2-Phosphoglyceric acid (BioDeep_00000018614)

 

Secondary id: BioDeep_00000003412, BioDeep_00001868854

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite natural product BioNovoGene_Lab2019


代谢物信息卡片


3-Hydroxy-2-(phosphonooxy)propanoic acid

化学式: C3H7O7P (185.9929)
中文名称: 2-磷酸甘油酸
谱图信息: 最多检出来源 Homo sapiens(blood) 9.5%

Reviewed

Last reviewed on 2024-11-04.

Cite this Page

2-Phosphoglyceric acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/2-phosphoglyceric_acid (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000018614). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(C(C(=O)O)OP(=O)(O)O)O
InChI: InChI=1S/C3H7O7P/c4-1-2(3(5)6)10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)

描述信息

2-Phosphoglyceric acid (2PGA) is a glyceric acid which serves as the substrate in the ninth step of glycolysis. It is catalyzed by enolase into phosphoenolpyruvate (PEP), the penultimate step in the conversion of glucose to pyruvate. Enolase catalyzes the beta-elimination reaction in a stepwise manner wherein OH- is eliminated from C3 of a discrete carbanion (enolate) intermediate. This intermediate is created by removal of the proton from C2 of 2PGA by a base in the active site. (PMID: 8994873, Wikipedia) [HMDB]
2-Phosphoglyceric acid (2PGA) is a glyceric acid which serves as the substrate in the ninth step of glycolysis. It is catalyzed by enolase into phosphoenolpyruvate (PEP), the penultimate step in the conversion of glucose to pyruvate. Enolase catalyzes the beta-elimination reaction in a stepwise manner wherein OH- is eliminated from C3 of a discrete carbanion (enolate) intermediate. This intermediate is created by removal of the proton from C2 of 2PGA by a base in the active site (PMID: 8994873, Wikipedia).

2-Phosphoglyceric acid. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=2553-59-5 (retrieved 2024-11-04) (CAS RN: 2553-59-5). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

同义名列表

24 个代谢物同义名

3-Hydroxy-2-(phosphonooxy)propanoic acid; 3-Hydroxy-2-phosphonooxypropanoic acid; 2-(Dihydrogen phosphate)glyceric acid; 3-Hydroxy-2-(phosphonooxy)propanoate; 2-Phosphoglycerate, monosodium salt; 3-Hydroxy-2-phosphonooxypropanoate; 2-(Dihydrogen phosphate)glycerate; 2-Phosphoglycerate, (+-)-isomer; 2-Phosphoglycerate, (R)-isomer; 2-Phosphoglycerate, (S)-isomer; 2-phospho-DL-Glyceric acid; 2-Phospho-D-glyceric acid; Glyceric acid 2-phosphate; 2-phosphoglyceric acid; DL-2-Phosphoglycerate; 2-phospho-D-Glycerate; Glycerate 2-phosphate; 2-P-D-Glyceric acid; 2-phosphoglycerate; 2-P-Glyceric acid; Phosphoglycerate; 2-P-D-Glycerate; 2-P-Glycerate; 2-Phosphoglyceric acid



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(6)

PlantCyc(0)

代谢反应

8 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(4)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(4)

PharmGKB(0)

20 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 AIMP2, CDK6, ENO1, ENO2, ENO3, GLYCTK
Nucleus 3 AIMP2, CDK6, ENO1
cytosol 8 AIMP2, ARAF, CDK6, ENO1, ENO2, ENO3, GLYCTK, GOLPH3
trans-Golgi network 1 GOLPH3
centrosome 1 CDK6
nucleoplasm 1 CDK6
Cell membrane 3 ENO1, ENO2, GOLPH3
cell cortex 1 ENO1
cell surface 3 ENO1, PLAU, PLG
glutamatergic synapse 1 PLG
Golgi apparatus 2 GLYCTK, GOLPH3
Golgi membrane 1 GOLPH3
Cytoplasm, cytosol 1 AIMP2
endosome 1 GOLPH3
plasma membrane 6 ENO1, ENO2, ENO3, GOLPH3, PLAU, PLG
Membrane 5 AIMP2, ENO1, ENO2, ENO3, GOLPH3
extracellular exosome 7 CPVL, ENO1, ENO2, ENO3, PLAU, PLG, SPINK1
extracellular space 5 ENO1, ENO2, ENO3, PLAU, PLG
Schaffer collateral - CA1 synapse 1 PLG
mitochondrion 3 ARAF, GLYCTK, GOLPH3
intracellular membrane-bounded organelle 1 GOLPH3
Secreted 3 PLAU, PLG, SPINK1
extracellular region 2 PLAU, PLG
photoreceptor inner segment 1 ENO2
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 CDK6
external side of plasma membrane 2 PLAU, PLG
perikaryon 1 ENO2
focal adhesion 1 PLAU
mitochondrial intermembrane space 1 GOLPH3
collagen-containing extracellular matrix 1 PLG
nuclear outer membrane 1 ENO1
ruffle 1 CDK6
blood microparticle 1 PLG
Cytoplasm, myofibril, sarcomere, M line 1 ENO1
M band 1 ENO1
specific granule membrane 1 PLAU
tertiary granule membrane 1 PLAU
Golgi cisterna membrane 1 GOLPH3
[Isoform 1]: Cytoplasm 1 GLYCTK
platelet alpha granule lumen 1 PLG
serine-type endopeptidase complex 1 PLAU
Golgi cisterna 1 GOLPH3
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
serine protease inhibitor complex 1 PLAU
cyclin-dependent protein kinase holoenzyme complex 1 CDK6
protein complex involved in cell-matrix adhesion 1 PLAU
phosphopyruvate hydratase complex 3 ENO1, ENO2, ENO3
cyclin D1-CDK6 complex 1 CDK6
cyclin D3-CDK6 complex 1 CDK6
cyclin D2-CDK6 complex 1 CDK6


文献列表

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