5a-Tetrahydrocorticosterone (BioDeep_00000027579)
human metabolite Endogenous blood metabolite
代谢物信息卡片
化学式: C21H34O4 (350.24569640000004)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 1.15%
分子结构信息
SMILES: CC12CCC(CC1CCC3C2C(CC4(C3CCC4C(=O)CO)C)O)O
InChI: InChI=1S/C21H34O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h12-17,19,22-24H,3-11H2,1-2H3/t12-,13+,14-,15-,16+,17-,19+,20-,21-/m0/s1
描述信息
5a-tetrahydrocorticosterone is highly sensitive to adrenocorticotropic hormone (ACTH) secretion. High levels of 5a-Tetrahydrocorticosterone are a warning sign of hypertension. (PMID: 16597193,7473516).
5a-tetrahydrocorticosterone is highly sensitive to adrenocorticotropic hormone (ACTH) secretion. High levels of 5a-Tetrahydrocorticosterone are a warning sign of hypertension.
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
同义名列表
16 个代谢物同义名
1-[(1S,2S,5R,7S,10S,11S,14S,15S,17S)-5,17-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-14-yl]-2-hydroxyethan-1-one; Tetrahydrocorticosterone, (3alpha,5beta,11alpha)-isomer; Tetrahydrocorticosterone, (3beta,5alpha,11beta)-isomer; 3 beta,11 beta,21-Trihydroxy-5 alpha-pregnan-20-one; Tetrahydrocorticosterone, (3alpha,5alpha)-isomer; Tetrahydrocorticosterone, (3beta,5beta)-isomer; Allopregnane-3 beta,11 beta,21-triol-20-one; Tetrahydrocorticosterone, (5alpha)-isomer; 3a,11b,21-Trihydroxy-5a-pregnan-20-one; 5a-Pregnane-3a,11b,21-triol-20-one; 3a,5a-Tetrahydrocorticosterone; Allotetrahydrocorticosterone; 5a-Tetrahydrocorticosterone; 5Α-tetrahydrocorticosterone; Tetrahydrocorticosterone; AlloTHB
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:89328
- PubChem: 101790
- HMDB: HMDB0000449
- foodb: FDB022053
- chemspider: 91970
- CAS: 600-63-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(1)
- Mineralocorticoid biosynthesis:
5beta-Dihydrocorticosterone ⟶ Tetrahydrocorticosterone
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Emily P McQuarrie, Ellen Marie Freel, Patrick B Mark, Robert Fraser, John M C Connell, Alan G Jardine. Urinary sodium excretion is the main determinant of mineralocorticoid excretion rates in patients with chronic kidney disease.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2013 Jun; 28(6):1526-32. doi:
10.1093/ndt/gft007. [PMID: 23413088] - Shigeo Ikegawa. [Detailed characterization of bile acid and glucocorticoid world by mass spectrometry].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2013; 133(6):661-79. doi:
10.1248/yakushi.13-00099. [PMID: 23728093] - Ildikó Bíró, Anita Bufa, Ferenc Wilhelm, Zoltán Mánfai, Ferenc Kilár, Péter Miklós Gocze. Urinary steroid profile in early pregnancy after in vitro fertilization.
Acta obstetricia et gynecologica Scandinavica.
2012 May; 91(5):625-9. doi:
10.1111/j.1600-0412.2012.01387.x. [PMID: 22375705] - Calum Edward Ninnes, J R Waas, N Ling, S Nakagawa, J C Banks, D G Bell, A Bright, P W Carey, J Chandler, Q J Hudson, J R Ingram, K Lyall, D K J Morgan, M I Stevens, J Wallace, E Möstl. Comparing plasma and faecal measures of steroid hormones in Adelie penguins Pygoscelis adeliae.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology.
2010 Jan; 180(1):83-94. doi:
10.1007/s00360-009-0390-0. [PMID: 19609534] - Alicja Kotłowska, Edmund Maliński, Krzysztof Sworczak, Jolanta Kumirska, Piotr Stepnowski. The urinary steroid profile in patients diagnosed with adrenal incidentaloma.
Clinical biochemistry.
2009 Apr; 42(6):448-54. doi:
10.1016/j.clinbiochem.2008.12.027. [PMID: 19297679] - Molly A H Webb, J Alan Allert, Kevin M Kappenman, Josep Marcos, Grant W Feist, Carl B Schreck, Cedric H Shackleton. Identification of plasma glucocorticoids in pallid sturgeon in response to stress.
General and comparative endocrinology.
2007 Oct; 154(1-3):98-104. doi:
10.1016/j.ygcen.2007.06.002. [PMID: 17632105] - Sang Hee Lee, Han Min Woo, Byung Hwa Jung, Jeongae Lee, Oh Seung Kwon, Hee Soo Pyo, Man Ho Choi, Bong Chul Chung. Metabolomic approach to evaluate the toxicological effects of nonylphenol with rat urine.
Analytical chemistry.
2007 Aug; 79(16):6102-10. doi:
10.1021/ac070237e. [PMID: 17636880] - Viktória Poór, Susan Juricskay, Agnes Gáti, Péter Osváth, Tamás Tényi. Urinary steroid metabolites and 11beta-hydroxysteroid dehydrogenase activity in patients with unipolar recurrent major depression.
Journal of affective disorders.
2004 Jul; 81(1):55-9. doi:
10.1016/s0165-0327(03)00199-x. [PMID: 15183600] - Martin Schumacher, Felix J Frey, Jean-Pierre Montani, Bernhard Dick, Brigitte M Frey, Paolo Ferrari. Salt-sensitivity of blood pressure and decreased 11beta-hydroxysteroid dehydrogenase type 2 activity after renal transplantation.
Transplantation.
2002 Jul; 74(1):66-72. doi:
10.1097/00007890-200207150-00012. [PMID: 12134101] - Bruno Vogt, Bernhard Dick, Hans-Peter Marti, Felix J Frey, Brigitte M Frey. Reduced 11beta-hydroxysteroid dehydrogenase activity in experimental nephrotic syndrome.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2002 May; 17(5):753-8. doi:
10.1093/ndt/17.5.753. [PMID: 11981059] - A Soro, M C Ingram, G Tonolo, N Glorioso, R Fraser. Mildly raised corticosterone excretion rates in patients with essential hypertension.
Journal of human hypertension.
1995 Jun; 9(6):391-3. doi:
. [PMID: 7473516] - J Imperato-McGinley, R E Peterson, T Gautier, A Arthur, C Shackleton. Decreased urinary C19 and C21 steroid 5 alpha-metabolites in parents of male pseudohermaphrodites with 5 alpha-reductase deficiency: detection of carriers.
The Journal of clinical endocrinology and metabolism.
1985 Mar; 60(3):553-8. doi:
10.1210/jcem-60-3-553. [PMID: 3972966] - V I Tropina, N N Sukhareva-Nemakova. [Lipid composition of a Corynebacterium mediolanum culture transforming steroids].
Mikrobiologiia.
1982; 51(5):740-6. doi:
". [PMID: 7176970] - R A Tigranian, L I Voronin. Changes of corticosteroid spectrum in urine in members of crew of spaceship 'Soyuz-22'.
Endocrinologia experimentalis.
1980 Mar; 14(1):3-7. doi:
NULL. [PMID: 6967399] - H D Colby. Mechanism of action of prolactin on adrenocortical steroid secretion in hypophysectomized female rats.
Endocrinology.
1979 May; 104(5):1299-303. doi:
10.1210/endo-104-5-1299. [PMID: 220030] - M Kodama, T Kodama, M Yoshida, R Totania, K Aoki. Hormonal status of breast cancer. II. Abnormal urinary steroid excretion.
Journal of the National Cancer Institute.
1975 Jun; 54(6):1275-82. doi:
10.1093/jnci/54.6.1275. [PMID: 1133844] - N J HOLNESS, C H GRAY. The characterization of tetrahydrocorticosterone and of some alpha beta-unsaturated ketonic compounds simulating adrenal steroid metabolites in urine.
The Journal of endocrinology.
1958 Sep; 17(3):237-47. doi:
10.1677/joe.0.0170237. [PMID: 13587828]