Fexaramine (BioDeep_00000010812)

   


代谢物信息卡片


3-[3-[[cyclohexyl(oxo)methyl]-[[4-[4-(dimethylamino)phenyl]phenyl]methyl]amino]phenyl]-2-propenoic acid methyl ester

  化学式: C32H36N2O3 (496.2726)
中文名称:
  谱图信息: 最多检出来源 Pteris henryi Christ(plant) 11.67%

分子结构信息

SMILES: CN(C)C1=CC=C(C=C1)C2=CC=C(C=C2)CN(C3=CC=CC(=C3)C=CC(=O)OC)C(=O)C4CCCCC4
InChI: InChI=1S/C32H36N2O3/c1-33(2)29-19-17-27(18-20-29)26-15-12-25(13-16-26)23-34(32(36)28-9-5-4-6-10-28)30-11-7-8-24(22-30)14-21-31(35)37-3/h7-8,11-22,28H,4-6,9-10,23H2,1-3H3/b21-14+



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 AIMP2, FASN, FGF19, GPBAR1, NFATC1, NR0B2, PPFIA1, TLR4, TNFSF11
Peripheral membrane protein 1 CYP1B1
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 3 CYP1B1, CYP7A1, SLC7A11
Nucleus 5 AIMP2, FOS, NFATC1, NR0B2, NR1H4
cytosol 6 AIMP2, FASN, FOS, NFATC1, PPFIA1, TNFRSF11A
nuclear body 2 CSF1, NFATC1
nucleoplasm 5 FOS, LGR5, NFATC1, NR0B2, NR1H4
RNA polymerase II transcription regulator complex 2 FOS, NR1H4
Cell membrane 6 CSF1, GPBAR1, LGR5, SLC7A11, TLR4, TNFSF11
Multi-pass membrane protein 3 GPBAR1, LGR5, SLC7A11
cell cortex 1 PPFIA1
cell surface 2 SLC7A11, TLR4
Golgi apparatus 2 FASN, LGR5
Golgi membrane 1 INS
Cytoplasm, cytosol 1 AIMP2
plasma membrane 9 CSF1, FASN, GCG, GPBAR1, LGR5, SLC7A11, TLR4, TNFRSF11A, TNFSF11
presynaptic active zone 1 PPFIA1
Membrane 7 AIMP2, CSF1, CYP1B1, FASN, SLC7A11, TLR4, TNFSF11
axon 1 PPFIA1
basolateral plasma membrane 1 SLC7A11
extracellular exosome 1 FASN
endoplasmic reticulum 1 FOS
extracellular space 6 CSF1, FGF19, GCG, IL6, INS, TNFSF11
perinuclear region of cytoplasm 3 CSF1, NFATC1, TLR4
Schaffer collateral - CA1 synapse 1 PPFIA1
mitochondrion 1 CYP1B1
protein-containing complex 2 NR0B2, PPFIA1
intracellular membrane-bounded organelle 3 CYP1B1, CYP7A1, NR0B2
Microsome membrane 2 CYP1B1, CYP7A1
Single-pass type I membrane protein 4 CSF1, SLC7A11, TLR4, TNFRSF11A
Secreted 4 GCG, IL6, INS, TNFSF11
extracellular region 6 CSF1, FGF19, GCG, IL6, INS, TNFSF11
Single-pass membrane protein 1 CYP7A1
transcription regulator complex 1 NFATC1
external side of plasma membrane 2 TLR4, TNFRSF11A
sarcoplasm 1 NFATC1
Early endosome 1 TLR4
apical part of cell 1 SLC7A11
Single-pass type II membrane protein 1 TNFSF11
Membrane raft 1 TNFRSF11A
focal adhesion 1 PPFIA1
lateral plasma membrane 1 SLC7A11
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 3 GPBAR1, NR1H4, TLR4
chromatin 4 FOS, NFATC1, NR0B2, NR1H4
phagocytic cup 1 TLR4
[Isoform 3]: Nucleus 1 NR1H4
brush border membrane 1 SLC7A11
Cytoplasm, cell cortex 1 PPFIA1
Basolateral cell membrane 1 SLC7A11
Cell projection, microvillus membrane 1 SLC7A11
microvillus membrane 1 SLC7A11
endosome lumen 1 INS
Melanosome 1 FASN
euchromatin 1 NR1H4
trans-Golgi network membrane 1 LGR5
lipopolysaccharide receptor complex 1 TLR4
secretory granule lumen 2 GCG, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 CSF1, GCG, IL6, INS
nuclear matrix 1 FOS
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
[Isoform 2]: Cytoplasm 1 TNFSF11
[Tumor necrosis factor ligand superfamily member 11, soluble form]: Secreted 1 TNFSF11
[Isoform 2]: Nucleus 1 NR1H4
[Isoform 1]: Nucleus 1 NR1H4
protein-DNA complex 1 FOS
[Isoform 1]: Cell membrane 1 TNFRSF11A
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
[Isoform 4]: Nucleus 1 NR1H4
astrocyte projection 1 SLC7A11
transcription factor AP-1 complex 1 FOS
[Glucagon-like peptide 1]: Secreted 1 GCG
interleukin-6 receptor complex 1 IL6
CSF1-CSF1R complex 1 CSF1
spine apparatus 1 PPFIA1
glycogen granule 1 FASN
[Isoform RANK-e5a]: Cell membrane 1 TNFRSF11A


文献列表

  • Wanqiu Huang, Zhijun Cao, Wenxin Wang, Zhongcheng Yang, Shixuan Jiao, Ya Chen, Siliang Chen, Luyong Zhang, Zheng Li. Discovery of LH10, a novel fexaramine-based FXR agonist for the treatment of liver disease. Bioorganic chemistry. 2024 Feb; 143(?):107071. doi: 10.1016/j.bioorg.2023.107071. [PMID: 38199141]
  • Yiming Yin, Mengge Wang, Wenjie Gu, Lili Chen. Intestine-specific FXR agonists as potential therapeutic agents for colorectal cancer. Biochemical pharmacology. 2021 04; 186(?):114430. doi: 10.1016/j.bcp.2021.114430. [PMID: 33556338]
  • Yujie Liu, An Song, Xi Yang, Yunfeng Zhen, Weiwei Chen, Linquan Yang, Chao Wang, Huijuan Ma. Farnesoid X receptor agonist decreases lipid accumulation by promoting hepatic fatty acid oxidation in db/db mice. International journal of molecular medicine. 2018 Sep; 42(3):1723-1731. doi: 10.3892/ijmm.2018.3715. [PMID: 29901078]
  • C Daniel De Magalhaes Filho, Michael Downes, Ronald M Evans. Farnesoid X Receptor an Emerging Target to Combat Obesity. Digestive diseases (Basel, Switzerland). 2017; 35(3):185-190. doi: 10.1159/000450909. [PMID: 28249279]
  • Shi-Ying Cai, Liangshi Xiong, Charles G Wray, Nazzareno Ballatori, James L Boyer. The farnesoid X receptor FXRalpha/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution. American journal of physiology. Regulatory, integrative and comparative physiology. 2007 Sep; 293(3):R1400-9. doi: 10.1152/ajpregu.00781.2006. [PMID: 17567710]
  • Thierry Claudel, Ekkehard Sturm, Folkert Kuipers, Bart Staels. The farnesoid X receptor: a novel drug target?. Expert opinion on investigational drugs. 2004 Sep; 13(9):1135-48. doi: 10.1517/13543784.13.9.1135. [PMID: 15330745]
  • Michael Downes, Mark A Verdecia, A J Roecker, Robert Hughes, John B Hogenesch, Heidi R Kast-Woelbern, Marianne E Bowman, Jean-Luc Ferrer, Andrew M Anisfeld, Peter A Edwards, John M Rosenfeld, Jacqueline G A Alvarez, Joseph P Noel, K C Nicolaou, Ronald M Evans. A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Molecular cell. 2003 Apr; 11(4):1079-92. doi: 10.1016/s1097-2765(03)00104-7. [PMID: 12718892]
  • B K Tang, T Inaba, W Kalow. N-hydroxyamobarbital: the second major metabolite of amobarbital in man. Drug metabolism and disposition: the biological fate of chemicals. 1975 Nov; 3(6):479-86. doi: NULL. [PMID: 1222]