Corynanthin (BioDeep_00000017577)

Main id: BioDeep_00000000695

 

human metabolite PANOMIX_OTCML-2023 blood metabolite


代谢物信息卡片


Methyl 18-hydroxy-3,13- diazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa- 2(10),4,6,8-tetraene-19-carboxylate

化学式: C21H26N2O3 (354.1943)
中文名称: Beta-育亨宾, 离子交换树脂, 异柯楠碱, 柯楠质
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O
InChI: InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3

描述信息

Methyl 17-hydroxy-20xi-yohimban-16-carboxylate is a yohimban alkaloid, a methyl ester and an organic heteropentacyclic compound.
Methyl 17-hydroxy-20xi-yohimban-16-carboxylate is a natural product found in Aspidosperma oblongum, Aspidosperma ramiflorum, and other organisms with data available.
D001697 - Biomedical and Dental Materials > D003764 - Dental Materials

同义名列表

35 个代谢物同义名

Methyl 18-hydroxy-3,13- diazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa- 2(10),4,6,8-tetraene-19-carboxylate; methyl 18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate; yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16beta,17alpha,20alpha)-; Yohimban-16.alpha.-carboxylic acid, 17.alpha.-hydroxy-, methyl ester; Benz[g]indolo[2,3-a]quinolizine, yohimban-16-carboxylic acid deriv.; Yohimban-16-carboxylicacid, 17-hydroxy-, methyl ester, (16b,17a)-; Yohimban-16-carboxylic acid, methyl ester, (16.beta.,17.alpha.)-; Yohimban-16-carboxylic acid, methyl ester, (16.alpha.,17.beta.)-; Yohimbol-16.alpha.-carboxylic acid, methyl ester; Yohimban-16.alpha.-carboxylic acid, methyl ester; Yohimban-16.beta.-carboxylic acid, methyl ester; methyl 17-hydroxy-20xi-yohimban-16-carboxylate; alpha-Yohimbine;Corynanthidine;Isoyohimbine; Methyl 17-hydroxyyohimban-16-carboxylate #; Methyl 17-hydroxyyohimban-16-carboxylate; 3-Epirauwolscine; 3-epi-Rauwolscine; BLGXFZZNTVWLAY-UHFFFAOYSA-N; 3-epi-a-Yohimbine; .beta.-Yohimbine; Amberlite Cg-400; beta-Yohimbine; Isorauhimbine; MEGxp0_002061; MEGxp0_001106; NCI60_001630; Isorauhimbin; ACon1_000625; NCI60_003875; EC-Yohimbine; NCI60_003876; A.-Yohimbine; ACon1_000583; COYNANTHINE; Corynanthin; b-Yohimbine



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

5 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ADRA1A, ADRA2A, HSPA1B, ITPR3, NR4A2, QKI, RGS2
Endosome membrane 1 SLC6A4
Endoplasmic reticulum membrane 4 DRD1, GABBR1, ITPR3, PTGDS
Nucleus 7 ADRA1A, DRD1, DYNLL2, HSPA1B, NR4A2, QKI, RGS2
cytosol 7 ADRA1A, ADRA2B, DYNLL2, HSPA1B, PDE10A, QKI, RGS2
dendrite 1 ADORA2A
mitochondrial membrane 1 GABBR1
centrosome 2 DYNLL2, HSPA1B
nucleoplasm 4 ADRA1A, HSPA1B, ITPR3, NR4A2
Cell membrane 9 ADORA2A, ADRA1A, ADRA2A, ADRA2B, ADRB3, CCKBR, DRD1, GABBR1, SLC6A4
Multi-pass membrane protein 11 ADORA2A, ADRA1A, ADRA2A, ADRA2B, ADRB3, CACNA1I, CCKBR, DRD1, GABBR1, ITPR3, SLC6A4
Synapse 3 QKI, SLC6A4, TAC1
cell surface 1 ADRA2B
dendritic shaft 1 GABBR1
glutamatergic synapse 5 ADORA2A, ADRA2A, DRD1, DYNLL2, GABBR1
Golgi apparatus 1 PTGDS
Golgi membrane 1 INS
neuronal cell body 5 ADORA2A, ADRA2A, GABBR1, ITPR3, TAC1
postsynapse 1 DYNLL2
presynaptic membrane 4 ADORA2A, DRD1, GABBR1, SLC6A4
synaptic vesicle 1 GABBR1
Cytoplasm, cytosol 1 PDE10A
Presynapse 1 SLC6A4
plasma membrane 13 ADORA2A, ADRA1A, ADRA2A, ADRA2B, ADRB3, CACNA1I, CCKBR, DRD1, DYNLL2, GABBR1, ITPR3, RGS2, SLC6A4
presynaptic active zone 1 ADORA2A
Membrane 7 ADORA2A, CACNA1I, CCKBR, DYNLL2, GABBR1, ITPR3, SLC6A4
axon 1 TAC1
basolateral plasma membrane 1 ADRA2A
brush border 1 ITPR3
caveola 1 ADRA1A
extracellular exosome 2 HSPA1B, PTGDS
endoplasmic reticulum 2 HSPA1B, ITPR3
extracellular space 4 GABBR1, INS, PTGDS, TAC1
perinuclear region of cytoplasm 2 HSPA1B, PTGDS
Schaffer collateral - CA1 synapse 1 GABBR1
mitochondrion 2 HSPA1B, RGS2
protein-containing complex 2 HSPA1B, NR4A2
intracellular membrane-bounded organelle 3 ADRA1A, ADRA2B, CCKBR
Secreted 2 INS, PTGDS
extracellular region 4 HSPA1B, INS, PTGDS, TAC1
cytoplasmic side of plasma membrane 1 RGS2
transcription regulator complex 1 NR4A2
ciliary membrane 1 DRD1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 HSPA1B
Nucleus membrane 2 ADRA1A, PTGDS
nuclear membrane 2 ADRA1A, PTGDS
dendritic spine 2 DRD1, GABBR1
nucleolus 2 ITPR3, RGS2
apical part of cell 1 ITPR3
vesicle 1 HSPA1B
postsynaptic membrane 4 ADORA2A, DRD1, GABBR1, SLC6A4
presynaptic active zone membrane 1 ADRA2A
Cytoplasm, perinuclear region 1 PTGDS
Membrane raft 1 SLC6A4
Cell junction, focal adhesion 1 SLC6A4
Cytoplasm, cytoskeleton 1 DYNLL2
focal adhesion 2 HSPA1B, SLC6A4
microtubule 1 DYNLL2
axolemma 2 ADORA2A, GABBR1
G protein-coupled GABA receptor complex 1 GABBR1
GABA-ergic synapse 3 ADRA2A, DRD1, GABBR1
sarcoplasmic reticulum 1 ITPR3
Cell projection, dendritic spine 1 DRD1
intermediate filament 1 ADORA2A
ciliary tip 1 DYNLL2
nuclear speck 2 HSPA1B, NR4A2
nuclear outer membrane 1 ITPR3
Postsynaptic cell membrane 1 GABBR1
receptor complex 3 ADRA2A, ADRB3, ITPR3
Cell projection, neuron projection 1 SLC6A4
neuron projection 1 SLC6A4
cilium 2 DRD1, DYNLL2
chromatin 1 NR4A2
cytoskeleton 1 DYNLL2
centriole 1 HSPA1B
Nucleus, nucleolus 1 RGS2
blood microparticle 1 HSPA1B
non-motile cilium 1 DRD1
[Isoform 2]: Cell membrane 1 RGS2
Endomembrane system 1 SLC6A4
endosome lumen 1 INS
Membrane, caveola 1 ADRA1A
Cell projection, dendrite 2 DRD1, GABBR1
Cytoplasm, Stress granule 1 QKI
cytoplasmic stress granule 1 QKI
ficolin-1-rich granule lumen 1 HSPA1B
secretory granule lumen 1 INS
secretory granule membrane 1 ITPR3
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
axon terminus 1 ADRA2A
voltage-gated calcium channel complex 1 CACNA1I
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
postsynaptic density membrane 1 ADRA2A
cytoplasmic dynein complex 1 DYNLL2
aggresome 1 HSPA1B
9+0 non-motile cilium 1 DYNLL2
ribonucleoprotein complex 1 HSPA1B
platelet dense tubular network membrane 1 ITPR3
[Isoform 1]: Cell membrane 1 RGS2
dopaminergic synapse 1 ADRA2A
Cytoplasmic vesicle, secretory vesicle membrane 1 ITPR3
Rough endoplasmic reticulum 1 PTGDS
Cell projection, cilium membrane 1 DRD1
G protein-coupled receptor heterodimeric complex 1 GABBR1
[Isoform 3]: Cell membrane 1 RGS2
transport vesicle membrane 1 ITPR3
inclusion body 1 HSPA1B
asymmetric synapse 1 ADORA2A
[Isoform 4]: Cell membrane 1 RGS2
G protein-coupled receptor complex 1 DRD1
cytoplasmic side of endoplasmic reticulum membrane 1 ITPR3
serotonergic synapse 1 SLC6A4
myosin V complex 1 DYNLL2
[Isoform QKI5]: Nucleus 1 QKI
[Isoform QKI6]: Cytoplasm, cytosol 1 QKI
[Isoform QKI7]: Cytoplasm, cytosol 1 QKI
[Isoform 1E]: Secreted 1 GABBR1


文献列表

  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]