Zaleplon (BioDeep_00000406063)
Main id: BioDeep_00000002677
代谢物信息卡片
Zaleplon
化学式: C17H15N5O (305.1277)
中文名称: 扎莱普隆
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCN(C1=CC=CC(=C1)C2=CC=NC3=C(C=NN23)C#N)C(=O)C
InChI: InChI=1S/C17H15N5O/c1-3-21(12(2)23)15-6-4-5-13(9-15)16-7-8-19-17-14(10-18)11-20-22(16)17/h4-9,11H,3H2,1-2H3
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
N - Nervous system > N05 - Psycholeptics > N05C - Hypnotics and sedatives > N05CF - Benzodiazepine related drugs
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018757 - GABA Modulators
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
同义名列表
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:10102
- KEGG: C07484
- KEGGdrug: D00530
- PubChem: 5719
- DrugBank: DB00962
- ChEMBL: CHEMBL1521
- CAS: 1007130-22-4
- CAS: 151319-34-5
- MoNA: FiehnHILIC002424
- MoNA: FiehnHILIC000865
- PubChem: 9687
- NIKKAJI: J575.185C
- KNApSAcK: 10102
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sarah A Ali, Nabil A Alhakamy, Khaled M Hosny, Eman Alfayez, Deena M Bukhary, Awaji Y Safhi, Moutaz Y Badr, Rayan Y Mushtaq, Majed Alharbi, Bader Huwaimel, Mohammed Alissa, Sameer Alshehri, Ali H Alamri, Taha Alqahtani. Rapid oral transmucosal delivery of zaleplon-lavender oil utilizing self-nanoemulsifying lyophilized tablets technology: development, optimization and pharmacokinetic evaluation.
Drug delivery.
2022 Dec; 29(1):2773-2783. doi:
10.1080/10717544.2022.2115165. [PMID: 36036168] - Jennifer R Goldschmied, Arjun Sengupta, Anup Sharma, Lynne Taylor, Knashawn H Morales, Michael E Thase, Michael E Thase, Aalim Weljie, Matthew S Kayser. Treatment of Insomnia with Zaleplon in HIV+ Significantly Improves Sleep and Depression.
Psychopharmacology bulletin.
2021 06; 51(3):50-64. doi:
. [PMID: 34421144] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Yusuf A Haggag, Ahmed Kh Abosalha, Murtaza M Tambuwala, Enass Y Osman, Sanaa A El-Gizawy, Ebtessam A Essa, Ahmed A Donia. Polymeric nanoencapsulation of zaleplon into PLGA nanoparticles for enhanced pharmacokinetics and pharmacological activity.
Biopharmaceutics & drug disposition.
2021 Jan; 42(1):12-23. doi:
10.1002/bdd.2255. [PMID: 33320969] - Wee Kiat Tan, Alyssa Rui Yi Tan, Punitha Sivanandam, Ernest Jing Hui Goh, Ze Ping Yap, Nur Fazilah Saburulla, Karl Austin-Muttitt, Jonathan G L Mullins, Aik Jiang Lau. In Vitro Inhibition of Human Aldehyde Oxidase Activity by Clinically Relevant Concentrations of Gefitinib and Erlotinib: Comparison with Select Metabolites, Molecular Docking Analysis, and Impact on Hepatic Metabolism of Zaleplon and Methotrexate.
The Journal of pharmacology and experimental therapeutics.
2020 08; 374(2):295-307. doi:
10.1124/jpet.120.265249. [PMID: 32393528] - Keigo Nakayama, Hidetaka Kamimura, Hiroshi Suemizu, Nao Yoneda, Megumi Nishiwaki, Kazuhiko Iwamoto, Mari Mizunaga, Tamotsu Negoro, Soichiro Ito, Hiroshi Yamazaki, Yukihiro Nomura. Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data.
Drug metabolism and pharmacokinetics.
2020 Aug; 35(4):389-396. doi:
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Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Eman Abd-Elrasheed, Sara Nageeb El-Helaly, Manal M El-Ashmoony, Salwa Salah. Brain-targeted intranasal zaleplon solid dispersion in hydrophilic carrier system; 23 full-factorial design and in vivo determination of GABA neurotransmitter.
Drug development and industrial pharmacy.
2018 May; 44(5):741-749. doi:
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2018 Mar; 48(3):219-231. doi:
10.1080/00498254.2017.1296208. [PMID: 28281401] - Eman Abd-Elrasheed, Sara Nageeb El-Helaly, Manal M El-Ashmoony, Salwa Salah. Brain Targeted Intranasal Zaleplon Nano-emulsion: In-Vitro Characterization and Assessment of Gamma Aminobutyric Acid Levels in Rabbits' Brain and Plasma at Low and High Doses.
Current drug delivery.
2018; 15(6):898-906. doi:
10.2174/1567201814666171130121732. [PMID: 29189154] - Narendar Dudhipala, Karthik Yadav Janga. Lipid nanoparticles of zaleplon for improved oral delivery by Box-Behnken design: optimization, in vitro and in vivo evaluation.
Drug development and industrial pharmacy.
2017 Jul; 43(7):1205-1214. doi:
10.1080/03639045.2017.1304957. [PMID: 28274147] - Chiaki Tanoue, Kazumi Sugihara, Yoshitaka Tayama, Naoto Uramaru, Yoko Watanabe, Shigeru Ohta, Shigeyuki Kitamura. Variability of Zaleplon 5-Oxidase Activity in Mice and Humans, and Inhibition by Raloxifene.
Drug metabolism letters.
2017; 10(4):278-285. doi:
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Fa yi xue za zhi.
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2014 Jan; 406(3):803-18. doi:
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Xenobiotica; the fate of foreign compounds in biological systems.
2013 Nov; 43(11):956-62. doi:
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2013 Jun; 9(2):155-62. doi:
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Journal of clinical pharmacology.
2013 Feb; 53(2):140-50. doi:
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2012 Aug; 1249(?):147-54. doi:
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Biopharmaceutics & drug disposition.
2011 Dec; 32(9):489-97. doi:
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2011 Oct; 3(10):705-16. doi:
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2011 Sep; 401(4):1341-52. doi:
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European journal of pharmacology.
2011 Jul; 661(1-3):22-6. doi:
10.1016/j.ejphar.2011.04.016. [PMID: 21540024] - Monique A J Mets, Edmund R Volkerts, Berend Olivier, Joris C Verster. Effect of hypnotic drugs on body balance and standing steadiness.
Sleep medicine reviews.
2010 Aug; 14(4):259-67. doi:
10.1016/j.smrv.2009.10.008. [PMID: 20171127] - Daniel T Anderson, Robert D Budd. Zaleplon (Sonata) analysis in postmortem specimens by gas chromatography-electron capture detection.
Journal of analytical toxicology.
2009 Oct; 33(8):481-5. doi:
10.1093/jat/33.8.481. [PMID: 19874656] - Kim Huynh, Guohong Wang, Christine Moore, Rehka Barhate, Cynthia Coulter, Warren Rodrigues, Philip Catbagan, James Soares. Development of a homogeneous immunoassay for the detection of zolpidem in urine.
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2009 Oct; 33(8):486-90. doi:
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2009 Aug; 52(15):4844-52. doi:
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Biochemistry.
2009 Feb; 48(4):800-9. doi:
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Journal of analytical toxicology.
2008 Oct; 32(8):688-94. doi:
10.1093/jat/32.8.688. [PMID: 19007522] - Clint Jean Louis, Bernabe Fernandez, Carlos Beaumont, Miguel Angel Pinillos, Anabel Bardom, Yolanda Encina. A case of zaleplon overdose.
Clinical toxicology (Philadelphia, Pa.).
2008 Sep; 46(8):782. doi:
10.1080/15563650701589417. [PMID: 19238743] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
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BMC pharmacology.
2008 Jun; 8(?):11. doi:
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Human psychopharmacology.
2008 Jan; 23(1):13-20. doi:
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2008; 22(12):1021-36. doi:
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Neuropsychiatric disease and treatment.
2007 Aug; 3(4):441-53. doi:
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2007 Jul; 854(1-2):143-51. doi:
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Annals of general psychiatry.
2007 Jan; 6(?):3. doi:
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Biomedical chromatography : BMC.
2006 Aug; 20(8):794-9. doi:
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The Journal of pharmacology and experimental therapeutics.
2006 Apr; 317(1):369-77. doi:
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Clinical therapeutics.
2006 Apr; 28(4):491-516. doi:
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Journal of pharmaceutical and biomedical analysis.
2006 Feb; 40(3):707-14. doi:
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Arzneimittel-Forschung.
2006; 56(7):517-23. doi:
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Journal of chromatographic science.
2005 Nov; 43(10):532-5. doi:
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Journal of analytical toxicology.
2005 May; 29(4):234-9. doi:
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2005 Feb; 816(1-2):215-21. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2004 Dec; 813(1-2):247-54. doi:
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2004 Jul; 806(2):205-19. doi:
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2004; 43(4):227-38. doi:
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British journal of cancer.
2003 Nov; 89(10):1855-9. doi:
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Journal of chromatography. A.
2003 Oct; 1014(1-2):71-81. doi:
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Journal of pharmacological sciences.
2003 Oct; 93(2):204-9. doi:
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Forensic science international.
2003 Jul; 134(2-3):120-2. doi:
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Lakartidningen.
2003 Feb; 100(8):622-3. doi:
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Drug safety.
2003; 26(4):261-82. doi:
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Journal of chromatographic science.
2003 Jan; 41(1):17-21. doi:
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Sleep.
2002 Mar; 25(2):224-31. doi:
10.1093/sleep/25.2.224. [PMID: 11905433] - Jonas Höjer, Heléne Salmonson, Pierre Sundin. Zaleplon-induced coma and bluish-green urine: possible antidotal effect by flumazenil.
Journal of toxicology. Clinical toxicology.
2002; 40(5):571-2. doi:
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Human psychopharmacology.
2001 Jul; 16(5):369-392. doi:
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International journal of clinical practice. Supplement.
2001 Jan; ?(116):9-13. doi:
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Drug and alcohol dependence.
2000 Dec; 61(1):69-84. doi:
10.1016/s0376-8716(00)00122-8. [PMID: 11064185] - N A Ator. Zaleplon and triazolam: drug discrimination, plasma levels, and self-administration in baboons.
Drug and alcohol dependence.
2000 Dec; 61(1):55-68. doi:
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American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2000 Dec; 57(24):2267-70. doi:
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American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2000 Jun; 57(12):1137-41. doi:
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Expert opinion on investigational drugs.
2000 Apr; 9(4):841-58. doi:
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