carbacyclin (BioDeep_00000272022)
Volatile Flavor Compounds
代谢物信息卡片
Carboprostacyclin
化学式: C21H34O4 (350.24569640000004)
中文名称: 碳环素(碳环PGI 2)
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O
InChI: InChI=1S/C21H34O4/c1-2-3-4-8-17(22)10-11-18-19-13-15(7-5-6-9-21(24)25)12-16(19)14-20(18)23/h7,10-11,16-20,22-23H,2-6,8-9,12-14H2,1H3,(H,24,25)/b11-10+,15-7+/t16-,17-,18+,19-,20+/m0/s1
描述信息
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
同义名列表
3 个代谢物同义名
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:190588
- ChEBI: CHEBI:173208
- PubChem: 6436393
- PubChem: 5311242
- PubChem: 2552
- Metlin: METLIN43396
- ChEMBL: CHEMBL435828
- ChEMBL: CHEMBL148319
- CAS: 69552-46-1
- CAS: 69609-77-4
- PMhub: MS000003288
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Patrizia Amadio, Eva Tarantino, Leonardo Sandrini, Elena Tremoli, Silvia S Barbieri. Prostaglandin-endoperoxide synthase-2 deletion affects the natural trafficking of Annexin A2 in monocytes and favours venous thrombosis in mice.
Thrombosis and haemostasis.
2017 07; 117(8):1486-1497. doi:
10.1160/th16-12-0968. [PMID: 28536720] - Tomoyo Yoshinaga, Kenichiro Uwabe, Shoichi Naito, Kenichi Higashino, Toru Nakano, Yoshito Numata, Akio Kihara. AM251 Suppresses Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells.
PloS one.
2016; 11(12):e0167848. doi:
10.1371/journal.pone.0167848. [PMID: 27936102] - Evi X Stavrou, Chao Fang, Alona Merkulova, Omar Alhalabi, Nadja Grobe, Silvio Antoniak, Nigel Mackman, Alvin H Schmaier. Reduced thrombosis in Klkb1-/- mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor.
Blood.
2015 Jan; 125(4):710-9. doi:
10.1182/blood-2014-01-550285. [PMID: 25339356] - Jessica R C Priestley, Matthew W Buelow, Scott T McEwen, Brian D Weinberg, Melanie Delaney, Sarah F Balus, Carlyn Hoeppner, Lynn Dondlinger, Julian H Lombard. Reduced angiotensin II levels cause generalized vascular dysfunction via oxidant stress in hamster cheek pouch arterioles.
Microvascular research.
2013 Sep; 89(?):134-45. doi:
10.1016/j.mvr.2013.04.004. [PMID: 23628292] - Melisa Kurtz, Evangelina Capobianco, Nora Martínez, Jimena Fernández, Romina Higa, Verónica White, Alicia Jawerbaum. Carbaprostacyclin, a PPARdelta agonist, ameliorates excess lipid accumulation in diabetic rat placentas.
Life sciences.
2010 May; 86(21-22):781-90. doi:
10.1016/j.lfs.2010.03.008. [PMID: 20338185] - Wei Zhou, Tong Lu, Arthur A Spector, Hon-Chi Lee. Inhibition of PGI2 signaling by miconazole in vascular smooth muscle cells.
Prostaglandins & other lipid mediators.
2006 Jul; 80(1-2):28-34. doi:
10.1016/j.prostaglandins.2006.03.005. [PMID: 16846784] - A C Maurin, P M Chavassieux, P J Meunier. Expression of PPARgamma and beta/delta in human primary osteoblastic cells: influence of polyunsaturated fatty acids.
Calcified tissue international.
2005 May; 76(5):385-92. doi:
10.1007/s00223-004-0108-y. [PMID: 15868283] - Per Sauerberg, Ingrid Pettersson, Lone Jeppesen, Paul S Bury, John P Mogensen, Karsten Wassermann, Christian L Brand, Jeppe Sturis, Helle F Wöldike, Jan Fleckner, Anne-Sofie T Andersen, Steen B Mortensen, L Anders Svensson, Hanne B Rasmussen, Søren V Lehmann, Zdenek Polivka, Karel Sindelar, Vladimira Panajotova, Lars Ynddal, Erik M Wulff. Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity.
Journal of medicinal chemistry.
2002 Feb; 45(4):789-804. doi:
10.1021/jm010964g. [PMID: 11831892] - M J Kim, D Deplewski, N Ciletti, S Michel, U Reichert, R L Rosenfield. Limited cooperation between peroxisome proliferator-activated receptors and retinoid X receptor agonists in sebocyte growth and development.
Molecular genetics and metabolism.
2001 Nov; 74(3):362-9. doi:
10.1006/mgme.2001.3242. [PMID: 11708867] - M J Mason, M P Mahaut-Smith. Voltage-dependent Ca2+ release in rat megakaryocytes requires functional IP3 receptors.
The Journal of physiology.
2001 May; 533(Pt 1):175-83. doi:
10.1111/j.1469-7793.2001.0175b.x. [PMID: 11351026] - M Abramovitz, M Adam, Y Boie, M Carrière, D Denis, C Godbout, S Lamontagne, C Rochette, N Sawyer, N M Tremblay, M Belley, M Gallant, C Dufresne, Y Gareau, R Ruel, H Juteau, M Labelle, N Ouimet, K M Metters. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs.
Biochimica et biophysica acta.
2000 Jan; 1483(2):285-93. doi:
10.1016/s1388-1981(99)00164-x. [PMID: 10634944] - J Aubert, O Champigny, P Saint-Marc, R Negrel, S Collins, D Ricquier, G Ailhaud. Up-regulation of UCP-2 gene expression by PPAR agonists in preadipose and adipose cells.
Biochemical and biophysical research communications.
1997 Sep; 238(2):606-11. doi:
10.1006/bbrc.1997.7348. [PMID: 9299560] - T Kawamura, T Akira, M Watanabe, Y Kagitani. Prostaglandin E1 prevents apoptotic cell death in superficial dorsal horn of rat spinal cord.
Neuropharmacology.
1997 Aug; 36(8):1023-30. doi:
10.1016/s0028-3908(97)00096-8. [PMID: 9294966] - R L Hébert, L Regnier, L N Peterson. Rabbit cortical collecting ducts express a novel prostacyclin receptor.
The American journal of physiology.
1995 Jan; 268(1 Pt 2):F145-54. doi:
10.1152/ajprenal.1995.268.1.f145. [PMID: 7530913] - C Darimont, D Gaillard, G Ailhaud, R Negrel. Terminal differentiation of mouse preadipocyte cells: adipogenic and antimitogenic role of triiodothyronine.
Molecular and cellular endocrinology.
1993 Dec; 98(1):67-73. doi:
10.1016/0303-7207(93)90238-f. [PMID: 7511547] - S Karmiol, D G Remick, S L Kunkel, S H Phan. Regulation of rat pulmonary endothelial cell interleukin-6 production by bleomycin: effects of cellular fatty acid composition.
American journal of respiratory cell and molecular biology.
1993 Dec; 9(6):628-36. doi:
10.1165/ajrcmb/9.6.628. [PMID: 7504928] - R M Catalioto, D Gaillard, G Ailhaud, R Négrel. Terminal differentiation of mouse preadipocyte cells: the mitogenic-adipogenic role of growth hormone is mediated by the protein kinase C signalling pathway.
Growth factors (Chur, Switzerland).
1992; 6(3):255-64. doi:
10.3109/08977199209026932. [PMID: 1389231] - N S Doherty, T H Beaver, K Y Chan, R J Dinerstein, K A Diekema. The antinociceptive activity of paracetamol in zymosan-induced peritonitis in mice: the role of prostacyclin and reactive oxygen species.
British journal of pharmacology.
1990 Dec; 101(4):869-74. doi:
10.1111/j.1476-5381.1990.tb14173.x. [PMID: 1707707] - S Ito, O A Carretero, K Abe, W H Beierwaltes, K Yoshinaga. Effect of prostanoids on renin release from rabbit afferent arterioles with and without macula densa.
Kidney international.
1989 May; 35(5):1138-44. doi:
10.1038/ki.1989.102. [PMID: 2504984] - L K Ren, A V Vasil'ev, A N Orekhov, V A Tutel'ian. [The effect of eicosapentaenoic acid and various prostaglandins on cholesterol accumulation and proliferation of intima cells from human aorta].
Voprosy meditsinskoi khimii.
1989 Mar; 35(2):112-5. doi:
NULL. [PMID: 2545044] - R Négrel, D Gaillard, G Ailhaud. Prostacyclin as a potent effector of adipose-cell differentiation.
The Biochemical journal.
1989 Jan; 257(2):399-405. doi:
10.1042/bj2570399. [PMID: 2539085] - V V Tertov, A G Panosyan, S E Akopov, A N Orekhov. The effects of eicozanoids and lipoxygenase inhibitors on the lipid metabolism of aortic cells.
Biomedica biochimica acta.
1988; 47(10-11):S286-8. doi:
". [PMID: 3150271] - M B Perlman, S K Lo, A B Malik. Effect of prostacyclin on pulmonary vascular response to thrombin in awake sheep.
Journal of applied physiology (Bethesda, Md. : 1985).
1986 Feb; 60(2):546-53. doi:
10.1152/jappl.1986.60.2.546. [PMID: 3512510] - V V Tertov, A N Orekhov, V N Smirnov. Agents that increase cellular cyclic AMP inhibit proliferative activity and decrease lipid content in cells cultured from atherosclerotic human aorta.
Artery.
1986; 13(6):365-72. doi:
". [PMID: 2430551] - S Hamid, B J Whittle. Interaction of prostaglandin D2 with prostacyclin, carbacyclin and the hydantoin prostaglandin, BW245C, in guinea-pig platelets.
British journal of pharmacology.
1985 May; 85(1):285-90. doi:
10.1111/j.1476-5381.1985.tb08858.x. [PMID: 2992652] - U N Das. Atherosclerosis and prostaglandins.
International journal of tissue reactions.
1982; 4(2):127-32. doi:
". [PMID: 6749663] - B J Whittle, S Moncada, F Whiting, J R Vane. Carbacyclin--a potent stable prostacyclin analogue for the inhibition of platelet aggregation.
Prostaglandins.
1980 Apr; 19(4):605-27. doi:
10.1016/s0090-6980(80)80010-4. [PMID: 6992234]