9,13-cis-Retinoic acid (BioDeep_00000032760)

Main id: BioDeep_00000001595

 

human metabolite PANOMIX_OTCML-2023 Endogenous Antitumor activity BioNovoGene_Lab2019


代谢物信息卡片


(2Z,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid

化学式: C20H28O2 (300.2089)
中文名称: 维A酸, 视黄酸, Va酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1(C)C(/C=C/C(C)=C/C=C/C(C)=C/C(O)=O)=C(C)CCC1
InChI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+

描述信息

9,13-cis-Retinoic acid belongs to the class of organic compounds known as retinoids. These are oxygenated derivatives of 3,7-dimethyl-1-(2,6,6-trimethylcyclohex-1-enyl)nona-1,3,5,7-tetraene and derivatives thereof. Retinoids (vitamin A and its analogs) are essential dietary substances that are needed by mammals for reproduction, normal embryogenesis, growth, vision, and maintaining normal cellular differentiation and the integrity of the immune system. Within cells, retinoids regulate gene transcription acting through ligand-dependent transcription factors, the retinoic acid receptors (RARs), and the retinoid X receptors (RXRs).
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL). [HMDB]
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01X - Other antineoplastic agents > L01XF - Retinoids for cancer treatment
D - Dermatologicals > D10 - Anti-acne preparations > D10A - Anti-acne preparations for topical use > D10AD - Retinoids for topical use in acne
C274 - Antineoplastic Agent > C2122 - Cell Differentiating Agent > C1934 - Differentiation Inducer
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C804 - Retinoic Acid Agent
C308 - Immunotherapeutic Agent > C129820 - Antineoplastic Immunomodulating Agent
D020011 - Protective Agents > D000975 - Antioxidants > D002338 - Carotenoids
D003879 - Dermatologic Agents > D007641 - Keratolytic Agents
D000970 - Antineoplastic Agents
Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.
Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.
Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.

同义名列表

21 个代谢物同义名

(2Z,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-(2E,4Z,6E,8Z)-nonatetraen-1-Oic acid; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-(2E,4Z,6E,8Z)-nonatetraen-1-Oate; 9,13-cis-Retinoic acid anion; 9,13-cis-Vitamin-alpha-acid; 9-cis,13-cis-Retinoic acid; 9,13-di-cis-retinoic acid; 9,13-cis-Vitamin-a-acid; 9-cis,13-cis-Retinoate; 9,13-cis-Retinoic acid; 9,13-Di-cis-retinoate; 9,13-cis-Retinoate; 9,13-Retinoic acid; 9,13-Di-cis-ra; Tretinoin; DcVA; Retinoate; Vitamin A acid; all-trans-Retinoic acid; ATRA; Retinoic acid



数据库引用编号

23 个数据库交叉引用编号

分类词条

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ALDH1A3, BDNF, FGF8, FOXP3, GFAP, IFIH1, IRF3, MYC, PAX6, PPARG, RXRA, RXRG
Nucleus 10 FOXP3, IFIH1, IRF3, JUN, MYC, PAX6, PPARG, RXRA, RXRG, ZBTB16
cytosol 10 ALDH1A3, FOXP3, GFAP, IFIH1, IRF3, NGF, PAX6, PPARG, RXRA, ZBTB16
dendrite 2 BDNF, NGF
mitochondrial membrane 1 MAVS
nuclear body 1 ZBTB16
nucleoplasm 8 FOXP3, IRF3, JUN, MYC, PAX6, PPARG, RXRA, RXRG
RNA polymerase II transcription regulator complex 4 JUN, PPARG, RXRA, RXRG
synaptic vesicle 2 BDNF, NGF
plasma membrane 2 CSF2, PRAM1
Membrane 3 BDNF, MYC, PAX6
axon 2 BDNF, NGF
extracellular exosome 1 ALDH1A3
extracellular space 6 BDNF, CSF2, CSF3, FGF8, IFNA1, NGF
lysosomal lumen 1 CSF3
perinuclear region of cytoplasm 2 BDNF, PPARG
mitochondrion 4 IFIH1, IRF3, MAVS, RXRA
protein-containing complex 4 FOXP3, MYC, PRAM1, ZBTB16
intracellular membrane-bounded organelle 2 CSF2, PPARG
Secreted 6 BDNF, CSF2, CSF3, FGF8, IFNA1, NGF
extracellular region 5 BDNF, CSF2, CSF3, FGF8, NGF
Mitochondrion outer membrane 1 MAVS
Single-pass membrane protein 1 MAVS
mitochondrial outer membrane 1 MAVS
astrocyte end-foot 1 GFAP
transcription regulator complex 2 JUN, RXRA
external side of plasma membrane 1 FGF8
nucleolus 1 MYC
Peroxisome 1 MAVS
peroxisomal membrane 1 MAVS
PML body 1 ZBTB16
intermediate filament 1 GFAP
nuclear speck 1 ZBTB16
receptor complex 2 PPARG, RXRA
chromatin 8 FOXP3, IRF3, JUN, MYC, PAX6, PPARG, RXRA, RXRG
cell projection 1 GFAP
Nucleus, nucleolus 1 MYC
nuclear chromosome 1 JUN
nuclear envelope 1 MYC
endosome lumen 1 NGF
Nucleus, nucleoplasm 1 MYC
euchromatin 1 JUN
cell body 1 GFAP
intermediate filament cytoskeleton 1 GFAP
ubiquitin ligase complex 1 MAVS
Golgi lumen 1 NGF
endoplasmic reticulum lumen 1 BDNF
transcription repressor complex 1 ZBTB16
male germ cell nucleus 1 ZBTB16
RNA polymerase II transcription repressor complex 1 MYC
[Isoform 1]: Nucleus 1 PAX6
Rough endoplasmic reticulum 1 MYC
granulocyte macrophage colony-stimulating factor receptor complex 1 CSF2
cytoplasmic side of lysosomal membrane 1 GFAP
endocytic vesicle lumen 1 CSF3
transcription factor AP-1 complex 1 JUN
Myc-Max complex 1 MYC
Nucleus, nuclear body 1 ZBTB16
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
[Isoform 5a]: Nucleus 1 PAX6
nucleoplasmic reticulum 1 MYC


文献列表

  • Yoshihiro Shidoji. Induction of Hepatoma Cell Pyroptosis by Endogenous Lipid Geranylgeranoic Acid-A Comparison with Palmitic Acid and Retinoic Acid. Cells. 2024 May; 13(10):. doi: 10.3390/cells13100809. [PMID: 38786033]
  • Lindsay C Czuba, Nina Isoherranen. LX-2 Stellate Cells Are a Model System for Investigating the Regulation of Hepatic Vitamin A Metabolism and Respond to Tumor Necrosis Factor α and Interleukin 1β. Drug metabolism and disposition: the biological fate of chemicals. 2024 Apr; 52(5):442-454. doi: 10.1124/dmd.124.001679. [PMID: 38485281]
  • Yuki Mori, Masashi Masuda, Risa Yoshida-Shimizu, Saki Aoyagi, Yuichiro Adachi, Anh The Nguyen, Yusuke Maruyama, Yosuke Okumura, Yuki Kamei, Maiko Sakai, Kohta Ohnishi, Hirokazu Ohminami, Yutaka Taketani. All-trans retinoic acid induces lipophagy through the activation of the AMPK-Beclin1 signaling pathway and reduces Rubicon expression in adipocytes. The Journal of nutritional biochemistry. 2024 Apr; 126(?):109589. doi: 10.1016/j.jnutbio.2024.109589. [PMID: 38295886]
  • Cheng Zhang, Lite Ge, Huali Xie, Xiaoqian Liu, Chengfeng Xun, Yan Chen, Haiyan Chen, Ming Lu, Ping Chen. Retinoic acid induced specific changes in the phosphoproteome of C17.2 neural stem cells. Journal of cellular and molecular medicine. 2024 Apr; 28(7):e18205. doi: 10.1111/jcmm.18205. [PMID: 38506089]
  • Samuel Kesse, Yuhong Xu, Sanyuan Shi, Shanshan Jin, Shafi Ullah, Yongchao Dai, Miao He, Anjie Zheng, Fengwei Xu, Zixiu Du, Raphael N Alolga, Jinliang Peng. MDSC-targeted liposomal all-trans retinoic acid suppresses mMdscs and improves immunotherapy in HBV infection. Expert opinion on drug delivery. 2024 Feb; 21(2):347-363. doi: 10.1080/17425247.2024.2317936. [PMID: 38406829]
  • Li Sun, Meifang Zheng, Yanhang Gao, David R Brigstock, Runping Gao. Retinoic acid signaling pathway in pancreatic stellate cells: Insight into the anti-fibrotic effect and mechanism. European journal of pharmacology. 2024 Feb; ?(?):176374. doi: 10.1016/j.ejphar.2024.176374. [PMID: 38309676]
  • Suting Xiao, Yizhen Yan, Mingyin Shao, Xuan Zhou, Zhenyu Niu, Yanli Wu, Yanwu Li, Yong Cui, Yu Long, Qun Du. Kuijieling decoction regulates the Treg/Th17 cell balance in ulcerative colitis through the RA/RARα signaling pathway. Journal of ethnopharmacology. 2024 Jan; 318(Pt A):116909. doi: 10.1016/j.jep.2023.116909. [PMID: 37451490]
  • Feifan Wu, Ruichao Chen, Yu Li, Yi Wan, Jianying Hu. Unregistered Hexaphenoxycyclotriphosphazene and Its Metabolite Antagonize Retinoic Acid and Retinoic X Receptors and Cause Early Developmental Damage. Environmental science & technology. 2023 Dec; 57(49):20551-20558. doi: 10.1021/acs.est.3c07997. [PMID: 38037888]
  • Wensheng Wang, Lin Wang. Protective effect of tretinoin derivative and TXNRD1 protein on streptozotocin induced gestational diabetes via an age-rage signaling-pathway. Acta biochimica Polonica. 2023 Dec; 70(4):985-990. doi: 10.18388/abp.2020_6947. [PMID: 38060807]
  • Dan-Ping Huang, Liang-Chun Yang, Yi-Qiao Chen, Wu-Qing Wan, Dun-Hua Zhou, Hui-Rong Mai, Wan-Li Li, Li-Hua Yang, He-Kui Lan, Hui-Qin Chen, Bi-Yun Guo, Zi-Jun Zhen, Ri-Yang Liu, Guo-Hua Chen, Xiao-Qin Feng, Cong Liang, Li-Na Wang, Yu Li, Jie-Si Luo, Zhong Fan, Xue-Qun Luo, Bin Li, Yan-Lai Tang, Xiao-Li Zhang, Li-Bin Huang. Long-term outcome of children with acute promyelocytic leukemia: a randomized study of oral versus intravenous arsenic by SCCLG-APL group. Blood cancer journal. 2023 12; 13(1):178. doi: 10.1038/s41408-023-00949-w. [PMID: 38052803]
  • Jixin Chen, Shuqi Chen, Huiyan Luo, Wanyin Wu, Sumei Wang. The application of arsenic trioxide in cancer: An umbrella review of meta-analyses based on randomized controlled trials. Journal of ethnopharmacology. 2023 Nov; 316(?):116734. doi: 10.1016/j.jep.2023.116734. [PMID: 37290735]
  • Baldeep Singh, Isha Pahuja, Priyanka Yadav, Aishwarya Shaji, Shivam Chaturvedi, Anand Ranganathan, Ved Prakash Dwivedi, Gobardhan Das. Adjunct therapy with all-trans-retinoic acid improves therapeutic efficacy through immunomodulation while treating tuberculosis with antibiotics in a murine model. The Journal of infectious diseases. 2023 Oct; ?(?):. doi: 10.1093/infdis/jiad460. [PMID: 37863472]
  • Jacqueline Taylor, Leonie Uhl, Iris Moll, Sana Safatul Hasan, Lena Wiedmann, Jakob Morgenstern, Benedetto Daniele Giaimo, Tobias Friedrich, Elisenda Alsina-Sanchis, Francesca De Angelis Rigotti, Ronja Mülfarth, Sarah Kaltenbach, Darius Schenk, Felix Nickel, Thomas Fleming, David Sprinzak, Carolin Mogler, Thomas Korff, Adrian T Billeter, Beat P Müller-Stich, Mauricio Berriel Diaz, Tilman Borggrefe, Stephan Herzig, Maria Rohm, Juan Rodriguez-Vita, Andreas Fischer. Endothelial Notch1 signaling in white adipose tissue promotes cancer cachexia. Nature cancer. 2023 Sep; ?(?):. doi: 10.1038/s43018-023-00622-y. [PMID: 37749321]
  • Hamed Rezaie, Reza Alipanah-Moghadam, Farhad Jeddi, Cain C T Clark, Vahideh Aghamohammadi, Ali Nemati. Combined dandelion extract and all-trans retinoic acid induces cytotoxicity in human breast cancer cells. Scientific reports. 2023 Sep; 13(1):15074. doi: 10.1038/s41598-023-42177-z. [PMID: 37700002]
  • Jakub Maciej Surmacki, Halina Abramczyk. Confocal Raman imaging reveals the impact of retinoids on human breast cancer via monitoring the redox status of cytochrome c. Scientific reports. 2023 Sep; 13(1):15049. doi: 10.1038/s41598-023-42301-z. [PMID: 37700001]
  • Yin-Ku Lin, Chien-Yu Hsiao, Abdullah Alshetaili, Ibrahim A Aljuffali, En-Li Chen, Jia-You Fang. Lipid-based nanoformulation optimization for achieving cutaneous targeting: Niosomes as the potential candidates to fulfill this aim. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2023 Jul; 186(?):106458. doi: 10.1016/j.ejps.2023.106458. [PMID: 37137418]
  • Samiksha Sardana, Anneroos E Nederstigt, Marc P Baggelaar. S-Palmitoylation during Retinoic Acid-Induced Neuronal Differentiation of SH-SY5Y Neuroblastoma Cells. Journal of proteome research. 2023 Jun; ?(?):. doi: 10.1021/acs.jproteome.3c00151. [PMID: 37294931]
  • Xueyan Li, Xiaoqi Luo, Siru Chen, Jiayi Chen, Xue Deng, Jiahui Zhong, Hui Wu, Xuhui Huang, Changjun Wang. All-trans-retinoic acid inhibits hepatocellular carcinoma progression by targeting myeloid-derived suppressor cells and inhibiting angiogenesis. International immunopharmacology. 2023 Jun; 121(?):110413. doi: 10.1016/j.intimp.2023.110413. [PMID: 37301119]
  • Xudong Shan, Xueguang Zhang, Gelin Huang, Jiao Lv, Zixia Ye, Chuan Jiang, Xiaohui Jiang, Jianxing Cheng, Haocheng Lin, Hui Jiang, Huanxun Yue, Zhengrong Wang, Wenming Xu. A novel SNP in HUWE1 promoter confers increased risk of NOA by affecting the RA/RARα pathway in Chinese individuals. Andrology. 2023 Jun; ?(?):. doi: 10.1111/andr.13474. [PMID: 37290064]
  • Wen Cui, Zheng Xue, Ling-Ling Zhao, Ying Li, Jian-Qing Mi. [Effect of a Novel Dihydroartemisinin Dimer Containing Nitrogen Atoms SM 1044 on Apoptosis of Human Leukemia Cell Line NB4-R1]. Zhongguo shi yan xue ye xue za zhi. 2023 Jun; 31(3):659-665. doi: 10.19746/j.cnki.issn.1009-2137.2023.03.007. [PMID: 37356923]
  • Rui Pedro Moura, Eva Daniela Carvalho, Cláudia Martins, Anne des Rieux, Ana Paula Pêgo, Bruno Sarmento. Functionalized retinoic acid lipid nanocapsules promotes a two-front attack on inflammation and lack of demyelination on neurodegenerative disorders. Journal of controlled release : official journal of the Controlled Release Society. 2023 06; 358(?):43-58. doi: 10.1016/j.jconrel.2023.04.034. [PMID: 37088306]
  • Leila Parsa, Rouhollah Motafakkerazad, Sarvin Taleb Soheyli, Amin Haratian, Morteza Kosari-Nasab, Majid Mahdavi. Silymarin in combination with ATRA enhances apoptosis induction in human acute promyelocytic NB4 cells. Toxicon : official journal of the International Society on Toxinology. 2023 Jun; 228(?):107127. doi: 10.1016/j.toxicon.2023.107127. [PMID: 37085055]
  • Md Jakaria, Abdel A Belaidi, Ashley I Bush, Scott Ayton. Vitamin A metabolites inhibit ferroptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 May; 164(?):114930. doi: 10.1016/j.biopha.2023.114930. [PMID: 37236031]
  • Xinliang Wang, Chanjuan Yang, Yanrong Li, Qiang Gong, Yi Ru, Liangqi Xie, Baoguo Xiao, Xiaoming Jin, Cungen Ma, Zhi Chai, Huijie Fan. Wuzi Yanzong Pill protects neural tube defects by activating PI3K/Akt signaling pathway. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2023 May; ?(?):. doi: 10.1002/jdn.10267. [PMID: 37211717]
  • Guoshu Bi, Jiaqi Liang, Guangyao Shan, Yunyi Bian, Zhencong Chen, Yiwei Huang, Tao Lu, Ming Li, Valeria Besskaya, Mengnan Zhao, Hong Fan, Qun Wang, Boyi Gan, Cheng Zhan. Retinol saturase mediates retinoid metabolism to impair a ferroptosis defense system in cancer cells. Cancer research. 2023 May; ?(?):. doi: 10.1158/0008-5472.can-22-3977. [PMID: 37184371]
  • Reza Zolfaghari, Jessica A Bonzo, Frank J Gonzalez, A Catharine Ross. Hepatocyte Nuclear Factor 4α (HNF4α) Plays a Controlling Role in Expression of the Retinoic Acid Receptor β (RARβ) Gene in Hepatocytes. International journal of molecular sciences. 2023 May; 24(10):. doi: 10.3390/ijms24108608. [PMID: 37239961]
  • Xinliang Wang, Chanjuan Yang, Yi Ru, Liangqi Xie, Baoguo Xiao, Xiaoming Jin, Cungen Ma, Zhi Chai, Huijie Fan. An optimal combination of five main monomer components in Wuzi Yanzong Pill that prevents neural tube defects and reduces apoptosis and oxidative stress. Journal of ethnopharmacology. 2023 Apr; 313(?):116540. doi: 10.1016/j.jep.2023.116540. [PMID: 37088238]
  • Yuan-Yuan Liu, Yun-Feng Ding, Hai-Juan Sui, Wei Liu, Zhen-Qiu Zhang, Feng Li. Pilose antler (Cervus elaphus Linnaeus) polysaccharide and polypeptide extract inhibits bone resorption in high turnover type osteoporosis by stimulating the MAKP and MMP-9 signaling pathways. Journal of ethnopharmacology. 2023 Mar; 304(?):116052. doi: 10.1016/j.jep.2022.116052. [PMID: 36529246]
  • Marzieh Moazeny, Moein Dehbashi, Zohreh Hojati, Fariba Esmaeili. Investigating neural differentiation of mouse P19 embryonic stem cells in a time-dependent manner by bioinformatic, microscopic and transcriptional analyses. Molecular biology reports. 2023 Mar; 50(3):2183-2194. doi: 10.1007/s11033-022-08166-7. [PMID: 36565416]
  • Xueni You, Tianjiao Li, Youjie Cui, Wei Liu, Zechao Cheng, Wenxian Zeng, Peng Wang, Yi Zheng. Retinoic acid-induced differentiation of porcine prospermatogonia in vitro. Theriogenology. 2023 Mar; 198(?):344-355. doi: 10.1016/j.theriogenology.2023.01.007. [PMID: 36640739]
  • Q N Ye, K Zheng. Expression and function of patatin-like phospholipase domain-containing 2 in cleft palate induced by retinoic acid. The British journal of oral & maxillofacial surgery. 2023 Feb; ?(?):. doi: 10.1016/j.bjoms.2023.02.002. [PMID: 36906446]
  • Jiayi Chen, Mei Li, Yeqing Liu, Tangming Guan, Xiao Yang, Yalei Wen, Yingjie Zhu, Zeyu Xiao, Xiangchun Shen, Haoxing Zhang, Hui Tang, Tongzheng Liu. PIN1 and CDK1 cooperatively govern pVHL stability and suppressive functions. Cell death and differentiation. 2023 Feb; ?(?):. doi: 10.1038/s41418-023-01128-x. [PMID: 36813923]
  • Eshani Karmakar, Nabanita Das, Bidisha Mukherjee, Prosenjit Das, Satinath Mukhopadhyay, Sib Sankar Roy. Lipid induced alteration in retinoic acid signaling leads to mitochondrial dysfunction in HepG2 and Huh7 cells. Biochemistry and cell biology = Biochimie et biologie cellulaire. 2023 Feb; ?(?):. doi: 10.1139/bcb-2022-0266. [PMID: 36787544]
  • Andréa Carolina Pinheiro de Freitas, Roberta Balansin Rigon, Ediléia Bagatin, Gislaine Ricci Leonardi. Perspectives of topical formulations for melasma. International journal of dermatology. 2023 Feb; 62(2):260-268. doi: 10.1111/ijd.16421. [PMID: 36083295]
  • Hongru Jia, Zhangqing Wu, Jianbing Tan, Silin Wu, Chaoqun Yang, Sayed Haidar Abbas Raza, Meng Wang, Guibing Song, Yujie Shi, Linsen Zan, Wucai Yang. Lnc-TRTMFS promotes milk fat synthesis via the miR-132x/RAI14/mTOR pathway in BMECs. Journal of animal science. 2023 Jan; 101(?):. doi: 10.1093/jas/skad218. [PMID: 37367933]
  • Yu-Zhen Tan, Hao-Ran Shen, Yong-Li Wang, Qiang-Li Wang, Xue-Ping Wu, Shu-Na Yu, Hai-Jie Wang. Retinoic acid released from self-assembling peptide activates cardiomyocyte proliferation and enhances repair of infarcted myocardium. Experimental cell research. 2023 01; 422(1):113440. doi: 10.1016/j.yexcr.2022.113440. [PMID: 36481206]
  • Jian-Yong Zhao, Xiang-Kun Yuan, Rui-Zhen Luo, Li-Xin Wang, Wei Gu, Daisuke Yamane, Hui Feng. Phospholipase A and acyltransferase 4/retinoic acid receptor responder 3 at the intersection of tumor suppression and pathogen restriction. Frontiers in immunology. 2023; 14(?):1107239. doi: 10.3389/fimmu.2023.1107239. [PMID: 37063830]
  • Dan Huang, Xia Qian, Jinqing Chen, Yating Peng, Yunxia Zhu. Factors and Molecular Mechanisms of Vitamin A and Childhood Obesity Relationship: A Review. Journal of nutritional science and vitaminology. 2023; 69(3):157-163. doi: 10.3177/jnsv.69.157. [PMID: 37394420]
  • Liang Qi, Han Han, Meng-Meng Han, Ying Sun, Lei Xing, Hu-Lin Jiang, Stephen J Pandol, Ling Li. Remodeling of imbalanced extracellular matrix homeostasis for reversal of pancreatic fibrosis. Biomaterials. 2023 01; 292(?):121945. doi: 10.1016/j.biomaterials.2022.121945. [PMID: 36508773]
  • Gabriel A Aguirre, Michelle R Goulart, Jesmond Dalli, Hemant M Kocher. Arachidonate 15-lipoxygenase-mediated production of Resolvin D5n-3 DPA abrogates pancreatic stellate cell-induced cancer cell invasion. Frontiers in immunology. 2023; 14(?):1248547. doi: 10.3389/fimmu.2023.1248547. [PMID: 38035115]
  • Ya-Ting Jiao, Wen-Shu Zhang, Shan-Shan Pan, Ming-Jie Xie. [Multi-omics analysis of regulating effects of hyperoside on lipid metabolism in high-fat diet mice]. Sheng li xue bao : [Acta physiologica Sinica]. 2022 Dec; 74(6):970-978. doi: ". [PMID: 36594385]
  • Zuzana Toušová, Jana Priebojová, Jakub Javůrek, Jaroslava Večerková, Olga Lepšová-Skácelová, Eliška Sychrová, Marie Smutná, Klára Hilscherová. Estrogenic and retinoid-like activity in stagnant waters with mass occurrence of water blooms. The Science of the total environment. 2022 Dec; 852(?):158257. doi: 10.1016/j.scitotenv.2022.158257. [PMID: 36037903]
  • Johana Coronel, Jianshi Yu, Nageswara Pilli, Maureen A Kane, Jaume Amengual. The conversion of β-carotene to vitamin A in adipocytes drives the anti-obesogenic effects of β-carotene in mice. Molecular metabolism. 2022 12; 66(?):101640. doi: 10.1016/j.molmet.2022.101640. [PMID: 36400405]
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