Resolvin E1 (BioDeep_00000012124)

 

Secondary id: BioDeep_00000605100

human metabolite Endogenous blood metabolite


代谢物信息卡片


(6Z,8E,10E,14Z,16E)-5,12,18-trihydroxyicosa-6,8,10,14,16-pentaenoic acid

化学式: C20H30O5 (350.209313)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 8.63%

分子结构信息

SMILES: CCC(C=CC=CCC(C=CC=CC=CC(CCCC(=O)O)O)O)O
InChI: InChI=1S/C20H30O5/c1-2-17(21)11-8-5-9-14-18(22)12-6-3-4-7-13-19(23)15-10-16-20(24)25/h3-9,11-13,17-19,21-23H,2,10,14-16H2,1H3,(H,24,25)

描述信息

Resolvin E1 is a resolvin, a bioactive oxygenated product of EPA (eicosapentaenoic acid). It is a inflammation-resolving lipid mediator. RvE1 reduces neutrophil hyper-function, it also prevents the initiation and progression of tissue destruction (PMID: 16373400). RvE1, can also act as a host response modulator in the control of the inflammatory diseases that also involve bone loss such as periodontitis and arthritis. RvE1 has been shown to display specific binding sites on human neutrophils with an apparent Kd of 47 nM (PMID: 15753205; 16373400). RvE1 is a potent modulator of leukocytes as well as selective platelet responses in blood and platelet-rich plasma (PMID: 18480426). [HMDB]
Resolvin E1 is a resolvin, a bioactive oxygenated product of EPA (eicosapentaenoic acid). It is a inflammation-resolving lipid mediator. RvE1 reduces neutrophil hyper-function, it also prevents the initiation and progression of tissue destruction (PMID: 16373400). RvE1, can also act as a host response modulator in the control of the inflammatory diseases that also involve bone loss such as periodontitis and arthritis. RvE1 has been shown to display specific binding sites on human neutrophils with an apparent Kd of 47 nM (PMID: 15753205; 16373400). RvE1 is a potent modulator of leukocytes as well as selective platelet responses in blood and platelet-rich plasma (PMID: 18480426).

同义名列表

8 个代谢物同义名

(6Z,8E,10E,14Z,16E)-5,12,18-trihydroxyicosa-6,8,10,14,16-pentaenoic acid; (6Z,8E,10E,14Z,16E)-5,12,18-Trihydroxyicosa-6,8,10,14,16-pentaenoate; 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid; 5S,12R,18R-Trihydroxy-6Z,8E,10E,14Z,16E-epa; SCHEMBL19668625; Resolvin E1; ResolvinE1; RvE1



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(5)

BioCyc(0)

PlantCyc(0)

代谢反应

85 个相关的代谢反应过程信息。

Reactome(85)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Rachel Grazda, Allison N Seyfried, Krishna Rao Maddipati, Gabrielle Fredman, Katherine C MacNamara. Resolvin E1 improves efferocytosis and rescues severe aplastic anemia in mice. Cell death & disease. 2024 May; 15(5):324. doi: 10.1038/s41419-024-06705-7. [PMID: 38724533]
  • Maëlle Briottet, Khadeeja Sy, Charlie London, Abdel Aissat, Mickael Shum, Virginie Escabasse, Bruno Louis, Valérie Urbach. Specialized proresolving mediator resolvin E1 corrects the altered cystic fibrosis nasal epithelium cilia beating dynamics. Proceedings of the National Academy of Sciences of the United States of America. 2024 Jan; 121(5):e2313089121. doi: 10.1073/pnas.2313089121. [PMID: 38252817]
  • Jishou Zhang, Zheng Yin, Yao Xu, Cheng Wei, Shanshan Peng, Mengmeng Zhao, Jianfang Liu, Shuwan Xu, Wei Pan, Zihui Zheng, Siqi Liu, Jing Ye, Juan-Juan Qin, Jun Wan, Menglong Wang. Resolvin E1/ChemR23 Protects Against Hypertension and Vascular Remodeling in Angiotensin II-Induced Hypertensive Mice. Hypertension (Dallas, Tex. : 1979). 2023 Oct; ?(?):. doi: 10.1161/hypertensionaha.123.21348. [PMID: 37800344]
  • Mohsen Molaei, Ramin Lotfi, Reza Heidarymoghadam, Alireza Rezaiemanesh, Ali Gorgin Karaji, Farhad Salari. Imbalanced serum levels of resolvin E1 (RvE1) and leukotriene B4 (LTB4) may contribute to the pathogenesis of atherosclerosis. Prostaglandins & other lipid mediators. 2023 Sep; ?(?):106781. doi: 10.1016/j.prostaglandins.2023.106781. [PMID: 37704124]
  • Kübra Karakoç Güvenç, Özlem Fentoğlu, Mustafa Calapoğlu, Fatih Aksoy, Hikmet Orhan. Periodontal and cardiovascular therapies modify specialized pro-resolving lipid mediator (sPRLM) (LPXA4, PD1, RvE1, RvD1, and MaR1)-mediated pathway: the first pilot clinical study. Clinical oral investigations. 2023 Aug; ?(?):. doi: 10.1007/s00784-023-05174-0. [PMID: 37535198]
  • Magnus Bäck. Icosapent ethyl in cardiovascular prevention: Resolution of inflammation through the eicosapentaenoic acid - resolvin E1 - ChemR23 axis. Pharmacology & therapeutics. 2023 May; ?(?):108439. doi: 10.1016/j.pharmthera.2023.108439. [PMID: 37201735]
  • Annamaria Tisi, Giulia Carozza, Alessandro Leuti, Rita Maccarone, Mauro Maccarrone. Dysregulation of Resolvin E1 Metabolism and Signaling in a Light-Damage Model of Age-Related Macular Degeneration. International journal of molecular sciences. 2023 Apr; 24(7):. doi: 10.3390/ijms24076749. [PMID: 37047721]
  • Jenaro A Espitia-Corredor, Licia Shamoon, Francisco Olivares-Silva, Constanza Rimassa-Taré, Claudia Muñoz-Rodríguez, Claudio Espinoza-Pérez, Carlos F Sánchez-Ferrer, Concepción Peiró, Guillermo Díaz-Araya. Resolvin E1 attenuates doxorubicin-induced cardiac fibroblast senescence: A key role for IL-1β. Biochimica et biophysica acta. Molecular basis of disease. 2022 11; 1868(11):166525. doi: 10.1016/j.bbadis.2022.166525. [PMID: 35987478]
  • Abrar E Al-Shaer, Anandita Pal, Qing Shi, Meredith S Carson, Jennifer Regan, Madeline Behee, Nicole Buddenbaum, Catie Drawdy, Traci Davis, Rafia Virk, Saame Raza Shaikh. Modeling human heterogeneity of obesity with diversity outbred mice reveals a fat mass-dependent therapeutic window for resolvin E1. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2022 06; 36(6):e22354. doi: 10.1096/fj.202200350r. [PMID: 35616343]
  • Finosh G Thankam, Victoria E D Wilson, Mohamed M Radwan, Aleem Siddique, Devendra K Agrawal. Involvement of ischemia-driven 5-lipoxygenase-resolvin-E1-chemokine like receptor-1 axis in the resolution of post-coronary artery bypass graft inflammation in coronary arteries. Molecular biology reports. 2022 Apr; 49(4):3123-3134. doi: 10.1007/s11033-022-07143-4. [PMID: 35061143]
  • Shun Aoki, Satoshi Deyama, Rinako Sugie, Kohei Ishimura, Hayato Fukuda, Satoshi Shuto, Masabumi Minami, Katsuyuki Kaneda. The antidepressant-like effect of resolvin E1 in repeated prednisolone-induced depression model mice. Behavioural brain research. 2022 02; 418(?):113676. doi: 10.1016/j.bbr.2021.113676. [PMID: 34801580]
  • Ellen C Keeley, Han J Li, Christopher R Cogle, Eileen M Handberg, C Noel Bairey Merz, Carl J Pepine. Specialized Proresolving Mediators in Symptomatic Women With Coronary Microvascular Dysfunction (from the Women's Ischemia Trial to Reduce Events in Nonobstructive CAD [WARRIOR] Trial). The American journal of cardiology. 2022 01; 162(?):1-5. doi: 10.1016/j.amjcard.2021.09.015. [PMID: 34728061]
  • Habil Yücel, Alper Tunga Özdemir. Low LXA4, RvD1 and RvE1 levels may be an indicator of the development of hypertension. Prostaglandins, leukotrienes, and essential fatty acids. 2021 11; 174(?):102365. doi: 10.1016/j.plefa.2021.102365. [PMID: 34740030]
  • Arzu Ulu, Abigail Burr, Art J Heires, Jacqueline Pavlik, Tricia Larsen, Pedro A Perez, Carissa Bravo, Nicholas V DiPatrizio, Michelle Baack, Debra J Romberger, Tara M Nordgren. A high docosahexaenoic acid diet alters lung inflammation and recovery following repetitive exposure to aqueous organic dust extracts. The Journal of nutritional biochemistry. 2021 11; 97(?):108797. doi: 10.1016/j.jnutbio.2021.108797. [PMID: 34126202]
  • Eluisa Perna, Javier Aguilera-Lizarraga, Morgane V Florens, Piyush Jain, Stavroula A Theofanous, Nikita Hanning, Joris G De Man, Maya Berg, Benedicte De Winter, Yeranddy A Alpizar, Karel Talavera, Pieter Vanden Berghe, Mira Wouters, Guy Boeckxstaens. Effect of resolvins on sensitisation of TRPV1 and visceral hypersensitivity in IBS. Gut. 2021 07; 70(7):1275-1286. doi: 10.1136/gutjnl-2020-321530. [PMID: 33023902]
  • Sarah E Kleinstein, Jamison McCorrison, Alaa Ahmed, Hatice Hasturk, Thomas E Van Dyke, Marcelo Freire. Transcriptomics of type 2 diabetic and healthy human neutrophils. BMC immunology. 2021 06; 22(1):37. doi: 10.1186/s12865-021-00428-6. [PMID: 34134627]
  • Jing Song, Rongxin Sun, Yuanyuan Zhang, Jing Ke, Dong Zhao. Serum resolvin E1 levels and its relationship with thyroid autoimmunity in Hashimoto's thyroiditis: a preliminary study. BMC endocrine disorders. 2021 Apr; 21(1):66. doi: 10.1186/s12902-021-00730-9. [PMID: 33849519]
  • Francine K Welty, Fabian Schulte, Abdulhamied Alfaddagh, Tarec K Elajami, Bruce R Bistrian, Markus Hardt. Regression of human coronary artery plaque is associated with a high ratio of (18-hydroxy-eicosapentaenoic acid + resolvin E1) to leukotriene B4. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2021 04; 35(4):e21448. doi: 10.1096/fj.202002471r. [PMID: 33749913]
  • Kohei Ishimura, Hayato Fukuda, Koichi Fujiwara, Ryuta Muromoto, Koki Hirashima, Yuto Murakami, Mizuki Watanabe, Jun Ishihara, Tadashi Matsuda, Satoshi Shuto. Synthesis of Resolvin E1 and Its Conformationally Restricted Cyclopropane Congeners with Potent Anti-Inflammatory Effect. ACS medicinal chemistry letters. 2021 Feb; 12(2):256-261. doi: 10.1021/acsmedchemlett.0c00639. [PMID: 33603972]
  • Gustavo Ignacio Diaz-Rubio, Fernanda-Isadora Corona-Meraz, Perla-Monserrat Madrigal-Ruiz, Jesús-Aureliano Robles-De Anda, Eduardo Gómez-Bañuelos, Jorge Castro-Albarran, Luis-Javier Flores-Alvarado, Mónica Vázquez-Del Mercado, Felipe de Jesús Pérez-Vázquez, Oscar-Enrique Pizano-Martínez, Rosa-Elena Navarro-Hernández. CCR2/CCL2 and CMKLR1/RvE1 chemokines system levels are associated with insulin resistance in rheumatoid arthritis. PloS one. 2021; 16(1):e0246054. doi: 10.1371/journal.pone.0246054. [PMID: 33508012]
  • Javier Perez-Hernandez, Valerio Chiurchiù, Sylvain Perruche, Sylvaine You. Regulation of T-Cell Immune Responses by Pro-Resolving Lipid Mediators. Frontiers in immunology. 2021; 12(?):768133. doi: 10.3389/fimmu.2021.768133. [PMID: 34868025]
  • Fatma Oner, Carla Alvarez, Wael Yaghmoor, Danielle Stephens, Hatice Hasturk, Erhan Firatli, Alpdogan Kantarci. Resolvin E1 Regulates Th17 Function and T Cell Activation. Frontiers in immunology. 2021; 12(?):637983. doi: 10.3389/fimmu.2021.637983. [PMID: 33815391]
  • Hiroe Suzuki, Takahisa Otsuka, Natsuko Hitora-Imamura, Kohei Ishimura, Hayato Fukuda, Koichi Fujiwara, Satoshi Shuto, Satoshi Deyama, Masabumi Minami. Resolvin E1 Attenuates Chronic Pain-Induced Depression-Like Behavior in Mice: Possible Involvement of Chemerin Receptor ChemR23. Biological & pharmaceutical bulletin. 2021; 44(10):1548-1550. doi: 10.1248/bpb.b21-00461. [PMID: 34602564]
  • Iryna A Khasabova, Mikhail Y Golovko, Svetlana A Golovko, Donald A Simone, Sergey G Khasabov. Intrathecal administration of Resolvin D1 and E1 decreases hyperalgesia in mice with bone cancer pain: Involvement of endocannabinoid signaling. Prostaglandins & other lipid mediators. 2020 12; 151(?):106479. doi: 10.1016/j.prostaglandins.2020.106479. [PMID: 32745525]
  • Maria José Rodríguez, Francisca Herrera, Wendy Donoso, Iván Castillo, Roxana Orrego, Daniel R González, Jessica Zúñiga-Hernández. Pro-Resolving Lipid Mediator Resolvin E1 Mitigates the Progress of Diethylnitrosamine-Induced Liver Fibrosis in Sprague-Dawley Rats by Attenuating Fibrogenesis and Restricting Proliferation. International journal of molecular sciences. 2020 Nov; 21(22):. doi: 10.3390/ijms21228827. [PMID: 33266360]
  • Rabia Bilge Özgül Özdemir, Özgül Soysal Gündüz, Alper Tunga Özdemir, Özgür Akgül. Low levels of pro-resolving lipid mediators lipoxin-A4, resolvin-D1 and resolvin-E1 in patients with rheumatoid arthritis. Immunology letters. 2020 11; 227(?):34-40. doi: 10.1016/j.imlet.2020.08.006. [PMID: 32818598]
  • Ramin Lotfi, Akram Davoodi, Seyed Hamidreza Mortazavi, Ali Gorgin Karaji, Hanieh Tarokhian, Alireza Rezaiemanesh, Farhad Salari. Imbalanced serum levels of resolvin E1 (RvE1) and leukotriene B4 (LTB4) in patients with allergic rhinitis. Molecular biology reports. 2020 Oct; 47(10):7745-7754. doi: 10.1007/s11033-020-05849-x. [PMID: 32960415]
  • Gonzalo Artiach, Miguel Carracedo, Oscar Plunde, Craig E Wheelock, Silke Thul, Peter Sjövall, Anders Franco-Cereceda, Andres Laguna-Fernandez, Hildur Arnardottir, Magnus Bäck. Omega-3 Polyunsaturated Fatty Acids Decrease Aortic Valve Disease Through the Resolvin E1 and ChemR23 Axis. Circulation. 2020 08; 142(8):776-789. doi: 10.1161/circulationaha.119.041868. [PMID: 32506925]
  • Eric D Hamlett, Erik Hjorth, Aurélie Ledreux, Anah Gilmore, Marianne Schultzberg, Ann Charlotte Granholm. RvE1 treatment prevents memory loss and neuroinflammation in the Ts65Dn mouse model of Down syndrome. Glia. 2020 07; 68(7):1347-1360. doi: 10.1002/glia.23779. [PMID: 31944407]
  • Menglu Yang, Marit Lippestad, Robin R Hodges, Haakon K Fjærvoll, Ketil A Fjærvoll, Jeffery A Bair, Tor P Utheim, Charles N Serhan, Darlene A Dartt. RvE1 uses the LTB4 receptor BLT1 to increase [Ca2+]i and stimulate mucin secretion in cultured rat and human conjunctival goblet cells. The ocular surface. 2020 07; 18(3):470-482. doi: 10.1016/j.jtos.2020.04.011. [PMID: 32361084]
  • Miguel Quiros, Darius Feier, Dorothee Birkl, Rachit Agarwal, Dennis W Zhou, Andrés J García, Charles A Parkos, Asma Nusrat. Resolvin E1 is a pro-repair molecule that promotes intestinal epithelial wound healing. Proceedings of the National Academy of Sciences of the United States of America. 2020 04; 117(17):9477-9482. doi: 10.1073/pnas.1921335117. [PMID: 32300016]
  • Dominika Maciejewska, Arleta Drozd, Karolina Skonieczna-Żydecka, Marta Skórka-Majewicz, Karolina Dec, Karolina Jakubczyk, Anna Pilutin, Ewa Stachowska. Eicosanoids in Nonalcoholic Fatty Liver Disease (NAFLD) Progression. Do Serum Eicosanoids Profile Correspond with Liver Eicosanoids Content during NAFLD Development and Progression?. Molecules (Basel, Switzerland). 2020 Apr; 25(9):. doi: 10.3390/molecules25092026. [PMID: 32349225]
  • Jianmin Chen, Gareth S D Purvis, Debora Collotta, Sura Al Zoubi, Michelle A Sugimoto, Antonino Cacace, Lukas Martin, Roman A Colas, Massimo Collino, Jesmond Dalli, Christoph Thiemermann. RvE1 Attenuates Polymicrobial Sepsis-Induced Cardiac Dysfunction and Enhances Bacterial Clearance. Frontiers in immunology. 2020; 11(?):2080. doi: 10.3389/fimmu.2020.02080. [PMID: 32983159]
  • Emmanuel Albuquerque-Souza, Fabian Schulte, Tsute Chen, Markus Hardt, Hatice Hasturk, Thomas E Van Dyke, Marinella Holzhausen, Alpdogan Kantarci. Maresin-1 and Resolvin E1 Promote Regenerative Properties of Periodontal Ligament Stem Cells Under Inflammatory Conditions. Frontiers in immunology. 2020; 11(?):585530. doi: 10.3389/fimmu.2020.585530. [PMID: 33101318]
  • Stephanie G Dakin, Romain A Colas, Kim Wheway, Bridget Watkins, Louise Appleton, Jonathan Rees, Stephen Gwilym, Christopher Little, Jesmond Dalli, Andrew J Carr. Proresolving Mediators LXB4 and RvE1 Regulate Inflammation in Stromal Cells from Patients with Shoulder Tendon Tears. The American journal of pathology. 2019 11; 189(11):2258-2268. doi: 10.1016/j.ajpath.2019.07.011. [PMID: 31437425]
  • Huaxing Xu, Jie Chen, Jianping Ge, Kun Xia, Shuo Tao, Yue Su, Qi Zhang. Resolvin E1 Ameliorates Pulpitis by Suppressing Dental Pulp Fibroblast Activation in a Chemerin Receptor 23-dependent Manner. Journal of endodontics. 2019 Sep; 45(9):1126-1134.e1. doi: 10.1016/j.joen.2019.05.005. [PMID: 31353056]
  • Miguel Carracedo, Gonzalo Artiach, Anna Witasp, Joan Clària, Mattias Carlström, Andres Laguna-Fernandez, Peter Stenvinkel, Magnus Bäck. The G-protein coupled receptor ChemR23 determines smooth muscle cell phenotypic switching to enhance high phosphate-induced vascular calcification. Cardiovascular research. 2019 08; 115(10):1557-1566. doi: 10.1093/cvr/cvy316. [PMID: 30597013]
  • Armaan Siddiquee, Mehaben Patel, Sahith Rajalingam, Deven Narke, Mangesh Kurade, Dovenia S Ponnoth. Effect of omega-3 fatty acid supplementation on resolvin (RvE1)-mediated suppression of inflammation in a mouse model of asthma. Immunopharmacology and immunotoxicology. 2019 Apr; 41(2):250-257. doi: 10.1080/08923973.2019.1584903. [PMID: 30849257]
  • F Echeverría, R Valenzuela, A Espinosa, A Bustamante, D Álvarez, D Gonzalez-Mañan, M Ortiz, S A Soto-Alarcon, L A Videla. Reduction of high-fat diet-induced liver proinflammatory state by eicosapentaenoic acid plus hydroxytyrosol supplementation: involvement of resolvins RvE1/2 and RvD1/2. The Journal of nutritional biochemistry. 2019 01; 63(?):35-43. doi: 10.1016/j.jnutbio.2018.09.012. [PMID: 30321750]
  • Konstantin Mayer, Natascha Sommer, Karl Hache, Andreas Hecker, Sylvia Reiche, Emmanuel Schneck, Norbert Weissmann, Werner Seeger, Matthias Hecker. Resolvin E1 Improves Mitochondrial Function in Human Alveolar Epithelial Cells during Severe Inflammation. Lipids. 2019 01; 54(1):53-65. doi: 10.1002/lipd.12119. [PMID: 30697748]
  • Andres Laguna-Fernandez, Antonio Checa, Miguel Carracedo, Gonzalo Artiach, Marcelo H Petri, Roland Baumgartner, Maria J Forteza, Xintong Jiang, Teodora Andonova, Mary E Walker, Jesmond Dalli, Hildur Arnardottir, Anton Gisterå, Silke Thul, Craig E Wheelock, Gabrielle Paulsson-Berne, Daniel F J Ketelhuth, Göran K Hansson, Magnus Bäck. ERV1/ChemR23 Signaling Protects Against Atherosclerosis by Modifying Oxidized Low-Density Lipoprotein Uptake and Phagocytosis in Macrophages. Circulation. 2018 10; 138(16):1693-1705. doi: 10.1161/circulationaha.117.032801. [PMID: 29739755]
  • Matthias Hecker, Natascha Sommer, Sebastian Foch, Andreas Hecker, Holger Hackstein, Martin Witzenrath, Norbert Weissmann, Werner Seeger, Konstantin Mayer. Resolvin E1 and its precursor 18R-HEPE restore mitochondrial function in inflammation. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2018 09; 1863(9):1016-1028. doi: 10.1016/j.bbalip.2018.06.011. [PMID: 29902569]
  • Luke A Baker, Neil R W Martin, Marc C Kimber, Gareth J Pritchard, Martin R Lindley, Mark P Lewis. Resolvin E1 (Rv E1 ) attenuates LPS induced inflammation and subsequent atrophy in C2C12 myotubes. Journal of cellular biochemistry. 2018 07; 119(7):6094-6103. doi: 10.1002/jcb.26807. [PMID: 29574938]
  • Melanie Jannaway, Christopher Torrens, Jane A Warner, Anthony P Sampson. Resolvin E1, resolvin D1 and resolvin D2 inhibit constriction of rat thoracic aorta and human pulmonary artery induced by the thromboxane mimetic U46619. British journal of pharmacology. 2018 04; 175(7):1100-1108. doi: 10.1111/bph.14151. [PMID: 29352769]
  • Guizhu Liu, Qian Liu, Yujun Shen, Deping Kong, Yanjun Gong, Bo Tao, Guilin Chen, Shumin Guo, Juanjuan Li, Shengkai Zuo, Yu Yu, Huiyong Yin, Li Zhang, Bin Zhou, Colin D Funk, Jian Zhang, Ying Yu. Early treatment with Resolvin E1 facilitates myocardial recovery from ischaemia in mice. British journal of pharmacology. 2018 04; 175(8):1205-1216. doi: 10.1111/bph.14041. [PMID: 28925017]
  • Madhur P Motwani, Romain A Colas, Marc J George, Julia D Flint, Jesmond Dalli, Angela Richard-Loendt, Roel Ph De Maeyer, Charles N Serhan, Derek W Gilroy. Pro-resolving mediators promote resolution in a human skin model of UV-killed Escherichia coli-driven acute inflammation. JCI insight. 2018 03; 3(6):. doi: 10.1172/jci.insight.94463. [PMID: 29563331]
  • Nahla E El-Ashmawy, Naglaa F Khedr, Hoda A El-Bahrawy, Sara A Helal. Upregulation of PPAR-γ mediates the renoprotective effect of omega-3 PUFA and ferulic acid in gentamicin-intoxicated rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Mar; 99(?):504-510. doi: 10.1016/j.biopha.2018.01.036. [PMID: 29665653]
  • Alpdogan Kantarci, Nurgul Aytan, Iro Palaska, Danielle Stephens, Leah Crabtree, Claudia Benincasa, Bruce G Jenkins, Isabel Carreras, Alpaslan Dedeoglu. Combined administration of resolvin E1 and lipoxin A4 resolves inflammation in a murine model of Alzheimer's disease. Experimental neurology. 2018 02; 300(?):111-120. doi: 10.1016/j.expneurol.2017.11.005. [PMID: 29126887]
  • Corneliu Sima, Bruce Paster, Thomas E Van Dyke. Function of Pro-Resolving Lipid Mediator Resolvin E1 in Type 2 Diabetes. Critical reviews in immunology. 2018; 38(5):343-365. doi: 10.1615/critrevimmunol.2018026750. [PMID: 30806214]
  • Satoshi Deyama, Kento Shimoda, Hiroe Suzuki, Yuka Ishikawa, Kohei Ishimura, Hayato Fukuda, Natsuko Hitora-Imamura, Soichiro Ide, Masamichi Satoh, Katsuyuki Kaneda, Satoshi Shuto, Masabumi Minami. Resolvin E1/E2 ameliorate lipopolysaccharide-induced depression-like behaviors via ChemR23. Psychopharmacology. 2018 01; 235(1):329-336. doi: 10.1007/s00213-017-4774-7. [PMID: 29090333]
  • Karim El Kholy, Marcelo Freire, Tsute Chen, Thomas E Van Dyke. Resolvin E1 Promotes Bone Preservation Under Inflammatory Conditions. Frontiers in immunology. 2018; 9(?):1300. doi: 10.3389/fimmu.2018.01300. [PMID: 29946319]
  • Valene H L See, Emilie Mas, Susan L Prescott, Lawrence J Beilin, Sally Burrows, Anne E Barden, Rae-Chi Huang, Trevor A Mori. Effects of prenatal n-3 fatty acid supplementation on offspring resolvins at birth and 12 years of age: a double-blind, randomised controlled clinical trial. The British journal of nutrition. 2017 Dec; 118(11):971-980. doi: 10.1017/s0007114517002914. [PMID: 29173199]
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  • Shalini Muralikumar, Umashankar Vetrivel, Angayarkanni Narayanasamy, Undurti N Das. Probing the intermolecular interactions of PPARγ-LBD with polyunsaturated fatty acids and their anti-inflammatory metabolites to infer most potential binding moieties. Lipids in health and disease. 2017 Jan; 16(1):17. doi: 10.1186/s12944-016-0404-3. [PMID: 28109294]
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