1,1-Diethyl-2-hydroxy-2-nitrosohydrazine (BioDeep_00001028874)
代谢物信息卡片
1,1-Diethyl-2-hydroxy-2-nitrosohydrazine
化学式: C4H10N3O2- (132.0773)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCN(CC)N(N=O)[O-]
InChI: InChI=1S/C4H10N3O2/c1-3-6(4-2)7(9)5-8/h3-4H2,1-2H3/q-1
描述信息
D002317 - Cardiovascular Agents > D020030 - Nitric Oxide Donors
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:77713
- PubChem: 6331148
- CAS: 86831-65-4
- KEGG: C13773
- PubChem: 854019
- KNApSAcK: 77713
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Annette M Sysel, Michael J Dunphy, Joseph A Bauer. Antimicrobial properties of diethylamine NONOate, a nitric oxide donor, against Escherichia coli: a pilot study.
The Journal of antibiotics.
2021 04; 74(4):260-265. doi:
10.1038/s41429-020-00397-9. [PMID: 33361779] - Sébastien Dumont, Natalia V Bykova, Alexia Khaou, Yasmine Besserour, Maude Dorval, Jean Rivoal. Arabidopsis thaliana alcohol dehydrogenase is differently affected by several redox modifications.
PloS one.
2018; 13(9):e0204530. doi:
10.1371/journal.pone.0204530. [PMID: 30252897] - Mohammad R Karim, David H Petering. Detection of Zn2+ release in nitric oxide treated cells and proteome: dependence on fluorescent sensor and proteomic sulfhydryl groups.
Metallomics : integrated biometal science.
2017 04; 9(4):391-401. doi:
10.1039/c6mt00220j. [PMID: 27918051] - Julia Dolinina, Kristinn Sverrisson, Anna Rippe, Carl M Öberg, Bengt Rippe. Nitric oxide synthase inhibition causes acute increases in glomerular permeability in vivo, dependent upon reactive oxygen species.
American journal of physiology. Renal physiology.
2016 11; 311(5):F984-F990. doi:
10.1152/ajprenal.00152.2016. [PMID: 27681559] - Svetlana I Sofronova, Anna A Borzykh, Dina K Gaynullina, Ilya V Kuzmin, Anastasia A Shvetsova, Elena V Lukoshkova, Olga S Tarasova. Endothelial nitric oxide weakens arterial contractile responses and reduces blood pressure during early postnatal development in rats.
Nitric oxide : biology and chemistry.
2016 05; 55-56(?):1-9. doi:
10.1016/j.niox.2016.02.005. [PMID: 26923819] - Camila Bononi Almeida, Lucas Eduardo Botelho Souza, Flavia Costa Leonardo, Fabio Trindade Maranhão Costa, Claudio C Werneck, Dimas Tadeu Covas, Fernando Ferreira Costa, Nicola Conran. Acute hemolytic vascular inflammatory processes are prevented by nitric oxide replacement or a single dose of hydroxyurea.
Blood.
2015 Aug; 126(6):711-20. doi:
10.1182/blood-2014-12-616250. [PMID: 26019278] - Krittapoom Akrawinthawong, Ji Won Park, Barbora Piknova, Nathawut Sibmooh, Suthat Fucharoen, Alan N Schechter. A flow cytometric analysis of the inhibition of platelet reactivity due to nitrite reduction by deoxygenated erythrocytes.
PloS one.
2014; 9(3):e92435. doi:
10.1371/journal.pone.0092435. [PMID: 24642865] - Kunihiro Sonoda, Kazuo Ohtake, Yoshinori Kubo, Hiroyuki Uchida, Masaki Uchida, Hideshi Natsume, Miya Kobayashi, Jun Kobayashi. Aldehyde dehydrogenase 2 partly mediates hypotensive effect of nitrite on L-NAME-induced hypertension in normoxic rat.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2014; 36(6):410-8. doi:
10.3109/10641963.2013.846355. [PMID: 24164360] - Yvan Cam, Olivier Pierre, Eric Boncompagni, Didier Hérouart, Eliane Meilhoc, Claude Bruand. Nitric oxide (NO): a key player in the senescence of Medicago truncatula root nodules.
The New phytologist.
2012 Oct; 196(2):548-560. doi:
10.1111/j.1469-8137.2012.04282.x. [PMID: 22937888] - Yu-Hua Wang, Xiao-Cheng Li, Qiang Zhu-Ge, Xin Jiang, Wei-Dong Wang, Wan-Ping Fang, Xuan Chen, Xing-Hui Li. Nitric oxide participates in cold-inhibited Camellia sinensis pollen germination and tube growth partly via cGMP in vitro.
PloS one.
2012; 7(12):e52436. doi:
10.1371/journal.pone.0052436. [PMID: 23272244] - Chong Wei Jin, Shao Ting Du, Yong Song Zhang, Xian Yong Lin, Cai Xian Tang. Differential regulatory role of nitric oxide in mediating nitrate reductase activity in roots of tomato (Solanum lycocarpum).
Annals of botany.
2009 Jul; 104(1):9-17. doi:
10.1093/aob/mcp087. [PMID: 19376780] - M V Wenzl, G Wölkart, H Stessel, M Beretta, K Schmidt, B Mayer. Different effects of ascorbate deprivation and classical vascular nitrate tolerance on aldehyde dehydrogenase-catalysed bioactivation of nitroglycerin.
British journal of pharmacology.
2009 Apr; 156(8):1248-55. doi:
10.1111/j.1476-5381.2009.00126.x. [PMID: 19254277] - Eve de Lamirande, Geneviève Lamothe. Reactive oxygen-induced reactive oxygen formation during human sperm capacitation.
Free radical biology & medicine.
2009 Feb; 46(4):502-10. doi:
10.1016/j.freeradbiomed.2008.11.004. [PMID: 19071212] - David B Casey, Adeleke M Badejo, Jasdeep S Dhaliwal, Subramanyam N Murthy, Albert L Hyman, Bobby D Nossaman, Philip J Kadowitz. Pulmonary vasodilator responses to sodium nitrite are mediated by an allopurinol-sensitive mechanism in the rat.
American journal of physiology. Heart and circulatory physiology.
2009 Feb; 296(2):H524-33. doi:
10.1152/ajpheart.00543.2008. [PMID: 19074675] - Maxime Pellegrin, Alain Berthelot, Christophe Houdayer, Vincent Gaume, Valérie Deckert, Pascal Laurant. New insights into the vascular mechanisms underlying the beneficial effect of swimming training on the endothelial vasodilator function in apolipoprotein E-deficient mice.
Atherosclerosis.
2007 Jan; 190(1):35-42. doi:
10.1016/j.atherosclerosis.2006.02.001. [PMID: 16529753] - C Cereda, E Cova, C Di Poto, A Galli, G Mazzini, M Corato, M Ceroni. Effect of nitric oxide on lymphocytes from sporadic amyotrophic lateral sclerosis patients: toxic or protective role?.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology.
2006 Nov; 27(5):312-6. doi:
10.1007/s10072-006-0702-z. [PMID: 17122939] - Catia Cipriano, Marco Malavolta, Laura Costarelli, Robertina Giacconi, Elisa Muti, Nazzarena Gasparini, Maurizio Cardelli, Daniela Monti, Erminia Mariani, Eugenio Mocchegiani. Polymorphisms in MT1a gene coding region are associated with longevity in Italian Central female population.
Biogerontology.
2006 Oct; 7(5-6):357-65. doi:
10.1007/s10522-006-9050-x. [PMID: 16955215] - Roman E Perri, Daniel A Langer, Suvro Chatterjee, Simon J Gibbons, Jay Gadgil, Sheng Cao, Gianrico Farrugia, Vijay H Shah. Defects in cGMP-PKG pathway contribute to impaired NO-dependent responses in hepatic stellate cells upon activation.
American journal of physiology. Gastrointestinal and liver physiology.
2006 Mar; 290(3):G535-42. doi:
10.1152/ajpgi.00297.2005. [PMID: 16269521] - Katherine A Blackwell, Joseph P Sorenson, Darcy M Richardson, Leslie A Smith, Osamu Suda, Karl Nath, Zvonimir S Katusic. Mechanisms of aging-induced impairment of endothelium-dependent relaxation: role of tetrahydrobiopterin.
American journal of physiology. Heart and circulatory physiology.
2004 Dec; 287(6):H2448-53. doi:
10.1152/ajpheart.00248.2004. [PMID: 15319209] - Rachel Hopper, Barrie Lancaster, John Garthwaite. On the regulation of NMDA receptors by nitric oxide.
The European journal of neuroscience.
2004 Apr; 19(7):1675-82. doi:
10.1111/j.1460-9568.2004.03306.x. [PMID: 15078541] - Maribel Murillo-Carretero, María José Ruano, Esperanza R Matarredona, Antonio Villalobo, Carmen Estrada. Antiproliferative effect of nitric oxide on epidermal growth factor-responsive human neuroblastoma cells.
Journal of neurochemistry.
2002 Oct; 83(1):119-31. doi:
10.1046/j.1471-4159.2002.01116.x. [PMID: 12358735] - Carlos Zaragoza, Milagros Balbín, Carlos López-Otín, Santiago Lamas. Nitric oxide regulates matrix metalloprotease-13 expression and activity in endothelium.
Kidney international.
2002 Mar; 61(3):804-8. doi:
10.1046/j.1523-1755.2002.00224.x. [PMID: 11849429] - A C Souici, A L Fitzhugh, L K Keefer, E Felley-Bosco. L-tyrosine and nitric oxide synergize to prevent cytotoxic effects of superoxide.
Toxicology.
2001 Aug; 165(2-3):163-70. doi:
10.1016/s0300-483x(01)00428-0. [PMID: 11522374] - L V d'Uscio, T A Baker, C B Mantilla, L Smith, D Weiler, G C Sieck, Z S Katusic. Mechanism of endothelial dysfunction in apolipoprotein E-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology.
2001 Jun; 21(6):1017-22. doi:
10.1161/01.atv.21.6.1017. [PMID: 11397713] - K B Sandau, J Fandrey, B Brüne. Accumulation of HIF-1alpha under the influence of nitric oxide.
Blood.
2001 Feb; 97(4):1009-15. doi:
10.1182/blood.v97.4.1009. [PMID: 11159530] - M Belén Herrero, S Chatterjee, L Lefièvre, E de Lamirande, C Gagnon. Nitric oxide interacts with the cAMP pathway to modulate capacitation of human spermatozoa.
Free radical biology & medicine.
2000 Sep; 29(6):522-36. doi:
10.1016/s0891-5849(00)00339-7. [PMID: 11025196] - P A Rosenberg, Y Li, M Le, Y Zhang. Nitric oxide-stimulated increase in extracellular adenosine accumulation in rat forebrain neurons in culture is associated with ATP hydrolysis and inhibition of adenosine kinase activity.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2000 Aug; 20(16):6294-301. doi:
10.1523/jneurosci.20-16-06294.2000. [PMID: 10934281] - F C Tanner, P Meier, H Greutert, C Champion, E G Nabel, T F Lüscher. Nitric oxide modulates expression of cell cycle regulatory proteins: a cytostatic strategy for inhibition of human vascular smooth muscle cell proliferation.
Circulation.
2000 Apr; 101(16):1982-9. doi:
10.1161/01.cir.101.16.1982. [PMID: 10779466] - A C Souici, J Mirkovitch, P Hausel, L K Keefer, E Felley-Bosco. Transition mutation in codon 248 of the p53 tumor suppressor gene induced by reactive oxygen species and a nitric oxide-releasing compound.
Carcinogenesis.
2000 Feb; 21(2):281-7. doi:
10.1093/carcin/21.2.281. [PMID: 10657969] - E Schmid, A Hotz-Wagenblatt, W Dröge. Inhibition of the insulin receptor kinase phosphorylation by nitric oxide: functional and structural aspects.
Antioxidants & redox signaling.
1999; 1(1):45-53. doi:
10.1089/ars.1999.1.1-45. [PMID: 11225731] - E G DeMaster, B J Quast, B Redfern, H T Nagasawa. Reaction of nitric oxide with the free sulfhydryl group of human serum albumin yields a sulfenic acid and nitrous oxide.
Biochemistry.
1995 Sep; 34(36):11494-9. doi:
10.1021/bi00036a023. [PMID: 7547878] - A Zini, E De Lamirande, C Gagnon. Low levels of nitric oxide promote human sperm capacitation in vitro.
Journal of andrology.
1995 Sep; 16(5):424-31. doi:
NULL. [PMID: 8575982] - D A Wink, J Laval. The Fpg protein, a DNA repair enzyme, is inhibited by the biomediator nitric oxide in vitro and in vivo.
Carcinogenesis.
1994 Oct; 15(10):2125-9. doi:
10.1093/carcin/15.10.2125. [PMID: 7955043]
