Asitribin (BioDeep_00000006845)

 

Secondary id: BioDeep_00000640721

human metabolite Endogenous


代谢物信息卡片


3-(13-{5-[5-(1,5-dihydroxyundecyl)oxolan-2-yl]oxolan-2-yl}-13-hydroxytridecyl)-5-methyl-2,5-dihydrofuran-2-one

化学式: C37H66O7 (622.4808)
中文名称:
谱图信息: 最多检出来源 not specific(not specific) 0%

分子结构信息

SMILES: CCCCCCC(CCCC(C1CCC(O1)C2CCC(O2)C(CCCCCCCCCCCCC3=CC(OC3=O)C)O)O)O
InChI: InChI=1S/C37H66O7/c1-3-4-5-15-19-30(38)20-17-22-32(40)34-24-26-36(44-34)35-25-23-33(43-35)31(39)21-16-13-11-9-7-6-8-10-12-14-18-29-27-28(2)42-37(29)41/h27-28,30-36,38-40H,3-26H2,1-2H3/t28-,30-,31+,32-,33+,34+,35+,36+/m0/s1

描述信息

Asiminacin is found in fruits. Asiminacin is a constituent of Asimina triloba (pawpaw) and Annona squamosa (sugar apple).
Constituent of the seeds of Asimina triloba (pawpaw). Asitribin is found in fruits.

同义名列表

5 个代谢物同义名

3-(13-{5-[5-(1,5-dihydroxyundecyl)oxolan-2-yl]oxolan-2-yl}-13-hydroxytridecyl)-5-methyl-2,5-dihydrofuran-2-one; 3-(13-{5-[5-(1,5-dihydroxyundecyl)oxolan-2-yl]oxolan-2-yl}-13-hydroxytridecyl)-5-methyl-5H-furan-2-one; Squamocin; Asitribin; Squamocin



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 15 AIMP2, AQP4, BCL2, BCL2L1, CASP3, CCNB1, CCND3, CDC25C, CDK1, CDK2, CDK4, MAPK8, MAPK9, MYL9, PGP
Endosome membrane 1 AQP4
Endoplasmic reticulum membrane 2 BCL2, CDK1
Mitochondrion membrane 1 BCL2L1
Nucleus 13 AIMP2, AURKB, BCL2, CASP3, CCNB1, CCND3, CDC25C, CDK1, CDK2, CDK4, MAPK8, MAPK9, PARP1
cytosol 15 AIMP2, AURKB, BCL2, BCL2L1, CASP3, CCNB1, CCND3, CDC25C, CDK1, CDK2, CDK4, MAPK8, MAPK9, MYL9, PARP1
nuclear body 1 PARP1
centrosome 5 BCL2L1, CCNB1, CCND3, CDK1, CDK2
nucleoplasm 11 AURKB, CASP3, CCNB1, CCND3, CDC25C, CDK1, CDK2, CDK4, MAPK8, MAPK9, PARP1
Cell membrane 1 AQP4
Cytoplasmic side 1 BCL2L1
Multi-pass membrane protein 1 AQP4
Synapse 1 MAPK8
cell cortex 1 MYL9
glutamatergic synapse 1 CASP3
mitochondrial inner membrane 1 BCL2L1
neuronal cell body 1 CASP3
sarcolemma 1 AQP4
Cytoplasm, cytosol 3 AIMP2, BCL2L1, PARP1
endosome 1 CDK2
plasma membrane 2 AQP4, MAPK9
synaptic vesicle membrane 1 BCL2L1
Membrane 6 AIMP2, AQP4, BCL2, CCNB1, CDK1, PARP1
axon 1 MAPK8
basolateral plasma membrane 1 AQP4
extracellular exosome 1 CDK1
endoplasmic reticulum 2 BCL2, BCL2L1
perinuclear region of cytoplasm 1 CDC25C
Schaffer collateral - CA1 synapse 1 MAPK9
bicellular tight junction 1 CDK4
mitochondrion 6 BCL2, BCL2L1, CDK1, MAPK9, PARP1, RTL10
protein-containing complex 2 BCL2, PARP1
postsynaptic density 1 CASP3
extracellular region 1 AQP4
Mitochondrion outer membrane 2 BCL2, BCL2L1
Single-pass membrane protein 2 BCL2, BCL2L1
mitochondrial outer membrane 2 BCL2, BCL2L1
astrocyte end-foot 1 AQP4
Mitochondrion matrix 1 BCL2L1
mitochondrial matrix 3 BCL2L1, CCNB1, CDK1
transcription regulator complex 3 CDK2, CDK4, PARP1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 3 BCL2L1, CDK1, CDK2
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 BCL2L1
Nucleus membrane 3 BCL2, BCL2L1, CDK4
Bcl-2 family protein complex 2 BCL2, BCL2L1
nuclear membrane 3 BCL2, BCL2L1, CDK4
external side of plasma membrane 1 AQP4
Z disc 1 MYL9
microtubule cytoskeleton 1 AURKB
nucleolus 2 CDK4, PARP1
midbody 2 AURKB, CDK1
spindle midzone 1 AURKB
Cell membrane, sarcolemma 1 AQP4
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 MYL9
Cytoplasm, cytoskeleton, spindle 1 AURKB
spindle 1 AURKB
myofibril 1 MYL9
mitochondrial intermembrane space 1 CDC25C
nuclear speck 1 MAPK9
chromatin 2 CDK4, PARP1
cell projection 1 AQP4
mitotic spindle 1 CDK1
Chromosome 2 AURKB, PARP1
Nucleus, nucleolus 1 PARP1
spindle pole 1 CCNB1
nuclear replication fork 1 PARP1
chromosome, telomeric region 3 CDK1, CDK2, PARP1
condensed chromosome, centromeric region 1 AURKB
Cytoplasm, cell cortex 1 MYL9
Basolateral cell membrane 1 AQP4
site of double-strand break 1 PARP1
nuclear envelope 2 CDK2, PARP1
Chromosome, centromere 1 AURKB
Chromosome, centromere, kinetochore 1 AURKB
myelin sheath 1 BCL2
stress fiber 1 MYL9
male germ cell nucleus 1 CDK2
kinetochore 1 AURKB
mitotic spindle midzone 1 AURKB
mitotic spindle pole 1 AURKB
chromosome, centromeric region 1 AURKB
outer kinetochore 1 CCNB1
chromosome passenger complex 1 AURKB
spindle pole centrosome 1 AURKB
Cajal body 1 CDK2
protein-DNA complex 1 PARP1
spindle microtubule 2 AURKB, CDK1
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
chromocenter 1 AURKB
condensed chromosome 1 CDK2
Nucleus, Cajal body 1 CDK2
X chromosome 1 CDK2
Y chromosome 1 CDK2
site of DNA damage 1 PARP1
cyclin-dependent protein kinase holoenzyme complex 4 CCND3, CDK1, CDK2, CDK4
cyclin E1-CDK2 complex 1 CDK2
cyclin E2-CDK2 complex 1 CDK2
muscle myosin complex 1 MYL9
cyclin A1-CDK1 complex 1 CDK1
cyclin A2-CDK1 complex 1 CDK1
cyclin B1-CDK1 complex 2 CCNB1, CDK1
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 1 CDK4
cyclin D2-CDK4 complex 1 CDK4
cyclin D3-CDK4 complex 2 CCND3, CDK4
cyclin A2-CDK2 complex 1 CDK2
cyclin A1-CDK2 complex 1 CDK2
cyclin D3-CDK6 complex 1 CCND3
[Isoform Bcl-X(L)]: Mitochondrion inner membrane 1 BCL2L1


文献列表

  • Kevin Tran, Sean Ryan, Miranda McDonald, Andrew L Thomas, José Guilherme S Maia, Robert E Smith. Annonacin and Squamocin Contents of Pawpaw (Asimina triloba) and Marolo (Annona crassiflora) Fruits and Atemoya (A. squamosa × A. cherimola) Seeds. Biological trace element research. 2021 06; 199(6):2320-2329. doi: 10.1007/s12011-020-02320-7. [PMID: 32761515]
  • Y Miao, X Xu, F Yuan, Y Shi, Y Chen, J Chen, X Li. Four cytotoxic annonaceous acetogenins from the seeds of Annona squamosa. Natural product research. 2016 Jun; 30(11):1273-9. doi: 10.1080/14786419.2015.1055490. [PMID: 26181648]
  • Jing-Fang Shi, Ping Wu, Zi-Hua Jiang, Xiao-Yi Wei. Synthesis and tumor cell growth inhibitory activity of biotinylated annonaceous acetogenins. European journal of medicinal chemistry. 2014 Jan; 71(?):219-28. doi: 10.1016/j.ejmech.2013.11.012. [PMID: 24308999]
  • Haijun Yang, Ning Zhang, Xiang Li, Jianwei Chen, Baochang Cai. Structure-activity relationships of diverse annonaceous acetogenins against human tumor cells. Bioorganic & medicinal chemistry letters. 2009 Apr; 19(8):2199-202. doi: 10.1016/j.bmcl.2009.02.105. [PMID: 19285863]
  • Séverine Derbré, Erwan Poupon, Christophe Gleye, Reynald Hocquemiller. Biogenetic relationships between Annonaceous acetogenins: squamocin is not a precursor of chamuvarinin based on a semisynthetic study. Journal of natural products. 2007 Feb; 70(2):300-3. doi: 10.1021/np060376b. [PMID: 17279796]
  • Shyng-Shiou F Yuan, Hsueh-Ling Chang, Hsiao-Wen Chen, Fu-Chen Kuo, Chih-Chuang Liaw, Jinu-Huang Su, Yang-Chang Wu. Selective cytotoxicity of squamocin on T24 bladder cancer cells at the S-phase via a Bax-, Bad-, and caspase-3-related pathways. Life sciences. 2006 Jan; 78(8):869-74. doi: 10.1016/j.lfs.2005.05.068. [PMID: 16154156]
  • Djibril Fall, Romain A Duval, Christophe Gleye, Alain Laurens, Reynald Hocquemiller. Chamuvarinin, an acetogenin bearing a tetrahydropyran ring from the roots of Uvaria chamae. Journal of natural products. 2004 Jun; 67(6):1041-3. doi: 10.1021/np030521a. [PMID: 15217292]
  • Yuka Nakanishi, Fang-Rong Chang, Chih-Chuang Liaw, Yang-Chang Wu, Kenneth F Bastow, Kuo-Hsiung Lee. Acetogenins as selective inhibitors of the human ovarian 1A9 tumor cell line. Journal of medicinal chemistry. 2003 Jul; 46(15):3185-8. doi: 10.1021/jm020548b. [PMID: 12852747]
  • Li-Da Wang, De-You Qiu, Ji-Yun Chen, Yi-Fan Han, Jun-Hua Zheng, De-An Guo. Callus cultures of Annona squamosa for the production of annonaceous acetogenins. Journal of Asian natural products research. 2002 Sep; 4(3):171-4. doi: 10.1080/1028602021000000062. [PMID: 12118503]
  • L Sun, J G Yu, D Y Li, J Li, X D Yang, S L Yang. [Determination of annonaceous acetogenins in annonaceae plants by HPLC]. Yao xue xue bao = Acta pharmaceutica Sinica. 2001 Sep; 36(9):683-5. doi: . [PMID: 12580108]
  • E F Queiroz, F Roblot, P Duret, B Figadère, A Gouyette, O Laprévote, L Serani, R Hocquemiller. Synthesis, spectroscopy, and cytotoxicity of glycosylated acetogenin derivatives as promising molecules for cancer therapy. Journal of medicinal chemistry. 2000 Apr; 43(8):1604-10. doi: 10.1021/jm990568m. [PMID: 10780917]
  • S Raynaud, C Fourneau, A Laurens, R Hocquemiller, P Loiseau, C Bories. Squamocin and benzyl benzoate, acaricidal components of Uvaria pauci-ovulata bark extracts. Planta medica. 2000 Mar; 66(2):173-5. doi: 10.1055/s-0029-1243125. [PMID: 10763595]
  • E F Queiroz, F Roblot, A Cavé, R Hocquemiller, L Serani, O Laprévote, M Q Paulo. A new bistetrahydrofuran acetogenin from the roots of Annona salzmanii. Journal of natural products. 1999 May; 62(5):710-3. doi: 10.1021/np980482g. [PMID: 10346951]
  • B Akendengue, E Ngou-Milama, A Laurens, R Hocquemiller. Recent advances in the fight against leishmaniasis with natural products. Parasite (Paris, France). 1999 Mar; 6(1):3-8. doi: 10.1051/parasite/1999061003. [PMID: 10229931]
  • V Padmaja, V Thankamany, A Hisham. Antibacterial, antifungal and anthelmintic activities of root barks of Uvaria hookeri and Uvaria narum. Journal of ethnopharmacology. 1993 Dec; 40(3):181-6. doi: 10.1016/0378-8741(93)90066-e. [PMID: 8145573]