Andrographolide (BioDeep_00000176051)

   

human metabolite blood metabolite natural product


代谢物信息卡片


4-hydroxy-3-{2-[6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-decahydronaphthalen-1-yl]ethylidene}oxolan-2-one

化学式: C20H30O5 (350.209313)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C=C1CCC2C(C)(CO)C(O)CCC2(C)C1CC=C1C(=O)OCC1O
InChI: InChI=1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3

描述信息

同义名列表

2 个代谢物同义名

4-hydroxy-3-{2-[6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-decahydronaphthalen-1-yl]ethylidene}oxolan-2-one; Andrographolide



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

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BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

68 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Jie Xu, Zhanting Li, Min Cao, Han Zhang, Jifeng Sun, Jie Zhao, Qiang Zhou, Zhifen Wu, Lianjia Yang. Synergetic effect of Andrographis paniculata polysaccharide on diabetic nephropathy with andrographolide. International journal of biological macromolecules. 2012 Dec; 51(5):738-42. doi: 10.1016/j.ijbiomac.2012.06.035. [PMID: 22766034]
  • Minghua Yang, Junsong Wang, Lingyi Kong. Quantitative analysis of four major diterpenoids in Andrographis paniculata by 1H NMR and its application for quality control of commercial preparations. Journal of pharmaceutical and biomedical analysis. 2012 Nov; 70(?):87-93. doi: 10.1016/j.jpba.2012.05.037. [PMID: 22738787]
  • Feng Qiu, Liang Cui, Lixia Chen, Jiawen Sun, Xinsheng Yao. Two novel creatinine adducts of andrographolide in human urine. Xenobiotica; the fate of foreign compounds in biological systems. 2012 Sep; 42(9):911-6. doi: 10.3109/00498254.2012.680619. [PMID: 22568631]
  • S Kumar, H S Patil, P Sharma, D Kumar, S Dasari, V G Puranik, H V Thulasiram, G C Kundu. Andrographolide inhibits osteopontin expression and breast tumor growth through down regulation of PI3 kinase/Akt signaling pathway. Current molecular medicine. 2012 Sep; 12(8):952-66. doi: 10.2174/156652412802480826. [PMID: 22804248]
  • Yanchun Li, Pengfei Zhang, Feng Qiu, Lixia Chen, Caixia Miao, Jianchun Li, Wei Xiao, Enlong Ma. Inactivation of PI3K/Akt signaling mediates proliferation inhibition and G2/M phase arrest induced by andrographolide in human glioblastoma cells. Life sciences. 2012 Jun; 90(25-26):962-7. doi: 10.1016/j.lfs.2012.04.044. [PMID: 22634579]
  • Feng Qiu, Xiao-Long Hou, Kyoko Takahashi, Li-Xia Chen, Junichi Azuma, Ning Kang. Andrographolide inhibits the expression and metabolic activity of cytochrome P450 3A4 in the modified Caco-2 cells. Journal of ethnopharmacology. 2012 Jun; 141(2):709-13. doi: 10.1016/j.jep.2011.09.002. [PMID: 21925256]
  • Alireza Valdiani, Mihdzar Abdul Kadir, Soon Guan Tan, Daryush Talei, Mohd Puad Abdullah, Sonia Nikzad. Nain-e Havandi Andrographis paniculata present yesterday, absent today: a plenary review on underutilized herb of Iran's pharmaceutical plants. Molecular biology reports. 2012 May; 39(5):5409-24. doi: 10.1007/s11033-011-1341-x. [PMID: 22198549]
  • Yusrizam Sharifuddin, Elizabeth M Parry, James M Parry. The genotoxicity and cytotoxicity assessments of andrographolide in vitro. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2012 May; 50(5):1393-8. doi: 10.1016/j.fct.2012.01.039. [PMID: 22326971]
  • Agung Endro Nugroho, Mohamad Andrie, Ni Kadek Warditiani, Eka Siswanto, Suwidjiyo Pramono, Endang Lukitaningsih. Antidiabetic and antihiperlipidemic effect of Andrographis paniculata (Burm. f.) Nees and andrographolide in high-fructose-fat-fed rats. Indian journal of pharmacology. 2012 May; 44(3):377-81. doi: 10.4103/0253-7613.96343. [PMID: 22701250]
  • Subhankar Das, Ramu Periyasamy, Kailash N Pandey. Activation of IKK/NF-κB provokes renal inflammatory responses in guanylyl cyclase/natriuretic peptide receptor-A gene-knockout mice. Physiological genomics. 2012 Apr; 44(7):430-42. doi: 10.1152/physiolgenomics.00147.2011. [PMID: 22318993]
  • C Girish, S C Pradhan. Hepatoprotective activities of picroliv, curcumin, and ellagic acid compared to silymarin on carbon-tetrachloride-induced liver toxicity in mice. Journal of pharmacology & pharmacotherapeutics. 2012 Apr; 3(2):149-55. doi: 10.4103/0976-500x.95515. [PMID: 22629090]
  • Bhaskarmurthy Deepak Hiraganahalli, Velusami Chandrasekaran Chinampudur, Shekhar Dethe, Deepak Mundkinajeddu, Manoj Kumar Pandre, Jaya Balachandran, Amit Agarwal. Hepatoprotective and antioxidant activity of standardized herbal extracts. Pharmacognosy magazine. 2012 Apr; 8(30):116-23. doi: 10.4103/0973-1296.96553. [PMID: 22701284]
  • Parvataneni Radhika, Yejella Rajendra Prasad, Kattupalli Sowjanya. A new diterpene from the leaves of Andrographis paniculata Nees. Natural product communications. 2012 Apr; 7(4):485-6. doi: ". [PMID: 22574448]
  • Jonathan Chee Woei Lim, Tze Khee Chan, David S W Ng, Sreenivasa R Sagineedu, Johnson Stanslas, W S Fred Wong. Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer. Clinical and experimental pharmacology & physiology. 2012 Mar; 39(3):300-10. doi: 10.1111/j.1440-1681.2011.05633.x. [PMID: 22017767]
  • Shreesh Kumar Ojha, Saurabh Bharti, Sujata Joshi, Santosh Kumari, Dharamvir Singh Arya. Protective effect of hydroalcoholic extract of Andrographis paniculata on ischaemia-reperfusion induced myocardial injury in rats. The Indian journal of medical research. 2012 Mar; 135(?):414-21. doi: . [PMID: 22561631]
  • Garg Shivali, Lahorkar Praful, Gadgil Vijay. A validated Fourier transform infrared spectroscopy method for quantification of total lactones in Inula racemosa and Andrographis paniculata. Phytochemical analysis : PCA. 2012 Mar; 23(2):171-6. doi: 10.1002/pca.1339. [PMID: 21953688]
  • Jing Zhou, Shuai-Er Hu, Shi-Hao Tan, Ruoxi Cao, Yiyang Chen, Dajing Xia, Xinqiang Zhu, Xing-Fen Yang, Choon-Nam Ong, Han-Ming Shen. Andrographolide sensitizes cisplatin-induced apoptosis via suppression of autophagosome-lysosome fusion in human cancer cells. Autophagy. 2012 Mar; 8(3):338-49. doi: 10.4161/auto.18721. [PMID: 22302005]
  • Dingfang Wu, Xiaoji Cao, Shihua Wu. Overlapping elution-extrusion counter-current chromatography: a novel method for efficient purification of natural cytotoxic andrographolides from Andrographis paniculata. Journal of chromatography. A. 2012 Feb; 1223(?):53-63. doi: 10.1016/j.chroma.2011.12.036. [PMID: 22227359]
  • Chantana Aromdee. Modifications of andrographolide to increase some biological activities: a patent review (2006 - 2011). Expert opinion on therapeutic patents. 2012 Feb; 22(2):169-80. doi: 10.1517/13543776.2012.661718. [PMID: 22329509]
  • Changzhong Wang, Ning Han, Zhenhua Xu, Huijuan Cheng, Yan Guan, Yun Yun, Yan Wang. [Study on andrographolide-induced apoptosis of Candida albicans biofilm dispersion cells]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Feb; 37(3):362-5. doi: 10.4268/cjcmm20120322. [PMID: 22568241]
  • Leon I C Tang, Anna P K Ling, Rhun Y Koh, Soi M Chye, Kenny G L Voon. Screening of anti-dengue activity in methanolic extracts of medicinal plants. BMC complementary and alternative medicine. 2012 Jan; 12(?):3. doi: 10.1186/1472-6882-12-3. [PMID: 22244370]
  • Alak Manna, Piu Saha, Avijit Sarkar, Debanjan Mukhopadhyay, Ajay K Bauri, Deepak Kumar, Padma Das, Subrata Chattopadhyay, Mitali Chatterjee. Malabaricone-A induces a redox imbalance that mediates apoptosis in U937 cell line. PloS one. 2012; 7(5):e36938. doi: 10.1371/journal.pone.0036938. [PMID: 22590637]
  • C V Chandrasekaran, B Murali, M Deepak, Amit Agarwal. In vitro comparative evaluation of non-leaves and leaves extracts of Andrographis paniculata on modulation of inflammatory mediators. Anti-inflammatory & anti-allergy agents in medicinal chemistry. 2012; 11(2):191-7. doi: 10.2174/187152312803305731. [PMID: 22882083]
  • Guojun Shi, Zhijian Zhang, Rong Zhang, Xiaofang Zhang, Yan Lu, Jian Yang, Di Zhang, Zhiguo Zhang, Xiaoying Li, Guang Ning. Protective effect of andrographolide against concanavalin A-induced liver injury. Naunyn-Schmiedeberg's archives of pharmacology. 2012 Jan; 385(1):69-79. doi: 10.1007/s00210-011-0685-z. [PMID: 21947229]
  • Shuang-Qing Zhang, Xiang-Hong Chen, Min Yu, Xu Sun, Zuo-Gang Li. Quantification of andrographolide sodium bisulphite in urine after intravenous injection to rats by LC-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Jan; 880(1):163-7. doi: 10.1016/j.jchromb.2011.11.006. [PMID: 22130502]
  • Khalijah Awang, Nor Hayati Abdullah, A Hamid A Hadi, Yew Su Fong. Cardiovascular activity of labdane diterpenes from Andrographis paniculata in isolated rat hearts. Journal of biomedicine & biotechnology. 2012; 2012(?):876458. doi: 10.1155/2012/876458. [PMID: 22536026]
  • Anil U Tatiya, Sanjay J Surana, Manisha P Sutar, Nehal H Gamit. Hepatoprotective effect of poly herbal formulation against various hepatotoxic agents in rats. Pharmacognosy research. 2012 Jan; 4(1):50-6. doi: 10.4103/0974-8490.91040. [PMID: 22224062]
  • Ye-Ming Lee, Kuo-Hsien Hsieh, Wan-Jung Lu, Hsiu-Chu Chou, Duen-Suey Chou, Li-Ming Lien, Joen-Rong Sheu, Kuan-Hung Lin. Xanthohumol, a Prenylated Flavonoid from Hops (Humulus lupulus), Prevents Platelet Activation in Human Platelets. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):852362. doi: 10.1155/2012/852362. [PMID: 22611436]
  • Raymond I Ozolua, Adesola Adejayan, Osaretin P Aigbe, Dickson O Uwaya, Amit Argawal. Some characteristic relaxant effects of aqueous leaf extract of Andrographis paniculata and andrographolide on guinea pig tracheal rings. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria. 2011 Dec; 26(2):119-24. doi: ". [PMID: 22547179]
  • Gui-Fu Dai, Jin Zhao, Zhi-Wen Jiang, Li-Ping Zhu, Hai-Wei Xu, Wen-Yan Ma, Xiao-Rang Chen, Rui-Jing Dong, Wei-Yi Li, Hong-Min Liu. Anti-inflammatory effect of novel andrographolide derivatives through inhibition of NO and PGE2 production. International immunopharmacology. 2011 Dec; 11(12):2144-9. doi: 10.1016/j.intimp.2011.09.010. [PMID: 21983643]
  • Waranya Chatuphonprasert, Tawun Remsungnen, Nobuo Nemoto, Kanokwan Jarukamjorn. Different AhR binding sites of diterpenoid ligands from Andrographis paniculata caused differential CYP1A1 induction in primary culture in mouse hepatocytes. Toxicology in vitro : an international journal published in association with BIBRA. 2011 Dec; 25(8):1757-63. doi: 10.1016/j.tiv.2011.09.004. [PMID: 21963808]
  • Shiv Narayan Sharma, Zenu Jha, D K Sharma. Chemometrics evaluation of the herbal drug Andrographis paniculata. Natural product communications. 2011 Dec; 6(12):1929-32. doi: ". [PMID: 22312742]
  • Muhammad R Khan, Iram Badar, Aisha Siddiquah. Prevention of hepatorenal toxicity with Sonchus asper in gentamicin treated rats. BMC complementary and alternative medicine. 2011 Nov; 11(?):113. doi: 10.1186/1472-6882-11-113. [PMID: 22082144]
  • Sangeetha Sukumari-Ramesh, J Nicole Bentley, Melissa D Laird, Nagendra Singh, John R Vender, Krishnan M Dhandapani. Dietary phytochemicals induce p53- and caspase-independent cell death in human neuroblastoma cells. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2011 Nov; 29(7):701-10. doi: 10.1016/j.ijdevneu.2011.06.002. [PMID: 21704149]
  • Ling Ye, Tao Wang, Lan Tang, Wei Liu, Zhen Yang, Juan Zhou, Zhijie Zheng, Zheng Cai, Ming Hu, Zhongqiu Liu. Poor oral bioavailability of a promising anticancer agent andrographolide is due to extensive metabolism and efflux by P-glycoprotein. Journal of pharmaceutical sciences. 2011 Nov; 100(11):5007-17. doi: 10.1002/jps.22693. [PMID: 21721007]
  • Jalli Madhu Sudhana, Rachakunta Munikishore, Mopuru Vijayabhaskar Reddy, Duvvuru Gunasekar, Alain Blond, Bernard Bodo. A new diacylated labdane diterpenoid from Andrographis wightiana. Natural product communications. 2011 Nov; 6(11):1569-72. doi: ". [PMID: 22224261]
  • L-J Wang, X Zhou, W Wang, F Tang, C-L Qi, X Yang, S Wu, Y-Q Lin, J-T Wang, J-G Geng. Andrographolide inhibits oral squamous cell carcinogenesis through NF-κB inactivation. Journal of dental research. 2011 Oct; 90(10):1246-52. doi: 10.1177/0022034511418341. [PMID: 21841043]
  • Nilanjan Ghosh, Rituparna Ghosh, Vivekananda Mandal, Subhash C Mandal. Recent advances in herbal medicine for treatment of liver diseases. Pharmaceutical biology. 2011 Sep; 49(9):970-88. doi: 10.3109/13880209.2011.558515. [PMID: 21595500]
  • Saranya Panneerselvam, Geetha Arumugam, Narmadha Selvamathy Selvaperumal Munis Karthikeyan. Effect of andrographolide on cysteamine-induced duodenal ulcer in rats. Natural product research. 2011 Sep; 25(16):1560-4. doi: 10.1080/14786419.2010.541159. [PMID: 21848489]
  • P Saranya, A Geetha, S M K Narmadha Selvamathy. A biochemical study on the gastroprotective effect of andrographolide in rats induced with gastric ulcer. Indian journal of pharmaceutical sciences. 2011 Sep; 73(5):550-7. doi: 10.4103/0250-474x.99012. [PMID: 22923868]
  • Lili Ji, Kaikai Shen, Ping Jiang, Grant Morahan, Zhengtao Wang. Critical roles of cellular glutathione homeostasis and jnk activation in andrographolide-mediated apoptotic cell death in human hepatoma cells. Molecular carcinogenesis. 2011 Aug; 50(8):580-91. doi: 10.1002/mc.20741. [PMID: 21319226]
  • Yan Gao, Zhong-Lan Wang, Gui-Hua Huang. [Intestinal absorption of enteric coating potassium sodium dehydroandroan drographolide succinate pellets in rat and in vivo pharmacokinetics study]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2011 Aug; 34(8):1247-50. doi: NULL. [PMID: 22233041]
  • Juan Li, Zu-Yue Tu, Jun-Yuan Yin, Guo-Xia Yue, Hong-Min Liu. Identification of potassium dehydroandrographolidi succinas and its major metabolites in rat urine by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Jul; 879(22):2107-12. doi: 10.1016/j.jchromb.2011.05.046. [PMID: 21703947]
  • Yan Pan, Badrul Amini Abd-Rashid, Zakiah Ismail, Rusli Ismail, Joon Wah Mak, Peter C K Pook, Hui Meng Er, Chin Eng Ong. In vitro determination of the effect of Andrographis paniculata extracts and andrographolide on human hepatic cytochrome P450 activities. Journal of natural medicines. 2011 Jul; 65(3-4):440-7. doi: 10.1007/s11418-011-0516-z. [PMID: 21365364]
  • Hong Lu, Xin-yue Zhang, Yan-quan Zhou, Xin Wen, Li-ying Zhu. Proteomic alterations in mouse kidney induced by andrographolide sodium bisulfite. Acta pharmacologica Sinica. 2011 Jul; 32(7):888-94. doi: 10.1038/aps.2011.39. [PMID: 21685926]
  • Hui-lan Zhu, Cheng-liang Huang, Wen-jun Wang, Xiao-qin Zhan, Xian-ming Fan. [Effects of andrographolide on the concentration of cytokines in BALF and the expressions of type I and III collagen mRNA in lung tissue in bleomycin-induced rat pulmonary fibrosis]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2011 Jul; 27(7):725-9. doi: NULL. [PMID: 21722520]
  • S Jhon Premendran, Kartik J Salwe, Swanand Pathak, Ranjana Brahmane, K Manimekalai. Anti-cobra venom activity of plant Andrographis paniculata and its comparison with polyvalent anti-snake venom. Journal of natural science, biology, and medicine. 2011 Jul; 2(2):198-204. doi: 10.4103/0976-9668.92326. [PMID: 22346236]
  • Sumaira Sahreen, Muhammad R Khan, Rahmat A Khan. Hepatoprotective effects of methanol extract of Carissa opaca leaves on CCl4-induced damage in rat. BMC complementary and alternative medicine. 2011 Jun; 11(?):48. doi: 10.1186/1472-6882-11-48. [PMID: 21699742]
  • Shou-Ping Guan, Li-Ren Kong, Chang Cheng, Jonathan C W Lim, W S Fred Wong. Protective role of 14-deoxy-11,12-didehydroandrographolide, a noncytotoxic analogue of andrographolide, in allergic airway inflammation. Journal of natural products. 2011 Jun; 74(6):1484-90. doi: 10.1021/np2002572. [PMID: 21598983]
  • Ellen J Gunn, John T Williams, Daniel T Huynh, Michael J Iannotti, Changho Han, Francis J Barrios, Stephen Kendall, Carlotta A Glackin, David A Colby, Julia Kirshner. The natural products parthenolide and andrographolide exhibit anti-cancer stem cell activity in multiple myeloma. Leukemia & lymphoma. 2011 Jun; 52(6):1085-97. doi: 10.3109/10428194.2011.555891. [PMID: 21417826]
  • Xiaoying Yin, Qingshan Liu, Yifan Jiang, Yongming Luo. Development of andrographolide molecularly imprinted polymer for solid-phase extraction. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2011 Jun; 79(1):191-6. doi: 10.1016/j.saa.2011.02.034. [PMID: 21420352]
  • Ko-Chen Lee, Hen-Hong Chang, Ying-Hui Chung, Tzung-Yan Lee. Andrographolide acts as an anti-inflammatory agent in LPS-stimulated RAW264.7 macrophages by inhibiting STAT3-mediated suppression of the NF-κB pathway. Journal of ethnopharmacology. 2011 Jun; 135(3):678-84. doi: 10.1016/j.jep.2011.03.068. [PMID: 21497192]
  • Chantana Aromdee, Supawadee Suebsasana, Tipaya Ekalaksananan, Chamsai Pientong, Sasithorn Thongchai. Stage of action of naturally occurring andrographolides and their semisynthetic analogues against herpes simplex virus type 1 in vitro. Planta medica. 2011 Jun; 77(9):915-21. doi: 10.1055/s-0030-1250659. [PMID: 21259187]
  • Chong Xu, Zheng-Tao Wang. [Chemical constituents from roots of Andrographis paniculata]. Yao xue xue bao = Acta pharmaceutica Sinica. 2011 Mar; 46(3):317-21. doi: ". [PMID: 21626787]
  • K Bharavi, A Gopala Reddy, G S Rao, P Ravi Kumar, D Srinivas Kumar, P Prabhu Prasadini. Prevention of cadmium bioaccumulation by herbal adaptogens. Indian journal of pharmacology. 2011 Feb; 43(1):45-9. doi: 10.4103/0253-7613.75669. [PMID: 21455421]
  • Dijendra Nath Roy, Gargi Sen, Kaustav Dutta Chowdhury, Tuli Biswas. Combination therapy with andrographolide and d-penicillamine enhanced therapeutic advantage over monotherapy with d-penicillamine in attenuating fibrogenic response and cell death in the periportal zone of liver in rats during copper toxicosis. Toxicology and applied pharmacology. 2011 Jan; 250(1):54-68. doi: 10.1016/j.taap.2010.09.027. [PMID: 20946909]
  • C V Chandrasekaran, P Thiyagarajan, H B Deepak, Amit Agarwal. In vitro modulation of LPS/calcimycin induced inflammatory and allergic mediators by pure compounds of Andrographis paniculata (King of bitters) extract. International immunopharmacology. 2011 Jan; 11(1):79-84. doi: 10.1016/j.intimp.2010.10.009. [PMID: 21034865]
  • Wen-Wan Chao, Yueh-Hsiung Kuo, Shie-Liang Hsieh, Bi-Fong Lin. Inhibitory Effects of Ethyl Acetate Extract of Andrographis paniculata on NF-κB Trans-Activation Activity and LPS-Induced Acute Inflammation in Mice. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):254531. doi: 10.1093/ecam/nep120. [PMID: 19745004]
  • Ju-Feng Ye, Hang Zhu, Zhi-Feng Zhou, Ri-Bo Xiong, Xi-Wen Wang, Li-Xian Su, Bing-De Luo. Protective mechanism of andrographolide against carbon tetrachloride-induced acute liver injury in mice. Biological & pharmaceutical bulletin. 2011; 34(11):1666-70. doi: 10.1248/bpb.34.1666. [PMID: 22040877]
  • I M Liu, J T Cheng. Mediation of Endogenous β-Endorphin in the Plasma Glucose-Lowering Action of Herbal Products Observed in Type 1-Like Diabetic Rats. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):987876. doi: 10.1093/ecam/nen078. [PMID: 19095661]
  • Astha Varma, Harish Padh, Neeta Shrivastava. Andrographolide: a new plant-derived antineoplastic entity on horizon. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):815390. doi: 10.1093/ecam/nep135. [PMID: 19752167]
  • Rajesh Arora, R Chawla, Rohit Marwah, P Arora, R K Sharma, Vinod Kaushik, R Goel, A Kaur, M Silambarasan, R P Tripathi, J R Bhardwaj. Potential of Complementary and Alternative Medicine in Preventive Management of Novel H1N1 Flu (Swine Flu) Pandemic: Thwarting Potential Disasters in the Bud. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):586506. doi: 10.1155/2011/586506. [PMID: 20976081]
  • Sau Har Lee, Indu Bala Jaganath, Seok Mui Wang, Shamala Devi Sekaran. Antimetastatic effects of Phyllanthus on human lung (A549) and breast (MCF-7) cancer cell lines. PloS one. 2011; 6(6):e20994. doi: 10.1371/journal.pone.0020994. [PMID: 21698198]
  • Ranjana I Brahmane, Swanand S Pathak, Vikrant V Wanmali, Kartik J Salwe, S John Premendran, Bhawna B Shinde. Partial in vitro and in vivo red scorpion venom neutralization activity of Andrographis paniculata. Pharmacognosy research. 2011 Jan; 3(1):44-8. doi: 10.4103/0974-8490.79115. [PMID: 21731395]
  • Chantana Aromdee, Nongluksna Sriubolmas, Suthep Wiyakrutta, Supawadee Suebsasna, Watcharee Khunkitti. Effect of the derivatives of andrographolide on the morphology of Bacillus subtilis. Archives of pharmacal research. 2011 Jan; 34(1):71-7. doi: 10.1007/s12272-011-0108-1. [PMID: 21468917]
  • Chang Cheng, W Eugene Ho, Fera Y Goh, Shou Ping Guan, Li Ren Kong, Wen-Qi Lai, Bernard P Leung, W S Fred Wong. Anti-malarial drug artesunate attenuates experimental allergic asthma via inhibition of the phosphoinositide 3-kinase/Akt pathway. PloS one. 2011; 6(6):e20932. doi: 10.1371/journal.pone.0020932. [PMID: 21695271]
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