Flavin mononucleotide (BioDeep_00000407817)

Main id: BioDeep_00000002940

 

natural product PANOMIX_OTCML-2023


代谢物信息卡片


Flavin mononucleotide

化学式: C17H21N4O9P (456.10461060000006)
中文名称: 2,6-蒽二酚
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CC2=C(C=C1C)N(C3=NC(=O)NC(=O)C3=N2)CC(C(C(COP(=O)(O)O)O)O)O
InChI: InChI=1S/C17H21N4O9P/c1-7-3-9-10(4-8(7)2)21(15-13(18-9)16(25)20-17(26)19-15)5-11(22)14(24)12(23)6-30-31(27,28)29/h3-4,11-12,14,22-24H,5-6H2,1-2H3,(H,20,25,26)(H2,27,28,29)/t11-,12+,14-/m0/s1

描述信息

A flavin mononucleotide that is riboflavin (vitamin B2) in which the primary hydroxy group has been converted to its dihydrogen phosphate ester.
D018977 - Micronutrients > D014815 - Vitamins

同义名列表

3 个代谢物同义名

Flavin mononucleotide; Riboflavine phosphate; FMN



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(5)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Xin Sun, Jiang-Zhe Zhao, Chuan-Shuo Wu, Ke-Wei Zhang, Liang Cheng. Flavin mononucleotide regulated photochemical isomerization and degradation of zeatin. Organic & biomolecular chemistry. 2024 03; 22(10):2021-2026. doi: 10.1039/d4ob00028e. [PMID: 38372990]
  • Nowshin Farjana, Hiromitsu Furukawa, Hisako Sumi, Isao Yumoto. Effect of Fermentation Scale on Microbiota Dynamics and Metabolic Functions for Indigo Reduction. International journal of molecular sciences. 2023 Sep; 24(19):. doi: 10.3390/ijms241914696. [PMID: 37834143]
  • Joseph H Lynch, Sanja Roje. A higher plant FAD synthetase is fused to an inactivated FAD pyrophosphatase. The Journal of biological chemistry. 2022 12; 298(12):102626. doi: 10.1016/j.jbc.2022.102626. [PMID: 36273586]
  • Hai Ying Wen, Li Bin Pan, Shu Rong Ma, Xin Yu Yang, Jia Chun Hu, Hai Fan Zhao, Zeng Qiang Gao, Yu Hui Dong, Yan Wang, Heng Zhang. Structural basis for the transformation of the traditional medicine berberine by bacterial nitroreductase. Acta crystallographica. Section D, Structural biology. 2022 Oct; 78(Pt 10):1273-1282. doi: 10.1107/s2059798322008373. [PMID: 36189746]
  • Fabian Piskol, Kerstin Neubauer, Maurice Eggers, Lisa Margarete Bode, Jan Jasper, Alan Slusarenko, Edward Reijerse, Wolfgang Lubitz, Dieter Jahn, Jürgen Moser. Two-component carnitine monooxygenase from Escherichia coli: functional characterization, inhibition and mutagenesis of the molecular interface. Bioscience reports. 2022 09; 42(9):. doi: 10.1042/bsr20221102. [PMID: 36066069]
  • Yeshveer Singh, Ruby Sharma, Manasi Mishra, Praveen Kumar Verma, Ajay Kumar Saxena. Crystal structure of ArOYE6 reveals a novel C-terminal helical extension and mechanistic insights into the distinct class III OYEs from pathogenic fungi. The FEBS journal. 2022 09; 289(18):5531-5550. doi: 10.1111/febs.16445. [PMID: 35313092]
  • Surabhi Bangarbale, Blythe D Shepard, Shivani Bansal, Meth M Jayatilake, Ryan Kurtz, Moshe Levi, Carolyn M Ecelbarger. Renal Metabolome in Obese Mice Treated with Empagliflozin Suggests a Reduction in Cellular Respiration. Biomolecules. 2022 08; 12(9):. doi: 10.3390/biom12091176. [PMID: 36139016]
  • Maria Tolomeo, Guglielmina Chimienti, Martina Lanza, Roberto Barbaro, Alessia Nisco, Tiziana Latronico, Piero Leone, Giuseppe Petrosillo, Grazia Maria Liuzzi, Bryony Ryder, Michal Inbar-Feigenberg, Matilde Colella, Angela M S Lezza, Rikke K J Olsen, Maria Barile. Retrograde response to mitochondrial dysfunctions associated to LOF variations in FLAD1 exon 2: unraveling the importance of RFVT2. Free radical research. 2022 Jul; 56(7-8):511-525. doi: 10.1080/10715762.2022.2146501. [PMID: 36480241]
  • Xiaoying Jing, Shanchao Hong, Jian Zhang, Xue Yang, Xianlong Geng, Yan Ye, Zhigang Hu. A rapid and quantitative detection method for plasma soluble growth stimulating gene protein 2 based on time resolved fluorescence immunochromatography. Analytical methods : advancing methods and applications. 2022 06; 14(22):2179-2187. doi: 10.1039/d2ay00120a. [PMID: 35608240]
  • Changjing Zhang, Leilei Zhu, Shuaifei Lu, Mengyuan Li, Ming Bai, Yucheng Li, Erping Xu. The antidepressant-like effect of formononetin on chronic corticosterone-treated mice. Brain research. 2022 05; 1783(?):147844. doi: 10.1016/j.brainres.2022.147844. [PMID: 35218705]
  • Bankala Krishnarjuna, Thirupathi Ravula, Ayyalusamy Ramamoorthy. Detergent-free isolation of CYP450-reductase's FMN-binding domain in E. coli lipid-nanodiscs using a charge-free polymer. Chemical communications (Cambridge, England). 2022 Apr; 58(31):4913-4916. doi: 10.1039/d1cc07193a. [PMID: 35356954]
  • Rafael Rivera-Lugo, Samuel H Light, Nicholas E Garelis, Daniel A Portnoy. RibU is an essential determinant of Listeria pathogenesis that mediates acquisition of FMN and FAD during intracellular growth. Proceedings of the National Academy of Sciences of the United States of America. 2022 03; 119(13):e2122173119. doi: 10.1073/pnas.2122173119. [PMID: 35316134]
  • Jiayu Liu, Yangyang Zhao, Zheng Qing Fu, Fengquan Liu. Monooxygenase LaPhzX is Involved in Self-Resistance Mechanisms during the Biosynthesis of N-Oxide Phenazine Myxin. Journal of agricultural and food chemistry. 2021 Nov; 69(45):13524-13532. doi: 10.1021/acs.jafc.1c05206. [PMID: 34735148]
  • Reinmar Eggers, Alexandra Jammer, Shalinee Jha, Bianca Kerschbaumer, Majd Lahham, Emilia Strandback, Marina Toplak, Silvia Wallner, Andreas Winkler, Peter Macheroux. The scope of flavin-dependent reactions and processes in the model plant Arabidopsis thaliana. Phytochemistry. 2021 Sep; 189(?):112822. doi: 10.1016/j.phytochem.2021.112822. [PMID: 34118767]
  • Hanna Grajek, Jacek Kubicki, Ignacy Gryczyński, Jerzy Karolczak, Grażyna Żurkowska, Agnieszka I Piotrowicz-Cieślak, Piotr Bojarski. Effect of Dimer Structure and Inhomogeneous Broadening of Energy Levels on the Action of Flavomononucleotide in Rigid Polyvinyl Alcohol Films. International journal of molecular sciences. 2021 Jul; 22(14):. doi: 10.3390/ijms22147759. [PMID: 34299377]
  • Mariana Voicescu, Oana Craciunescu, Daniel G Angelescu, Rodica Tatia, Lucia Moldovan. Spectroscopic, molecular dynamics simulation and biological studies of Flavin MonoNucleotide and Flavin Adenine Dinucleotide in biomimetic systems. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2021 Feb; 246(?):118997. doi: 10.1016/j.saa.2020.118997. [PMID: 33032115]
  • E V Ekusheva, V B Voitenkov, O A Rizakhanova. [The effectiveness of cytoflavin in complex therapy of patients with the coronavirus infection COVID-19]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2021; 121(12):33-39. doi: 10.17116/jnevro202112112133. [PMID: 35041310]
  • M V Putilina, N V Teplova, K I Bairova, A E Petrikeeva, N I Shabalina. [The result of prospective randomized study CITADEL - the efficacy and safety of drug cytoflavin in postcovid rehabilitation]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2021; 121(10):45-51. doi: 10.17116/jnevro202112110145. [PMID: 34874654]
  • Sweta Narayanan Iyer, Nemeshwaree Behary, Vincent Nierstrasz, Jinping Guan. Glow-in-the-Dark Patterned PET Nonwoven Using Air-Atmospheric Plasma Treatment and Vitamin B2-Derivative (FMN). Sensors (Basel, Switzerland). 2020 Nov; 20(23):. doi: 10.3390/s20236816. [PMID: 33260671]
  • Yang Hai, Mengbin Chen, Arthur Huang, Yi Tang. Biosynthesis of Mycotoxin Fusaric Acid and Application of a PLP-Dependent Enzyme for Chemoenzymatic Synthesis of Substituted l-Pipecolic Acids. Journal of the American Chemical Society. 2020 11; 142(46):19668-19677. doi: 10.1021/jacs.0c09352. [PMID: 33155797]
  • James N Iuliano, Jinnette Tolentino Collado, Agnieszka A Gil, Pavithran T Ravindran, Andras Lukacs, SeungYoun Shin, Helena A Woroniecka, Katrin Adamczyk, James M Aramini, Uthama R Edupuganti, Christopher R Hall, Gregory M Greetham, Igor V Sazanovich, Ian P Clark, Taraneh Daryaee, Jared E Toettcher, Jarrod B French, Kevin H Gardner, Carlos L Simmerling, Stephen R Meech, Peter J Tonge. Unraveling the Mechanism of a LOV Domain Optogenetic Sensor: A Glutamine Lever Induces Unfolding of the Jα Helix. ACS chemical biology. 2020 10; 15(10):2752-2765. doi: 10.1021/acschembio.0c00543. [PMID: 32880430]
  • Gongquan Liu, Weiwei Wang, Fangyuan He, Peng Zhang, Ping Xu, Hongzhi Tang. Structural Insights into 6-Hydroxypseudooxynicotine Amine Oxidase from Pseudomonas geniculata N1, the Key Enzyme Involved in Nicotine Degradation. Applied and environmental microbiology. 2020 09; 86(19):. doi: 10.1128/aem.01559-20. [PMID: 32737127]
  • Patrick Schall, Lucas Marutschke, Bernhard Grimm. The Flavoproteome of the Model Plant Arabidopsis thaliana. International journal of molecular sciences. 2020 Jul; 21(15):. doi: 10.3390/ijms21155371. [PMID: 32731628]
  • Martina Petrenčáková, Rastislav Varhač, Tibor Kožár, Michal Nemergut, Daniel Jancura, Marc-Simon Schwer, Erik Sedlák. Conformational properties of LOV2 domain and its C450A variant within broad pH region. Biophysical chemistry. 2020 04; 259(?):106337. doi: 10.1016/j.bpc.2020.106337. [PMID: 32126442]
  • Sanghwan Ko, Bora Hwang, Jung-Hyun Na, Jisun Lee, Sang Taek Jung. Engineered Arabidopsis Blue Light Receptor LOV Domain Variants with Improved Quantum Yield, Brightness, and Thermostability. Journal of agricultural and food chemistry. 2019 Oct; 67(43):12037-12043. doi: 10.1021/acs.jafc.9b05473. [PMID: 31581772]
  • M Cicuéndez, V S Silva, J Santos, A Coimbra, H Oliveira, M Ayán-Varela, J I Paredes, S Villar-Rodil, M Vila. MoS2 flakes stabilized with DNA/RNA nucleotides: In vitro cell response. Materials science & engineering. C, Materials for biological applications. 2019 Jul; 100(?):11-22. doi: 10.1016/j.msec.2019.02.002. [PMID: 30948045]
  • Eva-Maria Theismann, Julia Katharina Keppler, Jörg-Rainer Knipp, Daniela Fangmann, Esther Appel, Stanislav N Gorb, Georg H Waetzig, Stefan Schreiber, Matthias Laudes, Karin Schwarz. Adjustment of triple shellac coating for precise release of bioactive substances with different physico-chemical properties in the ileocolonic region. International journal of pharmaceutics. 2019 Jun; 564(?):472-484. doi: 10.1016/j.ijpharm.2019.04.039. [PMID: 30991131]
  • Irina A Rodionova, Fereshteh Heidari Tajabadi, Zhongge Zhang, Dmitry A Rodionov, Milton H Saier. A Riboflavin Transporter in Bdellovibrio exovorous JSS. Journal of molecular microbiology and biotechnology. 2019; 29(1-6):27-34. doi: 10.1159/000501354. [PMID: 31509826]
  • Yujie Liu, Wei Wu, Zhongzhou Chen. Structures of glycolate oxidase from Nicotiana benthamiana reveal a conserved pH sensor affecting the binding of FMN. Biochemical and biophysical research communications. 2018 09; 503(4):3050-3056. doi: 10.1016/j.bbrc.2018.08.092. [PMID: 30143257]
  • Elke Prade, Mukesh Mahajan, Sang-Choul Im, Meng Zhang, Katherine A Gentry, G M Anantharamaiah, Lucy Waskell, Ayyalusamy Ramamoorthy. A Minimal Functional Complex of Cytochrome P450 and FBD of Cytochrome P450 Reductase in Nanodiscs. Angewandte Chemie (International ed. in English). 2018 07; 57(28):8458-8462. doi: 10.1002/anie.201802210. [PMID: 29722926]
  • Carlo Barnaba, Thirupathi Ravula, Ilce G Medina-Meza, Sang-Choul Im, G M Anantharamaiah, Lucy Waskell, Ayyalusamy Ramamoorthy. Lipid-exchange in nanodiscs discloses membrane boundaries of cytochrome-P450 reductase. Chemical communications (Cambridge, England). 2018 Jun; 54(49):6336-6339. doi: 10.1039/c8cc02003e. [PMID: 29863198]
  • James N Iuliano, Agnieszka A Gil, Sergey P Laptenok, Christopher R Hall, Jinnette Tolentino Collado, Andras Lukacs, Safaa A Hag Ahmed, Jenna Abyad, Taraneh Daryaee, Gregory M Greetham, Igor V Sazanovich, Boris Illarionov, Adelbert Bacher, Markus Fischer, Michael Towrie, Jarrod B French, Stephen R Meech, Peter J Tonge. Variation in LOV Photoreceptor Activation Dynamics Probed by Time-Resolved Infrared Spectroscopy. Biochemistry. 2018 02; 57(5):620-630. doi: 10.1021/acs.biochem.7b01040. [PMID: 29239168]
  • Benjamin Ricken, Boris A Kolvenbach, Christian Bergesch, Dirk Benndorf, Kevin Kroll, Hynek Strnad, Čestmír Vlček, Ricardo Adaixo, Frederik Hammes, Patrick Shahgaldian, Andreas Schäffer, Hans-Peter E Kohler, Philippe F-X Corvini. FMNH2-dependent monooxygenases initiate catabolism of sulfonamides in Microbacterium sp. strain BR1 subsisting on sulfonamide antibiotics. Scientific reports. 2017 Nov; 7(1):15783. doi: 10.1038/s41598-017-16132-8. [PMID: 29150672]
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  • Bastian Daniel, Barbara Konrad, Marina Toplak, Majd Lahham, Julia Messenlehner, Andreas Winkler, Peter Macheroux. The family of berberine bridge enzyme-like enzymes: A treasure-trove of oxidative reactions. Archives of biochemistry and biophysics. 2017 10; 632(?):88-103. doi: 10.1016/j.abb.2017.06.023. [PMID: 28676375]
  • Francisco J Corpas, Juan B Barroso. Nitric oxide synthase-like activity in higher plants. Nitric oxide : biology and chemistry. 2017 08; 68(?):5-6. doi: 10.1016/j.niox.2016.10.009. [PMID: 27816665]
  • Tatsuya Iwata, Dai Nozaki, Atsushi Yamamoto, Takayuki Koyama, Yasuzo Nishina, Kiyoshi Shiga, Satoru Tokutomi, Masashi Unno, Hideki Kandori. Hydrogen Bonding Environment of the N3-H Group of Flavin Mononucleotide in the Light Oxygen Voltage Domains of Phototropins. Biochemistry. 2017 06; 56(24):3099-3108. doi: 10.1021/acs.biochem.7b00057. [PMID: 28530801]
  • Congyun Jin, Yoshiaki Yao, Atsushi Yonezawa, Satoshi Imai, Hiroki Yoshimatsu, Yuki Otani, Tomohiro Omura, Shunsaku Nakagawa, Takayuki Nakagawa, Kazuo Matsubara. Riboflavin Transporters RFVT/SLC52A Mediate Translocation of Riboflavin, Rather than FMN or FAD, across Plasma Membrane. Biological & pharmaceutical bulletin. 2017; 40(11):1990-1995. doi: 10.1248/bpb.b17-00292. [PMID: 29093349]
  • A V Deriugina, A V Shumilova. [An influence of cytoflavin on oxidative stress and activity of Na/K-ATPase of erythrocytes after brain trauma]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2017 ; 117(11):51-55. doi: 10.17116/jnevro201711711151-55. [PMID: 29265087]
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  • O A Vodop'ianova, I Ia Moiseeva, O P Rodina, I N Kustikova, N V Antropova. [The influence of cytoflavin and cardioxipin on the indices of lipid peroxidation and antioxidant protection in the blood of rat with dyslipidemia]. Eksperimental'naia i klinicheskaia farmakologiia. 2014; 77(6):27-9. doi: ". [PMID: 25102732]
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  • E A Kartashova, M G Romantsov, I V Sarvilina. [The study of the effectiveness of drug prevention mechanisms of cardiovascular aging by cytoflavin]. Advances in gerontology = Uspekhi gerontologii. 2014; 27(4):737-45. doi: ". [PMID: 25946853]
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