of the Regulatory Components Mediated by the Cyclic di-GMP Receptor Filp and Its Interactor PilZX3 and Functioning in Virulence of Xanthomonas oryzae pv. oryzae.
Molecular plant-microbe interactions : MPMI.
2020 Oct; 33(10):1196-1208. doi:
10.1094/mpmi-04-20-0088-r. [PMID: 32720873] - Vivek K Mutalik, Benjamin A Adler, Harneet S Rishi, Denish Piya, Crystal Zhong, Britt Koskella, Elizabeth M Kutter, Richard Calendar, Pavel S Novichkov, Morgan N Price, Adam M Deutschbauer, Adam P Arkin. High-throughput mapping of the phage resistance landscape in E. coli.
PLoS biology.
2020 10; 18(10):e3000877. doi:
10.1371/journal.pbio.3000877. [PMID: 33048924] - Raj Kumar Verma, Anindya Biswas, Akanksha Kakkar, Santosh Kumar Lomada, Binod Bihari Pradhan, Subhadeep Chatterjee. A Bacteriophytochrome Mediates Interplay between Light Sensing and the Second Messenger Cyclic Di-GMP to Control Social Behavior and Virulence.
Cell reports.
2020 09; 32(13):108202. doi:
10.1016/j.celrep.2020.108202. [PMID: 32997993] - Laura Barrientos-Moreno, María Antonia Molina-Henares, María Isabel Ramos-González, Manuel Espinosa-Urgel. Arginine as an environmental and metabolic cue for cyclic diguanylate signalling and biofilm formation in Pseudomonas putida.
Scientific reports.
2020 08; 10(1):13623. doi:
10.1038/s41598-020-70675-x. [PMID: 32788689] - Lisa Juliane Kahl, Alexa Price-Whelan, Lars E P Dietrich. Light-Mediated Decreases in Cyclic di-GMP Levels Inhibit Structure Formation in Pseudomonas aeruginosa Biofilms.
Journal of bacteriology.
2020 06; 202(14):. doi:
10.1128/jb.00117-20. [PMID: 32366589] - Xuexiang Ren, Shuangshuang Ren, Gaoge Xu, Wen Dou, Shan-Ho Chou, Yu Chen, Guoliang Qian. Knockout of Diguanylate Cyclase Genes in Lysobacter enzymogenes to Improve Production of Antifungal Factor and Increase Its Application in Seed Coating.
Current microbiology.
2020 Jun; 77(6):1006-1015. doi:
10.1007/s00284-020-01902-x. [PMID: 32002625] - Delia A Narváez-Barragán, Andrés de Sandozequi, Mabel Rodríguez, Karel Estrada, Omar E Tovar-Herrera, Claudia Martínez-Anaya. Analysis of two Mexican Pectobacterium brasiliense strains reveals an inverted relationship between c-di-GMP levels with exopolysaccharide production and swarming motility.
Microbiological research.
2020 May; 235(?):126427. doi:
10.1016/j.micres.2020.126427. [PMID: 32109688] - Kenichi Kitanishi, Jotaro Igarashi, Ariki Matsuoka, Masaki Unno. Identification and Characterization of a Redox Sensor Phosphodiesterase from Ferrovum sp. PN-J185 Containing Bacterial Hemerythrin and HD-GYP Domains.
Biochemistry.
2020 03; 59(8):983-991. doi:
10.1021/acs.biochem.0c00021. [PMID: 32045213] - Wei Liu, Yan Li, Xue Bai, Haiguang Wu, Lanxing Bian, Xiaoke Hu. LuxR-Type Regulator AclR1 of Azorhizobium caulinodans Regulates Cyclic di-GMP and Numerous Phenotypes in Free-Living and Symbiotic States.
Molecular plant-microbe interactions : MPMI.
2020 Mar; 33(3):528-538. doi:
10.1094/mpmi-10-19-0306-r. [PMID: 31789101] - Xiaochen Yuan, Quan Zeng, Jingsheng Xu, Geoffrey B Severin, Xiang Zhou, Christopher M Waters, George W Sundin, Abasiofiok M Ibekwe, Fengquan Liu, Ching-Hong Yang. Tricarboxylic Acid (TCA) Cycle Enzymes and Intermediates Modulate Intracellular Cyclic di-GMP Levels and the Production of Plant Cell Wall-Degrading Enzymes in Soft Rot Pathogen Dickeya dadantii.
Molecular plant-microbe interactions : MPMI.
2020 Feb; 33(2):296-307. doi:
10.1094/mpmi-07-19-0203-r. [PMID: 31851880] - Sen Han, Danyu Shen, Yu-Chuan Wang, Shan-Ho Chou, Mark Gomelsky, Yong-Gui Gao, Guoliang Qian. A YajQ-LysR-like, cyclic di-GMP-dependent system regulating biosynthesis of an antifungal antibiotic in a crop-protecting bacterium, Lysobacter enzymogenes.
Molecular plant pathology.
2020 02; 21(2):218-229. doi:
10.1111/mpp.12890. [PMID: 31747123] - Lisa-Marie Nisbett, Lucas Binnenkade, Bezalel Bacon, Sajjad Hossain, Nicholas J Kotloski, Evan D Brutinel, Raimo Hartmann, Knut Drescher, Dhruv P Arora, Sandhya Muralidharan, Kai M Thormann, Jeffrey A Gralnick, Elizabeth M Boon. NosP Signaling Modulates the NO/H-NOX-Mediated Multicomponent c-Di-GMP Network and Biofilm Formation in Shewanella oneidensis.
Biochemistry.
2019 12; 58(48):4827-4841. doi:
10.1021/acs.biochem.9b00706. [PMID: 31682418] - Prabhani U Atukorale, Shruti P Raghunathan, Vanitha Raguveer, Taylor J Moon, Carolyn Zheng, Peter A Bielecki, Michelle L Wiese, Amy L Goldberg, Gil Covarrubias, Christopher J Hoimes, Efstathios Karathanasis. Nanoparticle Encapsulation of Synergistic Immune Agonists Enables Systemic Codelivery to Tumor Sites and IFNβ-Driven Antitumor Immunity.
Cancer research.
2019 10; 79(20):5394-5406. doi:
10.1158/0008-5472.can-19-0381. [PMID: 31431457] - Shou-Ting Cheng, Fang-Fang Wang, Wei Qian. Cyclic-di-GMP binds to histidine kinase RavS to control RavS-RavR phosphotransfer and regulates the bacterial lifestyle transition between virulence and swimming.
PLoS pathogens.
2019 08; 15(8):e1007952. doi:
10.1371/journal.ppat.1007952. [PMID: 31408509] - Xiaochen Yuan, Quan Zeng, Devanshi Khokhani, Fang Tian, Geoffrey B Severin, Christopher M Waters, Jingsheng Xu, Xiang Zhou, George W Sundin, Abasiofiok M Ibekwe, Fengquan Liu, Ching-Hong Yang. A feed-forward signalling circuit controls bacterial virulence through linking cyclic di-GMP and two mechanistically distinct sRNAs, ArcZ and RsmB.
Environmental microbiology.
2019 08; 21(8):2755-2771. doi:
10.1111/1462-2920.14603. [PMID: 30895662] - Ronan R McCarthy, Manda Yu, Kira Eilers, Yi-Chieh Wang, Erh-Min Lai, Alain Filloux. Cyclic di-GMP inactivates T6SS and T4SS activity in Agrobacterium tumefaciens.
Molecular microbiology.
2019 08; 112(2):632-648. doi:
10.1111/mmi.14279. [PMID: 31102484] - Jingjing Guo, Jie Wang, Jingrong Fan, Yan Zhang, Wenpei Dong, Chang-Po Chen. Distinct Dynamic and Conformational Features of Human STING in Response to 2'3'-cGAMP and c-di-GMP.
Chembiochem : a European journal of chemical biology.
2019 07; 20(14):1838-1847. doi:
10.1002/cbic.201900051. [PMID: 30895657] - Gabriela A Farias, Adela Olmedilla, María-Trinidad Gallegos. Visualization and characterization of Pseudomonas syringae pv. tomato DC3000 pellicles.
Microbial biotechnology.
2019 07; 12(4):688-702. doi:
10.1111/1751-7915.13385. [PMID: 30838765] - Tingting Wang, Zhao Cai, Xiaolong Shao, Weitong Zhang, Yingpeng Xie, Yingchao Zhang, Canfeng Hua, Stephan C Schuster, Liang Yang, Xin Deng. Pleiotropic Effects of c-di-GMP Content in Pseudomonas syringae.
Applied and environmental microbiology.
2019 05; 85(10):. doi:
10.1128/aem.00152-19. [PMID: 30850427] - Nikola Zlatkov, Bernt Eric Uhlin. Absence of Global Stress Regulation in Escherichia coli Promotes Pathoadaptation and Novel c-di-GMP-dependent Metabolic Capability.
Scientific reports.
2019 02; 9(1):2600. doi:
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PloS one.
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Proceedings of the National Academy of Sciences of the United States of America.
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Applied and environmental microbiology.
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PLoS genetics.
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Environmental microbiology.
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Applied and environmental microbiology.
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