623-05-2 (BioDeep_00000865335)

Main id: BioDeep_00000000440

 

PANOMIX_OTCML-2023


代谢物信息卡片


InChI=1\C7H8O2\c8-5-6-1-3-7(9)4-2-6\h1-4,8-9H,5H

化学式: C7H8O2 (124.0524)
中文名称: 对羟基苯甲醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CC=C1CO)O
InChI: InChI=1S/C7H8O2/c8-5-6-1-3-7(9)4-2-6/h1-4,8-9H,5H2

描述信息

4-Hydroxybenzyl alcohol is a phenolic compound widely distributed in various kinds of plants. Anti-inflammatory, anti-oxidant, anti-nociceptive activity. Neuroprotective effect. Inhibitor of tumor angiogenesis and growth[1][2][3][4].
4-Hydroxybenzyl alcohol is a phenolic compound widely distributed in various kinds of plants. Anti-inflammatory, anti-oxidant, anti-nociceptive activity. Neuroprotective effect. Inhibitor of tumor angiogenesis and growth[1][2][3][4].

同义名列表

27 个代谢物同义名

InChI=1\C7H8O2\c8-5-6-1-3-7(9)4-2-6\h1-4,8-9H,5H; Benzenemethanol, 4-hydroxy- (9CI); Benzyl alcohol, p-hydroxy- (8CI); Benzenemethanol, 4-hydroxy-; Benzyl alcohol, p-hydroxy-; 4-Hydroxybenzenemethanol; .alpha.-Hydroxy-p-cresol; 4-HYDROXY-BENZYL-ALCOHOL; p-hydroxybenzyl alcohol; p-(Hydroxymethyl)phenol; 4-Hydroxybenzyl alcohol; 4-(Hydroxymethyl)phenol; alpha-Hydroxy-p-cresol; p-Methylolphenol; EINECS 210-768-0; 4-Methylolphenol; W398705_ALDRICH; H20806_ALDRICH; ZINC00388762; 54860_FLUKA; NSC 227926; CCRIS 5114; ST5331811; NSC227926; 623-05-2; p-Hydroxybenzyl alcohol; 4-Hydroxybenzyl alcohol



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

22 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ANG, BCL2, BDNF, CASP3, CASP9, DCX, MAPK8, PRKAA2, SIRT1, SRARP, TYR, VEGFA
Endoplasmic reticulum membrane 2 BCL2, HMOX1
Nucleus 12 ANG, BCL2, CASP3, CASP9, GABPA, HMOX1, MAPK8, MKI67, PRKAA2, SIRT1, SRARP, VEGFA
cytosol 10 ANG, BCL2, CASP3, CASP9, DCX, HMOX1, LIPE, MAPK8, PRKAA2, SIRT1
dendrite 3 BDNF, HTR1A, PRKAA2
nuclear body 1 MKI67
nucleoplasm 7 CASP3, GABPA, HMOX1, MAPK8, MKI67, PRKAA2, SIRT1
Cell membrane 3 HTR1A, LIPE, TNF
Cytoplasmic side 1 HMOX1
Multi-pass membrane protein 1 HTR1A
Synapse 2 HTR1A, MAPK8
cell surface 2 TNF, VEGFA
glutamatergic synapse 2 CASP3, DCX
Golgi apparatus 3 GDNF, PRKAA2, VEGFA
growth cone 1 ANG
neuronal cell body 4 ANG, CASP3, PRKAA2, TNF
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 1 LIPE
Lysosome 1 TYR
plasma membrane 2 HTR1A, TNF
Membrane 7 BCL2, BDNF, HMOX1, LIPE, MKI67, PRKAA2, VEGFA
axon 3 BDNF, MAPK8, PRKAA2
caveola 1 LIPE
endoplasmic reticulum 3 BCL2, HMOX1, VEGFA
extracellular space 7 ANG, BDNF, GDNF, HMOX1, PNLIP, TNF, VEGFA
perinuclear region of cytoplasm 3 BDNF, HMOX1, TYR
adherens junction 1 VEGFA
mitochondrion 3 BCL2, CASP9, SIRT1
protein-containing complex 2 BCL2, CASP9
intracellular membrane-bounded organelle 1 TYR
postsynaptic density 1 CASP3
chromatin silencing complex 1 SIRT1
Single-pass type I membrane protein 1 TYR
Secreted 5 ANG, BDNF, GDNF, PNLIP, VEGFA
extracellular region 6 ANG, BDNF, GDNF, PNLIP, TNF, VEGFA
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, HMOX1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 ANG
nucleolus 3 ANG, MKI67, SIRT1
Melanosome membrane 1 TYR
Golgi-associated vesicle 1 TYR
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
heterochromatin 1 SIRT1
Membrane raft 1 TNF
pore complex 1 BCL2
microtubule 1 DCX
extracellular matrix 1 VEGFA
basement membrane 1 ANG
Nucleus, PML body 1 SIRT1
PML body 1 SIRT1
secretory granule 1 VEGFA
nuclear speck 1 PRKAA2
nuclear inner membrane 1 SIRT1
Cell projection, neuron projection 1 DCX
neuron projection 1 DCX
chromatin 2 GABPA, SIRT1
microtubule associated complex 1 DCX
phagocytic cup 1 TNF
Chromosome 2 ANG, MKI67
cytoskeleton 1 DCX
Nucleus, nucleolus 2 ANG, MKI67
fibrillar center 1 SIRT1
nuclear envelope 1 SIRT1
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
Cell projection, dendrite 1 HTR1A
Melanosome 1 TYR
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 2 ANG, PRKAA2
euchromatin 1 SIRT1
myelin sheath 1 BCL2
endoplasmic reticulum lumen 1 BDNF
platelet alpha granule lumen 1 VEGFA
endocytic vesicle 1 ANG
Single-pass type IV membrane protein 1 HMOX1
apoptosome 1 CASP9
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
eNoSc complex 1 SIRT1
rDNA heterochromatin 1 SIRT1
nucleotide-activated protein kinase complex 1 PRKAA2
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
angiogenin-PRI complex 1 ANG
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
caspase complex 1 CASP9
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[SirtT1 75 kDa fragment]: Cytoplasm 1 SIRT1


文献列表

  • Prativa Chhetri, L M Dandurand, I Popova. Control of Globodera pallida Using Sinapis alba or 4-Hydroxybenzyl Alcohol with the Trap Crop Solanum sisymbriifolium or the Biofumigant Brassica juncea Seed Meal Extract. Plant disease. 2023 May; 107(5):1491-1498. doi: 10.1094/pdis-06-22-1280-re. [PMID: 36320132]
  • Sha Wu, Rong Huang, Ruiqin Zhang, Chuang Xiao, Lueli Wang, Min Luo, Na Song, Jie Zhang, Fang Yang, Xuan Liu, Weimin Yang. Gastrodin and Gastrodigenin Improve Energy Metabolism Disorders and Mitochondrial Dysfunction to Antagonize Vascular Dementia. Molecules (Basel, Switzerland). 2023 Mar; 28(6):. doi: 10.3390/molecules28062598. [PMID: 36985572]
  • Rui Cheng, Tian-Rui Liu, Yang-Hua Li, Jun-Hui Zhou, Yu-Yang Zhao, Yuan Yuan. [Screening of an Armillaria gallica strain for Gastrodia elata cultivation]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Jan; 48(2):374-381. doi: 10.19540/j.cnki.cjcmm.20221014.101. [PMID: 36725227]
  • Mingchun Liao, Congyong Sun, Ran Li, Wenjing Li, Zhumei Ge, Michael Adu-Frimpong, Ximing Xu, Jiangnan Yu. Amelioration action of gastrodigenin rhamno-pyranoside from Moringa seeds on non-alcoholic fatty liver disease. Food chemistry. 2022 Jun; 379(?):132087. doi: 10.1016/j.foodchem.2022.132087. [PMID: 35086000]
  • Di Zhang, Hong-Yan Zhu, Xing-Bo Bian, Yan Zhao, Pu Zang, Yu-Gang Gao, Lian-Xue Zhang. The antidepressant effect of 4-hydroxybenzyl alcohol 2-naphthoate through monoaminergic, GABAergic system and BDNF signaling pathway. Natural product research. 2020 Aug; 34(16):2328-2331. doi: 10.1080/14786419.2018.1531862. [PMID: 30580589]
  • Yahui Mi, Siyu Guo, Huan Cheng, Mingping Liu, Pinqing Wei, Meijing Wang, Yukang Mao, Guohan Ke. Pharmacokinetic comparative study of tetramethylpyrazine and ferulic acid and their compatibility with different concentration of gastrodin and gastrodigenin on blood-stasis migraine model by blood-brain microdialysis method. Journal of pharmaceutical and biomedical analysis. 2020 Jan; 177(?):112885. doi: 10.1016/j.jpba.2019.112885. [PMID: 31563759]
  • Zhi-Long Zhang, Yu-Gang Gao, Pu Zang, Pei-Pei Gu, Yan Zhao, Zhong-Mei He, Hong-Yan Zhu. [Research progress on mechanism of gastrodin and p-hydroxybenzyl alcohol on central nervous system]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2020 Jan; 45(2):312-320. doi: 10.19540/j.cnki.cjcmm.20190730.401. [PMID: 32237313]
  • Yahui Mi, Yukang Mao, Huan Cheng, Guohan Ke, Mingping Liu, Chunping Fang, Qian Wang. Studies of blood-brain barrier permeability of gastrodigenin in vitro and in vivo. Fitoterapia. 2020 Jan; 140(?):104447. doi: 10.1016/j.fitote.2019.104447. [PMID: 31805306]
  • Chih-Sheng Yang, Ming-Chi Lai, Ping-Yen Liu, Yi-Ching Lo, Chin-Wei Huang, Sheng-Nan Wu. Characterization of the Inhibitory Effect of Gastrodigenin and Gastrodin on M-type K+ Currents in Pituitary Cells and Hippocampal Neurons. International journal of molecular sciences. 2019 Dec; 21(1):. doi: 10.3390/ijms21010117. [PMID: 31877994]
  • Juan Antonio Méndez-Líter, Isabel Tundidor, Manuel Nieto-Domínguez, Beatriz Fernández de Toro, Andrés González Santana, Laura Isabel de Eugenio, Alicia Prieto, Juan Luis Asensio, Francisco Javier Cañada, Cristina Sánchez, María Jesús Martínez. Transglycosylation products generated by Talaromyces amestolkiae GH3 β-glucosidases: effect of hydroxytyrosol, vanillin and its glucosides on breast cancer cells. Microbial cell factories. 2019 May; 18(1):97. doi: 10.1186/s12934-019-1147-4. [PMID: 31151435]
  • Minhui Hu, Hui Yan, Yuanyuan Fu, Yulan Jiang, Weifeng Yao, Sheng Yu, Li Zhang, Qinan Wu, Anwei Ding, Mingqiu Shan. Optimal Extraction Study of Gastrodin-Type Components from Gastrodia Elata Tubers by Response Surface Design with Integrated Phytochemical and Bioactivity Evaluation. Molecules (Basel, Switzerland). 2019 Feb; 24(3):. doi: 10.3390/molecules24030547. [PMID: 30717352]
  • Jun-Hui Choi, Soo-Hwan Yeo, Myung-Kon Kim, Hyo-Jeong Lee, Seung Kim. p-Hydroxybenzyl alcohol inhibits four obesity-related enzymes in vitro. Journal of biochemical and molecular toxicology. 2018 Dec; 32(12):e22223. doi: 10.1002/jbt.22223. [PMID: 30273962]
  • Wang Bing, Sun Yan-Tao, Pei Zhi-Dong, Kang Ting-Guo, Zhang Hui. Pharmacokinetic and tissue distributions study of adenosine, 4-hydroxybenzyl alcohol and Parishin C from Gastrodia elata extract in rats. Pakistan journal of pharmaceutical sciences. 2018 Sep; 31(5(Supplementary)):2053-2060. doi: . [PMID: 30393212]
  • Chunlan Tang, Bingchu Wu, Jinyi Wu, Zheng Zhang, Bocheng Yu. Novel Strategies Using Total Gastrodin and Gastrodigenin, or Total Gastrodigenin for Quality Control of Gastrodia elata. Molecules (Basel, Switzerland). 2018 Jan; 23(2):. doi: 10.3390/molecules23020270. [PMID: 29382151]
  • Yang Liu, Gangliang Huang. The Content Analysis of Gastrodin and Gastrodigenin Obtained by Different Processing Methods. Journal of chromatographic science. 2018 Jan; 56(1):65-67. doi: 10.1093/chromsci/bmx085. [PMID: 29036301]
  • Wei-Cheng Chen, Yi-Syuan Lai, Shih-Hang Lin, Kuan-Hung Lu, Yu-En Lin, Suraphan Panyod, Chi-Tang Ho, Lee-Yan Sheen. Anti-depressant effects of Gastrodia elata Blume and its compounds gastrodin and 4-hydroxybenzyl alcohol, via the monoaminergic system and neuronal cytoskeletal remodeling. Journal of ethnopharmacology. 2016 Apr; 182(?):190-9. doi: 10.1016/j.jep.2016.02.001. [PMID: 26899441]
  • Evelyn Auyeung, William Morris, Joseph E Mondloch, Joseph T Hupp, Omar K Farha, Chad A Mirkin. Controlling structure and porosity in catalytic nanoparticle superlattices with DNA. Journal of the American Chemical Society. 2015 Feb; 137(4):1658-62. doi: 10.1021/ja512116p. [PMID: 25611764]
  • Lung-Yuan Wu, Wang-Chuan Chen, Fan-Shiu Tsai, Chin-Chuan Tsai, Chi-Rei Wu, Li-Wei Lin. p-Hydroxybenzyl Alcohol, an Active Phenolic Ingredient of Gastrodia elata, Reverses the Cycloheximide-Induced Memory Deficit by Activating the Adrenal Gland in Rats. The American journal of Chinese medicine. 2015; 43(8):1593-604. doi: 10.1142/s0192415x15500901. [PMID: 26621444]
  • Yuanwei Jia, Xin Li, Haitang Xie, Jie Shen, Jun Luo, Junsong Wang, Kelvin D G Wang, Qingwang Liu, Lingyi Kong. Analysis and pharmacokinetics studies of gastrodin and p-hydroxybenzyl alcohol in dogs using ultra fast liquid chromatography-tandem mass spectrometry method. Journal of pharmaceutical and biomedical analysis. 2014 Oct; 99(?):83-8. doi: 10.1016/j.jpba.2014.07.004. [PMID: 25108372]
  • Yuanwei Jia, Jie Shen, Xin Li, Haitang Xie, Junsong Wang, Jun Luo, Kelvin D G Wang, Qingwang Liu, Lingyi Kong. Identification and analysis of gastrodin and its five metabolites using ultra fast liquid chromatography electrospray ionization tandem mass spectrometry to investigate influence of multiple-dose and food. Journal of chromatography. A. 2014 Sep; 1358(?):110-6. doi: 10.1016/j.chroma.2014.06.080. [PMID: 25022479]
  • Qin Zheng, Wen-Hai Xiong, Jia-Yu Liu, Ya-Qin Wang, Peng-Yi Hu, Shuang Hu, Xin Xue, Ming Yang. [Study on effect of combined application on distribution of gastrodigenin in rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2013 Oct; 38(19):3368-72. doi: ". [PMID: 24422410]
  • Xiao-Hua Duan, Zi-Lei Li, Da-Song Yang, Feng-Lei Zhang, Qing Lin, Rong Dai. [Study on the chemical constituents of Gastrodia elata]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2013 Oct; 36(10):1608-11. doi: . [PMID: 24761669]
  • Linlin Fan, Yachen Dong, Tengyang Xu, Haifeng Zhang, Qihe Chen. Gastrodin production from p-2-hydroxybenzyl alcohol through biotransformation by cultured cells of Aspergillus foetidus and Penicillium cyclopium. Applied biochemistry and biotechnology. 2013 May; 170(1):138-48. doi: 10.1007/s12010-013-0166-6. [PMID: 23483410]
  • Juan Huang, Hui Luo, Yun Gong, Zhongqiu Liu, Zheng Cai. [Intestinal absorption characteristics of gastrodigenin in rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Mar; 37(6):858-61. doi: ". [PMID: 22715738]
  • Byung-Wook Kim, Sushruta Koppula, Jae-Won Kim, Hyung-Woo Lim, Jin-Woo Hwang, In-Su Kim, Pyo-Jam Park, Dong-Kug Choi. Modulation of LPS-stimulated neuroinflammation in BV-2 microglia by Gastrodia elata: 4-hydroxybenzyl alcohol is the bioactive candidate. Journal of ethnopharmacology. 2012 Jan; 139(2):549-57. doi: 10.1016/j.jep.2011.11.048. [PMID: 22155394]
  • M W Laschke, A E Vorsterman van Oijen, C Scheuer, M D Menger. In vitro and in vivo evaluation of the anti-angiogenic actions of 4-hydroxybenzyl alcohol. British journal of pharmacology. 2011 Jun; 163(4):835-44. doi: 10.1111/j.1476-5381.2011.01292.x. [PMID: 21366552]
  • Ling-Ling Yu, Wei-Cheng Hu, Gang Ding, Rong-Tao Li, Jian-He Wei, Zhong-Mei Zou, Myeong-Hyeon Wang. Gusanlungionosides A-D, potential tyrosinase inhibitors from Arcangelisia gusanlung. Journal of natural products. 2011 May; 74(5):1009-14. doi: 10.1021/np100900k. [PMID: 21500777]
  • Ursula Kües, Martin Rühl. Multiple multi-copper oxidase gene families in basidiomycetes - what for?. Current genomics. 2011 Apr; 12(2):72-94. doi: 10.2174/138920211795564377. [PMID: 21966246]
  • Thomas Louveau, Celine Leitao, Sol Green, Cyril Hamiaux, Benoît van der Rest, Odile Dechy-Cabaret, Ross G Atkinson, Christian Chervin. Predicting the substrate specificity of a glycosyltransferase implicated in the production of phenolic volatiles in tomato fruit. The FEBS journal. 2011 Jan; 278(2):390-400. doi: 10.1111/j.1742-4658.2010.07962.x. [PMID: 21166996]
  • Zhenggang Yue, Jiachen Zi, Chenggen Zhu, Sheng Lin, Yongchun Yang, Jiangong Shi. [Constituents of Gymnadenia conopsea]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2010 Nov; 35(21):2852-61. doi: . [PMID: 21322946]
  • Krishna K Sharma, Ramesh C Kuhad. Genetic transformation of lignin degrading fungi facilitated by Agrobacterium tumefaciens. BMC biotechnology. 2010 Sep; 10(?):67. doi: 10.1186/1472-6750-10-67. [PMID: 20836896]
  • Niloufar Choubdar, Shuliu Li, Richard A Holley. Supercritical fluid chromatography of myrosinase reaction products in ground yellow mustard seed oil. Journal of food science. 2010 May; 75(4):C341-5. doi: 10.1111/j.1750-3841.2010.01584.x. [PMID: 20546392]
  • Haihui Xie, Yaoguang Liang, Jinghua Xue, Qiaolin Xu, Yueming Jiang, Xiaoyi Wei. Secondary metabolites of the phytopathogen Peronophythora litchii. Natural product communications. 2010 Feb; 5(2):245-8. doi: ". [PMID: 20334136]
  • Wen-Jun Dai, Jiao Wu, Zhuang Han, Wen-Li Mei, Hao-Fu Dai. Metabolites from endophytic fungus S20 of Cephalotaxus hainanensis. Journal of Asian natural products research. 2009 Aug; 11(8):704-9. doi: 10.1080/10286020902858846. [PMID: 20183311]
  • Elodie Descamps, Maud Petrault-Laprais, Pierre Maurois, Nicole Pages, Pierre Bac, Régis Bordet, Joseph Vamecq. Experimental stroke protection induced by 4-hydroxybenzyl alcohol is cancelled by bacitracin. Neuroscience research. 2009 Jun; 64(2):137-42. doi: 10.1016/j.neures.2009.02.005. [PMID: 19428693]
  • Luigi Gennari, Daniela Merlotti, Vincenzo De Paola, Giuseppe Martini, Ranuccio Nuti. Bazedoxifene for the prevention of postmenopausal osteoporosis. Therapeutics and clinical risk management. 2008 Dec; 4(6):1229-42. doi: 10.2147/tcrm.s3476. [PMID: 19337430]
  • Lei-Chwen Lin, Yen-Fei Chen, Wen-Chuan Lee, Yu-Tse Wu, Tung-Hu Tsai. Pharmacokinetics of gastrodin and its metabolite p-hydroxybenzyl alcohol in rat blood, brain and bile by microdialysis coupled to LC-MS/MS. Journal of pharmaceutical and biomedical analysis. 2008 Nov; 48(3):909-17. doi: 10.1016/j.jpba.2008.07.013. [PMID: 18757149]
  • W Zhang, Y X Sheng, J L Zhang. Determination and pharmacokinetics of gastrodin and p-hydroxybenzylalcohol after oral administration of Gastrodia elata Bl. extract in rats by high-performance liquid chromatography-electrospray ionization mass spectrometric method. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2008 Oct; 15(10):844-50. doi: 10.1016/j.phymed.2008.02.012. [PMID: 18407483]
  • Zheng Cai, Shi-Xiang Hou, Zhao-Xiang Yang, Xiang-Rong Song, Qiu-Hong Chen, Yuan-Bo Li, Bin-Bin Zhao. [Brain targeting of gastrodin nasal in situ gel]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 2008 May; 39(3):438-40. doi: NULL. [PMID: 18575335]
  • Shiuan-Pey Lin, Shang-Yuan Tsai, Yun-Lian Lin, Sheng-Chu Kuo, Yu-Chi Hou, Pei-Dawn Lee Chao. Biotransformation and pharmacokinetics of 4-(3,4-dihydroxybenzoyloxymethyl)phenyl-O-beta-D-glucopyranoside, an antioxidant isolated from Origanum vulgare. Journal of agricultural and food chemistry. 2008 Apr; 56(8):2852-6. doi: 10.1021/jf703730e. [PMID: 18376843]
  • Zheng Cai, Shixiang Hou, Yuanbo Li, Binbin Zhao, Zhaoxiang Yang, Shuguang Xu, Junxue Pu. Effect of borneol on the distribution of gastrodin to the brain in mice via oral administration. Journal of drug targeting. 2008 Feb; 16(2):178-84. doi: 10.1080/10611860701794395. [PMID: 18274938]
  • Qiao Wang, Guoshen Chen, Su Zeng. Distribution and metabolism of gastrodin in rat brain. Journal of pharmaceutical and biomedical analysis. 2008 Jan; 46(2):399-404. doi: 10.1016/j.jpba.2007.10.017. [PMID: 18053670]
  • Hyeon Ju Kim, In Koo Hwang, Moo Ho Won. Vanillin, 4-hydroxybenzyl aldehyde and 4-hydroxybenzyl alcohol prevent hippocampal CA1 cell death following global ischemia. Brain research. 2007 Nov; 1181(?):130-41. doi: 10.1016/j.brainres.2007.08.066. [PMID: 17945203]
  • Niels Agerbirk, Carl Erik Olsen, Henrik Bak Topbjerg, Jens Christian Sørensen. Host plant-dependent metabolism of 4-hydroxybenzylglucosinolate in Pieris rapae: substrate specificity and effects of genetic modification and plant nitrile hydratase. Insect biochemistry and molecular biology. 2007 Nov; 37(11):1119-30. doi: 10.1016/j.ibmb.2007.06.009. [PMID: 17916498]
  • B N Shyamala, M Madhava Naidu, G Sulochanamma, P Srinivas. Studies on the antioxidant activities of natural vanilla extract and its constituent compounds through in vitro models. Journal of agricultural and food chemistry. 2007 Sep; 55(19):7738-43. doi: 10.1021/jf071349+. [PMID: 17715988]
  • Ying Yuan, Wei-Dong Zhang, Chuan Zhang, Run-Hui Liu, Juan Su, Hui-Zi Jin. [Studies on chemical constituents from root of Cynanchum atratum]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2007 Sep; 32(18):1895-8. doi: . [PMID: 18051900]
  • Xiao-Dong Yang, Jie Zhu, Rong Yang, Jing-Ping Liu, Liang Li, Hong-Bin Zhang. Phenolic constituents from the rhizomes of Gastrodia elata. Natural product research. 2007 Feb; 21(2):180-6. doi: 10.1080/14786410601081997. [PMID: 17365706]
  • Arun Kumar Sinha, Subash Chandra Verma, Upendra Kumar Sharma. Development and validation of an RP-HPLC method for quantitative determination of vanillin and related phenolic compounds in Vanilla planifolia. Journal of separation science. 2007 Jan; 30(1):15-20. doi: 10.1002/jssc.200600193. [PMID: 17313136]
  • Min Cai, Yan Zhou, Suolang Gesang, Ciren Bianba, Li-Sheng Ding. Chemical fingerprint analysis of rhizomes of Gymnadenia conopsea by HPLC-DAD-MSn. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2006 Dec; 844(2):301-7. doi: 10.1016/j.jchromb.2006.07.043. [PMID: 16934540]
  • Ji Yun Lee, Young Woon Jang, Hyo Sook Kang, Hee Moon, Sang Soo Sim, Chang Jong Kim. Anti-inflammatory action of phenolic compounds from Gastrodia elata root. Archives of pharmacal research. 2006 Oct; 29(10):849-58. doi: 10.1007/bf02973905. [PMID: 17121179]
  • Jia-Shun Gong, Wei-Peng Ma, Jun-Xue Pu, Shu-Guan Xu, Shuang-Qing Zheng, Chun-Jie Xiao. [The production of gastrodin through biotransformation of p-hydroxybenzaldehyde by cell suspension culture of Datura stramonium]. Yao xue xue bao = Acta pharmaceutica Sinica. 2006 Oct; 41(10):963-6. doi: ". [PMID: 17184114]
  • Ji Wook Jung, Byung Hoon Yoon, Hye Rim Oh, Jae-Hyeong Ahn, Sun Yeou Kim, Sang-Yong Park, Jong Hoon Ryu. Anxiolytic-like effects of Gastrodia elata and its phenolic constituents in mice. Biological & pharmaceutical bulletin. 2006 Feb; 29(2):261-5. doi: 10.1248/bpb.29.261. [PMID: 16462028]
  • Luis B Rojas, Stéphane Quideau, Patrick Pardon, Zoubida Charrouf. Colorimetric evaluation of phenolic content and GC-MS characterization of phenolic composition of alimentary and cosmetic argan oil and press cake. Journal of agricultural and food chemistry. 2005 Nov; 53(23):9122-7. doi: 10.1021/jf051082j. [PMID: 16277411]
  • Seong Jin Yu, Ju Ran Kim, Chae Kwan Lee, Jeong Eun Han, Jae Hyun Lee, Hye-Sook Kim, Jeong Hwa Hong, Sung Goo Kang. Gastrodia elata blume and an active component, p-hydroxybenzyl alcohol reduce focal ischemic brain injury through antioxidant related gene expressions. Biological & pharmaceutical bulletin. 2005 Jun; 28(6):1016-20. doi: 10.1248/bpb.28.1016. [PMID: 15930737]
  • Sheng-Yang Huang, Guo-Qiang Li, Jian-Gong Shi, Shun-Yan Mo. Chemical constituents of the rhizomes of Coeloglossum viride var. bracteatum. Journal of Asian natural products research. 2004 Mar; 6(1):49-61. doi: 10.1080/1028602031000119826. [PMID: 14989381]
  • Toshihiro Kobayashi, Katsumi Higashi, Hiroshi Kamada. 4-Hydroxybenzyl alcohol accumulates in flowers and developing fruits of carrot and inhibits seed formation. Journal of plant physiology. 2003 Jun; 160(6):713-6. doi: 10.1078/0176-1617-00967. [PMID: 12872494]
  • Hye-Dong Yoo, Sharon O Ketchum, Dennis France, Ken Bair, William H Gerwick. Vidalenolone, a novel phenolic metabolite from the tropical red alga Vidalia sp. Journal of natural products. 2002 Jan; 65(1):51-3. doi: 10.1021/np010319c. [PMID: 11809064]
  • J H Ha, S M Shin, S K Lee, J S Kim, U S Shin, K Huh, J A Kim, C S Yong, N J Lee, D U Lee. In vitro effects of hydroxybenzaldehydes from Gastrodia elata and their analogues on GABAergic neurotransmission, and a structure-activity correlation. Planta medica. 2001 Dec; 67(9):877-80. doi: 10.1055/s-2001-18844. [PMID: 11745032]
  • Y Cao, X Zhang, Y Fang, J Ye. Determination of the active ingredients in Gastrodia rhizoma by capillary electrophoresis with electrochemical detection. The Analyst. 2001 Sep; 126(9):1524-8. doi: 10.1039/b103653j. [PMID: 11592643]
  • R Debowska, A Podstolski. Properties of diphenolase from Vanilla planifolia (Andr.) shoot primordia cultured in vitro. Journal of agricultural and food chemistry. 2001 Jul; 49(7):3432-7. doi: 10.1021/jf001180z. [PMID: 11453787]
  • M J Mayer, A Narbad, A J Parr, M L Parker, N J Walton, F A Mellon, A J Michael. Rerouting the plant phenylpropanoid pathway by expression of a novel bacterial enoyl-CoA hydratase/lyase enzyme function. The Plant cell. 2001 Jul; 13(7):1669-82. doi: 10.1105/tpc.010063. [PMID: 11449058]
  • H X Li, M Y Ding, J Y Yu. Simultaneous determination of p-hydroxybenzaldehyde, p-hydroxybenzyl alcohol, 4-(beta-D-glucopyranosyloxy)-benzyl alcohol, and sugars in Gastrodia elata blume measured as their acetylated derivatives by GC-MS. Journal of chromatographic science. 2001 Jun; 39(6):251-4. doi: 10.1093/chromsci/39.6.251. [PMID: 11396690]
  • S Buskov, J Hasselstrøm, C E Olsen, H Sørensen, J C Sørensen, S Sørensen. Supercritical fluid chromatography as a method of analysis for the determination of 4-hydroxybenzylglucosinolate degradation products. Journal of biochemical and biophysical methods. 2000 Jul; 43(1-3):157-74. doi: 10.1016/s0165-022x(00)00081-6. [PMID: 10869674]
  • T Kobayashi, K Higashi, K Sasaki, T Asami, S Yoshida, H Kamada. Purification from conditioned medium and chemical identification of a factor that inhibits somatic embryogenesis in carrot. Plant & cell physiology. 2000 Mar; 41(3):268-73. doi: 10.1093/pcp/41.3.268. [PMID: 10805589]
  • C R Wu, M T Hsieh, S C Huang, W H Peng, Y S Chang, C F Chen. Effects of Gastrodia elata and its active constituents on scopolamine-induced amnesia in rats. Planta medica. 1996 Aug; 62(4):317-21. doi: 10.1055/s-2006-957892. [PMID: 8792662]
  • J You, T Tan, A Kuang, Y Zhong, S He. [Biodistribution and metabolism of 3H-gastrodigenin and 3H-gastrodin in mice]. Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao. 1994 Sep; 25(3):325-8. doi: NULL. [PMID: 7896254]
  • J Liu, A Mori. Antioxidant and pro-oxidant activities of p-hydroxybenzyl alcohol and vanillin: effects on free radicals, brain peroxidation and degradation of benzoate, deoxyribose, amino acids and DNA. Neuropharmacology. 1993 Jul; 32(7):659-69. doi: 10.1016/0028-3908(93)90079-i. [PMID: 7689708]
  • L Li, Q Zhu. [A trial of utilizing TDP (specific electromagnetic wave) in cultivating Gastrodia elata Bl]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 1990 Aug; 15(8):463-5, 511. doi: ". [PMID: 2093317]