Phenylacetylglycine (BioDeep_00000405375)

Main id: BioDeep_00000002795

 

PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


Phenylacetylglycine

化学式: C10H11NO3 (193.0738896)
中文名称: 苯乙酰甘氨酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C=C1)CC(=O)NCC(=O)O
InChI: InChI=1S/C10H11NO3/c12-9(11-7-10(13)14)6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H,11,12)(H,13,14)

描述信息

A N-acylglycine that is glycine substituted on nitrogen with a phenylacetyl group.
Phenylacetylglycine is a gut microbial metabolite that can activate β2AR. Phenylacetylglycine protects against cardiac injury caused by ischemia/reperfusion[1].
Phenylacetylglycine is a gut microbial metabolite that can activate β2AR. Phenylacetylglycine protects against cardiac injury caused by ischemia/reperfusion[1].

同义名列表

1 个代谢物同义名

Phenylacetylglycine



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Ming-Yuan Xu, Ying-Jian Sun, Pan Wang, Lin Yang, Yi-Jun Wu. Metabolomic biomarkers in urine of rats following long-term low-dose exposure of cadmium and/or chlorpyrifos. Ecotoxicology and environmental safety. 2020 Jun; 195(?):110467. doi: 10.1016/j.ecoenv.2020.110467. [PMID: 32182532]
  • Mengran Li, Chunxiao Wu, Hongbin Guo, Ce Chu, Mingye Hu, Chengyan Zhou. Mangiferin improves hepatic damage-associated molecular patterns, lipid metabolic disorder and mitochondrial dysfunction in alcohol hepatitis rats. Food & function. 2019 Jun; 10(6):3514-3534. doi: 10.1039/c9fo00153k. [PMID: 31144698]
  • Zhenzhao Wang, Rui Xu, Guiping Shen, Jianghua Feng. Metabolic Response in Rabbit Urine to Occurrence and Relief of Unilateral Ureteral Obstruction. Journal of proteome research. 2018 09; 17(9):3184-3194. doi: 10.1021/acs.jproteome.8b00304. [PMID: 30024170]
  • Gregorio Peron, Stefano Dall'Acqua, Stefania Sut. Supplementation with resveratrol as Polygonum cuspidatum Sieb. et Zucc. extract induces changes in the excretion of urinary markers associated to aging in rats. Fitoterapia. 2018 Sep; 129(?):154-161. doi: 10.1016/j.fitote.2018.06.022. [PMID: 29959053]
  • Ning Ma, Yajun Yang, Xiwang Liu, Xiaojun Kong, Shihong Li, Zhe Qin, Zenghua Jiao, Jianyong Li. UPLC-Q-TOF/MS-based metabonomic studies on the intervention effects of aspirin eugenol ester in atherosclerosis hamsters. Scientific reports. 2017 09; 7(1):10544. doi: 10.1038/s41598-017-11422-7. [PMID: 28874840]
  • Nishikant Wase, Boqiang Tu, James W Allen, Paul N Black, Concetta C DiRusso. Identification and Metabolite Profiling of Chemical Activators of Lipid Accumulation in Green Algae. Plant physiology. 2017 Aug; 174(4):2146-2165. doi: 10.1104/pp.17.00433. [PMID: 28652262]
  • You Jin Kim, Iksoo Huh, Ji Yeon Kim, Saejong Park, Sung Ha Ryu, Kyu-Bong Kim, Suhkmann Kim, Taesung Park, Oran Kwon. Integration of Traditional and Metabolomics Biomarkers Identifies Prognostic Metabolites for Predicting Responsiveness to Nutritional Intervention against Oxidative Stress and Inflammation. Nutrients. 2017 Mar; 9(3):. doi: 10.3390/nu9030233. [PMID: 28273855]
  • Hidenori Kamiguchi, Mika Murabayashi, Ikuo Mori, Akira Horinouchi, Kazutaka Higaki. Biomarker discovery for drug-induced phospholipidosis: phenylacetylglycine to hippuric acid ratio in urine and plasma as potential markers. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2017 Mar; 22(2):178-188. doi: 10.1080/1354750x.2016.1252958. [PMID: 27775443]
  • Liqiang Gu, Huiyan Shi, Ruowen Zhang, Zhe Wei, Kai-Shun Bi, Xiao-Hui Chen. Simultaneous Determination of Five Specific and Sensitive Nephrotoxicity Biomarkers in Serum and Urine Samples of Four Drug-Induced Kidney Injury Models. Journal of chromatographic science. 2017 01; 55(1):60-68. doi: 10.1093/chromsci/bmw150. [PMID: 27993865]
  • Hidenori Kamiguchi, Masashi Yamaguchi, Mika Murabayashi, Ikuo Mori, Akira Horinouchi. Method development and validation for simultaneous quantitation of endogenous hippuric acid and phenylacetylglycine in rat urine using liquid chromatography coupled with electrospray ionization tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Nov; 1035(?):76-83. doi: 10.1016/j.jchromb.2016.09.036. [PMID: 27697729]
  • Donald F Stec, Suwan Wang, Cody Stothers, Josh Avance, Deon Denson, Raymond Harris, Paul Voziyan. Alterations of urinary metabolite profile in model diabetic nephropathy. Biochemical and biophysical research communications. 2015 Jan; 456(2):610-4. doi: 10.1016/j.bbrc.2014.12.003. [PMID: 25499815]
  • Lorena González-Guardia, Elena María Yubero-Serrano, Javier Delgado-Lista, Pablo Perez-Martinez, Antonio Garcia-Rios, Carmen Marin, Antonio Camargo, Nieves Delgado-Casado, Helen M Roche, Francisco Perez-Jimenez, Lorraine Brennan, José López-Miranda. Effects of the Mediterranean diet supplemented with coenzyme q10 on metabolomic profiles in elderly men and women. The journals of gerontology. Series A, Biological sciences and medical sciences. 2015 Jan; 70(1):78-84. doi: 10.1093/gerona/glu098. [PMID: 24986061]
  • Jeeyoun Jung, Youngae Jung, Eun Jung Bang, Sung-il Cho, You-Jin Jang, Jung-Myun Kwak, Do Hyun Ryu, Sungsoo Park, Geum-Sook Hwang. Noninvasive diagnosis and evaluation of curative surgery for gastric cancer by using NMR-based metabolomic profiling. Annals of surgical oncology. 2014 Dec; 21 Suppl 4(?):S736-42. doi: 10.1245/s10434-014-3886-0. [PMID: 25092158]
  • Rune Gangsøy Kristiansen, Christopher F Rose, Ole-Martin Fuskevåg, Hanne Mæhre, Arthur Revhaug, Rajiv Jalan, Lars Marius Ytrebø. L-Ornithine phenylacetate reduces ammonia in pigs with acute liver failure through phenylacetylglycine formation: a novel ammonia-lowering pathway. American journal of physiology. Gastrointestinal and liver physiology. 2014 Nov; 307(10):G1024-31. doi: 10.1152/ajpgi.00244.2014. [PMID: 25258408]
  • Huawei Zhang, Peng Fu, Beilei Ke, Shuping Wang, Min Li, Lin Han, Chengcheng Peng, Weidong Zhang, Runhui Liu. Metabolomic analysis of biochemical changes in the plasma and urine of collagen-induced arthritis in rats after treatment with Huang-Lian-Jie-Du-Tang. Journal of ethnopharmacology. 2014 May; 154(1):55-64. doi: 10.1016/j.jep.2014.03.007. [PMID: 24709313]
  • Liqiang Gu, Xiaofan Wang, Yuanyuan Zhang, Yu Jiang, Huan Lu, Kaishun Bi, Xiaohui Chen. Determination of 12 potential nephrotoxicity biomarkers in rat serum and urine by liquid chromatography with mass spectrometry and its application to renal failure induced by Semen Strychni. Journal of separation science. 2014 May; 37(9-10):1058-66. doi: 10.1002/jssc.201400053. [PMID: 24610835]
  • Zhi-Hao Zhang, Ying-Yong Zhao, Xian-Long Cheng, Rui-Chao Lin, Zhong Dai, Chao Zhou. Metabonomic study of biochemical changes in the rat urine induced by Pinellia ternata (Thunb.) Berit. Journal of pharmaceutical and biomedical analysis. 2013 Nov; 85(?):186-93. doi: 10.1016/j.jpba.2013.07.026. [PMID: 23948763]
  • Kazuki Akira, Hiroyuki Hichiya, Mayu Morita, Akane Shimizu, Hidemichi Mitome. Metabonomic study on the biochemical response of spontaneously hypertensive rats to chronic taurine supplementation using (1)H NMR spectroscopic urinalysis. Journal of pharmaceutical and biomedical analysis. 2013 Nov; 85(?):155-61. doi: 10.1016/j.jpba.2013.07.018. [PMID: 23954436]
  • Xiao-Xia Gao, Jie Cui, Xing-Yu Zheng, Zhen-Yu Li, Young-Hae Choi, Yu-Zhi Zhou, Jun-Sheng Tian, Jie Xing, Xiao-Jie Tan, Guan-Hua Du, Xue-Mei Qin. An investigation of the antidepressant action of xiaoyaosan in rats using ultra performance liquid chromatography-mass spectrometry combined with metabonomics. Phytotherapy research : PTR. 2013 Jul; 27(7):1074-85. doi: 10.1002/ptr.4805. [PMID: 22975930]
  • Doris M Jacobs, Laura Spiesser, Maxime Garnier, Niels de Roo, Ferdi van Dorsten, Boudewijn Hollebrands, Ewoud van Velzen, Richard Draijer, John van Duynhoven. SPE-NMR metabolite sub-profiling of urine. Analytical and bioanalytical chemistry. 2012 Nov; 404(8):2349-61. doi: 10.1007/s00216-012-6339-2. [PMID: 22932811]
  • Avalyn Stanislaus, Kevin Guo, Liang Li. Development of an isotope labeling ultra-high performance liquid chromatography mass spectrometric method for quantification of acylglycines in human urine. Analytica chimica acta. 2012 Oct; 750(?):161-72. doi: 10.1016/j.aca.2012.05.006. [PMID: 23062437]
  • Yuanyuan Zhang, Fei Li, Andrew D Patterson, Yao Wang, Kristopher W Krausz, Geoffrey Neale, Sarah Thomas, Deepa Nachagari, Peter Vogel, Mary Vore, Frank J Gonzalez, John D Schuetz. Abcb11 deficiency induces cholestasis coupled to impaired β-fatty acid oxidation in mice. The Journal of biological chemistry. 2012 Jul; 287(29):24784-94. doi: 10.1074/jbc.m111.329318. [PMID: 22619174]
  • Xiaojun Zhang, Franky F K Choi, Yan Zhou, Feung P Leung, Shun Tan, Shuhai Lin, Hongxi Xu, Wei Jia, Joseph J Y Sung, Zongwei Cai, Zhaoxiang Bian. Metabolite profiling of plasma and urine from rats with TNBS-induced acute colitis using UPLC-ESI-QTOF-MS-based metabonomics--a pilot study. The FEBS journal. 2012 Jul; 279(13):2322-38. doi: 10.1111/j.1742-4658.2012.08612.x. [PMID: 22520047]
  • Kazuki Akira, Shigenori Masu, Misako Imachi, Hidemichi Mitome, Takao Hashimoto. A metabonomic study of biochemical changes characteristic of genetically hypertensive rats based on (1)H NMR spectroscopic urinalysis. Hypertension research : official journal of the Japanese Society of Hypertension. 2012 Apr; 35(4):404-12. doi: 10.1038/hr.2011.182. [PMID: 22089538]
  • Shangshang Zhang, Xinyu Liu, Shuning Zheng, Minyan Jiang, Changying Xin, Xiumei Lu, Famei Li, Zhili Xiong. [Metabonomic study on protective effect of ethanol extracts of drynariae rhizoma on osteoporosis in rats urine by using UPLC-MS/MS]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Mar; 37(5):658-62. doi: NULL. [PMID: 22693913]
  • Guangguo Tan, Wenting Liao, Xin Dong, Genjing Yang, Zhenyu Zhu, Wuhong Li, Yifeng Chai, Ziyang Lou. Metabonomic profiles delineate the effect of traditional Chinese medicine sini decoction on myocardial infarction in rats. PloS one. 2012; 7(4):e34157. doi: 10.1371/journal.pone.0034157. [PMID: 22493681]
  • M T Osorio, A P Moloney, L Brennan, F J Monahan. Authentication of beef production systems using a metabolomic-based approach. Animal : an international journal of animal bioscience. 2012 Jan; 6(1):167-72. doi: 10.1017/s1751731111001418. [PMID: 22436164]
  • Najla Gooda Sahib, Nazamid Saari, Amin Ismail, Alfi Khatib, Fawzi Mahomoodally, Azizah Abdul Hamid. Plants' metabolites as potential antiobesity agents. TheScientificWorldJournal. 2012; 2012(?):436039. doi: 10.1100/2012/436039. [PMID: 22666121]
  • Xiu-Ju Zhao, Chongyang Huang, Hehua Lei, Xiu Nie, Huiru Tang, Yulan Wang. Dynamic metabolic response of mice to acute mequindox exposure. Journal of proteome research. 2011 Nov; 10(11):5183-90. doi: 10.1021/pr2006457. [PMID: 21905750]
  • Takafumi Toyohara, Takehiro Suzuki, Yasutoshi Akiyama, Daisuke Yoshihara, Yoichi Takeuchi, Eikan Mishima, Koichi Kikuchi, Chitose Suzuki, Masayuki Tanemoto, Sadayoshi Ito, Shizuko Nagao, Tomoyoshi Soga, Takaaki Abe. Metabolomic profiling of the autosomal dominant polycystic kidney disease rat model. Clinical and experimental nephrology. 2011 Oct; 15(5):676-687. doi: 10.1007/s10157-011-0467-4. [PMID: 21695416]
  • Jia V Li, Jasmina Saric, Yulan Wang, Jennifer Keiser, Jürg Utzinger, Elaine Holmes. Chemometric analysis of biofluids from mice experimentally infected with Schistosoma mansoni. Parasites & vectors. 2011 Sep; 4(?):179. doi: 10.1186/1756-3305-4-179. [PMID: 21929782]
  • Morten R Clausen, Kirstine L Christensen, Mette S Hedemann, Ying Liu, Stig Purup, Mette Schmidt, Henrik Callesen, Jan Stagsted, Hanne C Bertram. Metabolomic phenotyping of a cloned pig model. BMC physiology. 2011 Aug; 11(?):14. doi: 10.1186/1472-6793-11-14. [PMID: 21859467]
  • Jonathan R Swann, Kieran M Tuohy, Peter Lindfors, Duncan T Brown, Glenn R Gibson, Ian D Wilson, James Sidaway, Jeremy K Nicholson, Elaine Holmes. Variation in antibiotic-induced microbial recolonization impacts on the host metabolic phenotypes of rats. Journal of proteome research. 2011 Aug; 10(8):3590-603. doi: 10.1021/pr200243t. [PMID: 21591676]
  • Peter G Mantle, Andrew W Nicholls, John P Shockcor. H NMR spectroscopy-based metabolomic assessment of uremic toxicity, with toxicological outcomes, in male rats following an acute, mid-life insult from ochratoxin a. Toxins. 2011 06; 3(6):504-19. doi: 10.3390/toxins3060504. [PMID: 22069722]
  • Seok-Min Kang, Jong-Chul Park, Min-Jeong Shin, Hyeran Lee, Jaewon Oh, Do Hyun Ryu, Geum-Sook Hwang, Ji Hyung Chung. ¹H nuclear magnetic resonance based metabolic urinary profiling of patients with ischemic heart failure. Clinical biochemistry. 2011 Mar; 44(4):293-9. doi: 10.1016/j.clinbiochem.2010.11.010. [PMID: 21167146]
  • Jeeyoun Jung, Minhwa Park, Hye Jin Park, Sun Bo Shim, Yang Ha Cho, Jinho Kim, Ho-Sub Lee, Do Hyun Ryu, Donwoong Choi, Geum-Sook Hwang. ¹H NMR-based metabolic profiling of naproxen-induced toxicity in rats. Toxicology letters. 2011 Jan; 200(1-2):1-7. doi: 10.1016/j.toxlet.2010.09.020. [PMID: 20932884]
  • Xiumei Lu, Zhili Xiong, Jingjing Li, Shuning Zheng, Taoguang Huo, Famei Li. Metabonomic study on 'Kidney-Yang Deficiency syndrome' and intervention effects of Rhizoma Drynariae extracts in rats using ultra performance liquid chromatography coupled with mass spectrometry. Talanta. 2011 Jan; 83(3):700-8. doi: 10.1016/j.talanta.2010.09.026. [PMID: 21147309]
  • James M Kinross, Nawar Alkhamesi, Richard H Barton, David B Silk, Ivan K S Yap, Ara W Darzi, Elaine Holmes, Jeremy K Nicholson. Global metabolic phenotyping in an experimental laparotomy model of surgical trauma. Journal of proteome research. 2011 Jan; 10(1):277-87. doi: 10.1021/pr1003278. [PMID: 21105667]
  • Jia V Li, Jasmina Saric, Yulan Wang, Jürg Utzinger, Elaine Holmes, Oliver Balmer. Metabonomic investigation of single and multiple strain Trypanosoma brucei brucei infections. The American journal of tropical medicine and hygiene. 2011 Jan; 84(1):91-8. doi: 10.4269/ajtmh.2011.10-0402. [PMID: 21212208]
  • Il Yong Kim, Jeeyoun Jung, Mi Jang, Yun Gyong Ahn, Jae Hoon Shin, Ji Won Choi, Mi Ra Sohn, Sun Mee Shin, Dae-Gil Kang, Ho-Sub Lee, Yun Soo Bae, Do Hyun Ryu, Je Kyung Seong, Geum-Sook Hwang. 1H NMR-based metabolomic study on resistance to diet-induced obesity in AHNAK knock-out mice. Biochemical and biophysical research communications. 2010 Dec; 403(3-4):428-34. doi: 10.1016/j.bbrc.2010.11.048. [PMID: 21094140]
  • Sander Michel Houten, Ronald J A Wanders. A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation. Journal of inherited metabolic disease. 2010 Oct; 33(5):469-77. doi: 10.1007/s10545-010-9061-2. [PMID: 20195903]
  • Junfang Wu, Wenxin Xu, Zhenping Ming, Huifen Dong, Huiru Tang, Yulan Wang. Metabolic changes reveal the development of schistosomiasis in mice. PLoS neglected tropical diseases. 2010 Aug; 4(8):. doi: 10.1371/journal.pntd.0000807. [PMID: 20824219]
  • Isabel Garcia-Perez, Marc E Earll, Santiago Angulo, Coral Barbas, Cristina Legido-Quigley. Chemometric analysis of urine fingerprints acquired by liquid chromatography-mass spectrometry and capillary electrophoresis: application to the schistosomiasis mouse model. Electrophoresis. 2010 Jul; 31(14):2349-55. doi: 10.1002/elps.200900492. [PMID: 20575107]
  • Jasmina Saric, Jia V Li, Jonathan R Swann, Jürg Utzinger, Gail Calvert, Jeremy K Nicholson, Stephan Dirnhofer, Maggie J Dallman, Magda Bictash, Elaine Holmes. Integrated cytokine and metabolic analysis of pathological responses to parasite exposure in rodents. Journal of proteome research. 2010 May; 9(5):2255-64. doi: 10.1021/pr901019z. [PMID: 20092362]
  • Jun-Fang Wu, Elaine Holmes, Jian Xue, Shu-Hua Xiao, Burton H Singer, Hui-Ru Tang, Jürg Utzinger, Yu-Lan Wang. Metabolic alterations in the hamster co-infected with Schistosoma japonicum and Necator americanus. International journal for parasitology. 2010 May; 40(6):695-703. doi: 10.1016/j.ijpara.2009.11.003. [PMID: 19951707]
  • Qian Bu, Guangyan Yan, Pengchi Deng, Feng Peng, Hongjun Lin, Youzhi Xu, Zhixing Cao, Tian Zhou, Aiqin Xue, Yanli Wang, Xiaobo Cen, Ying-Lan Zhao. NMR-based metabonomic study of the sub-acute toxicity of titanium dioxide nanoparticles in rats after oral administration. Nanotechnology. 2010 Mar; 21(12):125105. doi: 10.1088/0957-4484/21/12/125105. [PMID: 20203358]
  • Shuning Zheng, Mingyang Yu, Xiumei Lu, Taoguang Huo, Lin Ge, Jingyu Yang, Chunfu Wu, Famei Li. Urinary metabonomic study on biochemical changes in chronic unpredictable mild stress model of depression. Clinica chimica acta; international journal of clinical chemistry. 2010 Feb; 411(3-4):204-9. doi: 10.1016/j.cca.2009.11.003. [PMID: 19913000]
  • I Garcia-Perez, A Couto Alves, S Angulo, J V Li, J Utzinger, T M D Ebbels, C Legido-Quigley, J K Nicholson, E Holmes, C Barbas. Bidirectional correlation of NMR and capillary electrophoresis fingerprints: a new approach to investigating Schistosoma mansoni infection in a mouse model. Analytical chemistry. 2010 Jan; 82(1):203-10. doi: 10.1021/ac901728w. [PMID: 19961175]
  • Yulan Wang, Shu-Hua Xiao, Jian Xue, Burton H Singer, Jürg Utzinger, Elaine Holmes. Systems metabolic effects of a necator americanus infection in Syrian hamster. Journal of proteome research. 2009 Dec; 8(12):5442-50. doi: 10.1021/pr900711j. [PMID: 19810771]
  • So-Hyun Kim, Seung-Ok Yang, Hee-Su Kim, Yujin Kim, Taesun Park, Hyung-Kyoon Choi. 1H-nuclear magnetic resonance spectroscopy-based metabolic assessment in a rat model of obesity induced by a high-fat diet. Analytical and bioanalytical chemistry. 2009 Oct; 395(4):1117-24. doi: 10.1007/s00216-009-3054-8. [PMID: 19711056]
  • Jasmina Saric, Jia V Li, Yulan Wang, Jennifer Keiser, Kirill Veselkov, Stephan Dirnhofer, Ivan K S Yap, Jeremy K Nicholson, Elaine Holmes, Jürg Utzinger. Panorganismal metabolic response modeling of an experimental Echinostoma caproni infection in the mouse. Journal of proteome research. 2009 Aug; 8(8):3899-911. doi: 10.1021/pr900185s. [PMID: 19489577]
  • Santiago Angulo, Isabel García-Pérez, Cristina Legido-Quigley, Coral Barbas. The autocorrelation matrix probing biochemical relationships after metabolic fingerprinting with CE. Electrophoresis. 2009 Apr; 30(7):1221-7. doi: 10.1002/elps.200800554. [PMID: 19283696]
  • Bethanne M Warrack, Serhiy Hnatyshyn, Karl-Heinz Ott, Michael D Reily, Mark Sanders, Haiying Zhang, Dieter M Drexler. Normalization strategies for metabonomic analysis of urine samples. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Feb; 877(5-6):547-52. doi: 10.1016/j.jchromb.2009.01.007. [PMID: 19185549]
  • Lai Wei, Peiqiu Liao, Huifeng Wu, Xiaojing Li, Fengkui Pei, Weisheng Li, Yijie Wu. Metabolic profiling studies on the toxicological effects of realgar in rats by (1)H NMR spectroscopy. Toxicology and applied pharmacology. 2009 Feb; 234(3):314-25. doi: 10.1016/j.taap.2008.11.010. [PMID: 19073202]
  • Jong-Chul Park, Young-Shick Hong, Yeon Joo Kim, Ji-Young Yang, Eun-Young Kim, Seung Jun Kwack, Do Hyun Ryu, Geum-Sook Hwang, Byung Mu Lee. A metabonomic study on the biochemical effects of doxorubicin in rats using (1)H-NMR spectroscopy. Journal of toxicology and environmental health. Part A. 2009; 72(6):374-84. doi: 10.1080/15287390802647195. [PMID: 19199144]
  • Ivano Bertini, Antonio Calabrò, Valeria De Carli, Claudio Luchinat, Stefano Nepi, Berardino Porfirio, Daniela Renzi, Edoardo Saccenti, Leonardo Tenori. The metabonomic signature of celiac disease. Journal of proteome research. 2009 Jan; 8(1):170-7. doi: 10.1021/pr800548z. [PMID: 19072164]
  • Eszter Bohus, Muireann Coen, Hector C Keun, Timothy M D Ebbels, Olaf Beckonert, John C Lindon, Elaine Holmes, Béla Noszál, Jeremy K Nicholson. Temporal metabonomic modeling of l-arginine-induced exocrine pancreatitis. Journal of proteome research. 2008 Oct; 7(10):4435-45. doi: 10.1021/pr800407j. [PMID: 18710274]
  • Jia V Li, Yulan Wang, Jasmina Saric, Jeremy K Nicholson, Stephan Dirnhofer, Burton H Singer, Marcel Tanner, Sergio Wittlin, Elaine Holmes, Jürg Utzinger. Global metabolic responses of NMRI mice to an experimental Plasmodium berghei infection. Journal of proteome research. 2008 Sep; 7(9):3948-56. doi: 10.1021/pr800209d. [PMID: 18646786]
  • Ivan K S Yap, Jia V Li, Jasmina Saric, Francois-Pierre Martin, Huw Davies, Yulan Wang, Ian D Wilson, Jeremy K Nicholson, Jürg Utzinger, Julian R Marchesi, Elaine Holmes. Metabonomic and microbiological analysis of the dynamic effect of vancomycin-induced gut microbiota modification in the mouse. Journal of proteome research. 2008 Sep; 7(9):3718-28. doi: 10.1021/pr700864x. [PMID: 18698804]
  • Jasmina Saric, Jia V Li, Yulan Wang, Jennifer Keiser, Jake G Bundy, Elaine Holmes, Jürg Utzinger. Metabolic profiling of an Echinostoma caproni infection in the mouse for biomarker discovery. PLoS neglected tropical diseases. 2008 Jul; 2(7):e254. doi: 10.1371/journal.pntd.0000254. [PMID: 18596973]
  • Lai Wei, Peiqiu Liao, Huifeng Wu, Xiaojing Li, Fengkui Pei, Weisheng Li, Yijie Wu. Toxicological effects of cinnabar in rats by NMR-based metabolic profiling of urine and serum. Toxicology and applied pharmacology. 2008 Mar; 227(3):417-29. doi: 10.1016/j.taap.2007.11.015. [PMID: 18164359]
  • Francois-Pierre J Martin, Yulan Wang, Norbert Sprenger, Ivan K S Yap, Torbjörn Lundstedt, Per Lek, Serge Rezzi, Ziad Ramadan, Peter van Bladeren, Laurent B Fay, Sunil Kochhar, John C Lindon, Elaine Holmes, Jeremy K Nicholson. Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model. Molecular systems biology. 2008; 4(?):157. doi: 10.1038/msb4100190. [PMID: 18197175]
  • Francois-Pierre J Martin, Yulan Wang, Norbert Sprenger, Ivan K S Yap, Serge Rezzi, Ziad Ramadan, Emma Peré-Trepat, Florence Rochat, Christine Cherbut, Peter van Bladeren, Laurent B Fay, Sunil Kochhar, John C Lindon, Elaine Holmes, Jeremy K Nicholson. Top-down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model. Molecular systems biology. 2008; 4(?):205. doi: 10.1038/msb.2008.40. [PMID: 18628745]
  • Sandrine P Claus, Tsz M Tsang, Yulan Wang, Olivier Cloarec, Eleni Skordi, François-Pierre Martin, Serge Rezzi, Alastair Ross, Sunil Kochhar, Elaine Holmes, Jeremy K Nicholson. Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes. Molecular systems biology. 2008; 4(?):219. doi: 10.1038/msb.2008.56. [PMID: 18854818]
  • Mina Hasegawa, Shigeo Takenaka, Mitsuru Kuwamura, Jyoji Yamate, Shingo Tsuyama. Urinary metabolic fingerprinting for amiodarone-induced phospholipidosis in rats using FT-ICR MS. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 2007 Oct; 59(2):115-20. doi: 10.1016/j.etp.2007.04.001. [PMID: 17719757]
  • François-Pierre J Martin, Marc-Emmanuel Dumas, Yulan Wang, Cristina Legido-Quigley, Ivan K S Yap, Huiru Tang, Séverine Zirah, Gerard M Murphy, Olivier Cloarec, John C Lindon, Norbert Sprenger, Laurent B Fay, Sunil Kochhar, Peter van Bladeren, Elaine Holmes, Jeremy K Nicholson. A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model. Molecular systems biology. 2007; 3(?):112. doi: 10.1038/msb4100153. [PMID: 17515922]
  • Fredd Vergara, Ales Svatos, Bernd Schneider, Michael Reichelt, Jonathan Gershenzon, Ute Wittstock. Glycine conjugates in a lepidopteran insect herbivore--the metabolism of benzylglucosinolate in the cabbage white butterfly, Pieris rapae. Chembiochem : a European journal of chemical biology. 2006 Dec; 7(12):1982-9. doi: 10.1002/cbic.200600280. [PMID: 17086559]
  • Frank Dieterle, Alfred Ross, Götz Schlotterbeck, Hans Senn. Metabolite projection analysis for fast identification of metabolites in metabonomics. Application in an amiodarone study. Analytical chemistry. 2006 Jun; 78(11):3551-61. doi: 10.1021/ac0518351. [PMID: 16737207]
  • Yulan Wang, Jürg Utzinger, Shu-Hua Xiao, Jian Xue, Jeremy K Nicholson, Marcel Tanner, Burton H Singer, Elaine Holmes. System level metabolic effects of a Schistosoma japonicum infection in the Syrian hamster. Molecular and biochemical parasitology. 2006 Mar; 146(1):1-9. doi: 10.1016/j.molbiopara.2005.10.010. [PMID: 16337285]
  • Jane Delaney, William A Neville, Aubrey Swain, Adam Miles, Michael S Leonard, Catherine J Waterfield. Phenylacetylglycine, a putative biomarker of phospholipidosis: its origins and relevance to phospholipid accumulation using amiodarone treated rats as a model. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2004 May; 9(3):271-90. doi: 10.1080/13547500400018570. [PMID: 15764292]
  • Susan C Connor, Wen Wu, Brian C Sweatman, Jodi Manini, John N Haselden, Daniel J Crowther, Catherine J Waterfield. Effects of feeding and body weight loss on the 1H-NMR-based urine metabolic profiles of male Wistar Han rats: implications for biomarker discovery. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2004 Mar; 9(2):156-79. doi: 10.1080/13547500410001720767. [PMID: 15370873]
  • Andrew W Nicholls, Russell J Mortishire-Smith, Jeremy K Nicholson. NMR spectroscopic-based metabonomic studies of urinary metabolite variation in acclimatizing germ-free rats. Chemical research in toxicology. 2003 Nov; 16(11):1395-404. doi: 10.1021/tx0340293. [PMID: 14615964]
  • F G Russel, W G Vermeulen. Effect of substituted benzoylglycines (hippurates) and phenylacetylglycines on p-aminohippurate transport in dog renal membrane vesicles. Pharmaceutical research. 1994 Dec; 11(12):1829-33. doi: 10.1023/a:1018992106452. [PMID: 7899251]
  • M J Arín, M T Diez, J A Resines. Rapid and simple method for the determination of urinary benzoic and phenylacetic acids and their glycine conjugates in ruminants by reversed-phase high-performance liquid chromatography. Journal of chromatography. 1992 Nov; 582(1-2):13-8. doi: 10.1016/0378-4347(92)80296-3. [PMID: 1491031]
  • I Linhart, J Smejkal. Changes in the excretion of endogenous glycine conjugate as a possible artifact in toxicological experiments. Archives of toxicology. 1987; 61(1):83-5. doi: 10.1007/bf00324554. [PMID: 3439880]
  • K Maeda, T Niwa, H Asada, N Yamamoto, A Kawanishi, M Yokoyama, M Shibata. [Analysis of organic acids in uremic serum during intravenous infusion of essential amino acids using gas chromatography-mass spectrometry]. Nihon Jinzo Gakkai shi. 1983 Aug; 25(8):1003-9. doi: NULL. [PMID: 6668741]
  • L P Delbressine, H C Ketelaars, F Seutter-Berlage, F L Smeets. Phenaceturic acid, a new urinary metabolite of styrene in the rat. Xenobiotica; the fate of foreign compounds in biological systems. 1980 May; 10(5):337-42. doi: 10.3109/00498258009033765. [PMID: 7415215]
  • B B LEVINE. Studies on the dimensions of the rabbit antibenzylpenicilloyl antibody-combing sites. The Journal of experimental medicine. 1963 Jan; 117(?):161-83. doi: 10.1084/jem.117.1.161. [PMID: 13930142]