Exact Mass: 350.24569640000004
Exact Mass Matches: 350.24569640000004
Found 500 metabolites which its exact mass value is equals to given mass value 350.24569640000004,
within given mass tolerance error 0.05 dalton. Try search metabolite list with more accurate mass tolerance error
0.01 dalton.
Andrographolide
Andrographolide is a labdane diterpenoid isolated from the leaves and roots of Andrographis paniculata that exhibits anti-HIV, anti-inflammatory and antineoplastic properties. It has a role as a metabolite, an anti-inflammatory drug, an anti-HIV agent and an antineoplastic agent. It is a gamma-lactone, a primary alcohol, a secondary alcohol, a labdane diterpenoid and a carbobicyclic compound. Andrographolide (HMPL-004) is a botanical product extracted from a herb that occurs naturally in China. The herb has an extensive history of use in TCM for the treatment of upper respiratory tract infections and other inflammatory and infectious diseases. Andrographolide is a natural product found in Andrographis paniculata, Ginkgo biloba, and Cymbopogon schoenanthus with data available. Andrographolide is a labdane diterpenoid that is produced by the Andrographis paniculata plant, which has a broad range of therapeutic applications including anti-inflammatory and anti-platelet aggregation activities and potential antineoplastic properties. Since andrographolide has multiple therapeutic activities there are several proposed mechanisms of action for this agent. The anti-inflammatory effects of this agent appear to be related to the inhibition of nitric oxide (NO) production by macrophages. This agent may activate the NO/cyclic GMP pathway and inhibit both the phospholipase C gamma 2 (PLC gamma2)/protein kinase C (PKC) and PI3K/AKT-MAPK signaling pathways in activated platelets to inhibit platelet aggregation. In activated platelets, these three signaling pathways are downstream of integrin activation mediated by collagen binding and influence the association of fibrinogen with its receptors. Additionally, andrographolide may exert its anti-cancer activity through the induction of cell cycle arrest at G0/G1 phase and the stimulation of lymphocyte proliferation and activation. These processes could result in decreased proliferation of and increased immunocytotoxicity against tumor cells. A labdane diterpenoid isolated from the leaves and roots of Andrographis paniculata that exhibits anti-HIV, anti-inflammatory and antineoplastic properties. D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents C78275 - Agent Affecting Blood or Body Fluid > C1327 - Antiplatelet Agent D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors D002491 - Central Nervous System Agents > D000700 - Analgesics D000890 - Anti-Infective Agents > D000998 - Antiviral Agents D000893 - Anti-Inflammatory Agents D018501 - Antirheumatic Agents Origin: Plant; SubCategory_DNP: Diterpenoids, Andrographolide diterpenoids relative retention time with respect to 9-anthracene Carboxylic Acid is 0.941 relative retention time with respect to 9-anthracene Carboxylic Acid is 0.939 relative retention time with respect to 9-anthracene Carboxylic Acid is 0.936 relative retention time with respect to 9-anthracene Carboxylic Acid is 0.938 Andrographolide is a NF-κB inhibitor, which inhibits NF-κB activation through covalent modification of a cysteine residue on p50 in endothelial cells without affecting IκBα degradation or p50/p65 nuclear translocation. Andrographolide has antiviral effects. Andrographolide is a NF-κB inhibitor, which inhibits NF-κB activation through covalent modification of a cysteine residue on p50 in endothelial cells without affecting IκBα degradation or p50/p65 nuclear translocation. Andrographolide has antiviral effects.
(S)-[10]-Gingerol
(10)-Gingerol is a beta-hydroxy ketone, a member of phenols and a monomethoxybenzene. (10)-Gingerol is a natural product found in Zingiber officinale with data available. See also: Ginger (part of). (S)-[10]-Gingerol is found in ginger. (S)-[10]-Gingerol is a constituent of ginger, the rhizome of Zingiber officinale. Constituent of ginger, the rhizome of Zingiber officinale. (S)-[10]-Gingerol is found in herbs and spices and ginger. 10-Gingerol is a major pungent constituent in the ginger oleoresin from fresh rhizome, with anti-inflammatory, antioxidant and anti-proliferative activities. 10-Gingerol inhibits the proliferation of MDA-MB-231 tumor cell line with an IC50 of 12.1 μM[1][2]. 10-Gingerol is a major pungent constituent in the ginger oleoresin from fresh rhizome, with anti-inflammatory, antioxidant and anti-proliferative activities. 10-Gingerol inhibits the proliferation of MDA-MB-231 tumor cell line with an IC50 of 12.1 μM[1][2].
Tetrahydrocorticosterone
Tetrahydrocorticosterone belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone. Thus, tetrahydrocorticosterone is considered to be a steroid lipid molecule. Tetrahydrocorticosterone is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. Tetrahydrocorticosterone is one of the major urinary metabolites from corticosterone. Premenopausal patients with early breast cancer excrete subnormal amounts of tetrahydrocorticosterone as compared with the normal subjects of corresponding ages (PMID: 1133844). D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
15-Keto-prostaglandin E2
15-keto-PGE2 is one of the prostaglandin E2 metabolites. (PMID 7190512). It is a degradation product produced by 15-hydroxy prostaglandin dehydrogenase (PGDH or 15-PGDH). Dinoprostone is a naturally occurring prostaglandin E2 (PGE2) and the most common and most biologically active of the mammalian prostaglandins. It has important effects in labour and also stimulates osteoblasts to release factors which stimulate bone resorption by osteoclasts (a type of bone cell that removes bone tissue by removing the bones mineralized matrix). PGE2 has been shown to increase vasodilation and cAMP production, to enhance the effects of bradykinin and histamine, to induce uterine contractions and to activate platelet aggregation. PGE2 is also responsible for maintaining the open passageway of the fetal ductus arteriosus; decreasing T-cell proliferation and lymphocyte migration and activating the secretion of IL-1alpha and IL-2. PGE2 exhibits both pro- and anti-inflammatory effects, particularly on dendritic cells (DC). Depending on the nature of maturation signals, PGE2 has different and sometimes opposite effects on DC biology. PGE2 exerts an inhibitory action, reducing the maturation of DC and their ability to present antigen. PGE2 has also been shown to stimulate DC and promote IL-12 production when given in combination with TNF-alpha. PGE2 is an environmentally bioactive substance. Its action is prolonged and sustained by other factors especially IL-10. It modulates the activities of professional DC by acting on their differentiation, maturation and their ability to secrete cytokines. PGE2 is a potent inducer of IL-10 in bone marrow-derived DC (BM-DC), and PGE2-induced IL-10 is a key regulator of the BM-DC pro-inflammatory phenotype. (PMID: 16978535). Prostaglandins are eicosanoids. The eicosanoids consist of the prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs), and lipoxins (LXs). The PGs and TXs are collectively identified as prostanoids. Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes), and leukotrienes from leukocytes, hence the derivation of their names. All mammalian cells except erythrocytes synthesize eicosanoids. These molecules are extremely potent, able to cause profound physiological effects at very dilute concentrations. All eicosanoids function locally at the site of synthesis, through receptor-mediated G-protein linked signalling pathways. 15-keto-PGE2 is one of the prostaglandin E2 metabolites. (PMID 7190512). It is a degradation product produced by 15-hydroxy prostaglandin dehydrogenase (PGDH or 15-PGDH)
9S-hydroxy-11,15-dioxo-5Z,13E-prostadienoic acid
9S-hydroxy-11,15-dioxo-5Z,13E-prostadienoic acid is also known as 15-Deoxy-15-oxo-prostaglandin D2. 9S-hydroxy-11,15-dioxo-5Z,13E-prostadienoic acid is considered to be practically insoluble (in water) and acidic. 9S-hydroxy-11,15-dioxo-5Z,13E-prostadienoic acid is an eicosanoid lipid molecule
Prostaglandin E3
Prostaglandin E3 is from the cyclooxygenase metabolism of eicosapentaenoic acid.Prostaglandins are eicosanoids. The eicosanoids consist of the prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs), and lipoxins (LXs). The PGs and TXs are collectively identified as prostanoids. Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes), and leukotrienes from leukocytes, hence the derivation of their names. All mammalian cells except erythrocytes synthesize eicosanoids. These molecules are extremely potent, able to cause profound physiological effects at very dilute concentrations. All eicosanoids function locally at the site of synthesis, through receptor-mediated G-protein linked signalling pathways. Prostaglandin E3 is from the cyclooxygenase metabolism of eicosapentaenoic acid.
Prostaglandin D3
Prostaglandin D3 (PGD3) is a prostanoid that has been identified as an inhibitor of human platelet aggregation and as a modulator of autonomic nerve transmission. Prostanoids are a subclass of the lipid mediator group known as eicosanoids. They derive from C-20 polyunsaturated fatty acids, mainly dihomo-gamma-linoleic (20:3n-6), arachidonic (20:4n-6), and eicosapentaenoic (20:5n-3) acids, through the action of cyclooxygenases-1 and -2 (COX-1 and COX-2). The reaction product of COX is the unstable endoperoxide prostaglandin H (PGH) that is further transformed into the individual prostanoids by a series of specific prostanoid synthases. Prostanoids are local-acting mediators formed and inactivated within the same or neighbouring cells prior to their release into circulation as inactive metabolites (15-keto- and 13,14-dihydroketo metabolites). Non-enzymatic peroxidation of arachidonic acid and other fatty acids in vivo can result in prostaglandin-like substances isomeric to the COX-derived prostaglandins that are termed isoprostanes. Prostanoids take part in many physiological and pathophysiological processes in practically every organ, tissue and cell, including the vascular, renal, gastrointestinal and reproductive systems. Their activities are mediated through prostanoid-specific receptors and intracellular signalling pathways, whilst their biosynthesis and action are blocked by nonsteroidal antiinflammatory drugs (NSAID). Isoprostanes are considered to be reliable markers of oxidant stress status and have been linked to inflammation, ischaemia-reperfusion, diabetes, cardiovascular disease, reproductive disorders and diabetes. (PMID: 16986207, 6252026, 6952267, 4019112, 6945633Prostaglandins are eicosanoids. The eicosanoids consist of the prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs), and lipoxins (LXs). The PGs and TXs are collectively identified as prostanoids. Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes), and leukotrienes from leukocytes, hence the derivation of their names. All mammalian cells except erythrocytes synthesize eicosanoids. These molecules are extremely potent, able to cause profound physiological effects at very dilute concentrations. All eicosanoids function locally at the site of synthesis, through receptor-mediated G-protein linked signalling pathways. Prostaglandin D3 (PGD3) is a prostanoid that has been identified as an inhibitor of human platelet aggregation and as a modulator of autonomic nerve transmission. Prostanoids are a subclass of the lipid mediator group known as eicosanoids. They derive from C-20 polyunsaturated fatty acids, mainly dihomo-gamma-linoleic (20:3n-6), arachidonic (20:4n-6), and eicosapentaenoic (20:5n-3) acids, through the action of cyclooxygenases-1 and -2 (COX-1 and COX-2). The reaction product of COX is the unstable endoperoxide prostaglandin H (PGH) that is further transformed into the individual prostanoids by a series of specific prostanoid synthases. Prostanoids are local-acting mediators formed and inactivated within the same or neighbouring cells prior to their release into circulation as inactive metabolites (15-keto- and 13,14-dihydroketo metabolites). Non-enzymatic peroxidation of arachidonic acid and other fatty acids in vivo can result in prostaglandin-like substances isomeric to the COX-derived prostaglandins that are termed isoprostanes. Prostanoids take part in many physiological and pathophysiological processes in practically every organ, tissue and cell, including the vascular, renal, gastrointestinal and reproductive systems. Their activities are mediated through prostanoid-specific receptors and intracellular signalling pathways, whilst their biosynthesis and action are blocked by nonsteroidal antiinflammatory drugs (NSAID). Isoprostanes are considered to be reliable markers of oxidant stress status and have been linked to inflammation, ischaemia-reperfusion, diabetes, cardiovascular disease, reproductive disorders and diabetes. (PMID: 16986207, 6252026, 6952267, 4019112, 6945633
Tetrahydrodeoxycortisol
Tetrahydrodeoxycortisol (THS) is a mineralocorticoid, the main urinary metabolite of 11-deoxycortisol. THS excretion is significantly associated with tetrahydroaldosterone excretion, total androgen excretion, and cortisol metabolites. Aldosterone synthesis is highly heritable and is affected by genotype at CYP11B1. Variation in the region of chromosome 8 including the genes steroid 11-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) influences mineralocorticoid and glucocorticoid metabolism; differences in 11-hydroxylation efficiency can have downstream effects on mineralocorticoid synthesis. Such effects may be of relevance to the development of low-renin essential hypertension. Genotype differences in CYP11B1 explains approx. 5\\% of the variance in urinary THS excretion in the population. Excretion of THS is heritable (19.4\\%) and the T-allele of the −344 C/T polymorphism of CYP11B2 is more strongly assocd. with higher THS levels than the C-allele. (PMID: 16984984, 15522937, 15272911) [HMDB] Tetrahydrodeoxycortisol (THS) is a mineralocorticoid, the main urinary metabolite of 11-deoxycortisol. THS excretion is significantly associated with tetrahydroaldosterone excretion, total androgen excretion, and cortisol metabolites. Aldosterone synthesis is highly heritable and is affected by genotype at CYP11B1. Variation in the region of chromosome 8 including the genes steroid 11-beta-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) influences mineralocorticoid and glucocorticoid metabolism; differences in 11-hydroxylation efficiency can have downstream effects on mineralocorticoid synthesis. Such effects may be of relevance to the development of low-renin essential hypertension. Genotype differences in CYP11B1 explains approximately 5\\% of the variance in urinary THS excretion in the population. Excretion of THS is heritable (19.4\\%) and the T-allele of the -344 C/T polymorphism of CYP11B2 is more strongly associated with higher THS levels than the C-allele. (PMID: 16984984, 15522937, 15272911). D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
9-fluoro-11,17-dihydroxy-2,17-dimethylandrost-4-en-3-one
Pregnanetriolone
Pregnanetriolone belongs to the family of Sesterterpenes. These are terpenes compsed of five consecutive isoprene units.
Resolvin E1
Resolvin E1 is a resolvin, a bioactive oxygenated product of EPA (eicosapentaenoic acid). It is a inflammation-resolving lipid mediator. RvE1 reduces neutrophil hyper-function, it also prevents the initiation and progression of tissue destruction (PMID: 16373400). RvE1, can also act as a host response modulator in the control of the inflammatory diseases that also involve bone loss such as periodontitis and arthritis. RvE1 has been shown to display specific binding sites on human neutrophils with an apparent Kd of 47 nM (PMID: 15753205; 16373400). RvE1 is a potent modulator of leukocytes as well as selective platelet responses in blood and platelet-rich plasma (PMID: 18480426). [HMDB] Resolvin E1 is a resolvin, a bioactive oxygenated product of EPA (eicosapentaenoic acid). It is a inflammation-resolving lipid mediator. RvE1 reduces neutrophil hyper-function, it also prevents the initiation and progression of tissue destruction (PMID: 16373400). RvE1, can also act as a host response modulator in the control of the inflammatory diseases that also involve bone loss such as periodontitis and arthritis. RvE1 has been shown to display specific binding sites on human neutrophils with an apparent Kd of 47 nM (PMID: 15753205; 16373400). RvE1 is a potent modulator of leukocytes as well as selective platelet responses in blood and platelet-rich plasma (PMID: 18480426).
(5S)-hydroperoxy-18-hydroxy-EPE
(5S)-hydroperoxy-18-hydroxy-EPE is also known as (5S)-Hydroperoxy-18-hepe or 5(S)-HP-18-HEPE. (5S)-hydroperoxy-18-hydroxy-EPE is considered to be practically insoluble (in water) and acidic
Tetrahydro-21-deoxycortisol
5alpha-Androstane-2alpha-fluoro-17beta-ol-3-one acetate
8-iso-15-keto-PGE2
8-iso-15-keto-PGE2 is an isoprostane. Isoprostanes are arachidonic acid metabolites produced by peroxidative attack of membrane lipids. These accumulate to substantial levels in many clinical conditions characterized in part by accumulation of free radicals and reactive oxygen species, including asthma, hypertension and ischemia reperfusion injury. For this reason, they are frequently used as markers of oxidative stress; however, many are now finding that these molecules are not inert, but in fact evoke powerful biological responses in an increasing array of cell types. In many cases, these biological effects can account in part for the various features and manifestations of those clinical conditions. Thus, it may be possible that the isoprostanes are playing somewhat of a causal role in those disease states (PMID: 14504139). Dinoprostone is a naturally occurring prostaglandin E2 (PGE2) and the most common and most biologically active of the mammalian prostaglandins. It has important effects in labour and also stimulates osteoblasts to release factors which stimulate bone resorption by osteoclasts (a type of bone cell that removes bone tissue by removing the bones mineralized matrix). PGE2 has been shown to increase vasodilation and cAMP production, to enhance the effects of bradykinin and histamine, to induce uterine contractions and to activate platelet aggregation. PGE2 is also responsible for maintaining the open passageway of the fetal ductus arteriosus; decreasing T-cell proliferation and lymphocyte migration and activating the secretion of IL-1alpha and IL-2. PGE2 exhibits both pro- and anti-inflammatory effects, particularly on dendritic cells (DC). Depending on the nature of maturation signals, PGE2 has different and sometimes opposite effects on DC biology. PGE2 exerts an inhibitory action, reducing the maturation of DC and their ability to present antigen. PGE2 has also been shown to stimulate DC and promote IL-12 production when given in combination with TNF-alpha. PGE2 is an environmentally bioactive substance. Its action is prolonged and sustained by other factors especially IL-10. It modulates the activities of professional DC by acting on their differentiation, maturation and their ability to secrete cytokines. PGE2 is a potent inducer of IL-10 in bone marrow-derived DC (BM-DC), and PGE2-induced IL-10 is a key regulator of the BM-DC pro-inflammatory phenotype (PMID: 16978535). Prostaglandins are eicosanoids. The eicosanoids consist of the prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs), and lipoxins (LXs). The PGs and TXs are collectively identified as prostanoids. Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes), and leukotrienes from leukocytes, hence the derivation of their names. All mammalian cells except erythrocytes synthesize eicosanoids. These molecules are extremely potent, able to cause profound physiological effects at very dilute concentrations. All eicosanoids function locally at the site of synthesis, through receptor-mediated G-protein linked signalling pathways. 8-iso-15-keto-PGE2 is an isoprostane. Isoprostanes are arachidonic acid metabolites produced by peroxidative attack of membrane lipids. These accumulate to substantial levels in many clinical conditions characterized in part by accumulation of free radicals and reactive oxygen species, including asthma, hypertension and ischemia reperfusion injury. For this reason, they are frequently used as markers of oxidative stress; however, many are now finding that these molecules are not inert, but in fact evoke powerful biological responses in an increasing array of cell types. In many cases, these biological effects can account in part for the various features and manifestations of those clinical conditions. Thus, it may be possible that the isoprostanes are playing somewhat of a causal role in those disease states. (PMID: 14504139)
3,4-Dimethyl-5-pentyl-2-furanundecanoic acid
3,4-dimethyl-5-pentyl-2-furanundecanoic acid is a furan fatty acid (F-acid). F-acids are heterocyclic fatty acids containing a central furan moiety with a carboxylalkyl chain (mostly 7, 9, 11, or 13 carbons) in the 2-position and an alkyl chain (mostly 3 or 5 carbons) in the 5-position. Despite being found in low concentrations in food lipids, they are excellent antixoxidants and radical scavengers. This allows them to play an important role in preventing lipid peroxidation and protecting polyunsaturated fatty acids. They are often incorporated into phospholipids and cholesterol esters of fish and other marine organisms. 3,4-dimethyl-5-pentyl-2-furanundecanoic acid, in particular, can be described by the shorthand notation 11D5. This refers to its 11-carbon carboxyalkyl moiety, the dimethyl substitutions in the 3- and 4-positions of its furan moiety, and its 5-carbon alkyl moiety. It is found in animal foods, fish lipids, and is a component of F acid fraction present in beef blood serum. Present in fish lipids. Component of F acid fraction present in beef blood serum. 3,4-Dimethyl-5-pentyl-2-furanundecanoic acid is found in fishes and animal foods.
15-Epi-lipoxin B5
15-epi-lipoxin B5 is a lipoxin derivative. Lipoxins (LXs) and aspirin-triggered Lipoxin (ATL) are trihydroxytetraene-containing eicosanoids generated from arachidonic acid that are distinct in structure, formation, and function from the many other proinflammatory lipid-derived mediators. These endogenous eicosanoids have now emerged as founding members of the first class of lipid/chemical mediators involved in the resolution of the inflammatory response. Lipoxin A4 (LXA4), ATL, and their metabolic stable analogs elicit cellular responses and regulate leukocyte trafficking in vivo by activating the specific receptor, ALX. Many of the eicosanoids derived from arachidonic acid (AA2), including prostaglandins (PGs) and leukotrienes (LTs), play important roles as local mediators exerting a wide range of actions relevant in immune hypersensitivity and inflammation. However, recent observations indicate that other agents derived from the lipoxygenase (LO) pathways are formed and play a key role in initiating the resolution of acute inflammation. This phenomenon is an active process that is governed by specific lipid mediators and involves a series of well-orchestrated temporal events. Thus, potent locally released mediators serve as checkpoint controllers of inflammation. In addition to the well-appreciated ability of aspirin to inhibit PGs, aspirin also acetylates cyclooxygenase (COX)-2, triggering the formation of a 15-epimeric form of lipoxins, termed aspirin-triggered LXA4 (ATL). These eicosanoids (i.e., LXA4 and ATL) with a unique trihydroxytetraene structure function as stop signals in inflammation and actively participate in dampening host responses to bring the inflammation to a close, namely, resolution. LXA4 and ATL elicit the multicellular responses via a specific G protein-coupled receptor (GPCR) termed ALX that has been identified in human. (PMID: 16968948, 11478982). 15-epi-lipoxin B5 is a lipoxin derivative
Oryzalic acid B
Oryzalic acid B is found in cereals and cereal products. Oryzalic acid B is isolated from leaves of a blight-resistant rice cultivar. Isolated from leaves of a blight-resistant rice cultivariety Oryzalic acid B is found in cereals and cereal products.
(ent-6alpha,7alpha,12alpha)-6,7,12-Trihydroxy-16-kauren-19-oic acid
(ent-6alpha,7alpha,12alpha)-6,7,12-Trihydroxy-16-kauren-19-oic acid is found in fruits. (ent-6alpha,7alpha,12alpha)-6,7,12-Trihydroxy-16-kauren-19-oic acid is a constituent of Cucurbita maxima. Constituent of Cucurbita maxima. 6alpha,7alpha,12alpha-Trihydroxykaurenoic acid is found in fruits and japanese pumpkin.
Prostaglandin H3
Prostaglandin H3 (PGH3) can be enzymatically converted by platelets into thromboxane A3 (TXA3). Both prostaglandin H2 (PGH2) and thromboxane A2 (TXA2) aggregate human platelet-rich plasma. In contrast, PGH3 and TXA3 do not. PGH3 and TXA3 increase platelet cyclic AMP in platelet-rich plasma and thereby (1) inhibit aggregation by other agonists, (2) block the ADP-induced release reaction, and (3) suppress platelet phospholipase-A2 activity or events leading to its activation. PGI3 (A7-prostacyclin; synthesized from PGH3 by blood vessel enzyme) and PGI2 (prostacyclin) exert similar effects. Both compounds are potent coronary relaxants that also inhibit aggregation in human platelet-rich plasma and increase platelet adenylate cyclase activity. Prostaglandins are eicosanoids. The eicosanoids consist of the prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs), and lipoxins (LXs). The PGs and TXs are collectively identified as prostanoids. Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes), and leukotrienes from leukocytes, hence the derivation of their names. All mammalian cells except erythrocytes synthesize eicosanoids. These molecules are extremely potent and are able to cause profound physiological effects at very dilute concentrations. All eicosanoids function locally at the site of synthesis through receptor-mediated G-protein linked signalling pathways. Prostaglandin H3 (PGH3)can be enzymatically converted by platelets into thromboxane A3. Both PGH2 and thromboxane A2 aggregate human platelet-rich plasma. In contrast, PGH3 and thromboxane A3 do not. PGH3 and thromboxane A3 increase platelet cyclic AMP in platelet-rich plasma and thereby: (i) inhibit
MG(18:4(6Z,9Z,12Z,15Z)/0:0/0:0)
MG(18:4(6Z,9Z,12Z,15Z)/0:0/0:0) is a monoacylglyceride. A monoglyceride, more correctly known as a monoacylglycerol, is a glyceride consisting of one fatty acid chain covalently bonded to a glycerol molecule through an ester linkage. Monoacylglycerol can be broadly divided into two groups; 1-monoacylglycerols (or 3-monoacylglycerols) and 2-monoacylglycerols, depending on the position of the ester bond on the glycerol moiety. Normally the 1-/3-isomers are not distinguished from each other and are termed alpha-monoacylglycerols, while the 2-isomers are beta-monoacylglycerols. Monoacylglycerols are formed biochemically via release of a fatty acid from diacylglycerol by diacylglycerol lipase or hormone sensitive lipase. Monoacylglycerols are broken down by monoacylglycerol lipase. They tend to be minor components only of most plant and animal tissues, and indeed would not be expected to accumulate because their strong detergent properties would have a disruptive effect on membranes. 2-Monoacylglycerols are a major end product of the intestinal digestion of dietary fats in animals via the enzyme pancreatic lipase. They are taken up directly by the intestinal cells and converted to triacylglycerols via the monoacylglycerol pathway before being transported in lymph to the liver. Mono- and Diglycerides are commonly added to commercial food products in small quantities. They act as emulsifiers, helping to mix ingredients such as oil and water that would not otherwise blend well.
Oryzalic acid A
Oryzalic acid A is found in cereals and cereal products. Oryzalic acid A is isolated from rice leaves. Isolated from rice leaves. Oryzalic acid A is found in cereals and cereal products.
5a-Tetrahydrocorticosterone
5a-tetrahydrocorticosterone is highly sensitive to adrenocorticotropic hormone (ACTH) secretion. High levels of 5a-Tetrahydrocorticosterone are a warning sign of hypertension. (PMID: 16597193,7473516). 5a-tetrahydrocorticosterone is highly sensitive to adrenocorticotropic hormone (ACTH) secretion. High levels of 5a-Tetrahydrocorticosterone are a warning sign of hypertension. D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
MG(0:0/18:4(6Z,9Z,12Z,15Z)/0:0)
MG(0:0/18:4(6Z,9Z,12Z,15Z)/0:0) is a monoacylglyceride. A monoglyceride, more correctly known as a monoacylglycerol, is a glyceride consisting of one fatty acid chain covalently bonded to a glycerol molecule through an ester linkage. Monoacylglycerol can be broadly divided into two groups; 1-monoacylglycerols (or 3-monoacylglycerols) and 2-monoacylglycerols, depending on the position of the ester bond on the glycerol moiety. Normally the 1-/3-isomers are not distinguished from each other and are termed alpha-monoacylglycerols, while the 2-isomers are beta-monoacylglycerols. Monoacylglycerols are formed biochemically via release of a fatty acid from diacylglycerol by diacylglycerol lipase or hormone sensitive lipase. Monoacylglycerols are broken down by monoacylglycerol lipase. They tend to be minor components only of most plant and animal tissues, and indeed would not be expected to accumulate because their strong detergent properties would have a disruptive effect on membranes. 2-Monoacylglycerols are a major end product of the intestinal digestion of dietary fats in animals via the enzyme pancreatic lipase. They are taken up directly by the intestinal cells and converted to triacylglycerols via the monoacylglycerol pathway before being transported in lymph to the liver. Mono- and Diglycerides are commonly added to commercial food products in small quantities. They act as emulsifiers, helping to mix ingredients such as oil and water that would not otherwise blend well. [HMDB] MG(0:0/18:4(6Z,9Z,12Z,15Z)/0:0) is a monoacylglyceride. A monoglyceride, more correctly known as a monoacylglycerol, is a glyceride consisting of one fatty acid chain covalently bonded to a glycerol molecule through an ester linkage. Monoacylglycerol can be broadly divided into two groups; 1-monoacylglycerols (or 3-monoacylglycerols) and 2-monoacylglycerols, depending on the position of the ester bond on the glycerol moiety. Normally the 1-/3-isomers are not distinguished from each other and are termed alpha-monoacylglycerols, while the 2-isomers are beta-monoacylglycerols. Monoacylglycerols are formed biochemically via release of a fatty acid from diacylglycerol by diacylglycerol lipase or hormone sensitive lipase. Monoacylglycerols are broken down by monoacylglycerol lipase. They tend to be minor components only of most plant and animal tissues, and indeed would not be expected to accumulate because their strong detergent properties would have a disruptive effect on membranes. 2-Monoacylglycerols are a major end product of the intestinal digestion of dietary fats in animals via the enzyme pancreatic lipase. They are taken up directly by the intestinal cells and converted to triacylglycerols via the monoacylglycerol pathway before being transported in lymph to the liver. Mono- and Diglycerides are commonly added to commercial food products in small quantities. They act as emulsifiers, helping to mix ingredients such as oil and water that would not otherwise blend well.
12-Oxo-20-hydroxy-leukotriene B4
12-oxo-20-hydroxy-leukotriene B4 is the metabolite of lipid omega-oxidation of leukotriene B4 (LTB4). LTB4 is the major metabolite in neutrophil polymorphonuclear leukocytes. Omega-oxidation is the major pathway for the catabolism of leukotriene B4 in human polymorphonuclear leukocytes. Leukotrienes are metabolites of arachidonic acid derived from the action of 5-LO (5-lipoxygenase). The immediate product of 5-LO is LTA4 (leukotriene A4), which is enzymatically converted into either LTB4 (leukotriene B4) by LTA4 hydrolase or LTC4 (leukotriene C4) by LTC4 synthase. The regulation of leukotriene production occurs at various levels, including expression of 5-LO, translocation of 5-LO to the perinuclear region, and phosphorylation to either enhance or inhibit the activity of 5-LO. Biologically active LTB4 is metabolized by omega-oxidation carried out by specific cytochrome P450s (CYP4F) followed by beta-oxidation from the omega-carboxy position and after CoA ester formation (PMID: 7649996, 17623009, 2853166, 6088485). Leukotrienes are eicosanoids. The eicosanoids consist of the prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs), and lipoxins (LXs). The PGs and TXs are collectively identified as prostanoids. Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes), and leukotrienes from leukocytes, hence the derivation of their names. All mammalian cells except erythrocytes synthesize eicosanoids. These molecules are extremely potent, able to cause profound physiological effects at very dilute concentrations. All eicosanoids function locally at the site of synthesis, through receptor-mediated G-protein linked signalling pathways. 12-oxo-20-hydroxy-leukotriene B4 is the metabolite of lipid omega-oxidation of leukotriene B4 (LTB4). LTB4 is the major metabolite in neutrophil polymorphonuclear leukocytes. Omega-oxidation is the major pathway for the catabolism of leukotriene B4 in human polymorphonuclear leukocytes. Leukotrienes are metabolites of arachidonic acid derived from the action of 5-LO (5-lipoxygenase). The immediate product of 5-LO is LTA4 (leukotriene A4), which is enzymatically converted into either LTB4 (leukotriene B4) by LTA4 hydrolase or LTC4 (leukotriene C4) by LTC4 synthase. The regulation of leukotriene production occurs at various levels, including expression of 5-LO, translocation of 5-LO to the perinuclear region and phosphorylation to either enhance or inhibit the activity of 5-LO. Biologically active LTB4 is metabolized by w-oxidation carried out by specific cytochrome P450s (CYP4F) followed by beta-oxidation from the w-carboxy position and after CoA ester formation. (PMID: 7649996, 17623009, 2853166, 6088485)
15-Oxo-lipoxin A4
15-oxo-lipoxin A4 is a lipoxin derivative. Lipoxins (LXs) and aspirin-triggered Lipoxin (ATL) are trihydroxytetraene-containing eicosanoids generated from arachidonic acid that are distinct in structure, formation, and function from the many other proinflammatory lipid-derived mediators. These endogenous eicosanoids have now emerged as founding members of the first class of lipid/chemical mediators involved in the resolution of the inflammatory response. Lipoxin A4 (LXA4), ATL, and their metabolic stable analogs elicit cellular responses and regulate leukocyte trafficking in vivo by activating the specific receptor, ALX. Many of the eicosanoids derived from arachidonic acid (AA2), including prostaglandins (PGs) and leukotrienes (LTs), play important roles as local mediators exerting a wide range of actions relevant in immune hypersensitivity and inflammation. However, recent observations indicate that other agents derived from the lipoxygenase (LO) pathways are formed and play a key role in initiating the resolution of acute inflammation. This phenomenon is an active process that is governed by specific lipid mediators and involves a series of well-orchestrated temporal events. Thus, potent locally released mediators serve as checkpoint controllers of inflammation. In addition to the well-appreciated ability of aspirin to inhibit PGs, aspirin also acetylates cyclooxygenase (COX)-2, triggering the formation of a 15-epimeric form of lipoxins, termed aspirin-triggered LXA4 (ATL). These eicosanoids (i.e., LXA4 and ATL) with a unique trihydroxytetraene structure function as stop signals in inflammation and actively participate in dampening host responses to bring the inflammation to a close, namely, resolution. LXA4 and ATL elicit the multicellular responses via a specific G protein-coupled receptor (GPCR) termed ALX that has been identified in human. (PMID: 16968948, 11478982). 15-oxo-lipoxin A4 is a lipoxin derivative
20-oxo-leukotriene B4
20-oxo-leukotriene B4 is the metabolite of lipid omega-oxidation of leukotriene B4 (LTB4). LTB4 is the major metabolite in neutrophil polymorphonuclear leukocytes. Omega-oxidation is the major pathway for the catabolism of leukotriene B4 in human polymorphonuclear leukocytes. Leukotrienes are metabolites of arachidonic acid derived from the action of 5-LO (5-lipoxygenase). The immediate product of 5-LO is LTA4 (leukotriene A4), which is enzymatically converted into either LTB4 (leukotriene B4) by LTA4 hydrolase or LTC4 (leukotriene C4) by LTC4 synthase. The regulation of leukotriene production occurs at various levels, including expression of 5-LO, translocation of 5-LO to the perinuclear region, and phosphorylation to either enhance or inhibit the activity of 5-LO. Biologically active LTB4 is metabolized by omega-oxidation carried out by specific cytochrome P450s (CYP4F) followed by beta-oxidation from the omega-carboxy position and after CoA ester formation (PMID: 7649996, 17623009, 2853166, 6088485). Leukotrienes are eicosanoids. The eicosanoids consist of the prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs), and lipoxins (LXs). The PGs and TXs are collectively identified as prostanoids. Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes), and leukotrienes from leukocytes, hence the derivation of their names. All mammalian cells except erythrocytes synthesize eicosanoids. These molecules are extremely potent, able to cause profound physiological effects at very dilute concentrations. All eicosanoids function locally at the site of synthesis, through receptor-mediated G-protein linked signalling pathways. 20-oxo-leukotriene B4 is the metabolite of lipid omega-oxidation of leukotriene B4 (LTB4). LTB4 is the major metabolite in neutrophil polymorphonuclear leukocytes. Omega-oxidation is the major pathway for the catabolism of leukotriene B4 in human polymorphonuclear leukocytes. Leukotrienes are metabolites of arachidonic acid derived from the action of 5-LO (5-lipoxygenase). The immediate product of 5-LO is LTA4 (leukotriene A4), which is enzymatically converted into either LTB4 (leukotriene B4) by LTA4 hydrolase or LTC4 (leukotriene C4) by LTC4 synthase. The regulation of leukotriene production occurs at various levels, including expression of 5-LO, translocation of 5-LO to the perinuclear region and phosphorylation to either enhance or inhibit the activity of 5-LO. Biologically active LTB4 is metabolized by w-oxidation carried out by specific cytochrome P450s (CYP4F) followed by beta-oxidation from the w-carboxy position and after CoA ester formation. (PMID: 7649996, 17623009, 2853166, 6088485)
5,12,18R-TriHEPE
This compound belongs to the family of Leukotrienes. These are eicosanoids containing an hydroxyl group attached to the aliphati chain of an arachidonic acid.
15-oxo-5S,6R-dihydroxy-7E,9E,11Z,13E-eicosatetraenoic acid
15-oxo-5S,6R-dihydroxy-7E,9E,11Z,13E-eicosatetraenoic acid is also known as 15-keto-Lipoxin a4 or 15-oxo-LXA4. 15-oxo-5S,6R-dihydroxy-7E,9E,11Z,13E-eicosatetraenoic acid is considered to be practically insoluble (in water) and acidic. 15-oxo-5S,6R-dihydroxy-7E,9E,11Z,13E-eicosatetraenoic acid is an eicosanoid lipid molecule
(5S)-hydroperoxy-18-hydroxy-EPE(1-)
(5S)-hydroperoxy-18-hydroxy-EPE(1-) is considered to be practically insoluble (in water) and acidic
3,4-Dimethyl-5-propyl-2-furantridecanoic acid
3,4-Dimethyl-5-propyl-2-furantridecanoic acid is a furan fatty acid (F-acid). F-acids are heterocyclic fatty acids containing a central furan moiety with a carboxylalkyl chain (mostly 7, 9, 11, or 13 carbons) in the 2-position and an alkyl chain (mostly 3 or 5 carbons) in the 5-position. Despite being found in low concentrations in food lipids, they are excellent antixoxidants and radical scavengers. This allows them to play an important role in preventing lipid peroxidation and protecting polyunsaturated fatty acids. They are often incorporated into phospholipids and cholesterol esters of fish and other marine organisms. 3,4-Dimethyl-5-propyl-2-furantridecanoic acid, in particular, can be described by the shorthand notation 13D3. This refers to its 13-carbon carboxyalkyl moiety, the dimethyl substitutions in the 3- and 4-positions of its furan moiety, and its 3-carbon alkyl moiety.
(+)-cis-3-Methylfentanyl
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents D002491 - Central Nervous System Agents > D000700 - Analgesics
Butanamide, N-phenyl-N-[1-(2-phenylethyl)-4-piperidinyl]-
15-Hydroxy-11alpha,9alpha-(epoxymethano)prosta-5,13-dienoic acid
(Z)-7-[(1R,4S,5R,6S)-5-[(E,3R)-3-Hydroxyoct-1-enyl]-2-oxabicyclo[2.2.1]heptan-6-yl]hept-5-enoic acid
(5E)-5-[(3Ar,4S,5S,6aR)-5-hydroxy-4-[(E,3R)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a-hexahydro-1H-pentalen-2-ylidene]pentanoic acid
(Z)-7-[(1R,3R)-3-Hydroxy-2-[(1E,3S,5Z)-3-hydroxyocta-1,5-dienyl]-5-oxocyclopentyl]hept-5-enoic acid
Adamantylamide-alanyl-isoglutamine
C18H30N4O3 (350.23177899999996)
Andrographolide
N-[(S)-[1-(Dimethylamino)cyclopentyl](phenyl)methyl]-2,6-dimethylbenzamide
Isocarbacyclin
Prostaglandin I3
(3S,8R,9S,10R,13S,14S)-10,13-Dimethyl-17-pyrimidin-5-yl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-ol
(5S,12R,18R)-5,12,18-Trihydroxyicosa-6,8,10,14,16-pentaenoic acid
N-Phenyl-N-[1-[(2S)-1-phenylpropan-2-yl]piperidin-4-yl]propanamide
5-Heptenoic acid, 7-((1S,2R,3S,4R)-3-((1E,3R)-3-hydroxy-1-octen-1-yl)-7-oxabicyclo(2.2.1)hept-2-yl)-, (5Z)-
Thromboxane A3
7β-Hydroxylathyrol
7beta-Hydroxylathyrol is a natural product. 7beta-Hydroxylathyrol is a natural product.
17-Hydroxyisolathyrol
17-Hydroxyisolathyrol is a macrocychc lathyrol derivative isolated from seeds of Euphorbla luthyrrs[1].
[1R-(1alpha,4beta,4abeta,6alpha,8aalpha)]-6-(Acetyloxy)-4-ethoxy-1,2,3,4,4a,5,6,8a-octahydro-4,7-dimethyl-a-methylene-1-naphthaleneacetic acid methyl ester
16,17,18-Trihydroxy-2,6,10,14-phytatetraen-1,20-olide
ent-14S,15-Dihydroxy-1(10),13(16)-halimadien-18-oic acid methyl ester
(E,Z,E,Z)-2-(9-Hydroxy-4,8-dimethyl-3,7-nonadienyl)-6-methyl-2,6-octadienedioic acid
Methyl 2beta,3beta-dihydroxy-8(17),13E-labdadien-15-oate
8beta,17-Epoxy-3beta,7beta-Dihydroxy-12(E)-labden-16,15-olide
3,5-Dihydroxy-4-(3,7-dimethylocta-2,7-dienyl)bibenzyl
(ent-6alpha,13E)-6,16-Dihydroxy-17-oxo-7,13-labdadien-15-oic acid
(E,Z,Z,Z)-2-(9-Hydroxy-4,8-dimethyl-3,7-nonadienyl)-6-methyl-2,6-octadienedioic acid
16,17,18,20-Tetrahydroxynerylgeran-1-oic acid lactone
carbacyclin
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
Mefentanyl
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents D002491 - Central Nervous System Agents > D000700 - Analgesics
13,16alpha,17-trihydroxy-ent-9(11)-kauren-19-oic acid
7beta,18,19-trihydroxy-ent-clerodan-3,13-dien-16,15-diolide
2beta-hydroxy-ent-clerod-3-en-15-oic acid-18,19-olide
(3R,5R,6R,8S,9R,10R,13R,14R,17S,20R)-3,5-cyclopregnane-6,8,14,20-tetraol
3-Ac-(3beta,5alpha,6alpha,17beta)-Androstane-3,6,17-triol
methyl-2-oxo-3beta,4beta-epoxy-neo-clerodan-15-oate|methyl-3,4-beta-epoxy-kolavan-2-on-15-oate
methyl-(13R,14R)-epoxy-15-hydroxy-1(10)-ent-halimen-18-oate
18-acetoxy-3-ene-cis-clerodan-15-ol|18-acetoxy-cis-clerod-3-en-15-ol
3beta,8beta,14beta-Trihydroxy-20-oxo-5alpha,17alpha-pregnan
3alpha-angeloyloxy-4alpha,11-dihydroxy-eudesm-6-en-8-one|3alpha-angeloyloxy-4alpha,11-hihydroxyeudesm-6-en-8-one
11,12,15-Trihydroxy-16-kauren-19-oic acid|ent-11alpha,12alpha,15alpha-trihydroxykaur-16-en-19-oic acid
3alpha,16,18-trihydroxy-14beta-methoxy-ent-abieta-7,15(17)-diene|parvifoline M
3-desoxy-8-epi-hymenoxon(2-methylbutyrate)|3-desoxy-8-epi-hymenoxon<2-methylbutyrate>
3alpha,8beta,14beta-trihydroxyabiet-13,15-en-16,12-olide|suremulide
16-hydroxy-17-methoxy-ent-labda-7,13(14)-diene-15-oic acid
1-deoxyrabdoserrin B|7alpha,12alpha,14beta,20-tetrahydroxy-ent-kaur-16-en-15-one|excisanin I
7beta,16beta,17-trihydroxy-ent-kauran-6beta,19-olide
methyl-7alpha-hydroxyl-7,8-dihydro-8(17)-dehydrogrindeloate
3alpha-Hydroxy-15-oxo-seco-beyeran-16-saeure-methylester
3beta-hydroxy-abieta-8(14)-en-18-oic acid 9alpha,13alpha-endoperoxide
hydroperoxyclerodane|Methyl 3beta-hydroperoxy-4,18-dehydro-3,4-dihydrokolavenoate
(3alpha,5beta,17alphaOH,20S)-3,17,20-Trihydroxypregnan-1-one
3alpha,16,18-trihydroxy-7beta-methoxy-ent-abieta-8(14),15(17)-diene|parvifoline N
(+)-miliusane XX|[4alpha-methoxy-7alpha-(2,6-dimethyl-hepta-1,5-dienyl)-2-oxo-6beta-oxa-bicyclo[3.2.1]oct-1-yl]acetic acid methyl ester
2beta,3beta,17,19-tetrahydroxyspongia-13(16),14-diene
17-hydroxygrindelic acid methyl ester|methyl 17-oxygrindelate
7alpha,14beta,18,20-tetrahydroxy-ent-kaur-16-en-15-one|excisanin J
(3alpha,5beta,7beta,15beta)-3,7,15-Trihydroxypregnan-20-one
7alpha-13alpha,14beta,18-tetrahydroxy-ent-atis-16-en-15-one|alboatisin A
19-Carboxylic acid,Me ester-(ent-16betaOH)-16,17,19-Kauranetriol
pulchellin-2-O-isovalerate|pulchellin-2alpha-O-isovalerate
ceriopsin B|methyl 16(R)-16,17-dihydroxybeyeran-18-oate
10(S),11(S),12(S)-hepoxilin B3 methyl ester|erythro hepoxilin B3 methyl ester|Methyl (10S,11R,12S)-10-hydroxy-11,12,-epoxyeicosa-5(Z),8(Z),14(Z)-trienoate
19-Hydroxy-15-oxo-seco-beyeran-16-saeure-methylester
(ent-7alpha,15beta)-7,9,15-Trihydroxy-16-kauren-19-oic acid|ent-7alpha,9alpha,15beta-trihydroxy-kaurenic acidz
6alpha-isovaleryloxy-1-hydroxy-4alphaH-1,10-secoeudesma-5(10),11(13)-dien-12,8beta-olide
4,5-Dihydro-4alpha-hydroxyivangustin-2-methylbutyrat
8,9-diacetoxyheptadeca-1,11,14-triene|Di-Ac-1,11,14-Heptadecatriene-8,9-diol
(2R)-2-[(3aR,7aR)-3-Methoxy-5-[(1S)-1,3,3-trimethylcyclohexyl]-1,3,3a,6,7,7a-hexahydroisobenzofuran-4-yl]propanoic acid
(5R,Z)-3-[(9Z)-hexadec-9-enylidene]-5-hydroxymethyl-5-methyl-4,5-dihydrofuran-2-one|tornabeatin A
(1beta,2alpha,3betaH,6E,10E)-1,2-Dihydroxy-13-oxo-6,10,14-phytatrien-20,1-olide
3beta,12beta,14beta,20beta-Tetrahydroxy-pregnen-5-en, Boucerin
18,19-epoxy-18alpha-methoxy-ent-clerod-3-en-15-oic acid
3alpha,5alpha,8beta-trihydroxycleistanth-13(17),15-dien-18-oic acid
3beta,20alpha-dihydroxy-5alpha-pregnan-21-oic acid
7-oxo-13beta,15-dihydroxyabiet-8(14)-en-18-oic acid
(1RS,2SR,5RS,6SR,9RS,10SR,12RS)-10-hydroxy-1,5,9-trimethyl-13-methylidene-15,18,19-trioxatetracyclo[10.3.2.1(2,5).1(6,9)]nonadecan-14-one|sinulaparvalide B
3alpha,15-dihydroxy-14-oxo-labd-8(17),13(16)-dien-19-oic acid
6alpha-(2-methybutyryloxy)-1-hydroxy-4alphaH-1,10-secoeudesma-5(10),11(13)-dien-12,8beta-olide
3-Ac-(3beta,5alpha,16alpha,17alpha)-Androstane-3,16,17-triol
(8R,12R,15S)-11-deoxyprostaglandin E2 methyl ester|11-Desoxy-PGE(2)-methylester|methyl-(5Z,13E)-(8R,12R,15S)-15-hydroxy-9-oxoprosta-5,13-dienoate
methyl 13(S*)-acetoxy-9(Z),11(E),15(Z)-octadecatrienoate
(2alpha,6alpha)-2,6,19-Trihydroxy-8,13-labdadien-15,16-olide
ent-lab-8(17),14-dien-13,16-diol-18-oic acid methyl ester
15,16-epoxy-15alpha-methoxy-ent-clerod-3-en-18-oic acid
7-oxo-8,14beta-dihydroxy-15-isopimaren-18-oic acid|8,14beta-dihydroxy-7-oxo-15-isopimaren-18-oic acid
3alpha,17beta-dihydroxy-17alpha-methyl-5alpha-androstane-2beta-carboxylic acid
6,18-dihydroxy-ent-labda-7,13E-dien-15-oic acid methyl ester
3,18,19-trihydroxy-ent-labda-8(17),13-dien-16,15-olide
7alpha-hydroxy-ent-clerod-3-en-15-oic acid-18,19-olide
ent-13-epi-8,13-epoxy-2-oxa-3-oxolabd-14-ene-1R-carboxylic acid
17-Ac-(3beta,5alpha,6alpha,17beta)-Androstane-3,6,17-triol
5-(1-isovalerianoyloxy)ethyl-2-O-isopentenyl-1,3-di-O-methylpyrogallol
methyl (1R,4S,5S,9S,1R)-1-(1,5-dimethyl-4-oxohexyl)-9-hydroxy-4-methyl-spiro<4.5>dec-7-ene-8-carboxylate|methyl (1R,4S,5S,9S,1R)-1-(1,5-dimethyl-4-oxohexyl)-9-hydroxy-4-methyl-spiro[4.5]dec-7-ene-8-carboxylate
(ent-4alpha,13xi)-4-Hydroxy-2-cleroden-18,19-olid-15-oic acid|4beta-hydroxy-ent-clerod-2-en-15-oic acid-18,19-olide
(betaxi,1S,2R,4aR,7S,8aR)-7-formyloxy-1,2,3,4,4a,7,8,8a-octahydro-beta,1,2,4a,5-pentamethylnaphthalene-1-pentanoic acid|2beta-(formyloxy)clerod-3-en-15-oic acid
3beta,4alpha,20R-trihydroxy-5alpha-pregn-16-one|toonasterone A
(2E,6E)-8-{[ (2E,6E)-8-hydroxy-2,6-dimethylocta-2,6-dienoyl]oxy}-2,6-dimethylocta-2,6-dienoic acid
7-oxo-12alpha,13beta-dihydroxyabiet-8(14)-en-18-oic acid
14,15-Dihydro,13,14-didehydro,15-hydroxy-Ichthyouleolide|14-peroxy-15,17-dehydro-14,15-dihydroichthyouleolide
(+)-(1S*,4R*,8S*,10R*)-1,4,8-trihydroxycembra-2E,6E,11Z-trien-20,10-olide
(+)-(1S*,4S*,7R*,10R*)-1,4,7-trihydroxycembra-2E,8(19),11Z-trien-20,10-olide
13beta-dihydroxy-14-oxo-3,4-secoatis-16-en-3-oic acid
(8beta,12alphaH,16R)-8,12-Epoxy-16,17-dihydroxy-13-labden-15,16-olide
16alpha,17-Dihydroxy-7-oxo-(-)-kauran-19-saeure|ent-7-oxo-16alpha,17-dihydroxykauran-19-oic acid
(E)-3-hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)dodecan-6-en-5-one
6,9:15,16-diepoxy-6-hydroxy-6,7-seco-13(16),14-labdadien-7-oic acid|leosibiric acid B
(7alpha,17beta)-15,17-Epoxy-7,17-dihydroxy-16-spongianone|7alpha,17beta-dihydroxy-15,17-oxidospongian-16-one
15,16-epoxy-3alpha,6beta,9alpha-trihydroxylabda-13(16),14-dien-7-one
4R*-hydroxy-6S*-tigloyloxyeudesma-7S*-11(13)-en-12-oic acid
(1aS,3aS,4E,7S,7aR,10R)-dodecahydro-4-[(2E)-4-hydroxy-4-methylpent-2-en-1-ylidene]-1a-methyl-8-methylideneoxireno[5,6]cyclonona[1,2-c]pyran-7,10-diol|asterolaurin L
(4alpha,16alpha)-17-(acetyloxy)-19-nor-ent-kaurane-4,16-diol|rel-(2R,4aR,4bS,8R,8aS,10aS,12R)-12-[(acetyloxy)methyl]dodecahydro-4b,8-dimehyl-1H-2,10a-ethanophenanthrene-8,12-diol
(4E,10E)-9beta-hydroxy-3-(2-methylbutyroyloxy)-germacra-4,10(1)-diene-12,6alpha-olide|3beta-[2-methylbutyryloxy]-9beta-hydroxy-germacra-1(10),4-dienolide
12R-12,13-dihydroxylabda-8(20),14-diene-19-oic acid methyl ester
(12S,13E)-12-hydroxy-15-methoxylabda-8(17),13-dien-18-oic acid|(1R*,4aR*,5S*,8aR*)-5-[(2S,3E)-decahydro-2-hydroxy-5-methoxy-3-methylpent-3-en-1-yl]-1,4a-dimethyl-6-methylidenenaphthalene-1-carboxylic acid
(ent-1alpha,15alpha)-1,9,15-Trihydroxy-16-kauren-19-oci acid|ent-1alpha,9alpha,15alpha-trihydroxykaur-16-en-19-oic acid
Me ester-15-Hydroperoxy-5,8,11,13-eicosatetraenoic
17-Hydroxy-(2alpha,6alpha)-2,6-Dihydroxy-8,13-labdadien-15,16-olide
(3R,9S)-3-(9-hydroxyundecyl)-6,8-dihydroxy-3,4-dihydroisocoumarin
(1xi,3xi,5xi,20xi)-1,3,20-Trihydroxypregnan-11-one
1,19-dihydroxy-6,7-epoxy-12-oxo-smallantha-2Z,10E,14(21)-triene
3alpha-senecioyloxy-4alpha,11-dihydroxy-eudesm-6-en-8-one
3-Me ether-3,4-Dihydroxy-13-cleroden-15,16-olide|3alpha-metoxy-4beta-hydroxy-5beta,10beta-cis-17alpha,20alpha-cleroda-13(14)-en-15,16-olide
methyl (13E)-6alpha,18-dihydroxycleroda-3,13-dien-15-oate
methyl-(14S)-14,15-dihydroxylabda-8(17),13(16)-dien-19-oate
(16alpha)-16,17-dihydroxy-ent-atisan-19-oic acid methyl ester|methyl 16beta,17-dihydroxy-ent-atisan-19-oate|methyl 17-hydroxy-16beta-hydroxy-ent-atisan-19-oate
1,19-dihydroxy-6,7-epoxy-12-oxo-smallantha-2Z,10E,13E-triene
2-(3,7-dimethylocta-2,6-dienyl)-5-(2-phenylethyl)benzene-1,3-diol
12beta,17-Dihydroxy-16alpha-(-)-kauran-19-saeure-methylester
(2S,5R,8R,9S,10R)-2-hydroperoxy-ent-clerod-3,13-dien-15-oic acid methyl ester
2,4-bis(3-methylbut-2-enyl)-5-(2-phenylethyl)benzene-1,3-diol
(5R)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)tetradecan-3-one
10-gingerol
10-Gingerol is a major pungent constituent in the ginger oleoresin from fresh rhizome, with anti-inflammatory, antioxidant and anti-proliferative activities. 10-Gingerol inhibits the proliferation of MDA-MB-231 tumor cell line with an IC50 of 12.1 μM[1][2]. 10-Gingerol is a major pungent constituent in the ginger oleoresin from fresh rhizome, with anti-inflammatory, antioxidant and anti-proliferative activities. 10-Gingerol inhibits the proliferation of MDA-MB-231 tumor cell line with an IC50 of 12.1 μM[1][2].
C21H34O4_1-Naphthalenepentanoic acid, decahydro-5-(methoxycarbonyl)-beta,5,8a-trimethyl-2-methylene
(5R)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)tetradecan-3-one
2,4-bis(3-methylbut-2-enyl)-5-(2-phenylethyl)benzene-1,3-diol
5-(5-methoxycarbonyl-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl)-3-methylpentanoic acid
(5R)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)tetradecan-3-one [IIN-based on: CCMSLIB00000848859]
(5R)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)tetradecan-3-one [IIN-based: Match]
(5R)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)tetradecan-3-one_34.2\\%
(5R)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)tetradecan-3-one_major
(5R)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)tetradecan-3-one_36.6\\%
2,4-bis(3-methylbut-2-enyl)-5-(2-phenylethyl)benzene-1,3-diol_major
12,15-Epoxy-13,14-dimethyleicosa-12,14-dienoic acid
Allotetrahydrocorticosterone
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
5-[5-(Methoxycarbonyl)-5,8a-dimethyl-2-methylenedecahydro-1-naphthalenyl]-3-methylpentanoic acid
ST 21:1;O4
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
Pregnanetriolone
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
1-cis-1,2-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)heptene
C19H36B2O4 (350.27995560000005)
3-BETA,11-BETA,21-TRIHYDROXY-5-ALPHA-PREGNAN-20-ONE
Pentaethylene glycol monooctyl ether
D013501 - Surface-Active Agents > D011092 - Polyethylene Glycols D001697 - Biomedical and Dental Materials
9-O-methanoprostaglandin I
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors D006401 - Hematologic Agents > D005343 - Fibrinolytic Agents D050299 - Fibrin Modulating Agents D002317 - Cardiovascular Agents
15-Hydroxy-11alpha,9alpha-(epoxymethano)prosta-5,13-dienoic acid
D002317 - Cardiovascular Agents > D014662 - Vasoconstrictor Agents D009676 - Noxae > D016877 - Oxidants > D010545 - Peroxides
N-[[1-(Dimethylamino)cyclopentyl](phenyl)methyl]-2,6-dimethyl benzamide
(2alpha,5alpha,17beta)-17-(Acetyloxy)-2-fluoro-androstan-3-one
5alpha-Androstane-2beta-fluoro-17beta-ol-3-one acetate
Trimethylsilyl (3Z,6Z,9Z)-3,6,9-octadecatrienoate
C21H38O2Si (350.26409279999996)
Tetrahydrocorticosterone
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones Tetrahydrocorticosterone is one of the major urinary metabolites from corticosterone. Premenopausal patients with early breast cancer excrete subnormal amounts of tetrahydrocorticosterone as compared with the normal subjects of corresponding ages. (PMID 1133844) [HMDB]
3,5-Dihydroxy-4-(3,7-dimethyl-2,6-octadienyl) bibenzyl
(Z)-7-[(1R,2R,5S)-5-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-3-methylidenecyclopentyl]hept-5-enoic acid
(1E,3R,4S,10R,11S)-14-(methoxymethyl)-3,10-dimethyl-6-propan-2-yltricyclo[9.3.0.03,7]tetradeca-1,6-diene-4,9,14-triol
(Z)-7-[(1R,4S,5R,6S)-5-[(E,3R)-3-Hydroxyoct-1-enyl]-2-oxabicyclo[2.2.1]heptan-6-yl]hept-5-enoic acid
(5Z)-7-[(1alpha,4alpha)-3beta-[(1E,3S)-3-Hydroxy-1-octenyl]-7-oxabicyclo[2.2.1]heptane-2alpha-yl]-5-heptenoic acid
(5E)-5-[(3Ar,4S,5S,6aR)-5-hydroxy-4-[(E,3R)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a-hexahydro-1H-pentalen-2-ylidene]pentanoic acid
(5Z)-5-[(3aS,4R,5R,6aS)-5-hydroxy-4-[(3S)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a-hexahydro-1H-pentalen-2-ylidene]pentanoic acid
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
7-(1-Azepanyl)-3-(2-methoxyphenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine
1-[1-(1-Adamantyl)butyl]-3-(2-oxolanylmethyl)thiourea
C20H34N2OS (350.23917140000003)
(E)-7-[(1R,4S,5S,6R)-6-[(3S)-3-hydroxyoct-1-enyl]-2-oxabicyclo[2.2.1]heptan-5-yl]hept-5-enoic acid
N-tert-butyl-N-(2,6-diisopropyl-4-phenoxyphenyl)methanediimine
10,13-dimethyl-17-phenyl-2,3,4,5,6,7,8,9,11,12,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
(2S)-hydroxy[(9Z,12Z,15Z)-octadeca-9,12,15-trienoylamino]acetate
3alpha,20alpha,21-Trihydroxy-5beta-pregnane-11-one
2-(1,5-Diphenylpentan-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
C23H31BO2 (350.24169759999995)
9-Fluoro-11beta,17beta-dihydroxy-2,17-dimethylandrost-4-en-3-one
(2S)-2-[[(9Z,12Z)-octadeca-9,12-dienoyl]amino]propanoate
1-[(10S,13S,16R,17S)-3,16,17-trihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone
[1-[(4Z,7Z,10Z,13Z)-hexadeca-4,7,10,13-tetraenoxy]-3-hydroxypropan-2-yl] acetate
1-Formyl-8-(triisopropylsilyl)oxy-2-methyl-1beta,2alpha,(4A)alpha,5,6,7,8beta,(8A)beta-octahydronaphthalene
C21H38O2Si (350.26409279999996)
3,3,5,5-Tetra-methyl-4,4-dicyclopropyl-methyloxy-biphenyl
1-Methyl-4-(11-methoxycarbonyl-5,9-dimethyl-1-oxoundeca-4,8-dienyl)-piperadine
methyl (4Z,8E)-4,8-dimethyl-12-oxo-12-[4-(trideuteriomethyl)piperazin-1-yl]dodeca-4,8-dienoate
1-O-(1-Oxo-6,9,12,15-octadecatetraenyl)-L-glycerol
1,1,1-Trideuteriomethyl-4-(5,9-dimethyl-11-methoxycarbonyl-1-oxoundeca-4,8-dienyl)-piperadine
[(2S)-2,3-dihydroxypropyl] (9E,11E,13E,15E)-octadeca-9,11,13,15-tetraenoate
Gingerol
(10)-Gingerol is a beta-hydroxy ketone, a member of phenols and a monomethoxybenzene. (10)-Gingerol is a natural product found in Zingiber officinale with data available. See also: Ginger (part of). 10-Gingerol is a major pungent constituent in the ginger oleoresin from fresh rhizome, with anti-inflammatory, antioxidant and anti-proliferative activities. 10-Gingerol inhibits the proliferation of MDA-MB-231 tumor cell line with an IC50 of 12.1 μM[1][2]. 10-Gingerol is a major pungent constituent in the ginger oleoresin from fresh rhizome, with anti-inflammatory, antioxidant and anti-proliferative activities. 10-Gingerol inhibits the proliferation of MDA-MB-231 tumor cell line with an IC50 of 12.1 μM[1][2].
3alpha,11beta,17alpha-Trihydroxy-5beta-pregnan-20-one
Tetrahydrodeoxycortisol
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)tetradecan-3-one
DG(18:4)
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