Uroporphyrin I (BioDeep_00001868957)

Main id: BioDeep_00000005941

 


代谢物信息卡片


Uroporphyrin I

化学式: C40H38N4O16 (830.2283)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(CC(=O)O)c1c(CC(=O)O)c2/C=C\3/C(=C(CC(=O)O)C(=N3)/C=c\3/c(CCC(=O)O)c(CC(=O)O)/c(=C/C4=N/C(=C\c1[nH]2)/C(=C4CCC(=O)O)CC(=O)O)/[nH]3)CCC(=O)O
InChI: InChI=1S/C40H38N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h13-16,41-42H,1-12H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60)

描述信息

同义名列表

2 个代谢物同义名

Uroporphyrin I; Uroporphyrin I



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ALB, CAT, CD34, CPOX, ENO1, HMBS, HPGDS, PTK2
Peripheral membrane protein 2 ALAS2, PTK2
Nucleus 4 ALB, ENO1, GATA1, PTK2
cytosol 11 ALB, CAT, CLC, CPOX, ENO1, GSR, HMBS, HPGDS, PTK2, UROD, UROS
centrosome 2 ALB, PTK2
nucleoplasm 3 GATA1, HPGDS, UROD
Cell membrane 3 CD8A, ENO1, PTK2
Cytoplasmic side 1 PTK2
Cytoplasmic granule 1 CLC
cell cortex 2 ENO1, PTK2
cell surface 2 ENO1, EPO
Golgi apparatus 2 ALB, ATRN
Golgi membrane 1 INS
mitochondrial inner membrane 2 ALAS2, FECH
Cytoplasm, cytosol 1 CLC
Lysosome 1 CD34
plasma membrane 6 ATRN, CD34, CD8A, ENO1, GCG, PTK2
Membrane 4 CAT, CD34, CPOX, ENO1
apical plasma membrane 1 CD34
extracellular exosome 6 ALB, ATRN, CAT, ENO1, EPO, GSR
endoplasmic reticulum 1 ALB
extracellular space 7 ALB, ATRN, CLC, ENO1, EPO, GCG, INS
perinuclear region of cytoplasm 2 CD34, PTK2
mitochondrion 6 ALAS2, CAT, CPOX, FECH, GSR, UROS
protein-containing complex 2 ALB, CAT
intracellular membrane-bounded organelle 3 CAT, HPGDS, PTK2
Single-pass type I membrane protein 3 ATRN, CD34, CD8A
Secreted 5 ALB, CLC, EPO, GCG, INS
extracellular region 8 ALB, CAT, CD34, CD8A, CLC, EPO, GCG, INS
[Isoform 2]: Secreted 2 ATRN, CD8A
mitochondrial matrix 4 ALAS2, CAT, FECH, GSR
anchoring junction 2 ALB, PTK2
transcription regulator complex 1 GATA1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 PTK2
external side of plasma membrane 3 CD34, CD8A, GSR
dendritic spine 1 PTK2
Cytoplasm, perinuclear region 1 PTK2
Mitochondrion inner membrane 2 ALAS2, FECH
Cell junction, focal adhesion 1 PTK2
Cytoplasm, cytoskeleton 1 PTK2
focal adhesion 2 CAT, PTK2
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
mitochondrial intermembrane space 1 CPOX
collagen-containing extracellular matrix 1 CLC
nuclear outer membrane 1 ENO1
receptor complex 1 CD8A
ciliary basal body 2 ALB, PTK2
chromatin 1 GATA1
cell projection 1 PTK2
cytoskeleton 1 PTK2
Cytoplasm, cytoskeleton, cilium basal body 1 PTK2
centriole 1 ALB
spindle pole 1 ALB
Cytoplasm, cell cortex 1 PTK2
blood microparticle 1 ALB
[Isoform 3]: Secreted 1 ATRN
intercellular bridge 1 CD34
endosome lumen 1 INS
Cytoplasm, myofibril, sarcomere, M line 1 ENO1
M band 1 ENO1
cell body 1 EPO
stress fiber 1 PTK2
basal plasma membrane 1 CD34
plasma membrane raft 1 CD8A
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 4 CAT, EPO, GCG, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 ALB, GCG, INS
transcription repressor complex 1 GATA1
platelet alpha granule lumen 1 ALB
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
protein-DNA complex 1 GATA1
[Isoform 1]: Cell membrane 2 ATRN, CD8A
CRLF-CLCF1 complex 1 CLC
[Glucagon-like peptide 1]: Secreted 1 GCG
T cell receptor complex 1 CD8A
catalase complex 1 CAT
phosphopyruvate hydratase complex 1 ENO1
[Isoform 4]: Mitochondrion inner membrane 1 ALAS2
CNTFR-CLCF1 complex 1 CLC
glomerular endothelium fenestra 1 CD34
ciliary transition fiber 1 ALB


文献列表

  • Albrecht Pfäfflin. Remarks on the acute intermittent porphyria. Annals of clinical biochemistry. 2009 Jul; 46(Pt 4):347-8; author reply 348. doi: 10.1258/acb.2009.009069. [PMID: 19564164]
  • Ricardo Negroni, Alicia Arechavala, Elena Maiolo. [Clinical cases in medical mycology. Case no. 20]. Revista iberoamericana de micologia. 2006 Jun; 23(2):116-8. doi: 10.1016/s1130-1406(06)70028-6. [PMID: 16854192]
  • C Ged, M Mendez, E Robert, M Lalanne, I Lamrissi-Garcia, P Costet, J Y Daniel, P Dubus, F Mazurier, F Moreau-Gaudry, H de Verneuil. A knock-in mouse model of congenital erythropoietic porphyria. Genomics. 2006 Jan; 87(1):84-92. doi: 10.1016/j.ygeno.2005.08.018. [PMID: 16314073]
  • Peter Bozek, Milan Hutta, Barbora Hrivnáková. Rapid analysis of porphyrins at low ng/l and microg/l levels in human urine by a gradient liquid chromatography method using octadecylsilica monolithic columns. Journal of chromatography. A. 2005 Aug; 1084(1-2):24-32. doi: 10.1016/j.chroma.2005.06.007. [PMID: 16114232]
  • Naomi Shishido, Kenji Nakayama, Masao Nakamura. Porphyrin-induced photooxidation of conjugated bilirubin. Free radical research. 2003 Oct; 37(10):1061-7. doi: 10.1080/10715760310001600381. [PMID: 14703795]
  • Jordi To-Figueras, Dolores Ozalla, Carmen Herrero Mateu. Long-standing changes in the urinary profile of porphyrin isomers after clinical remission of porphyria cutanea tarda. Annals of clinical and laboratory science. 2003; 33(3):251-6. doi: . [PMID: 12956438]
  • Y Ding, B Lin, C W Huie. Binding studies of porphyrins to human serum albumin using affinity capillary electrophoresis. Electrophoresis. 2001 Jul; 22(11):2210-6. doi: 10.1002/1522-2683(20017)22:11<2210::aid-elps2210>3.0.co;2-w. [PMID: 11504054]
  • G Gu, C K Lim. Preparation and separation of hydroxy derivatives of uroporphyrinogen I by high-performance liquid chromatography with electrochemical detection. Journal of chromatography. A. 1996 Jan; 722(1-2):245-8. doi: 10.1016/0021-9673(95)00443-2. [PMID: 9019298]
  • R Guo, W Chai, J M Rideout, A M Lawson, C K Lim. Isolation and characterization of beta-hydroxypropionic acid- and hydroxyacetic acid-uroporphyrin I in the urine of a patient with congenital erythropoietic porphyria by high performance liquid chromatography and liquid secondary ion mass spectrometry. Biomedical chromatography : BMC. 1990 Jul; 4(4):141-3. doi: 10.1002/bmc.1130040404. [PMID: 2207373]
  • D R Bickers, M B Poh-Fitzpatrick. Günther's disease and the changing complexion of human porphyria. Photo-dermatology. 1986 Dec; 3(6):315-6. doi: NULL. [PMID: 3588350]
  • N Bauman, B S Pease. Depletion of complement by light and porphyrin does not depend on sequential activation. Complement (Basel, Switzerland). 1985; 2(2-3):127-32. doi: 10.1159/000467852. [PMID: 4085218]
  • M A El-Far, N R Pimstone. Tumour localization of uroporphyrin isomers I and III and their correlation to albumin and serum protein binding. Cell biochemistry and function. 1983 Oct; 1(3):156-60. doi: 10.1002/cbf.290010307. [PMID: 6678621]
  • F T G PRUNTY. Acute porphyria; investigations on the pathology of the porphyrins and identification of the excretion of uroporphyrin I. Archives of internal medicine (Chicago, Ill. : 1908). 1946 Jun; 77(?):623-42. doi: 10.1001/archinte.1946.00210410029003. [PMID: 20991229]