ST 21:2;O2 (BioDeep_00000637533)

 

Secondary id: BioDeep_00000002837, BioDeep_00000002838, BioDeep_00000014926, BioDeep_00000604016, BioDeep_00001867973, BioDeep_00001868341, BioDeep_00001868641

PANOMIX_OTCML-2023 Volatile Flavor Compounds


代谢物信息卡片


Pregn-4-en-3-one,20-hydroxy-, (20S)-

化学式: C21H32O2 (316.24021719999996)
中文名称: 20β-二氢黄体酮, 二氢孕酮, 二氢黄体酮
谱图信息: 最多检出来源 Viridiplantae(plant) 0.17%

分子结构信息

SMILES: C1CC2[C@@](C)([C@@]3([H])CC[C@@]4(C)[C@@]([H])(CC[C@@]4(C(C)O)[H])[C@]13[H])CCC(=O)C=2
InChI: InChI=1S/C21H32O2/c1-4-21(23)12-9-18-16-6-5-14-13-15(22)7-10-19(14,2)17(16)8-11-20(18,21)3/h13,16-18,23H,4-12H2,1-3H3/t16-,17+,18+,19+,20+,21+/m1/s1

描述信息

D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D011372 - Progestins
5a-Pregnane-3,20-dione is the endogenous progesterone metabolite.

同义名列表

33 个代谢物同义名

Ethyltestosterone; ST 21:2;O2; 5-alpha-dihydroprogesterone; 5alpha-pregnane-3,20-dione; 3,20-dioxo-5alpha-pregnane; 5alpha-dihydroprogesterone; 5α-Dihydroprogesterone; 3,20-allopregnanedione; Pregn-4-en-3-one,20-hydroxy-, (20S)-; (20R)-20-hydroxypregn-4-en-3-one; (20S)-20-hydroxypregn-4-en-3-one; 20alpha-Hydroxy-4-pregnen-3-one; 20alpha-Hydroxypregn-4-en-3-one; (S)-20-Hydroxypregn-4-en-3-one; 20alpha-Hydroxyprogesterone; 20alpha-dihydroprogesterone; dihydroprogesterone; 20beta-hydroxypregn-4-en-3-one; 20beta-hydroxy-4-pregnen-3-one; 20R-hydroxypregn-4-en-3-one; 20beta-dihydroprogesterone; 20-hydroxypregn-4-en-3-one; 20-hydroxy-4-pregnen-3-one; 20-dihydroprogesterone; (5BETA)-PREGNANE-3,20-DIONE; 5beta-dihydroprogesterone; 5beta-pregnane-3,20-dione; 5beta-pregnan-3,20-dione; 3,20-pregnanedione; 5a-Pregnane-3,20-dione; 5alpha-Pregnane-3,20-dione; 20alpha-Hydroxy-4-pregnen-3-one; 5beta-Pregnane-3,20-dione



数据库引用编号

54 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(1)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Cecilia Rustichelli, Emanuela Monari, Rossella Avallone, Elisa Bellei, Stefania Bergamini, Aldo Tomasi, Anna Ferrari. Dehydroepiandrosterone sulfate, dehydroepiandrosterone, 5α-dihydroprogesterone and pregnenolone in women with migraine: Analysis of serum levels and correlation with age, migraine years and frequency. Journal of pharmaceutical and biomedical analysis. 2021 Nov; 206(?):114388. doi: 10.1016/j.jpba.2021.114388. [PMID: 34597839]
  • Kristina M Deligiannidis, Aimee R Kroll-Desrosiers, Yanglan Tan, Michelle L Dubuke, Scott A Shaffer. Longitudinal proneuroactive and neuroactive steroid profiles in medication-free women with, without and at-risk for perinatal depression: A liquid chromatography-tandem mass spectrometry analysis. Psychoneuroendocrinology. 2020 11; 121(?):104827. doi: 10.1016/j.psyneuen.2020.104827. [PMID: 32828068]
  • Jie Wang, Xiang-Zhong Gu, Li-Ming He, Chen-Chen Li, Wen-Wei Qiu. Synthesis of ursodeoxycholic acid from plant-source (20S)-21-hydroxy-20-methylpregn-4-en-3-one. Steroids. 2020 05; 157(?):108600. doi: 10.1016/j.steroids.2020.108600. [PMID: 32068080]
  • Yu-Ling Wang, Wei Wu, Yong-Nan Su, Zhi-Peng Ai, Han-Chuan Mou, Luo-Sheng Wan, Ying Luo, Ming-Hua Qiu, Ji-Hong Zhang. Buxus alkaloid compound destabilizes mutant p53 through inhibition of the HSF1 chaperone axis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Mar; 68(?):153187. doi: 10.1016/j.phymed.2020.153187. [PMID: 32097779]
  • Philippe Liere, Charlotte A Cornil, Marie Pierre de Bournonville, Antoine Pianos, Matthieu Keller, Michael Schumacher, Jacques Balthazart. Steroid profiles in quail brain and serum: Sex and regional differences and effects of castration with steroid replacement. Journal of neuroendocrinology. 2019 02; 31(2):e12681. doi: 10.1111/jne.12681. [PMID: 30585662]
  • S L Pineles, Y I Nillni, G Pinna, J Irvine, A Webb, K A Arditte Hall, R Hauger, M W Miller, P A Resick, S P Orr, A M Rasmusson. PTSD in women is associated with a block in conversion of progesterone to the GABAergic neurosteroids allopregnanolone and pregnanolone measured in plasma. Psychoneuroendocrinology. 2018 07; 93(?):133-141. doi: 10.1016/j.psyneuen.2018.04.024. [PMID: 29727810]
  • Gaia Cermenati, Silvia Giatti, Matteo Audano, Marzia Pesaresi, Roberto Spezzano, Donatella Caruso, Nico Mitro, Roberto Cosimo Melcangi. Diabetes alters myelin lipid profile in rat cerebral cortex: Protective effects of dihydroprogesterone. The Journal of steroid biochemistry and molecular biology. 2017 04; 168(?):60-70. doi: 10.1016/j.jsbmb.2017.02.002. [PMID: 28167298]
  • Kristina M Deligiannidis, Aimee R Kroll-Desrosiers, Shunyan Mo, Hien P Nguyen, Abby Svenson, Nina Jaitly, Janet E Hall, Bruce A Barton, Anthony J Rothschild, Scott A Shaffer. Peripartum neuroactive steroid and γ-aminobutyric acid profiles in women at-risk for postpartum depression. Psychoneuroendocrinology. 2016 08; 70(?):98-107. doi: 10.1016/j.psyneuen.2016.05.010. [PMID: 27209438]
  • Erin L Legacki, Elizabeth L Scholtz, Barry A Ball, Scott D Stanley, Trish Berger, Alan J Conley. The dynamic steroid landscape of equine pregnancy mapped by mass spectrometry. Reproduction (Cambridge, England). 2016 Apr; 151(4):421-30. doi: 10.1530/rep-15-0547. [PMID: 26814209]
  • John P Wiebe, Kevin J Pawlak, Arthur Kwok. Mechanism of action of the breast cancer-promoter hormone, 5α-dihydroprogesterone (5αP), involves plasma membrane-associated receptors and MAPK activation. The Journal of steroid biochemistry and molecular biology. 2016 Jan; 155(Pt A):166-76. doi: 10.1016/j.jsbmb.2015.10.021. [PMID: 26519986]
  • L V Bayunova. [THE EFFECT OF HORMONAL STIMULATION OF STERLET (ACIPENSER RUTHENUS L.) ON STEROID LEVELS IN TISSUE INCUBATES]. Zhurnal evoliutsionnoi biokhimii i fiziologii. 2016 Jan; 52(1):17-25. doi: 10.1134/s0022093016010026. [PMID: 27220236]
  • Miguel Debono, Ashwini Mallappa, Verena Gounden, Aikaterini A Nella, Robert F Harrison, Christopher A Crutchfield, Peter S Backlund, Steven J Soldin, Richard J Ross, Deborah P Merke. Hormonal circadian rhythms in patients with congenital adrenal hyperplasia: identifying optimal monitoring times and novel disease biomarkers. European journal of endocrinology. 2015 Dec; 173(6):727-37. doi: 10.1530/eje-15-0064. [PMID: 26340969]
  • John P Wiebe, Martin A Rivas, Maria F Mercogliano, Patricia V Elizalde, Roxana Schillaci. Progesterone-induced stimulation of mammary tumorigenesis is due to the progesterone metabolite, 5α-dihydroprogesterone (5αP) and can be suppressed by the 5α-reductase inhibitor, finasteride. The Journal of steroid biochemistry and molecular biology. 2015 May; 149(?):27-34. doi: 10.1016/j.jsbmb.2015.01.004. [PMID: 25595041]
  • Donatella Caruso, Federico Abbiati, Silvia Giatti, Simone Romano, Letizia Fusco, Guido Cavaletti, Roberto Cosimo Melcangi. Patients treated for male pattern hair with finasteride show, after discontinuation of the drug, altered levels of neuroactive steroids in cerebrospinal fluid and plasma. The Journal of steroid biochemistry and molecular biology. 2015 Feb; 146(?):74-9. doi: 10.1016/j.jsbmb.2014.03.012. [PMID: 24717976]
  • Nico Mitro, Gaia Cermenati, Elisabetta Brioschi, Federico Abbiati, Matteo Audano, Silvia Giatti, Maurizio Crestani, Emma De Fabiani, Inigo Azcoitia, Luis Miguel Garcia-Segura, Donatella Caruso, Roberto Cosimo Melcangi. Neuroactive steroid treatment modulates myelin lipid profile in diabetic peripheral neuropathy. The Journal of steroid biochemistry and molecular biology. 2014 Sep; 143(?):115-21. doi: 10.1016/j.jsbmb.2014.02.015. [PMID: 24607810]
  • John P Wiebe, Guihua Zhang, Ian Welch, Heather-Anne T Cadieux-Pitre. Progesterone metabolites regulate induction, growth, and suppression of estrogen- and progesterone receptor-negative human breast cell tumors. Breast cancer research : BCR. 2013 May; 15(3):R38. doi: 10.1186/bcr3422. [PMID: 25927181]
  • Nico Mitro, Gaia Cermenati, Silvia Giatti, Federico Abbiati, Marzia Pesaresi, Donato Calabrese, Luis Miguel Garcia-Segura, Donatella Caruso, Roberto C Melcangi. LXR and TSPO as new therapeutic targets to increase the levels of neuroactive steroids in the central nervous system of diabetic animals. Neurochemistry international. 2012 May; 60(6):616-21. doi: 10.1016/j.neuint.2012.02.025. [PMID: 22406419]
  • Carolyn J Koonce, Alicia A Walf, Cheryl A Frye. Type 1 5α-reductase may be required for estrous cycle changes in affective behaviors of female mice. Behavioural brain research. 2012 Jan; 226(2):376-80. doi: 10.1016/j.bbr.2011.09.028. [PMID: 21946309]
  • M Dušková, K Simůnková, M Hill, M Velíková, J Kubátová, L Kancheva, H Kazihnitková, H Hruškovičová, H Pospíšilová, B Rácz, M Salátová, V Cirmanová, E Králíková, L Stárka, A Pařízek. Chronic cigarette smoking alters circulating sex hormones and neuroactive steroids in premenopausal women. Physiological research. 2012; 61(1):97-111. doi: 10.33549/physiolres.932164. [PMID: 22188108]
  • Sonja Janmaat, Yvette Akwa, Mohamed Doulazmi, Joëlle Bakouche, Vanessa Gautheron, Philippe Liere, Bernard Eychenne, Antoine Pianos, Paul Luiten, Ton Groothuis, Etienne-Emile Baulieu, Jean Mariani, Rachel M Sherrard, Florence Frédéric. Age-related Purkinje cell death is steroid dependent: RORα haplo-insufficiency impairs plasma and cerebellar steroids and Purkinje cell survival. Age (Dordrecht, Netherlands). 2011 Dec; 33(4):565-78. doi: 10.1007/s11357-010-9203-3. [PMID: 21222044]
  • Itsuki Adachi, Satoshi Kusuda, Hitomi Kawai, Megumi Ohazama, Atsushi Taniguchi, Natsuko Kondo, Masato Yoshihara, Ryuta Okuda, Tatsuya Ishikawa, Iwai Kanda, Osamu Doi. Fecal progestagens to detect and monitor pregnancy in captive female cheetahs (Acinonyx jubatus). The Journal of reproduction and development. 2011 Apr; 57(2):262-6. doi: 10.1262/jrd.10-057t. [PMID: 21242656]
  • Jason J Paris, Alicia A Walf, Cheryl A Frye. II. Cognitive performance of middle-aged female rats is influenced by capacity to metabolize progesterone in the prefrontal cortex and hippocampus. Brain research. 2011 Mar; 1379(?):149-63. doi: 10.1016/j.brainres.2010.10.099. [PMID: 21044614]
  • Cheryl A Frye, Alicia Walf. Progesterone, administered before kainic acid, prevents decrements in cognitive performance in the Morris Water Maze. Developmental neurobiology. 2011 Feb; 71(2):142-52. doi: 10.1002/dneu.20832. [PMID: 20715152]
  • Nasser Zangiabadi, Majid Asadi-Shekaari, Vahid Sheibani, Mandana Jafari, Mohammad Shabani, Ali Reza Asadi, Hale Tajadini, Morteza Jarahi. Date fruit extract is a neuroprotective agent in diabetic peripheral neuropathy in streptozotocin-induced diabetic rats: a multimodal analysis. Oxidative medicine and cellular longevity. 2011; 2011(?):976948. doi: 10.1155/2011/976948. [PMID: 22191015]
  • Ronald W Irwin, Jun Ming Wang, Shuhua Chen, Roberta Diaz Brinton. Neuroregenerative mechanisms of allopregnanolone in Alzheimer's disease. Frontiers in endocrinology. 2011; 2(?):117. doi: 10.3389/fendo.2011.00117. [PMID: 22654847]
  • I Adachi, S Kusuda, E Nagao, Y Taira, M Asano, T Tsubota, O Doi. Fecal steroid metabolites and reproductive monitoring in a female Tsushima leopard cat (Prionailurus bengalensis euptilurus). Theriogenology. 2010 Nov; 74(8):1499-503. doi: 10.1016/j.theriogenology.2010.04.031. [PMID: 20615533]
  • Cheryl A Frye, Alicia A Walf, Jason J Paris. Conjugated equine estrogen, with medroxyprogesterone acetate, enhances formation of 5alpha-reduced progestogens and reduces anxiety-like behavior of middle-aged rats. Behavioural pharmacology. 2010 Sep; 21(5-6):530-9. doi: 10.1097/fbp.0b013e32833e0a23. [PMID: 20679892]
  • Cheryl A Frye, Danielle C Llaneza. Corticosteroid and neurosteroid dysregulation in an animal model of autism, BTBR mice. Physiology & behavior. 2010 Jun; 100(3):264-7. doi: 10.1016/j.physbeh.2010.03.005. [PMID: 20298706]
  • Silvia Giatti, Giulia D'Intino, Omar Maschi, Marzia Pesaresi, Luis-Miguel Garcia-Segura, Laura Calza, Donatella Caruso, R C Melcangi. Acute experimental autoimmune encephalomyelitis induces sex dimorphic changes in neuroactive steroid levels. Neurochemistry international. 2010 Jan; 56(1):118-27. doi: 10.1016/j.neuint.2009.09.009. [PMID: 19772882]
  • M Hill, A Pařízek, J E Jirásek, M Jirkovská, M Velíková, M Dušková, M Klímková, A Pasková, Z Zizka, A Germanová, M Koucký, M Kalousová, L Stárka. Is maternal progesterone actually independent of the fetal steroids?. Physiological research. 2010; 59(2):211-224. doi: 10.33549/physiolres.931807. [PMID: 19537920]
  • K M Tripp, M Dubois, P Delahaut, J P Verstegen. Detection and identification of plasma progesterone metabolites in the female Florida manatee (Trichechus manatus latirostris) using GC/MS/MS. Theriogenology. 2009 Aug; 72(3):365-71. doi: 10.1016/j.theriogenology.2009.03.004. [PMID: 19464047]
  • Cheryl A Frye, Alicia A Walf. Progesterone reduces depression-like behavior in a murine model of Alzheimer's Disease. Age (Dordrecht, Netherlands). 2009 Jun; 31(2):143-53. doi: 10.1007/s11357-009-9091-6. [PMID: 19322681]
  • V Singh, K P Joy. Effects of hCG and ovarian steroid hormones on vasotocin levels in the female catfish Heteropneustes fossilis. General and comparative endocrinology. 2009 Jun; 162(2):172-8. doi: 10.1016/j.ygcen.2009.03.016. [PMID: 19332066]
  • V Herl, G Fischer, V A Reva, M Stiebritz, Y A Muller, F Müller-Uri, W Kreis. The VEP1 gene (At4g24220) encodes a short-chain dehydrogenase/reductase with 3-oxo-Delta4,5-steroid 5beta-reductase activity in Arabidopsis thaliana L. Biochimie. 2009 Apr; 91(4):517-25. doi: 10.1016/j.biochi.2008.12.005. [PMID: 19166903]
  • Rok Ocvirk, Keith B J Franklin, Beverley E Pearson Murphy. Measurement of ring A-reduced progesterone metabolites by enzyme-linked immunoassay with colorimetric detection: baseline levels of six metabolites, including pregnanolone, in male rat plasma. Analytical chemistry. 2009 Feb; 81(3):1191-7. doi: 10.1021/ac801538c. [PMID: 19132927]
  • Yonghua Zhang, Mélanie Nadeau, Frédérick Faucher, Odette Lescelleur, Simon Biron, Marleen Daris, Caroline Rhéaume, Van Luu-The, André Tchernof. Progesterone metabolism in adipose cells. Molecular and cellular endocrinology. 2009 Jan; 298(1-2):76-83. doi: 10.1016/j.mce.2008.09.034. [PMID: 18984031]
  • Laura A Jansen, Lindsey D Peugh, Jeffrey G Ojemann. GABA(A) receptor properties in catastrophic infantile epilepsy. Epilepsy research. 2008 Oct; 81(2-3):188-97. doi: 10.1016/j.eplepsyres.2008.05.011. [PMID: 18650066]
  • Andrea Thorn, Claudia Egerer-Sieber, Christof M Jäger, Vanessa Herl, Frieder Müller-Uri, Wolfgang Kreis, Yves A Muller. The crystal structure of progesterone 5beta-reductase from Digitalis lanata defines a novel class of short chain dehydrogenases/reductases. The Journal of biological chemistry. 2008 Jun; 283(25):17260-9. doi: 10.1074/jbc.m706185200. [PMID: 18032383]
  • Pia Rantakari, Leena Strauss, Riku Kiviranta, Heidi Lagerbohm, Jenni Paviala, Irma Holopainen, Seppo Vainio, Pirjo Pakarinen, Matti Poutanen. Placenta defects and embryonic lethality resulting from disruption of mouse hydroxysteroid (17-beta) dehydrogenase 2 gene. Molecular endocrinology (Baltimore, Md.). 2008 Mar; 22(3):665-75. doi: 10.1210/me.2007-0257. [PMID: 18048640]
  • Maho Ishida, Jae-hyek Choi, Keiji Hirabayashi, Takashi Matsuwaki, Masatoshi Suzuki, Keitaro Yamanouchi, Reiko Horai, Katsuko Sudo, Yoichiro Iwakura, Masugi Nishihara. Reproductive phenotypes in mice with targeted disruption of the 20alpha-hydroxysteroid dehydrogenase gene. The Journal of reproduction and development. 2007 Jun; 53(3):499-508. doi: 10.1262/jrd.18125. [PMID: 17272929]
  • Martin Hill, David Cibula, Helena Havlíková, Lyudmila Kancheva, Tomás Fait, Radmila Kancheva, Antonín Parízek, Luboslav Stárka. Circulating levels of pregnanolone isomers during the third trimester of human pregnancy. The Journal of steroid biochemistry and molecular biology. 2007 Jun; 105(1-5):166-75. doi: 10.1016/j.jsbmb.2006.10.010. [PMID: 17583491]
  • D Meffre, A Pianos, P Liere, B Eychenne, A Cambourg, M Schumacher, D G Stein, R Guennoun. Steroid profiling in brain and plasma of male and pseudopregnant female rats after traumatic brain injury: analysis by gas chromatography/mass spectrometry. Endocrinology. 2007 May; 148(5):2505-17. doi: 10.1210/en.2006-1678. [PMID: 17303653]
  • Eileen Jea Chien, Ching-Fong Liao, Ching-Pang Chang, Hsiao-Fung Pu, Li-Ming Lu, Mei-Chi Shie, Dennis J-Y Hsieh, Ming-Ta Hsu. The non-genomic effects on Na+/H+-exchange 1 by progesterone and 20alpha-hydroxyprogesterone in human T cells. Journal of cellular physiology. 2007 May; 211(2):544-50. doi: 10.1002/jcp.20962. [PMID: 17323380]
  • Tatsuya Higashi, Akihiro Nagahama, Norihiro Otomi, Kazutake Shimada. Studies on neurosteroids XIX. Development and validation of liquid chromatography-tandem mass spectrometric method for determination of 5alpha-reduced pregnane-type neurosteroids in rat brain and serum. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Apr; 848(2):188-99. doi: 10.1016/j.jchromb.2006.10.036. [PMID: 17085081]
  • George Wittemyer, André Ganswindt, Keith Hodges. The impact of ecological variability on the reproductive endocrinology of wild female African elephants. Hormones and behavior. 2007 Mar; 51(3):346-54. doi: 10.1016/j.yhbeh.2006.12.013. [PMID: 17320085]
  • E Leonelli, R Bianchi, G Cavaletti, D Caruso, D Crippa, L M Garcia-Segura, G Lauria, V Magnaghi, I Roglio, R C Melcangi. Progesterone and its derivatives are neuroprotective agents in experimental diabetic neuropathy: a multimodal analysis. Neuroscience. 2007 Feb; 144(4):1293-304. doi: 10.1016/j.neuroscience.2006.11.014. [PMID: 17187935]
  • J Bryndová, P Klusonová, M Kucka, K Mazancová-Vagnerová, I Miksík, J Pácha. Cloning and expression of chicken 20-hydroxysteroid dehydrogenase. Journal of molecular endocrinology. 2006 Dec; 37(3):453-62. doi: 10.1677/jme.1.02025. [PMID: 17170086]
  • Petra Brozic, Tina Smuc, Stanislav Gobec, Tea Lanisnik Rizner. Phytoestrogens as inhibitors of the human progesterone metabolizing enzyme AKR1C1. Molecular and cellular endocrinology. 2006 Oct; 259(1-2):30-42. doi: 10.1016/j.mce.2006.08.001. [PMID: 16962702]
  • L R G Nieminen, K K Makino, N Mehta, M Virkkunen, H Y Kim, J R Hibbeln. Relationship between omega-3 fatty acids and plasma neuroactive steroids in alcoholism, depression and controls. Prostaglandins, leukotrienes, and essential fatty acids. 2006 Oct; 75(4-5):309-14. doi: 10.1016/j.plefa.2006.07.012. [PMID: 16959481]
  • John P Wiebe. Progesterone metabolites in breast cancer. Endocrine-related cancer. 2006 Sep; 13(3):717-38. doi: 10.1677/erc.1.01010. [PMID: 16954427]
  • Iratxe Ciriza, Paloma Carrero, Cheryl A Frye, Luis M Garcia-Segura. Reduced metabolites mediate neuroprotective effects of progesterone in the adult rat hippocampus. The synthetic progestin medroxyprogesterone acetate (Provera) is not neuroprotective. Journal of neurobiology. 2006 Aug; 66(9):916-28. doi: 10.1002/neu.20293. [PMID: 16758493]
  • M Kucka, K Vagnerová, P Klusonová, I Miksík, J Pácha. Corticosterone metabolism in chicken tissues: evidence for tissue-specific distribution of steroid dehydrogenases. General and comparative endocrinology. 2006 Jul; 147(3):377-83. doi: 10.1016/j.ygcen.2006.02.007. [PMID: 16574115]
  • Sabina Luchetti, Flavia di Michele, Elena Romeo, Livia Brusa, Giorgio Bernardi, Brian J Cummings, Patrizia Longone. Comparative non-radioactive RT-PCR assay: an approach to study the neurosteroids biosynthetic pathway in humans. Journal of neuroscience methods. 2006 Jun; 153(2):290-8. doi: 10.1016/j.jneumeth.2005.11.005. [PMID: 16378642]
  • Hideaki Shimada, Kazumi Miura, Yorishige Imamura. Characteristics and inhibition by flavonoids of 20alpha-hydroxysteroid dehydrogenase activity in mouse tissues. Life sciences. 2006 May; 78(25):2931-6. doi: 10.1016/j.lfs.2005.11.022. [PMID: 16376383]
  • F Labombarda, A Pianos, P Liere, B Eychenne, S Gonzalez, A Cambourg, A F De Nicola, M Schumacher, R Guennoun. Injury elicited increase in spinal cord neurosteroid content analyzed by gas chromatography mass spectrometry. Endocrinology. 2006 Apr; 147(4):1847-59. doi: 10.1210/en.2005-0955. [PMID: 16396987]
  • C Schüle, E Romeo, D P Uzunov, D Eser, F di Michele, T C Baghai, A Pasini, M Schwarz, H Kempter, R Rupprecht. Influence of mirtazapine on plasma concentrations of neuroactive steroids in major depression and on 3alpha-hydroxysteroid dehydrogenase activity. Molecular psychiatry. 2006 Mar; 11(3):261-72. doi: 10.1038/sj.mp.4001782. [PMID: 16344854]
  • Vanessa Herl, Gabriele Fischer, Frieder Müller-Uri, Wolfgang Kreis. Molecular cloning and heterologous expression of progesterone 5beta-reductase from Digitalis lanata Ehrh. Phytochemistry. 2006 Feb; 67(3):225-31. doi: 10.1016/j.phytochem.2005.11.013. [PMID: 16386278]
  • Cheryl A Frye, Madeline E Rhodes. Progestin concentrations are increased following paced mating in midbrain, hippocampus, diencephalon, and cortex of rats in behavioral estrus, but only in midbrain of diestrous rats. Neuroendocrinology. 2006; 83(5-6):336-47. doi: 10.1159/000096051. [PMID: 17028418]
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