Enhydrin (BioDeep_00000268908)

Main id: BioDeep_00000007346

Secondary id: BioDeep_00001042940

natural product PANOMIX_OTCML-2023


代谢物信息卡片


CHEBI:604463

化学式: C23H28O10 (464.1682)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(not specific) 25%

分子结构信息

SMILES: C=C1C(=O)O[C@H]2[C@H]1[C@H](OC(=O)[C@]1(C)O[C@@H]1C)[C@@H](OC(C)=O)/C(C(=O)OC)=C\CC[C@@]1(C)O[C@H]21
InChI: InChI=1S/C23H28O10/c1-10-14-16(31-21(27)23(5)11(2)32-23)15(29-12(3)24)13(20(26)28-6)8-7-9-22(4)18(33-22)17(14)30-19(10)25/h8,11,14-18H,1,7,9H2,2-6H3/b13-8+/t11-,14+,15-,16-,17-,18-,22+,23-/m0/s1

描述信息

同义名列表

3 个代谢物同义名

CHEBI:604463; Enhydrin; Enhydrin



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

21 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 CASP3, CASP7, CDK2, EGFR, PTGS2
Peripheral membrane protein 1 PTGS2
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 2 EGFR, PTGS2
Nucleus 4 CASP3, CASP7, CDK2, EGFR
cytosol 4 CASP3, CASP7, CDK2, GPT
centrosome 1 CDK2
nucleoplasm 3 CASP3, CASP7, CDK2
Cell membrane 1 EGFR
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
cell junction 1 EGFR
cell surface 1 EGFR
glutamatergic synapse 2 CASP3, EGFR
Golgi membrane 2 EGFR, INS
lysosomal membrane 1 GAA
neuronal cell body 1 CASP3
Cytoplasm, cytosol 1 CASP7
Lysosome 1 GAA
endosome 2 CDK2, EGFR
plasma membrane 2 EGFR, GAA
Membrane 2 EGFR, GAA
apical plasma membrane 1 EGFR
basolateral plasma membrane 1 EGFR
caveola 1 PTGS2
extracellular exosome 3 GAA, GPT, MMP9
Lysosome membrane 1 GAA
endoplasmic reticulum 1 PTGS2
extracellular space 4 CASP7, EGFR, INS, MMP9
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 1 EGFR
protein-containing complex 2 EGFR, PTGS2
intracellular membrane-bounded organelle 1 GAA
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 EGFR
Secreted 2 GAA, INS
extracellular region 3 GAA, INS, MMP9
transcription regulator complex 1 CDK2
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 CDK2
nuclear membrane 1 EGFR
Secreted, extracellular space, extracellular matrix 1 MMP9
Membrane raft 1 EGFR
focal adhesion 1 EGFR
intracellular vesicle 1 EGFR
collagen-containing extracellular matrix 1 MMP9
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 1 EGFR
neuron projection 1 PTGS2
Secreted, extracellular space 1 CASP7
chromosome, telomeric region 1 CDK2
nuclear envelope 1 CDK2
endosome lumen 1 INS
tertiary granule membrane 1 GAA
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 1 MMP9
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 INS, PTGS2
male germ cell nucleus 1 CDK2
tertiary granule lumen 1 MMP9
transport vesicle 1 INS
azurophil granule membrane 1 GAA
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
clathrin-coated endocytic vesicle membrane 1 EGFR
Cajal body 1 CDK2
ficolin-1-rich granule membrane 1 GAA
death-inducing signaling complex 1 CASP3
condensed chromosome 1 CDK2
Nucleus, Cajal body 1 CDK2
X chromosome 1 CDK2
Y chromosome 1 CDK2
cyclin-dependent protein kinase holoenzyme complex 1 CDK2
cyclin E1-CDK2 complex 1 CDK2
cyclin E2-CDK2 complex 1 CDK2
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
autolysosome lumen 1 GAA
cyclin A2-CDK2 complex 1 CDK2
cyclin A1-CDK2 complex 1 CDK2


文献列表

  • Hady Anshory Tamhid, Triana Hertiani, Yosi Bayu Murti, Retno Murwanti. Quantification of Enhydrin and Uvedalin in the Ethanolic Extract of Smallanthus sonchifolius Leaves Validated by the HPLC Method. Molecules (Basel, Switzerland). 2023 Feb; 28(4):. doi: 10.3390/molecules28041913. [PMID: 36838901]
  • Xiao-Ku Ran, Khin Khin Win Aung, Jun Bai, Pei-Yuan Dou, Zheng Zeng, De-Qiang Dou. Two new sesquiterpene lactones from leaves of yacon, Smallanthus sonchifolius. Journal of Asian natural products research. 2018 Jun; 20(6):538-544. doi: 10.1080/10286020.2017.1411346. [PMID: 29210302]
  • Jerónimo L Ulloa, Renata Spina, Agustina Casasco, Patricia B Petray, Virginia Martino, Miguel A Sosa, Fernanda M Frank, Liliana V Muschietti. Germacranolide-type sesquiterpene lactones from Smallanthus sonchifolius with promising activity against Leishmania mexicana and Trypanosoma cruzi. Parasites & vectors. 2017 Nov; 10(1):567. doi: 10.1186/s13071-017-2509-6. [PMID: 29132413]
  • C Serra-Barcellona, N C Habib, S M Honoré, S S Sánchez, S B Genta. Enhydrin Regulates Postprandial Hyperglycemia in Diabetic Rats by Inhibition of α-Glucosidase Activity. Plant foods for human nutrition (Dordrecht, Netherlands). 2017 Jun; 72(2):156-160. doi: 10.1007/s11130-017-0600-y. [PMID: 28161878]
  • G Sánchez-Toranzo, J Zapata-Martínez, C Catalán, M I Bühler. Effect of different types of sesquiterpene lactones on the maturation of Rhinella arenarum oocytes. Zygote (Cambridge, England). 2015 Jun; 23(3):406-11. doi: 10.1017/s0967199413000695. [PMID: 24522008]
  • Adriana A Lopes, Edieidia S Pina, Denise B Silva, Ana Maria S Pereira, Maria Fátima das G F da Silva, Fernando B Da Costa, Norberto P Lopes, Mônica T Pupo. A biosynthetic pathway of sesquiterpene lactones in Smallanthus sonchifolius and their localization in leaf tissues by MALDI imaging. Chemical communications (Cambridge, England). 2013 Nov; 49(85):9989-91. doi: 10.1039/c3cc46213g. [PMID: 24042494]
  • Carolina Serra Barcellona, Wilfredo Marcelino Cabrera, Stella Maris Honoré, María Inés Mercado, Sara Serafina Sánchez, Susana Beatriz Genta. Safety assessment of aqueous extract from leaf Smallanthus sonchifolius and its main active lactone, enhydrin. Journal of ethnopharmacology. 2012 Nov; 144(2):362-70. doi: 10.1016/j.jep.2012.09.021. [PMID: 23000115]
  • Dalad Siriwan, Takayuki Naruse, Hirotoshi Tamura. Effect of epoxides and α-methylene-γ-lactone skeleton of sesquiterpenes from yacon (Smallanthus sonchifolius) leaves on caspase-dependent apoptosis and NF-κB inhibition in human cercival cancer cells. Fitoterapia. 2011 Oct; 82(7):1093-101. doi: 10.1016/j.fitote.2011.07.007. [PMID: 21787849]
  • J G Choi, O H Kang, Y S Lee, Y C Oh, H S Chae, B Obiang-Obounou, S C Park, D W Shin, B Y Hwang, D Y Kwon. Antimicrobial activity of the constituents of Smallanthus sonchifolius leaves against methicillin-resistant Staphylococcus aureus. European review for medical and pharmacological sciences. 2010 Dec; 14(12):1005-9. doi: . [PMID: 21375130]
  • Susana B Genta, Wilfredo M Cabrera, María I Mercado, Alfredo Grau, César A Catalán, Sara S Sánchez. Hypoglycemic activity of leaf organic extracts from Smallanthus sonchifolius: Constituents of the most active fractions. Chemico-biological interactions. 2010 Apr; 185(2):143-52. doi: 10.1016/j.cbi.2010.03.004. [PMID: 20211156]
  • Guoyi Ma, Shabana I Khan, Gloria Benavides, Wolfgang Schühly, Nikolaus H Fischer, Ikhlas A Khan, David S Pasco. Inhibition of NF-kappaB-mediated transcription and induction of apoptosis by melampolides and repandolides. Cancer chemotherapy and pharmacology. 2007 Jun; 60(1):35-43. doi: 10.1007/s00280-006-0344-0. [PMID: 17149609]