Isoteolin (BioDeep_00000001076)

   

PANOMIX_OTCML-2023


代谢物信息卡片


4H-Dibenzo(de,g)quinolinediol, 5,6,6a,7-tetrahydro-2,9(or 2,10)-dimethoxy-6-methyl-, (S)-

化学式: C19H21NO4 (327.1471)
中文名称: 异波尔定碱
谱图信息: 最多检出来源 Homo sapiens(lipidsearch) 43.82%

分子结构信息

SMILES: CN1CCC2=CC(=C(C3=C2C1CC4=CC(=C(C=C43)OC)O)O)OC
InChI: InChI=1S/C19H21NO4/c1-20-5-4-10-8-16(24-3)19(22)18-12-9-15(23-2)14(21)7-11(12)6-13(20)17(10)18/h7-9,13,21-22H,4-6H2,1-3H3/t13-/m0/s1

描述信息

Isoboldine is an aporphine alkaloid.
(+)-Isoboldine is a natural product found in Fumaria capreolata, Thalictrum foetidum, and other organisms with data available.
See also: Peumus boldus leaf (part of).

同义名列表

29 个代谢物同义名

4H-Dibenzo(de,g)quinolinediol, 5,6,6a,7-tetrahydro-2,9(or 2,10)-dimethoxy-6-methyl-, (S)-; 4H-DIBENZO(DE,G)QUINOLINE-1,9-DIOL, 5,6,6A,7-TETRAHYDRO-2,10-DIMETHOXY-6-METHYL-, (6AS)-; 4H-Dibenzo(de,g)quinoline-1,9-diol, 5,6,6a,7-tetrahydro-2,10-dimethoxy-6-methyl-, (S)-; 4H-Dibenzo[de,g]quinoline-1,9-diol, 5,6,6a,7-tetrahydro-2,10-dimethoxy-6-methyl-, (S)-; (6aS)-2,10-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-1,9-diol; 2,10-Dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-1,9-diol #; 6a.alpha.-Aporphine-1,9-diol, 2,10-dimethoxy-; 6aalpha-Aporphine-1,9-diol, 2,10-dimethoxy-; 2,10-Dimethoxy-6aalpha-aporphine-1,9-diol; LINHZVMHXABQLB-ZDUSSCGKSA-N; N-Methyllaurelliptine; (S)-(+)-Isoboldine; ISOBOLDINE , (+)-; ISOBOLDINE, (+)-; (S)-Isoboldine; (+)-Isoboldine; d-Isoboldine; Isoboldine; Isoteoline; AI3-27548; Isoteolin; Izoteolin; NCGC00017381-01; NCGC00142559-01; 95508-61-5; TNP00331; ST057702; C09541; (S)-Isoboldine



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

94 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 2 CYP2D6, PIK3CA
Peripheral membrane protein 2 ACHE, CYP1B1
Endoplasmic reticulum membrane 2 CYP1B1, CYP2D6
Nucleus 1 ACHE
cytosol 1 PIK3CA
dendrite 1 HTR2C
Cell membrane 4 ACHE, ADRB3, HTR2C, TNF
lamellipodium 1 PIK3CA
Multi-pass membrane protein 3 ADRB3, HTR2C, MT-CYB
Synapse 2 ACHE, HTR2C
cell surface 2 ACHE, TNF
Golgi apparatus 1 ACHE
lysosomal membrane 1 GAA
mitochondrial inner membrane 1 MT-CYB
neuromuscular junction 1 ACHE
neuronal cell body 1 TNF
Lysosome 1 GAA
plasma membrane 7 ACHE, ADRB3, GAA, HTR2C, PIK3CA, REN, TNF
Membrane 6 ACHE, CYP1B1, CYP2D6, GAA, MT-CYB, REN
extracellular exosome 1 GAA
Lysosome membrane 1 GAA
endoplasmic reticulum 1 CYP2D6
extracellular space 3 ACHE, REN, TNF
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 2 ACHE, PIK3CA
intercalated disc 1 PIK3CA
mitochondrion 3 CYP1B1, CYP2D6, MT-CYB
intracellular membrane-bounded organelle 3 CYP1B1, CYP2D6, GAA
Microsome membrane 2 CYP1B1, CYP2D6
Secreted 3 ACHE, GAA, REN
extracellular region 4 ACHE, GAA, REN, TNF
Single-pass membrane protein 1 CYP2D6
Extracellular side 1 ACHE
external side of plasma membrane 1 TNF
apical part of cell 1 REN
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Mitochondrion inner membrane 1 MT-CYB
Membrane raft 1 TNF
basement membrane 1 ACHE
receptor complex 1 ADRB3
phagocytic cup 1 TNF
Lipid-anchor, GPI-anchor 1 ACHE
tertiary granule membrane 1 GAA
side of membrane 1 ACHE
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
azurophil granule membrane 1 GAA
respiratory chain complex III 1 MT-CYB
synaptic cleft 1 ACHE
ficolin-1-rich granule membrane 1 GAA
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
autolysosome lumen 1 GAA
[Isoform H]: Cell membrane 1 ACHE
G protein-coupled serotonin receptor complex 1 HTR2C
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • Jongmin Ahn, Hee-Sung Chae, Young-Won Chin, Jinwoong Kim. Alkaloids from aerial parts of Houttuynia cordata and their anti-inflammatory activity. Bioorganic & medicinal chemistry letters. 2017 06; 27(12):2807-2811. doi: 10.1016/j.bmcl.2017.04.072. [PMID: 28499733]
  • Yu Li, Rong-jie Zeng, Jian-zhong Chen, Yan-bin Wu, Gui-xin Chou, Yu Gao, Jing-wei Shao, Hua-zhu Cai, Lee Jia. Pharmacokinetics and metabolism study of isoboldine, a major bioactive component from Radix Linderae in male rats by UPLC-MS/MS. Journal of ethnopharmacology. 2015 Aug; 171(?):154-60. doi: 10.1016/j.jep.2015.05.042. [PMID: 26055342]
  • Yi-Nan Zhang, Xiang-Gen Zhong, Zong-Ping Zheng, Xu-Dong Hu, Jian-Ping Zuo, Li-Hong Hu. Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr. Bioorganic & medicinal chemistry. 2007 Jan; 15(2):988-96. doi: 10.1016/j.bmc.2006.10.034. [PMID: 17081761]
  • Qi-Zhi Zhao, Yi-Min Zhao, Ke-Jun Wang. [Alkaloids from the root of Lindera angustifolia]. Yao xue xue bao = Acta pharmaceutica Sinica. 2005 Oct; 40(10):931-4. doi: . [PMID: 16408812]
  • Dennis J Milanowski, Rudolph E K Winter, Memory P F Elvin-Lewis, Walter H Lewis. Geographic distribution of three alkaloid chemotypes of Croton lechleri. Journal of natural products. 2002 Jun; 65(6):814-9. doi: 10.1021/np000270v. [PMID: 12088421]
  • M Böhlke, H Guinaudeau, C K Angerhofer, V Wongpanich, D D Soejarto, N R Farnsworth, G A Mora, L J Poveda. Costaricine, a new antiplasmodial bisbenzylisoquinoline alkaloid from Nectandra salicifolia trunk bark. Journal of natural products. 1996 Jun; 59(6):576-80. doi: 10.1021/np960195h. [PMID: 8786363]