Dexmedetomidine (BioDeep_00000018251)
Secondary id: BioDeep_00000002714, BioDeep_00001868218
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
化学式: C13H16N2 (200.1313)
中文名称: 右美托咪定, 美托咪定
谱图信息:
最多检出来源 Mentha canadensis(plant) 13.21%
分子结构信息
SMILES: CC(C1=CN=CN1)C2=CC=CC(C)=C2C
InChI: InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)
描述信息
Dexmedetomidine is only found in individuals that have used or taken this drug. It is an agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine. [PubChem]Dexmedetomidine is a specific and selective alpha-2 adrenoceptor agonist. By binding to the presynaptic alpha-2 adrenoceptors, it inhibits the release if norepinephrine, therefore, terminate the propagation of pain signals. Activation of the postsynaptic alpha-2 adrenoceptors inhibits the sympathetic activity decreases blood pressure and heart rate.
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
N - Nervous system > N05 - Psycholeptics > N05C - Hypnotics and sedatives
D002491 - Central Nervous System Agents > D000700 - Analgesics
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Dexmedetomidine ((+)-Medetomidine) is a potent, selective and orally active agonist of α2-adrenoceptor, with a Ki of 1.08 nM. Dexmedetomidine shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine exhibits anxiolysis, sedation, and modest analgesia effects[1][2][3].
Medetomidine is an orally active α2-adrenoceptor agonist (Ki: 1.08 nM). Medetomidine has sedative and analgesic effects. Medetomidine can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels[1][2][3][4].
同义名列表
19 个代谢物同义名
4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole; Hospira brand OF dexmedetomidine hydrochloride; (+)-4-((S)-alpha,2,3-Trimethylbenzyl)imidazole; (+)-4-((S)-a,2,3-Trimethylbenzyl)imidazole; (+)-4-((S)-Α,2,3-trimethylbenzyl)imidazole; Hydrochloride, dexmedetomidine; Dexmedetomidine hydrochloride; dexmedetomidine hcl; Dexmedetomidinum; Dexmedetomidina; Dexmedetomidine; Medetomidine; Precedex; MPV 1440; Dexdor; (+)-Medetomidine; (S)-Medetomidine; Dexmedetomidine; Medetomidine
数据库引用编号
24 个数据库交叉引用编号
- ChEBI: CHEBI:48552
- ChEBI: CHEBI:4466
- KEGG: C07450
- PubChem: 5311068
- PubChem: 68602
- HMDB: HMDB0014771
- DrugBank: DB11428
- DrugBank: DB00633
- ChEMBL: CHEMBL77921
- ChEMBL: CHEMBL778
- Wikipedia: Dexmedetomidine
- MeSH: Dexmedetomidine
- MeSH: Medetomidine
- chemspider: 4470605
- CAS: 113775-47-6
- CAS: 86347-14-0
- CAS: 6918-06-5
- PMhub: MS000004592
- PubChem: 9653
- PDB-CCD: CZX
- NIKKAJI: J263.999H
- medchemexpress: HY-12719
- medchemexpress: HY-17034
- KNApSAcK: 4466
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Minghao Liu, Xuezi Chen, Dan Guo. Effect of epidural dexmedetomidine in single-dose combined with ropivacaine for cesarean section.
BMC anesthesiology.
2024 Apr; 24(1):134. doi:
10.1186/s12871-024-02519-4. [PMID: 38589819] - Tongtong Zhang, Xincheng Liao, Yuzhi Chen, Xinru Shu, Deshan Liu, Yusheng Yao. Dexmedetomidine Prolongs Lidocaine Intravenous Regional Anesthesia in Rats by Blocking the Hyperpolarization-Activated Cation Current.
Drug design, development and therapy.
2024; 18(?):1103-1114. doi:
10.2147/dddt.s450971. [PMID: 38618283] - Yaqian Xu, Xue Zhang, Xiangxu Tang, Chanjuan Zhang, Jason G Cahoon, Yingwei Wang, Hongmei Li, Xiuxiu Lv, Yiyang Wang, Zhi Wang, Huadong Wang, Duomeng Yang. Dexmedetomidine post-treatment exacerbates metabolic disturbances in septic cardiomyopathy via α2A-adrenoceptor.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2024 Jan; 170(?):115993. doi:
10.1016/j.biopha.2023.115993. [PMID: 38091635] - Jiarou Li, Yansong Liu, Jingjing Bai, Tiantian Liu, Xionghai Qin, Tianyou Hu, Sicong Wang, Yunlong Li, Shanpeng Cui, Zhen Quan, Yiming Luo, Junbo Zheng, Hongliang Wang. Dexmedetomidine alleviates renal tubular ferroptosis in sepsis-associated AKI by KEAP1 regulating the degradation of GPX4.
European journal of pharmacology.
2023 Dec; 961(?):176194. doi:
10.1016/j.ejphar.2023.176194. [PMID: 38000722] - Shylo R Johnson, Christine K Ellis, Chad K Wickham, Molly R Selleck, Amy T Gilbert. Comparison of Ketamine-Xylazine, Butorphanol-Azaperone-Medetomidine, and Nalbuphine-Medetomidine-Azaperone for Raccoon (Procyon Lotor) Immobilization.
Journal of wildlife diseases.
2023 Nov; ?(?):. doi:
10.7589/jwd-d-23-00060. [PMID: 37924235] - Ahmet Sen, Basar Erdivanlı, Levent Tümkaya, Hüseyin Avni Uydu, Tolga Mercantepe, Şule Batcik, Abdullah Ozdemir. The effects of dexmedetomidine on trauma-induced secondary injury in rat brain.
Neurological research.
2023 Oct; ?(?):1-10. doi:
10.1080/01616412.2023.2257446. [PMID: 37842946] - Weiwei Gao, Liang Du, Nan Li, Yating Li, Jinfang Wu, Ze Zhang, Huan Chen. Dexmedetomidine attenuates myocardial ischemia-reperfusion injury in hyperlipidemic rats by inhibiting inflammation, oxidative stress and NF-κB.
Chemical biology & drug design.
2023 Aug; ?(?):. doi:
10.1111/cbdd.14324. [PMID: 37604597] - Silu Cao, Yiling Wu, Zilong Gao, Jinxuan Tang, Lize Xiong, Ji Hu, Cheng Li. Automated phenotyping of postoperative delirium-like behaviour in mice reveals the therapeutic efficacy of dexmedetomidine.
Communications biology.
2023 08; 6(1):807. doi:
10.1038/s42003-023-05149-7. [PMID: 37532767] - Kangjie Xie, Jinyan Chen, Lili Tian, Fulei Gu, Yafei Pan, Zhangxiang Huang, Jun Fang, Weifeng Yu, Huidan Zhou. Postoperative infusion of dexmedetomidine via intravenous patient-controlled analgesia for prevention of postoperative delirium in elderly patients undergoing surgery.
Aging clinical and experimental research.
2023 Jul; ?(?):. doi:
10.1007/s40520-023-02497-6. [PMID: 37470916] - H-B Wang, Y Jia, C-B Zhang, L Zhang, Y-N Li, J Ding, X Wu, Z Zhang, J-H Wang, Y Wang, F-X Yan, S Yuan, D I Sessler. A randomised controlled trial of dexmedetomidine for delirium in adults undergoing heart valve surgery.
Anaesthesia.
2023 05; 78(5):571-576. doi:
10.1111/anae.15983. [PMID: 36794600] - Xin Li, Jingjing Zhang, Changcui Zhou, Rui Ling, Deying Gong, Yi Kang, Qingrong Qi, Jun Yang. Design, Synthesis, and Bioevaluation of Dexmedetomidine Prodrug.
ACS medicinal chemistry letters.
2023 Apr; 14(4):405-410. doi:
10.1021/acsmedchemlett.2c00449. [PMID: 37077377] - Geun Joo Choi, Hyun Kang, Oh Haeng Lee, Ji Wung Kwon. Effect of Immature Rubus occidentalis on Postoperative Pain in a Rat Model.
Medicina (Kaunas, Lithuania).
2023 Jan; 59(2):. doi:
10.3390/medicina59020264. [PMID: 36837466] - Xiangxu Tang, Chanjuan Zhang, Tian Tian, Xiaomeng Dai, Yun Xing, Yingwei Wang, Duomeng Yang, Hongmei Li, Yiyang Wang, Xiuxiu Lv, Huadong Wang. Posttreatment with dexmedetomidine aggravates LPS-induced myocardial dysfunction partly via activating cardiac endothelial α2A-AR in mice.
International immunopharmacology.
2023 Jan; 116(?):109724. doi:
10.1016/j.intimp.2023.109724. [PMID: 36696856] - Yuan Lai, Qi Chen, Chunfang Xiang, Guanzhu Li, Ke Wei. Comparison of the Effects of Dexmedetomidine and Lidocaine on Stress Response and Postoperative Delirium of Older Patients Undergoing Thoracoscopic Surgery: A Randomized Controlled Trial.
Clinical interventions in aging.
2023; 18(?):1275-1283. doi:
10.2147/cia.s419835. [PMID: 37554513] - Xincheng Liao, Jie Lin, Xinru Shu, Shisen Hong, Yusheng Yao, Hao Li. Regional versus systemic dexmedetomidine as an adjuvant to lidocaine for intravenous regional anaesthesia in healthy volunteers: a randomized crossover study.
Annals of medicine.
2023; 55(2):2300663. doi:
10.1080/07853890.2023.2300663. [PMID: 38175807] - E Dil, L Tumkaya, T Mercantepe, S Rakici, A Yilmaz, T Celik Samanci, Z A Yazici. Radioprotective effects of dexmedetomidine on X-ray-induced testicular damage.
European review for medical and pharmacological sciences.
2023 01; 27(2):673-680. doi:
10.26355/eurrev_202301_31069. [PMID: 36734735] - Yin-Chin Wang, Ming-Jiuh Wang, Chih-Yuan Lee, Chien-Chia Chen, Ching-Tang Chiu, Anne Chao, Wing-Sum Chan, Meng-Kun Tsai, Yu-Chang Yeh. Effects of perioperative dexmedetomidine infusion on renal function and microcirculation in kidney transplant recipients: a randomised controlled trial.
Annals of medicine.
2022 12; 54(1):1233-1243. doi:
10.1080/07853890.2022.2067351. [PMID: 35486415] - Xing Liu, Qinxue Hu, Qianxiu Chen, Jing Jia, Yong-Hong Liao, Jianguo Feng. Effect of dexmedetomidine for prevention of acute kidney injury after cardiac surgery: an updated systematic review and meta-analysis.
Renal failure.
2022 Dec; 44(1):1150-1159. doi:
10.1080/0886022x.2022.2097923. [PMID: 35834360] - Meng-Si Luo, Guan-Jiang Huang. The effect of peritonsillar infiltration of tramadol vs dexmedetomidine on post‑tonsillectomy pain.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery.
2022 11; 279(11):5467-5468. doi:
10.1007/s00405-021-07212-7. [PMID: 35001165] - Lin Zeng, Juan Liu, Tianyao Zhang, Yusong Liu, Lumiu Liao, Xuelian Chen, Shuhua Dong. Study on the protective mechanism of dexmedetomidine on the liver of perioperative diabetic patients: A randomized controlled trial.
Medicine.
2022 Oct; 101(41):e30899. doi:
10.1097/md.0000000000030899. [PMID: 36254014] - Zhuoran Wang, Mengran Yao, Leyu Jiang, Lingyan Wang, Yuqiao Yang, Quan Wang, Xi Qian, Yu Zhao, Jinqiao Qian. Dexmedetomidine attenuates myocardial ischemia/reperfusion-induced ferroptosis via AMPK/GSK-3β/Nrf2 axis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Oct; 154(?):113572. doi:
10.1016/j.biopha.2022.113572. [PMID: 35988428] - Man-Jia Liu, Xiao-Chun Zhao, He-Song Gong, Yu-Qing You, Jing-Ya Li. Dexmedetomidine prevents hemorrhagic brain injury by reducing damage induced by ferroptosis in mice.
Neuroscience letters.
2022 09; 788(?):136842. doi:
10.1016/j.neulet.2022.136842. [PMID: 35995304] - Yu-Peng Qi, Wen-Jing Ma, Ying-Ya Cao, Qun Chen, Qian-Cheng Xu, Shi Xiao, Wei-Hua Lu, Zhen Wang. Effect of Dexmedetomidine on Intestinal Barrier in Patients Undergoing Gastrointestinal Surgery-A Single-Center Randomized Clinical Trial.
The Journal of surgical research.
2022 09; 277(?):181-188. doi:
10.1016/j.jss.2022.03.031. [PMID: 35500513] - Ya-Jing Zhang, Shu-Jun Lu, Hong-Yin Wang, Qing-Ling Qi. Effects of electroacupuncture with dexmedetomidine on myocardial ischemia/reperfusion injury in rats.
Annals of palliative medicine.
2022 Sep; 11(9):2916-2922. doi:
10.21037/apm-22-969. [PMID: 36217620] - Qiao-Qiao Han, Xin-Yan Li, Yong-Xiang Wang. Dexmedetomidine attenuates lipopolysaccharide-induced inflammation through macrophageal IL-10 expression following α7 nAchR activation.
International immunopharmacology.
2022 Aug; 109(?):108920. doi:
10.1016/j.intimp.2022.108920. [PMID: 35691275] - QiongHua Liu, JianE Wu, ShangShu Lai, Gan Li. MiR-665 Participates in the Protective Effect of Dexmedetomidine in Ischemic Stroke by ROCK2/NF-κB Axis.
Neurochemical research.
2022 Jul; 47(7):2064-2075. doi:
10.1007/s11064-022-03597-x. [PMID: 35538293] - Wei Wu, Zhen Du, Lei Wu. Dexmedetomidine attenuates hypoxia-induced cardiomyocyte injury by promoting telomere/telomerase activity: Possible involvement of ERK1/2-Nrf2 signaling pathway.
Cell biology international.
2022 Jul; 46(7):1036-1046. doi:
10.1002/cbin.11799. [PMID: 35312207] - Olivier Louis Levionnois, Andrea Barbarossa, Anisa Bardhi, Joelle Siegenthaler, Tekla Forss Pleyers, Monia Guidi, Claudia Spadavecchia, Mathieu Raillard. Enantiospecific pharmacokinetics of intravenous dexmedetomidine in beagles.
Journal of veterinary pharmacology and therapeutics.
2022 Jul; 45(4):366-372. doi:
10.1111/jvp.13063. [PMID: 35484944] - Tsugumi Fukunaga, Go Anan, Takuo Hirose, Yuka Miyake, Kento Hoshino, Akari Endo, Ryo Tajima, Hiroki Ito, Shingo Nakayama, Hideaki Hashimoto, Katsuya Ishiyama, Tomoyoshi Kimura, Takefumi Mori. Safety of peritoneal dialysis catheter surgery under dexmedetomidine and local anesthesia for elderly patients in Japan: a single-center prospective cohort study.
Clinical and experimental nephrology.
2022 Jul; 26(7):717-723. doi:
10.1007/s10157-022-02207-y. [PMID: 35275296] - Yu-Fang Liu, Rui Hu, Long-Fei Zhang, Yong Fan, Ji-Feng Xiao, Xing-Zhi Liao. Effects of dexmedetomidine on cognitive dysfunction and neuroinflammation via the HDAC2/HIF-1α/PFKFB3 axis in a murine model of postoperative cognitive dysfunction.
Journal of biochemical and molecular toxicology.
2022 Jun; 36(6):e23044. doi:
10.1002/jbt.23044. [PMID: 35499365] - Xi-Sheng Shan, Lin-Kun Hu, Yiqing Wang, Hua-Yue Liu, Jun Chen, Xiao-Wen Meng, Jin-Xian Pu, Yu-Hua Huang, Jian-Quan Hou, Xiao-Mei Feng, Hong Liu, Lingzhong Meng, Ke Peng, Fu-Hai Ji. Effect of Perioperative Dexmedetomidine on Delayed Graft Function Following a Donation-After-Cardiac-Death Kidney Transplant: A Randomized Clinical Trial.
JAMA network open.
2022 06; 5(6):e2215217. doi:
10.1001/jamanetworkopen.2022.15217. [PMID: 35657627] - Yu Wu, Yuhua Miao, Xuzhen Chen, Xiaojian Wan. A randomized placebo-controlled double-blind study of dexmedetomidine on postoperative sleep quality in patients with endoscopic sinus surgery.
BMC anesthesiology.
2022 06; 22(1):172. doi:
10.1186/s12871-022-01711-8. [PMID: 35650554] - Aleksi J Nummela, Lauri T Laaksonen, Timo T Laitio, Roosa E Kallionpää, Jaakko W Långsjö, Joonas M Scheinin, Tero J Vahlberg, Harri T Koskela, Viljami Aittomäki, Katja J Valli, Antti Revonsuo, Mikko Niemi, Markus Perola, Harry Scheinin. Effects of dexmedetomidine, propofol, sevoflurane and S-ketamine on the human metabolome: A randomised trial using nuclear magnetic resonance spectroscopy.
European journal of anaesthesiology.
2022 06; 39(6):521-532. doi:
10.1097/eja.0000000000001591. [PMID: 34534172] - Peng Zou, Xiaoping Zhang, Rui Zhang, Jun-Song Yang, Lei Chu, Xiang-Fu Wang, Jian-Min Wei, Xin Chai, Yuan-Ting Zhao, Bo Liao. The feasibility and safety of cocktail treatment of triple anti-inflammatory agents loaded with gelatin sponge promotes early recovery after posterior percutaneous endoscopic cervical discectomy.
Journal of orthopaedic surgery and research.
2022 May; 17(1):290. doi:
10.1186/s13018-022-03178-2. [PMID: 35619183] - Xiaoli Zhang, Wenping Zhao, Cong Sun, Zhihua Huang, Lifang Zhan, Chunlin Xiao, Luying Lai, Reai Shan. Effect of dexmedetomidine administration on analgesic, respiration and inflammatory responses in patients undergoing percutaneous endoscopic lumbar discectomy: a prospective observational study.
BMC anesthesiology.
2022 05; 22(1):152. doi:
10.1186/s12871-022-01691-9. [PMID: 35585483] - Linda L Chlan, Craig R Weinert, Mary Fran Tracy, Debra J Skaar, Ognjen Gajic, Jessica Ask, Jay Mandrekar. Study protocol to test the efficacy of self-administration of dexmedetomidine sedative therapy on anxiety, delirium, and ventilator days in critically ill mechanically ventilated patients: an open-label randomized clinical trial.
Trials.
2022 May; 23(1):406. doi:
10.1186/s13063-022-06391-w. [PMID: 35578315] - Shankun Zhao, Weizhou Wu, Xuezheng Lin, Maolei Shen, Zhenyu Yang, Sicong Yu, Yu Luo. Protective effects of dexmedetomidine in vital organ injury: crucial roles of autophagy.
Cellular & molecular biology letters.
2022 May; 27(1):34. doi:
10.1186/s11658-022-00335-7. [PMID: 35508984] - Peng Yu, Jing Zhang, Yi Ding, Dandan Chen, Haijian Sun, Fenglai Yuan, Siyuan Li, Xiaozhong Li, Pingping Yang, Linghua Fu, Shuchun Yu, Jiru Zhang. Dexmedetomidine post-conditioning alleviates myocardial ischemia-reperfusion injury in rats by ferroptosis inhibition via SLC7A11/GPX4 axis activation.
Human cell.
2022 May; 35(3):836-848. doi:
10.1007/s13577-022-00682-9. [PMID: 35212945] - Gianluca Bini, Eli B Cohen, Ludovica Chiavaccini, Kristen M Messenger, Kate M Bailey. Intravenous dexmedetomidine, morphine, or a combination can result in gallbladder wall thickening; with no significant association with plasma histamine concentrations.
Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association.
2022 May; 63(3):319-327. doi:
10.1111/vru.13056. [PMID: 35006624] - Z-H Yang, R Shen, F-F Zhan, J-L Shao, Y-J Lu, L Wang. Effects of dezocine combined with dexmedetomidine on adverse reactions and inflammatory factors in patients undergoing HIPEC after intestinal surgery and its protective effect on the heart in the perioperative period.
European review for medical and pharmacological sciences.
2022 05; 26(10):3437-3443. doi:
10.26355/eurrev_202205_28837. [PMID: 35647823] - Sang-Hwan Ji, Pyoyoon Kang, In-Sun Song, Young-Eun Jang, Ji-Hyun Lee, Jin-Tae Kim, Hee-Soo Kim, Eun-Hee Kim. The effect of dexmedetomidine on neuroprotection in pediatric cardiac surgery patients: study protocol for a prospective randomized controlled trial.
Trials.
2022 Apr; 23(1):271. doi:
10.1186/s13063-022-06217-9. [PMID: 35395776] - Jin Ha Park, Bon-Nyeo Koo, Min-Soo Kim, Dongkwan Shin, Young-Lan Kwak. Effects of intraoperative dexmedetomidine infusion on renal function in elective living donor kidney transplantation: a randomized controlled trial.
Canadian journal of anaesthesia = Journal canadien d'anesthesie.
2022 04; 69(4):448-459. doi:
10.1007/s12630-021-02173-1. [PMID: 34931289] - Nicole S Wilder, Dean B Andropoulos, Theron Paugh, Kathleen K Kibler, Susan C Nicolson, Athena F Zuppa, Ganesh S Moorthy. Sequestration of Dexmedetomidine in Ex Vivo Cardiopulmonary Bypass Circuits.
ASAIO journal (American Society for Artificial Internal Organs : 1992).
2022 04; 68(4):592-598. doi:
10.1097/mat.0000000000001536. [PMID: 34352815] - Mizuho Tashiro, Atsushi Tohei. Recommended doses of medetomidine-midazolam-butorphanol with atipamezole for preventing hypothermia in mice.
The Journal of veterinary medical science.
2022 Mar; 84(3):445-453. doi:
10.1292/jvms.21-0479. [PMID: 35135936] - Shigao Wang, Ju Wang, Jianping Yang. The Impact of Dexmedetomidine-loaded Nano-microsphere Combined with Percutaneous Acupoint Electrical Stimulation on the Postoperative Cognitive Function of Elderly Patients with Hip Fracture.
Cellular and molecular biology (Noisy-le-Grand, France).
2022 Mar; 68(3):77-85. doi:
10.14715/cmb/2022.68.3.10. [PMID: 35988196] - Seyed Morteza Aghamiri, Amir Saeed Samimi, Mehdi Hajian, Amir Masoud Samimi, Amin Oroumieh. Effect of xylazine, detomidine, medetomidine and dexmedetomidine during laparoscopic SCNT embryo transfer on pregnancy rate and some physiological variables in goats.
BMC veterinary research.
2022 Mar; 18(1):98. doi:
10.1186/s12917-022-03194-8. [PMID: 35292035] - Rohit S Loomba, Enrique G Villarreal, Janhavi Dhargalkar, Jacqueline Rausa, Vincent Dorsey, Juan S Farias, Saul Flores. The effect of dexmedetomidine on renal function after surgery: A systematic review and meta-analysis.
Journal of clinical pharmacy and therapeutics.
2022 Mar; 47(3):287-297. doi:
10.1111/jcpt.13527. [PMID: 34510502] - Osman Akyüz, Bahriye Kılıç, Sertan Gündoğan, Müslüm Ergün, Mehmet Nuri Bodakçı, Soner Çoban, Ahmet Hamdi Tefekli, Kamil Çam. The Effectiveness of Caudal Block with Low Doses of Dexmedetomidine and Pethidine in Transrectal Prostate Biopsy: Preliminary Results.
Journal of investigative surgery : the official journal of the Academy of Surgical Research.
2022 Mar; 35(3):511-516. doi:
10.1080/08941939.2021.1880671. [PMID: 33550855] - Z Liu, X Wang, L-P Wang, Y Bai, Y-X Li, X-N Gao, Y-B Sun. Dexmedetomidine combined with endotracheal intubation laryngeal mask in anesthesia of patients with a cervical spine injury.
European review for medical and pharmacological sciences.
2022 Mar; 26(5):1618-1624. doi:
10.26355/eurrev_202203_28229. [PMID: 35302208] - Yu-Ting Cheng, Kuang-Tso Lee, Chih-Hsiang Chang, Victor Chien-Chia Wu, Yi-Shin Chan, Dong-Yi Chen, Pao-Hsien Chu, An-Hsun Chou, Kuo-Sheng Liu, Shao-Wei Chen. Effects of dexmedetomidine on surgery for type A acute aortic dissection outcome.
Scientific reports.
2022 02; 12(1):2761. doi:
10.1038/s41598-022-06710-w. [PMID: 35177747] - Etienne Côté, Lesley A Zwicker, Erin L Anderson, Henrik Stryhn, Jenny Yu, Erin Andersen. Effects of dexmedetomidine and its reversal with atipamezole on echocardiographic measurements and circulating cardiac biomarker concentrations in normal cats.
Journal of the American Veterinary Medical Association.
2022 02; 260(8):1-9. doi:
10.2460/javma.21.06.0299. [PMID: 35175929] - Shu Yang, Lei Guo, Duozi Wang, Yanwei Yang, Jianhong Wang. Research on Mechanism of miR-106a Nanoparticles Carrying Dexmedetomidine in Regulating Recovery and Metabolism of Nerve Cells in Hypoxia-Reoxygenation Injury.
Journal of biomedical nanotechnology.
2022 Feb; 18(2):343-351. doi:
10.1166/jbn.2022.3244. [PMID: 35484744] - Yi-Nan Zhang, Ze-Nan Chang, Zi-Meng Liu, Shi-Hong Wen, Ya-Qing Zhan, Han-Jin Lai, Hu-Fei Zhang, Yi Guo, Xu-Yu Zhang. Dexmedetomidine Alleviates Gut-Vascular Barrier Damage and Distant Hepatic Injury Following Intestinal Ischemia/Reperfusion Injury in Mice.
Anesthesia and analgesia.
2022 02; 134(2):419-431. doi:
10.1213/ane.0000000000005810. [PMID: 34889823] - Ricardo Alvarez-Jimenez, Maud A S Weerink, Laura N Hannivoort, Hong Su, Michel M R F Struys, Stephan A Loer, Pieter J Colin. Dexmedetomidine Clearance Decreases with Increasing Drug Exposure: Implications for Current Dosing Regimens and Target-controlled Infusion Models Assuming Linear Pharmacokinetics.
Anesthesiology.
2022 02; 136(2):279-292. doi:
10.1097/aln.0000000000004049. [PMID: 34851425] - Yumo Li, Binbin Wu, Cong Hu, Jie Hu, Qingquan Lian, Jun Li, Daqing Ma. The role of the vagus nerve on dexmedetomidine promoting survival and lung protection in a sepsis model in rats.
European journal of pharmacology.
2022 Jan; 914(?):174668. doi:
10.1016/j.ejphar.2021.174668. [PMID: 34863997] - Zhenzhen Liu, Yanwu Jin, Chang Feng, Ge Liu, Yinghui Wang, Xin Zhao, Gang Liu. Renoprotective Effect of Intraoperative Dexmedetomidine in Renal Transplantation.
Computational and mathematical methods in medicine.
2022; 2022(?):9275406. doi:
10.1155/2022/9275406. [PMID: 35211189] - S R Karna, P Chambers, P Singh, N Lopez-Villalobos, K Kongara. Evaluation of analgesic interaction between morphine, maropitant and dexmedetomidine in dogs undergoing ovariohysterectomy.
New Zealand veterinary journal.
2022 Jan; 70(1):10-21. doi:
10.1080/00480169.2021.1927231. [PMID: 33950785] - Chuanding Li, Shigao Wang, Man Wang. Comment on 'Protective effect of dexmedetomidine on perioperative myocardial injury in patients with Stanford type-A aortic dissection'.
Revista da Associacao Medica Brasileira (1992).
2022; 68(11):1498. doi:
10.1590/1806-9282.20211099. [PMID: 36383874] - Bikram K Behera, Satyajeet Misra, Sritam S Jena, Chitta R Mohanty. The effect of perioperative dexmedetomidine on postoperative bowel function recovery in adult patients receiving general anesthesia.
Minerva anestesiologica.
2022 Jan; 88(1-2):51-61. doi:
10.23736/s0375-9393.21.15773-6. [PMID: 34527407] - Xue Feng, Binbin Zhao, Yongqiang Wang. Effect Evaluation of Dexmedetomidine Intravenous Anesthesia on Postoperative Agitation in Patients with Craniocerebral Injury by Magnetic Resonance Imaging Based on Sparse Reconstruction Algorithm.
Contrast media & molecular imaging.
2022; 2022(?):5161703. doi:
10.1155/2022/5161703. [PMID: 35833071] - Joshua M Bock, Kenichi Ueda, Andrew J Feider, Satoshi Hanada, Darren P Casey. Combined inorganic nitrate/nitrite supplementation blunts α-mediated vasoconstriction during exercise in patients with type 2 diabetes.
Nitric oxide : biology and chemistry.
2022 01; 118(?):17-25. doi:
10.1016/j.niox.2021.10.006. [PMID: 34718145] - Rong Zhou, Xiaoyan Chen. Dexmedetomidine represses TGF-β1-induced extracellular matrix production and proliferation of airway smooth muscle cells by inhibiting MAPK signaling pathway.
Allergologia et immunopathologia.
2022; 50(2):16-22. doi:
10.15586/aei.v50i2.505. [PMID: 35257541] - Shan Xu, Xiaofeng Zhao, Zhaoqiong Zhu, Miao He, Xue Zheng, Xiaoxi Zhang. A New Potential Antidepressant: Dexmedetomidine Alleviates Neuropathic Pain-Induced Depression by Increasing Neurogenesis in the Hippocampus.
Pharmacology.
2022; 107(5-6):317-329. doi:
10.1159/000521737. [PMID: 35196664] - Zhaojin Jia, Xiaowei Chen, Peng Sun, Mingxia Liu, Xiuhua Li. The Protective Mechanism of Dexmedetomidine on Renal in Hemorrhagic Shock.
Computational and mathematical methods in medicine.
2022; 2022(?):6394544. doi:
10.1155/2022/6394544. [PMID: 35186114] - Shenglan Mei, Yifan Jia, Jinjian Zhou, Ling Zhan, Jin Liu, Hao Ming, Huagang Liu. Effects of Different Anesthetics on Perioperative Organ Protection and Postoperative Cognitive Function in Patients Undergoing Cardiac Valve Replacement with Cardiopulmonary Bypass.
Computational intelligence and neuroscience.
2022; 2022(?):8994946. doi:
10.1155/2022/8994946. [PMID: 35676968] - Kristi Kobluk, Bruno H Pypendop. Effects of dopamine, norepinephrine or phenylephrine on the prevention of hypotension in isoflurane-anesthetized cats administered vatinoxan or vatinoxan and dexmedetomidine.
Veterinary anaesthesia and analgesia.
2022 Jan; 49(1):54-64. doi:
10.1016/j.vaa.2021.11.001. [PMID: 34906421] - Yang Mu, Yang Mei, Yaohua Chen, Yuping Li, Dan Zhu, Jian Cui, Lehua Yu. Perisciatic Nerve Dexmedetomidine Alleviates Spinal Oxidative Stress and Improves Peripheral Mitochondrial Dynamic Equilibrium in a Neuropathic Pain Mouse Model in an AMPK-Dependent Manner.
Disease markers.
2022; 2022(?):6889676. doi:
10.1155/2022/6889676. [PMID: 35769812] - Dan Longrois, Fabrice Petitjeans, Olivier Simonet, Marc de Kock, Marc Belliveau, Cyrille Pichot, Thomas Lieutaud, Marco Ghignone, Luc Quintin. How should dexmedetomidine and clonidine be prescribed in the critical care setting?.
Revista Brasileira de terapia intensiva.
2022; 33(4):600-615. doi:
10.5935/0103-507x.20210087. [PMID: 35081245] - Yuanyuan Gao, Fei Yan. Comparison of Intra and Post-operative Sedation Efficacy of Dexmedetomidinemidazolam and Dexmedetomidine-propofol for Major Abdominal Surgery.
Current drug metabolism.
2022; 23(1):45-56. doi:
10.2174/1389200222666211103121832. [PMID: 34732114] - Minhye Chang, Sung-Ae Cho, Seok-Jin Lee, Tae-Yun Sung, Choon-Kyu Cho, Young Seok Jee. Comparison of the effects of dexmedetomidine and propofol on hypothermia in patients under spinal anesthesia: a prospective, randomized, and controlled trial.
International journal of medical sciences.
2022; 19(5):909-915. doi:
10.7150/ijms.72754. [PMID: 35693746] - Yuanmao Zhu, Gang Pang, Bing Lu, Ling Jiang, Chuanhua Rao, Shanshan Tong. Anesthetic Effect of Dexmedetomidine in Clinical Functional Neurosurgery.
Disease markers.
2022; 2022(?):6000388. doi:
10.1155/2022/6000388. [PMID: 35655919] - Guangjun Hu, Zhen Shi, Weidong Shao, Bo Xu. MicroRNA-214-5p involves in the protection effect of Dexmedetomidine against neurological injury in Alzheimer's disease via targeting the suppressor of zest 12.
Brain research bulletin.
2022 01; 178(?):164-172. doi:
10.1016/j.brainresbull.2021.10.016. [PMID: 34715270] - Masayoshi Kondo, Makihiko Nagano, Mariko Yoshida, Naoki Yoshida, Naoya Tagui, Masato Yoshida, Kazutoshi Sugaya, Hisamitsu Takase. Physical Compatibility of Nafamostat with Analgesics, Sedatives, and Muscle Relaxants for Treatment of Coronavirus Disease 2019.
Journal of Nippon Medical School = Nippon Ika Daigaku zasshi.
2021 Dec; 88(6):533-539. doi:
10.1272/jnms.jnms.2022_89-104. [PMID: 33692301] - Xiao-Jiao He, Bin Xie, Song Huang, Ming-Hua Liu. [Dexmedetomidine alleviates LPS/D-Gal-induced acute liver injury via up-regulation of LC3-II expression in mice].
Sheng li xue bao : [Acta physiologica Sinica].
2021 Dec; 73(6):901-908. doi:
NULL. [PMID: 34961864] - Youran Wang, Xinyi Bu, Na Zhao, Shuxia Wang, Xiaoliang Wang, Yali Ge, Honggang Yi. Dexmedetomidine effect on delirium in elderly patients undergoing general anesthesia: A protocol for systematic review and meta-analysis.
Medicine.
2021 Dec; 100(48):e27782. doi:
10.1097/md.0000000000027782. [PMID: 35049173] - Hsin-Yu Huang, Kai-Yueh Liao, Wei-Yau Shia, Chao-Chin Chang, Hsien-Chi Wang. Effect of administering dexmedetomidine with or without atropine on cardiac troponin I level in isoflurane-anesthetized dogs.
The Journal of veterinary medical science.
2021 Dec; 83(12):1869-1876. doi:
10.1292/jvms.20-0657. [PMID: 34629333] - Na Li, Shuangfeng Li, Yehua Wu, Lu Xiong, Tiejun Li, Dandan Xing, Qiuchang Li, Duozhi Wu. Dexmedetomidine targets miR-146a and participates in the progress of chronic obstructive pulmonary disease in vivo and in vitro.
Genes & genomics.
2021 12; 43(12):1371-1379. doi:
10.1007/s13258-020-01019-2. [PMID: 33945148] - Qingduo Guo, Meina Ma, Qiuying Yang, Hong Yu, Xupeng Wang, Chunling Wu, Rui Li. Effects of different sedatives/analgesics on stress responses in patients undergoing craniotomy and bone flap decompression.
The Journal of international medical research.
2021 Dec; 49(12):3000605211062789. doi:
10.1177/03000605211062789. [PMID: 34898308] - Jae Jun Lee, Do-Young Kim, Jung-Taek Hwang, Dong-Keun Song, Han Na Lee, Ji Su Jang, Sang-Soo Lee, Sung Mi Hwang, Sung Hoon Moon, Jae-Hoon Shim. Dexmedetomidine combined with suprascapular nerve block and axillary nerve block has a synergistic effect on relieving postoperative pain after arthroscopic rotator cuff repair.
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA.
2021 Dec; 29(12):4022-4031. doi:
10.1007/s00167-020-06288-8. [PMID: 32975624] - Xinmei Cai, Bilian Li, Wei Wei, Yanping Guan, Xue Bai, Min Huang, Yaying Huang, Lili Rong, Xingrong Song, Guoping Zhong. Circulating microRNA-30a-5p, microRNA-101-3p, microRNA-140-3p and microRNA-141-3p as potential biomarkers for dexmedetomidine response in pediatric patients.
European journal of clinical pharmacology.
2021 Dec; 77(12):1853-1859. doi:
10.1007/s00228-021-03178-x. [PMID: 34216249] - Pin-Hsin Chen, Fon-Yih Tsuang, Chen-Tse Lee, Yu-Chang Yeh, Hsiao-Liang Cheng, Tzong-Shiun Lee, Ya-Wen Chang, Ya-Jung Cheng, Chun-Yu Wu. Neuroprotective effects of intraoperative dexmedetomidine versus saline infusion combined with goal-directed haemodynamic therapy for patients undergoing cranial surgery: A randomised controlled trial.
European journal of anaesthesiology.
2021 12; 38(12):1262-1271. doi:
10.1097/eja.0000000000001532. [PMID: 34101714] - Xi-Sheng Shan, Hui-Rong Dai, Dan Zhao, Bi-Wen Yang, Xiao-Mei Feng, Hong Liu, Ke Peng, Fu-Hai Ji. Dexmedetomidine reduces acute kidney injury after endovascular aortic repair of Stanford type B aortic dissection: A randomized, double-blind, placebo-controlled pilot study.
Journal of clinical anesthesia.
2021 12; 75(?):110498. doi:
10.1016/j.jclinane.2021.110498. [PMID: 34488061] - Guolong Jia, Yanping Li, Feng Yang. Comment on 'Intrathecal dexmedetomidine and postoperative pain: A systematic review and meta-analysis of randomized controlled trials'.
European journal of pain (London, England).
2021 11; 25(10):2278. doi:
10.1002/ejp.1852. [PMID: 34369035] - Mamoru Takeuchi, Shintaro Nemoto, Yasuyuki Suzuki, Naoki Takahashi, Nobuko Takenaka, Ami Takata, Mihoko Kobayashi. Age-Specific Dose Regimens of Dexmedetomidine for Pediatric Patients in Intensive Care Following Elective Surgery: A Phase 3, Multicenter, Open-Label Clinical Trial in Japan.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
2021 11; 22(11):e546-e557. doi:
10.1097/pcc.0000000000002730. [PMID: 33813550] - Chao Qin, Yi Jiang, Xing Chen, Yingxue Bian, Yaoqi Wang, Keliang Xie, Yonghao Yu. Dexmedetomidine protects against burn-induced intestinal barrier injury via the MLCK/p-MLC signalling pathway.
Burns : journal of the International Society for Burn Injuries.
2021 11; 47(7):1576-1585. doi:
10.1016/j.burns.2021.01.017. [PMID: 33933302] - Wenqin Sun, Fengling Li, Xianxue Wang, Hongbo Liu, Hong Mo, Daobo Pan, Shihong Wen, Aiguo Zhou. Effects of Dexmedetomidine on Patients Undergoing Laparoscopic Surgery for Colorectal Cancer.
The Journal of surgical research.
2021 11; 267(?):687-694. doi:
10.1016/j.jss.2021.06.043. [PMID: 34274907] - Panu Uusalo, Mika Valtonen, Mikko J Järvisalo. Hemodynamic and respiratory effects of dexmedetomidine sedation in critically ill Covid-19 patients: A retrospective cohort study.
Acta anaesthesiologica Scandinavica.
2021 11; 65(10):1447-1456. doi:
10.1111/aas.13970. [PMID: 34368946] - Rattaphol Seangrung, Koravee Pasutharnchat, Subundit Injampa, Sirima Kumdang, Rojnarin Komonhirun. Comparison of the hemodynamic response of dexmedetomidine versus additional intravenous lidocaine with propofol during tracheal intubation: a randomized controlled study.
BMC anesthesiology.
2021 10; 21(1):265. doi:
10.1186/s12871-021-01484-6. [PMID: 34717532] - Jef Van den Eynde, Nicolas Cloet, Robin Van Lerberghe, Michel Pompeu B O Sá, Dirk Vlasselaers, Jaan Toelen, Jan Y Verbakel, Werner Budts, Marc Gewillig, Shelby Kutty, Hans Pottel, Djalila Mekahli. Strategies to Prevent Acute Kidney Injury after Pediatric Cardiac Surgery: A Network Meta-Analysis.
Clinical journal of the American Society of Nephrology : CJASN.
2021 10; 16(10):1480-1490. doi:
10.2215/cjn.05800421. [PMID: 34620647] - Ling Yao, Bo Liu, Tianhui He, Feng Shen. [Comparative study of dexmedetomidine vs. midazolam on plasma catecholamine levels and hemodynamics in patients with septic shock].
Zhonghua wei zhong bing ji jiu yi xue.
2021 Oct; 33(10):1193-1197. doi:
10.3760/cma.j.cn121430-20210119-00105. [PMID: 34955127] - Yao Lu, Pan-Pan Fang, Yong-Qi Yu, Xin-Qi Cheng, Xiao-Mei Feng, Gordon Tin Chun Wong, Mervyn Maze, Xue-Sheng Liu. Effect of Intraoperative Dexmedetomidine on Recovery of Gastrointestinal Function After Abdominal Surgery in Older Adults: A Randomized Clinical Trial.
JAMA network open.
2021 10; 4(10):e2128886. doi:
10.1001/jamanetworkopen.2021.28886. [PMID: 34648009] - Hai Cai, Xing Fan, Pengjiu Feng, Xiaogang Wang, Yubo Xie. Optimal dose of perineural dexmedetomidine to prolong analgesia after brachial plexus blockade: a systematic review and Meta-analysis of 57 randomized clinical trials.
BMC anesthesiology.
2021 09; 21(1):233. doi:
10.1186/s12871-021-01452-0. [PMID: 34583650] - Xiaoyan Feng, Weiwei Ma, Jie Zhu, Wei Jiao, Yuhai Wang. Dexmedetomidine alleviates early brain injury following traumatic brain injury by inhibiting autophagy and neuroinflammation through the ROS/Nrf2 signaling pathway.
Molecular medicine reports.
2021 Sep; 24(3):. doi:
10.3892/mmr.2021.12300. [PMID: 34278508] - Stephan Neudeck, Lara Twele, Veronika Kopp, Sabine Kästner. Pharmacodynamics and plasma concentrations of dexmedetomidine with or without vatinoxan as a constant-rate infusion in horses anaesthetized with isoflurane-A pilot study.
Journal of veterinary pharmacology and therapeutics.
2021 Sep; 44(5):754-765. doi:
10.1111/jvp.12992. [PMID: 34159620] - Manuel Taboada, Aurora Baluja, Laura Dos Santos, Irene González, Sonia Veiras, Valentín Caruezo, Alberto Naveira, Paula Mirón, Carmen Novoa, Patricia Doldán, Andrea Calvo, Ana Tubio, Salomé Selas, María Eiras, Adrián Martínez, Olga Campaña, María Teresa Rodríguez, María Diaz-Vieito, Agustín Cariñena, Pablo Otero, Gumersindo Mariño, María Domínguez, Ignacio Muniategui, Francisco Aneiros, Julián Alvarez. Effectiveness of dexmedetomidine combined with high flow nasal oxygen and long periods of awake prone positioning in moderate or severe COVID-19 pneumonia.
Journal of clinical anesthesia.
2021 09; 72(?):110261. doi:
10.1016/j.jclinane.2021.110261. [PMID: 33839432] - Yi Liu, Yuxia Ma, Yunfeng Liu, Wenhao Wang, Feifei Liu. Propofol shows less negative effects on cognitive performances than dexmedetomidine in elderly intensive care unit patients.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology.
2021 Sep; 42(9):3767-3774. doi:
10.1007/s10072-020-04994-2. [PMID: 33449243] - Hannah Lee, Seongmi Choi, Eun Jin Jang, Juhee Lee, Dalho Kim, Seokha Yoo, Seung-Young Oh, Ho Geol Ryu. Effect of Sedatives on In-hospital and Long-term Mortality of Critically Ill Patients Requiring Extended Mechanical Ventilation for ≥ 48 Hours.
Journal of Korean medical science.
2021 Aug; 36(34):e221. doi:
10.3346/jkms.2021.36.e221. [PMID: 34463064] - Rohan Magoon. Dexmedetomidine in COVID-19: probing promises with prudence!.
The American journal of emergency medicine.
2021 08; 46(?):708-709. doi:
10.1016/j.ajem.2020.10.034. [PMID: 33168381] - Zhi-Hao Yang, Xiao-Qiong Xia, Xiang Gao, Yong-Bo Yu, Ren-Jie Gong, Yuan-Hai Li. [Effects of low-dose dexmedetomidine combined with hydromorphone in postoperative analgesia and on the serum IL-6 and CRP levels of prostate cancer patients].
Zhonghua nan ke xue = National journal of andrology.
2021 Aug; 27(8):713-717. doi:
. [PMID: 34914243]
