Tetrahydrodeoxycortisol (BioDeep_00001874177)
Main id: BioDeep_00000010004
代谢物信息卡片
3alpha,17alpha,21-Trihydroxy-5beta-pregnan-20-one
化学式: C21H34O4 (350.2457)
中文名称: 5β-Pregnane-3α,17α,21-triol-20-one
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC12CCC(CC1CCC3C2CCC4(C3CCC4(C(=O)CO)O)C)O
InChI: InChI=1S/C21H34O4/c1-19-8-5-14(23)11-13(19)3-4-15-16(19)6-9-20(2)17(15)7-10-21(20,25)18(24)12-22/h13-17,22-23,25H,3-12H2,1-2H3/t13-,14-,15-,16+,17+,19+,20+,21+/m1/s1
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:34352
- KEGG: C14594
- PubChem: 65555
- LipidMAPS: LMST05030014
- CAS: 68-60-0
- PubChem: 17395594
- NIKKAJI: J39.545E
- RefMet: Tetrahydrodeoxycortisol
- KNApSAcK: 34352
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- L I Velikanova, Z R Shafigullina, N V Vorokhobina, E V Malevanaya. Gas Chromatography-Mass Spectrometry Analysis of Urinary Steroid Metabolomics for Detection of Early Signs of Adrenal Neoplasm Malignancy in Patients with Cushing's Syndrome.
Bulletin of experimental biology and medicine.
2019 Sep; 167(5):676-680. doi:
10.1007/s10517-019-04597-8. [PMID: 31630306] - Christopher M Jones, Ashwini Mallappa, Nicole Reisch, Nikolaos Nikolaou, Nils Krone, Beverly A Hughes, Donna M O'Neil, Martin J Whitaker, Jeremy W Tomlinson, Karl-Heinz Storbeck, Deborah P Merke, Richard J Ross, Wiebke Arlt. Modified-Release and Conventional Glucocorticoids and Diurnal Androgen Excretion in Congenital Adrenal Hyperplasia.
The Journal of clinical endocrinology and metabolism.
2017 06; 102(6):1797-1806. doi:
10.1210/jc.2016-2855. [PMID: 27845856] - L I Velikanova, Z R Shafigullina, A A Lisitsin, N V Vorokhobina, K Grigoryan, E A Kukhianidze, E G Strelnikova, N S Krivokhizhina, L M Krasnov, E A Fedorov, I V Sablin, A L Moskvin, E A Bessonova. Different Types of Urinary Steroid Profiling Obtained by High-Performance Liquid Chromatography and Gas Chromatography-Mass Spectrometry in Patients with Adrenocortical Carcinoma.
Hormones & cancer.
2016 12; 7(5-6):327-335. doi:
10.1007/s12672-016-0267-0. [PMID: 27370636] - T M A Kerkhofs, M N Kerstens, I P Kema, T P Willems, H R Haak. Diagnostic Value of Urinary Steroid Profiling in the Evaluation of Adrenal Tumors.
Hormones & cancer.
2015 Aug; 6(4):168-75. doi:
10.1007/s12672-015-0224-3. [PMID: 25985881] - Kazuhito Mizuki. [Urinary tetrahydro-11-deoxycortisol].
Nihon rinsho. Japanese journal of clinical medicine.
2010 Jul; 68 Suppl 7(?):401-3. doi:
NULL. [PMID: 20960803] - Noura Meklat, Jean-Claude Tabet, Jacques de Ceaurriz. Urine ratio of tetrahydrocortisol to tetrahydrodeoxycortisol to screen for the systemic administration of cortisone and hydrocortisone.
Forensic science international.
2009 Mar; 185(1-3):e13-7. doi:
10.1016/j.forsciint.2008.12.011. [PMID: 19185436] - Helen Imrie, Marie Freel, Bongani M Mayosi, Eleanor Davies, Robert Fraser, Mary Ingram, Heather J Cordell, Martin Farrall, Peter J Avery, Hugh Watkins, Bernard Keavney, John M C Connell. Association between aldosterone production and variation in the 11beta-hydroxylase (CYP11B1) gene.
The Journal of clinical endocrinology and metabolism.
2006 Dec; 91(12):5051-6. doi:
10.1210/jc.2006-1481. [PMID: 16984984] - M Hoshiro, Y Ohno, H Masaki, H Iwase, N Aoki. Comprehensive study of urinary cortisol metabolites in hyperthyroid and hypothyroid patients.
Clinical endocrinology.
2006 Jan; 64(1):37-45. doi:
10.1111/j.1365-2265.2005.02412.x. [PMID: 16402926] - Kazuhito Mizuki, Toshihiko Yanase, Hajime Nawata. [Urinary tetrahydro-11-deoxycortisol (THS)].
Nihon rinsho. Japanese journal of clinical medicine.
2005 Aug; 63 Suppl 8(?):373-5. doi:
NULL. [PMID: 16149532] - Nicola Glorioso, Fabiana Filigheddu, Paolo Pinna Parpaglia, Aldo Soro, Chiara Troffa, Giuseppe Argiolas, Paolo Mulatero. 11beta-Hydroxysteroid dehydrogenase type 2 activity is associated with left ventricular mass in essential hypertension.
European heart journal.
2005 Mar; 26(5):498-504. doi:
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The Journal of clinical endocrinology and metabolism.
2005 Feb; 90(2):1072-7. doi:
10.1210/jc.2004-0870. [PMID: 15522937] - Brian Kennon, Mary C Ingram, Elaine C Friel, Niall H Anderson, Scott M MacKenzie, Eleanor Davies, Loai Shakerdi, A Michael Wallace, Robert Fraser, John M C Connell. Aldosterone synthase gene variation and adrenocortical response to sodium status, angiotensin II and ACTH in normal male subjects.
Clinical endocrinology.
2004 Aug; 61(2):174-81. doi:
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International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.
2004 Jan; 84(1):55-60. doi:
10.1016/s0020-7292(03)00336-9. [PMID: 14698830] - M N Kerstens, H Buter, G J Navis, R P F Dullaart. 11beta-hydroxysteroid dehydrogenase activity in proteinuric patients and the effect of angiotensin-II receptor blockade.
European journal of clinical investigation.
2002 Jul; 32(7):513-8. doi:
10.1046/j.1365-2362.2002.01013.x. [PMID: 12153552] - H Konishi, T Minouchi, A Yamaji. Interference by danazol with the Porter-Silber method for determination of urinary 17-hydroxycorticosteroids.
Annals of clinical biochemistry.
2001 May; 38(Pt 3):277-9. doi:
10.1258/0004563011900524. [PMID: 11392505] - Y Okatani, K Hayashi. [Urinary tetrahydro-11-deoxycortisol (THS)].
Nihon rinsho. Japanese journal of clinical medicine.
1999 Dec; 57 Suppl(?):202-4. doi:
NULL. [PMID: 10778100] - G C Inglis, M C Ingram, C D Holloway, L Swan, D Birnie, W S Hillis, E Davies, R Fraser, J M Connell. Familial pattern of corticosteroids and their metabolism in adult human subjects--the Scottish Adult Twin Study.
The Journal of clinical endocrinology and metabolism.
1999 Nov; 84(11):4132-7. doi:
10.1210/jcem.84.11.6146. [PMID: 10566661] - M Vogeser, T W Felbinger, W Röll, K Jacob. Cortisol metabolism in the postoperative period after cardiac surgery.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.
1999; 107(8):539-46. doi:
10.1055/s-0029-1232563. [PMID: 10612485] - D C Jaggers, W P Collins, S R Milligan. Potent inhibitory effects of steroids in an in vitro model of angiogenesis.
The Journal of endocrinology.
1996 Sep; 150(3):457-64. doi:
10.1677/joe.0.1500457. [PMID: 8882164] - G Tjeerdsma, W J Sluiter, J M Hew, W M Molenaar, W E de Lange, R P Dullaart. Hyperprolactinaemia is associated with a higher prevalence of pituitary-adrenal dysfunction in non-functioning pituitary macroadenoma.
European journal of endocrinology.
1996 Sep; 135(3):299-308. doi:
10.1530/eje.0.1350299. [PMID: 8890720] - S A Wudy, J Homoki, D Haack, D Jung, W Sorgo, W M Teller, P Bartman. Assessment of hypothalamic-pituitary-adrenocortical axis function in dexamethasone treated very low birth weight infants by a single dose metyrapone test and gas chromatographic mass spectrometric determination of urinary steroids.
Journal of pediatric endocrinology & metabolism : JPEM.
1995 Oct; 8(4):281-6. doi:
10.1515/jpem.1995.8.4.281. [PMID: 8821906] - Y Okatani. [Urinary tetrahydro-11-deoxycortisol (THS)].
Nihon rinsho. Japanese journal of clinical medicine.
1995 Mar; 53 Su Pt 2(?):499-501. doi:
NULL. [PMID: 8753290] - A D Proia, A Hirakata, J S McInnes, M W Scroggs, I Parikh. The effect of angiostatic steroids and beta-cyclodextrin tetradecasulfate on corneal neovascularization in the rat.
Experimental eye research.
1993 Dec; 57(6):693-8. doi:
10.1006/exer.1993.1177. [PMID: 7512045] - A P Scott, A V Canario. Plasma levels of ovarian steroids, including 17 alpha,21-dihydroxy-4-pregnene-3,20-dione and 3 alpha,17 alpha,21-trihydroxy-5 beta-pregnan-20-one, in female plaice (Pleuronectes platessa) induced to mature with human chorionic gonadotrophin.
General and comparative endocrinology.
1990 May; 78(2):286-98. doi:
10.1016/0016-6480(90)90015-e. [PMID: 2354768] - S Gröndal, B Eriksson, L Hagenäs, S Werner, T Curstedt. Steroid profile in urine: a useful tool in the diagnosis and follow up of adrenocortical carcinoma.
Acta endocrinologica.
1990 May; 122(5):656-63. doi:
10.1530/acta.0.1220656. [PMID: 2141212] - A V Canario, A P Scott. Identification of, and development of radioimmunoassays for 17 alpha, 21-dihydroxy-4-pregnene-3,20-dione and 3 alpha,17 alpha, 21-trihydroxy-5 beta-pregnan-20-one in the ovaries of mature plaice (Pleuronectes platessa).
General and comparative endocrinology.
1990 May; 78(2):273-85. doi:
10.1016/0016-6480(90)90014-d. [PMID: 2354767] - B Hamborg, H Frey, T Bøhmer, N Norman. [Carcinoma of the adrenal cortex].
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke.
1990 Mar; 110(8):956-9. doi:
NULL. [PMID: 2321225] - Y Sagara, Y Okatani. [Clinical significance of urinary tetrahydro-11-deoxycortisol analysis in endocrine tests of the adrenal cortex].
Nihon rinsho. Japanese journal of clinical medicine.
1989 Dec; 48 Suppl(?):1203-5. doi:
NULL. [PMID: 2560066] - A V Canario, A P Scott. Conjugates of ovarian steroids, including 17 alpha,20 beta-dihydroxy-4-pregnen-3-one (maturation-inducing steroid), accumulate in the urine of a marine teleost (plaice; Pleuronectes platessa).
The Journal of endocrinology.
1989 Oct; 123(1):R1-4. doi:
10.1677/joe.0.123r001. [PMID: 2809483] - A Rösler, N Weshler, E Leiberman, Z Hochberg, J Weidenfeld, J Sack, J Chemke. 11 Beta-hydroxylase deficiency congenital adrenal hyperplasia: update of prenatal diagnosis.
The Journal of clinical endocrinology and metabolism.
1988 Apr; 66(4):830-8. doi:
10.1210/jcem-66-4-830. [PMID: 3346360] - I A Hughes, O Arisaka, L A Perry, J W Honour. Early diagnosis of 11 beta-hydroxylase deficiency in two siblings confirmed by analysis of a novel steroid metabolite in newborn urine.
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1986 Mar; 111(3):349-54. doi:
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JAMA.
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Seminars in arthritis and rheumatism.
1984 Aug; 14(1):1-23. doi:
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1980 Mar; 14(1):3-7. doi:
NULL. [PMID: 6967399] - J R PASQUALINI, M F JAYLE. ISOLATION AND IDENTIFICATION OF 3ALPHA,17ALPHA,21TRIHYDROXY-5ALPHA-PREGNAN-20-ONE (ALLO-TETRAHYDRO-COMPOUND S) AFTER ADMINISTRATION OF 3BETA, 17ALPHA,21-TRIHYDROXYPREGN-5-EN-20-ONE(17ALPHA,21-DIHYDROXYPREGNENOLONE).
The Biochemical journal.
1963 Aug; 88(?):315-8. doi:
10.1042/bj0880315. [PMID: 14063869] - J C TOUCHSTONE, H BULASCHENKO, F C DOHAN. The isolation of 11-dehydrocorticosterone, corticosterone and tetrahydro compound S (pregnane-3 alpha, 17alpha, 21-triol-20-one) from the urine of a man receiving corticotropin.
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