15-Hydroxy-11alpha,9alpha-(epoxymethano)prosta-5,13-dienoic acid (BioDeep_00000842821)
代谢物信息卡片
15-Hydroxy-11alpha,9alpha-(epoxymethano)prosta-5,13-dienoic acid
化学式: C21H34O4 (350.24569640000004)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCC(C=CC1C2CC(C1CC=CCCCC(=O)O)CO2)O
InChI: InChI=1S/C21H34O4/c1-2-3-6-9-17(22)12-13-19-18(16-14-20(19)25-15-16)10-7-4-5-8-11-21(23)24/h4,7,12-13,16-20,22H,2-3,5-6,8-11,14-15H2,1H3,(H,23,24)/b7-4+,13-12+
描述信息
D002317 - Cardiovascular Agents > D014662 - Vasoconstrictor Agents
D009676 - Noxae > D016877 - Oxidants > D010545 - Peroxides
同义名列表
数据库引用编号
3 个数据库交叉引用编号
- PubChem: 5354027
- MeSH: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
- CAS: 76898-47-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Prostaglandins & other lipid mediators.
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2022 Dec; 165(?):106700. doi:
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The Journal of pharmacology and experimental therapeutics.
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American journal of physiology. Cell physiology.
2011 Jul; 301(1):C186-94. doi:
10.1152/ajpcell.00243.2010. [PMID: 21490312] - Angel Luis García-Villalón, Nuria Fernández, Luis Monge, Godofredo Diéguez. Coronary response to diadenosine tetraphosphate after ischemia-reperfusion in the isolated rat heart.
European journal of pharmacology.
2011 Jun; 660(2-3):394-401. doi:
10.1016/j.ejphar.2011.04.006. [PMID: 21513710] - Céline Cherdon, Stéphanie Rolin, Julien Hanson, Annie Ooms, Laurence de Leval, Pierre Drion, Carine Michiels, Bernard Pirotte, Bernard Masereel, Natzi Sakalihassan, Jean-Olivier Defraigne, Jean-Michel Dogné. BM-573 inhibits the development of early atherosclerotic lesions in Apo E deficient mice by blocking TP receptors and thromboxane synthase.
Prostaglandins & other lipid mediators.
2011 Apr; 94(3-4):124-32. doi:
10.1016/j.prostaglandins.2011.03.001. [PMID: 21397034] - Anne Barden, Emilie Mas, Peter Henry, Thierry Durand, Jean-Marie Galano, L Jackson Roberts, Kevin D Croft, Trevor A Mori. The effects of oxidation products of arachidonic acid and n3 fatty acids on vascular and platelet function.
Free radical research.
2011 Apr; 45(4):469-76. doi:
10.3109/10715762.2010.544730. [PMID: 21235285] - T Ulrych, A Böhm, A Polzin, G Daum, R M Nüsing, G Geisslinger, T Hohlfeld, K Schrör, B H Rauch. Release of sphingosine-1-phosphate from human platelets is dependent on thromboxane formation.
Journal of thrombosis and haemostasis : JTH.
2011 Apr; 9(4):790-8. doi:
10.1111/j.1538-7836.2011.04194.x. [PMID: 21251196] - P C J Armstrong, P D Leadbeater, M V Chan, N S Kirkby, J A Jakubowski, J A Mitchell, T D Warner. In the presence of strong P2Y12 receptor blockade, aspirin provides little additional inhibition of platelet aggregation.
Journal of thrombosis and haemostasis : JTH.
2011 Mar; 9(3):552-61. doi:
10.1111/j.1538-7836.2010.04160.x. [PMID: 21143373] - Christian B Poulsen, Rozh H Al-Mashhadi, Leanne L Cribbs, Ole Skøtt, Pernille B Hansen. T-type voltage-gated calcium channels regulate the tone of mouse efferent arterioles.
Kidney international.
2011 Feb; 79(4):443-51. doi:
10.1038/ki.2010.429. [PMID: 21068717] - Yumin Yang, Xiaoling Wang, Li Zhang, Huiping An, Zhigao Zao. Inhibitory effects of resveratrol on platelet activation induced by thromboxane a(2) receptor agonist in human platelets.
The American journal of Chinese medicine.
2011; 39(1):145-59. doi:
10.1142/s0192415x11008713. [PMID: 21213405] - Harold J Ting, Fadi T Khasawneh. Glybenclamide: an antidiabetic with in vivo antithrombotic activity.
European journal of pharmacology.
2010 Dec; 649(1-3):249-54. doi:
10.1016/j.ejphar.2010.09.009. [PMID: 20858477] - Xiao-Yan Bai, Xiao-Cheng Liu, Wen-Bin Jing, Qin Yang, Xiang-Dong Tang, Guo-Wei He. Effect of amlodipine in human internal mammary artery and clinical implications.
The Annals of thoracic surgery.
2010 Dec; 90(6):1952-7. doi:
10.1016/j.athoracsur.2010.08.007. [PMID: 21095344] - Isabelle Salles, Katleen Broos, Alexandre Fontayne, Tímea Szántó, Changgeng Ruan, Alan T Nurden, Karen Vanhoorelbeke, Hans Deckmyn. Development of a high-throughput ELISA assay for platelet function testing using platelet-rich plasma or whole blood.
Thrombosis and haemostasis.
2010 Aug; 104(2):392-401. doi:
10.1160/th09-07-0505. [PMID: 20508902] - Jin Gyun Lee, Yong Yook Lee, Bo Wu, Sun Young Kim, Yong Jae Lee, Hye Sook Yun-Choi, Jeong Hill Park. Inhibitory activity of ginsenosides isolated from processed ginseng on platelet aggregation.
Die Pharmazie.
2010 Jul; 65(7):520-2. doi:
". [PMID: 20662322] - Manash S Chatterjee, Jeremy E Purvis, Lawrence F Brass, Scott L Diamond. Pairwise agonist scanning predicts cellular signaling responses to combinatorial stimuli.
Nature biotechnology.
2010 Jul; 28(7):727-32. doi:
10.1038/nbt.1642. [PMID: 20562863] - Yukiko Enomoto, Seiji Adachi, Rie Matsushima-Nishiwaki, Tomoaki Doi, Masayuki Niwa, Shigeru Akamatsu, Haruhiko Tokuda, Shinji Ogura, Shinichi Yoshimura, Toru Iwama, Osamu Kozawa. Thromboxane A(2) promotes soluble CD40 ligand release from human platelets.
Atherosclerosis.
2010 Apr; 209(2):415-21. doi:
10.1016/j.atherosclerosis.2009.10.024. [PMID: 19932480] - Mohammad Newaz, Zivar Yousefipour, Adebayo Oyekan. Natriuretic and renoprotective effect of chronic oral neutral endopeptidase inhibition in acute renal failure.
Renal failure.
2010 Jan; 32(3):384-90. doi:
10.3109/08860221003611745. [PMID: 20370457] - J W Ou, Y Kumar, A Alioua, C Sailer, E Stefani, L Toro. Ca2+- and thromboxane-dependent distribution of MaxiK channels in cultured astrocytes: from microtubules to the plasma membrane.
Glia.
2009 Sep; 57(12):1280-95. doi:
10.1002/glia.20847. [PMID: 19170178] - Tom W Cherng, Matthew J Campen, Travis L Knuckles, Laura Gonzalez Bosc, Nancy L Kanagy. Impairment of coronary endothelial cell ET(B) receptor function after short-term inhalation exposure to whole diesel emissions.
American journal of physiology. Regulatory, integrative and comparative physiology.
2009 Sep; 297(3):R640-7. doi:
10.1152/ajpregu.90899.2008. [PMID: 19535675] - Ping Song, Miao Zhang, Shuangxi Wang, Jian Xu, Hyoung Chul Choi, Ming-Hui Zou. Thromboxane A2 receptor activates a Rho-associated kinase/LKB1/PTEN pathway to attenuate endothelium insulin signaling.
The Journal of biological chemistry.
2009 Jun; 284(25):17120-17128. doi:
10.1074/jbc.m109.012583. [PMID: 19403525] - Erik Noschka, James N Moore, John F Peroni, Stephen J Lewis, Jason D Morrow, Tom P Robertson. Thromboxane and isoprostanes as inflammatory and vasoactive mediators in black walnut heartwood extract induced equine laminitis.
Veterinary immunology and immunopathology.
2009 Jun; 129(3-4):200-10. doi:
10.1016/j.vetimm.2008.11.005. [PMID: 19111354] - Takahiro Shimizu, Kunihiko Yokotani. Effects of centrally administered prostaglandin E(3) and thromboxane A(3) on plasma noradrenaline and adrenaline in rats: comparison with prostaglandin E(2) and thromboxane A(2).
European journal of pharmacology.
2009 Jun; 611(1-3):30-4. doi:
10.1016/j.ejphar.2009.03.057. [PMID: 19344706] - Shin-ichi Tokue, Masako Sasaki, Norimichi Nakahata. Thromboxane A2-induced signal transduction is negatively regulated by KIAA1005 that directly interacts with thromboxane A2 receptor.
Prostaglandins & other lipid mediators.
2009 Jun; 89(1-2):8-15. doi:
10.1016/j.prostaglandins.2009.02.001. [PMID: 19464661] - Yuiko Nasu, Masaya Iwashita, Masaki Saito, Shinji Fushiya, Norimichi Nakahata. Inhibitory effects of Atractylodis lanceae rhizoma and Poria on collagen- or thromboxane A2-induced aggregation in rabbit platelets.
Biological & pharmaceutical bulletin.
2009 May; 32(5):856-60. doi:
10.1248/bpb.32.856. [PMID: 19420754] - Ewa Selg, Margareta Andersson, Lena Låstbom, Ake Ryrfeldt, Sven-Erik Dahlén. Two different mechanisms for modulation of bronchoconstriction in guinea-pigs by cyclooxygenase metabolites.
Prostaglandins & other lipid mediators.
2009 Apr; 88(3-4):101-10. doi:
10.1016/j.prostaglandins.2008.11.003. [PMID: 19103301] - C P M Hayward, M Pai, Y Liu, K A Moffat, J Seecharan, K E Webert, R J Cook, N M Heddle. Diagnostic utility of light transmission platelet aggregometry: results from a prospective study of individuals referred for bleeding disorder assessments.
Journal of thrombosis and haemostasis : JTH.
2009 Apr; 7(4):676-84. doi:
10.1111/j.1538-7836.2009.03273.x. [PMID: 19143930] - Jeff Reese, Patrick W O'Mara, Stanley D Poole, Naoko Brown, Chelsea Tolentino, Delrae M Eckman, Judy L Aschner. Regulation of the fetal mouse ductus arteriosus is dependent on interaction of nitric oxide and COX enzymes in the ductal wall.
Prostaglandins & other lipid mediators.
2009 Apr; 88(3-4):89-96. doi:
10.1016/j.prostaglandins.2008.11.001. [PMID: 19049898] - Sunny Sun-Kin Chan, Robert Leslie Jones, Ge Lin. Synergistic interaction between the Ligusticum chuanxiong constituent butylidenephthalide and the nitric oxide donor sodium nitroprusside in relaxing rat isolated aorta.
Journal of ethnopharmacology.
2009 Mar; 122(2):308-12. doi:
10.1016/j.jep.2009.01.002. [PMID: 19186210] - Jeong Mi Kim, Yean Kyoung Koo, Jingling Jin, Yong Yook Lee, Seonyang Park, Hye Sook Yun-Choi. Augmentation of U46619 induced human platelet aggregation by aspirin.
Platelets.
2009 Mar; 20(2):111-9. doi:
10.1080/09537100802632282. [PMID: 19235053] - David B Casey, Adeleke M Badejo, Jasdeep S Dhaliwal, Subramanyam N Murthy, Albert L Hyman, Bobby D Nossaman, Philip J Kadowitz. Pulmonary vasodilator responses to sodium nitrite are mediated by an allopurinol-sensitive mechanism in the rat.
American journal of physiology. Heart and circulatory physiology.
2009 Feb; 296(2):H524-33. doi:
10.1152/ajpheart.00543.2008. [PMID: 19074675] - Mi Ra Kim, Eun Su Jeon, Young Mi Kim, Jung Sub Lee, Jae Ho Kim. Thromboxane a(2) induces differentiation of human mesenchymal stem cells to smooth muscle-like cells.
Stem cells (Dayton, Ohio).
2009 Jan; 27(1):191-9. doi:
10.1634/stemcells.2008-0363. [PMID: 18845763] - Li Zhang, Lawrence F Brass, David R Manning. The Gq and G12 families of heterotrimeric G proteins report functional selectivity.
Molecular pharmacology.
2009 Jan; 75(1):235-41. doi:
10.1124/mol.108.050906. [PMID: 18952767] - Sandra L Pfister. Characterization of endothelial thromboxane receptors in rabbit aorta.
Prostaglandins & other lipid mediators.
2008 Dec; 87(1-4):54-61. doi:
10.1016/j.prostaglandins.2008.08.002. [PMID: 18812232] - Liang-Wu Fu, Andrew Phan, John C Longhurst. Myocardial ischemia-mediated excitatory reflexes: a new function for thromboxane A2?.
American journal of physiology. Heart and circulatory physiology.
2008 Dec; 295(6):H2530-40. doi:
10.1152/ajpheart.00790.2008. [PMID: 18952714] - K Nobe, Y Nezu, N Tsumita, T Hashimoto, K Honda. Intra- and extrarenal arteries exhibit different profiles of contractile responses in high glucose conditions.
British journal of pharmacology.
2008 Dec; 155(8):1204-13. doi:
10.1038/bjp.2008.365. [PMID: 18806819] - Christian Bopp, Stefan Hofer, Cornelius Busch, Fabian Spöhr, Markus A Weigand, Eike Martin, Alexandra Klein. Time-limited hyporesponsiveness to inhaled nitric oxide and pulmonary phosphodiesterase activity in endotoxemic rats.
The Journal of surgical research.
2008 Nov; 150(1):66-73. doi:
10.1016/j.jss.2008.01.009. [PMID: 18468638] - Ralf A Benndorf, Edzard Schwedhelm, Anke Gnann, Raihana Taheri, Ghainsom Kom, Michael Didié, Anna Steenpass, Süleyman Ergün, Rainer H Böger. Isoprostanes inhibit vascular endothelial growth factor-induced endothelial cell migration, tube formation, and cardiac vessel sprouting in vitro, as well as angiogenesis in vivo via activation of the thromboxane A(2) receptor: a potential link between oxidative stress and impaired angiogenesis.
Circulation research.
2008 Oct; 103(9):1037-46. doi:
10.1161/circresaha.108.184036. [PMID: 18802021] - Catherine P M Hayward, Karen A Moffat, Menaka Pai, Yang Liu, Jodi Seecharan, Heather McKay, Kathryn E Webert, Richard J Cook, Nancy M Heddle. An evaluation of methods for determining reference intervals for light transmission platelet aggregation tests on samples with normal or reduced platelet counts.
Thrombosis and haemostasis.
2008 Jul; 100(1):134-45. doi:
NULL. [PMID: 18612548] - Jeong Mi Kim, Hye Sook Yun-Choi. Anti-platelet effects of flavonoids and flavonoid-glycosides from Sophora japonica.
Archives of pharmacal research.
2008 Jul; 31(7):886-90. doi:
10.1007/s12272-001-1242-1. [PMID: 18704331] - Jinshan Cao, Tatsuro Nakamura, Takio Kitazawa, Naoko Yamashiki, Tsubasa Yamamoto, Tetsuro Taneike. Characterization of prostanoid receptors present on adrenergic neurons innervating the porcine uterine longitudinal muscle.
Prostaglandins & other lipid mediators.
2008 Jun; 86(1-4):26-34. doi:
10.1016/j.prostaglandins.2008.02.002. [PMID: 18403225] - S Muzaffar, N Shukla, M Bond, G Sala-Newby, G D Angelini, A C Newby, J Y Jeremy. Acute inhibition of superoxide formation and Rac1 activation by nitric oxide and iloprost in human vascular smooth muscle cells in response to the thromboxane A2 analogue, U46619.
Prostaglandins, leukotrienes, and essential fatty acids.
2008 Apr; 78(4-5):247-55. doi:
10.1016/j.plefa.2008.01.008. [PMID: 18420399] - Scott Segal, Steven Y Wang. The effect of maternal catecholamines on the caliber of gravid uterine microvessels.
Anesthesia and analgesia.
2008 Mar; 106(3):888-92, table of contents. doi:
10.1213/ane.0b013e3181617451. [PMID: 18292436] - Frédéric Michel, Serge Simonet, Christine Vayssettes-Courchay, Florence Bertin, Patricia Sansilvestri-Morel, Fabienne Bernhardt, Jérôme Paysant, Jean-Sébastien Silvestre, Bernard I Levy, Michel Félétou, Tony J Verbeuren. Altered TP receptor function in isolated, perfused kidneys of nondiabetic and diabetic ApoE-deficient mice.
American journal of physiology. Renal physiology.
2008 Jan; 294(1):F120-9. doi:
10.1152/ajprenal.00111.2007. [PMID: 17942572]