Methacycline (BioDeep_00000006568)

 

Secondary id: BioDeep_00000599933

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(4S,4aR,5S,5aR,12aS)-4-(dimethylamino)-5,10,12,12a-tetrahydroxy-6-methylidene-1,3,11-trioxo-1,2,3,4,4a,5,5a,6,11,12a-decahydrotetracene-2-carboxamide

化学式: C22H22N2O8 (442.1376)
中文名称: 甲环素
谱图信息: 最多检出来源 Homo sapiens(blood) 72.73%

分子结构信息

SMILES: C=C1c2cccc(c2C(=O)C2=C([C@]3([C@H]([C@@H](C(=C(C3=O)C(=O)N)O)N(C)C)[C@H]([C@H]12)O)O)O)O
InChI: InChI=1S/C22H22N2O8/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29/h4-6,10,14-15,17,25-27,30,32H,1H2,2-3H3,(H2,23,31)/t10-,14-,15+,17+,22+/m1/s1

描述信息

Methacycline is only found in individuals that have used or taken this drug. It is a broad-spectrum semisynthetic antibiotic related to tetracycline but excreted more slowly and maintaining effective blood levels for a more extended period. [PubChem]Methacycline, a tetracycline antibiotic, is a protein synthesis inhibitors, inhibiting the binding of aminoacyl-tRNA to the mRNA-ribosome complex. Methacycline inhibits cell growth by inhibiting translation. It binds to the 16S part of the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Tetracyclines also have been found to inhibit matrix metalloproteinases. This mechanism does not add to their antibiotic effects, but has led to extensive research on chemically modified tetracyclines or CMTs (like incyclinide) for the treatmet of rosacea, acne, and various types of neoplasms.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01A - Tetracyclines > J01AA - Tetracyclines
C784 - Protein Synthesis Inhibitor > C1595 - Tetracycline Antibiotic
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C254 - Anti-Infective Agent > C258 - Antibiotic

同义名列表

6 个代谢物同义名

(4S,4aR,5S,5aR,12aS)-4-(dimethylamino)-5,10,12,12a-tetrahydroxy-6-methylidene-1,3,11-trioxo-1,2,3,4,4a,5,5a,6,11,12a-decahydrotetracene-2-carboxamide; methacycline; Metacycline; Methacyclin; Bialatan; Methacycline



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 AIMP2, AKT1, CCNB1, CCND1, CDC25B, CDH1, CDK1, CTNNB1, MACC1, MARK2, SNAI1
Endoplasmic reticulum membrane 1 CDK1
Nucleus 14 AIMP2, AKT1, AURKA, CCNB1, CCND1, CDC25B, CDH1, CDK1, CTNNB1, FLG, MACC1, MET, SNAI1, TWIST1
cytosol 11 AIMP2, AKT1, AURKA, CCNB1, CCND1, CDC25B, CDH1, CDK1, CTNNB1, FLG, SNAI1
dendrite 1 MARK2
nuclear body 1 MET
trans-Golgi network 1 CDH1
centrosome 6 AURKA, CCNB1, CCND1, CDC25B, CDK1, CTNNB1
nucleoplasm 12 AKT1, AURKA, CCNB1, CCND1, CDC25B, CDH1, CDK1, CTNNB1, MARK2, MET, SNAI1, TWIST1
Cell membrane 4 AKT1, CDH1, CTNNB1, SCN8A
lamellipodium 3 AKT1, CDH1, CTNNB1
Cell projection, axon 1 SCN8A
Cytoplasmic granule 1 FLG
Multi-pass membrane protein 1 SCN8A
Synapse 1 CTNNB1
cell cortex 2 AKT1, CTNNB1
cell junction 3 CDH1, CTNNB1, SCN8A
cell surface 1 MET
glutamatergic synapse 6 AKT1, AURKA, CDH1, CTNNB1, FLG, SCN8A
Golgi apparatus 1 CDH1
mitochondrial inner membrane 1 OTC
postsynapse 4 AKT1, CDH1, FLG, MET
presynaptic membrane 1 CTNNB1
Cytoplasm, cytosol 1 AIMP2
endosome 1 CDH1
plasma membrane 8 AKT1, CDH1, CTNNB1, FLG, ICAM3, MARK2, MET, SCN8A
Membrane 11 AIMP2, AKT1, CCNB1, CDH1, CDK1, CTNNB1, FLG, ICAM3, MARK2, MET, SCN8A
axon 1 SCN8A
basolateral plasma membrane 2 AURKA, CTNNB1
extracellular exosome 6 CDH1, CDK1, CTNNB1, ICAM3, LYZ, MMP9
extracellular space 2 LYZ, MMP9
perinuclear region of cytoplasm 3 AURKA, CDH1, CTNNB1
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 2 CDH1, CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 2 CCND1, CTNNB1
mitochondrion 4 CDK1, MACC1, MARK2, OTC
protein-containing complex 2 AKT1, CTNNB1
intracellular membrane-bounded organelle 1 SNAI1
postsynaptic density 1 AURKA
pericentric heterochromatin 1 SNAI1
pronucleus 1 AURKA
Single-pass type I membrane protein 2 CDH1, ICAM3
extracellular region 5 CDH1, FLG, LYZ, MET, MMP9
cytoplasmic side of plasma membrane 1 CDH1
Single-pass membrane protein 1 MET
Mitochondrion matrix 1 OTC
mitochondrial matrix 3 CCNB1, CDK1, OTC
anchoring junction 1 SCN8A
transcription regulator complex 1 CTNNB1
Cell projection, cilium 1 AURKA
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 3 AURKA, CDC25B, CDK1
Nucleus membrane 1 CCND1
nuclear membrane 2 CCND1, CDH1
Secreted, extracellular space, extracellular matrix 1 MMP9
actin cytoskeleton 1 CDH1
Z disc 2 CTNNB1, SCN8A
beta-catenin destruction complex 1 CTNNB1
cytoplasmic vesicle 2 FLG, SCN8A
microtubule cytoskeleton 2 AKT1, AURKA
Wnt signalosome 1 CTNNB1
midbody 2 AURKA, CDK1
apical part of cell 1 CTNNB1
cell-cell junction 2 AKT1, CTNNB1
spindle midzone 1 AURKA
vesicle 1 AKT1
postsynaptic membrane 1 CTNNB1
presynaptic active zone membrane 1 SCN8A
Cytoplasm, cytoskeleton 1 CTNNB1
Cytoplasm, cytoskeleton, spindle 1 AURKA
focal adhesion 1 CTNNB1
microtubule 1 AURKA
spindle 2 AKT1, AURKA
Cell junction, adherens junction 2 CDH1, CTNNB1
flotillin complex 2 CDH1, CTNNB1
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 2 FLG, MMP9
fascia adherens 1 CTNNB1
lateral plasma membrane 3 CDH1, CTNNB1, MARK2
receptor complex 2 FLG, MET
Cell projection, neuron projection 1 AURKA
neuron projection 1 AURKA
ciliary basal body 2 AKT1, AURKA
cilium 1 AURKA
chromatin 1 TWIST1
cell periphery 1 CTNNB1
mitotic spindle 2 AURKA, CDK1
Cell projection, podosome 1 SCN8A
podosome 1 SCN8A
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole 1 AURKA
Cytoplasm, cytoskeleton, cilium basal body 2 AURKA, CTNNB1
centriole 1 AURKA
cytoplasmic ribonucleoprotein granule 1 FLG
Golgi apparatus, trans-Golgi network 1 CDH1
spindle pole 3 CCNB1, CDC25B, CTNNB1
chromosome, telomeric region 1 CDK1
actin filament 1 MARK2
postsynaptic density, intracellular component 1 CTNNB1
Basolateral cell membrane 1 AURKA
microvillus membrane 1 CTNNB1
Cytoplasm, cytoskeleton, spindle pole 2 AURKA, CDC25B
fibrillar center 1 SNAI1
Endomembrane system 1 CTNNB1
Cornified envelope 1 FLG
axon initial segment 1 SCN8A
Cell projection, dendrite 1 MARK2
euchromatin 1 CTNNB1
basal plasma membrane 1 MET
ficolin-1-rich granule lumen 1 MMP9
transcription repressor complex 1 CCND1
specific granule lumen 1 LYZ
tertiary granule lumen 2 LYZ, MMP9
kinetochore 1 AURKA
mitotic spindle pole 1 AURKA
node of Ranvier 1 SCN8A
beta-catenin-TCF complex 1 CTNNB1
azurophil granule lumen 1 LYZ
anaphase-promoting complex 1 CDH1
postsynaptic density membrane 1 SCN8A
parallel fiber to Purkinje cell synapse 1 SCN8A
outer kinetochore 1 CCNB1
presynaptic active zone cytoplasmic component 1 CTNNB1
axon hillock 1 AURKA
chromosome passenger complex 1 AURKA
germinal vesicle 1 AURKA
meiotic spindle 1 AURKA
spindle pole centrosome 1 AURKA
[Isoform 2]: Nucleus 1 CDH1
protein-DNA complex 1 CTNNB1
spindle microtubule 1 CDK1
apical junction complex 1 CDH1
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
Cell junction, desmosome 1 CDH1
desmosome 1 CDH1
catenin complex 2 CDH1, CTNNB1
voltage-gated sodium channel complex 1 SCN8A
cyclin-dependent protein kinase holoenzyme complex 2 CCND1, CDK1
cyclin A1-CDK1 complex 1 CDK1
cyclin A2-CDK1 complex 1 CDK1
cyclin B1-CDK1 complex 2 CCNB1, CDK1
keratohyalin granule 1 FLG
cyclin D1-CDK4 complex 1 CCND1
beta-catenin-TCF7L2 complex 1 CTNNB1
cyclin D1-CDK6 complex 1 CCND1
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
microtubule bundle 1 MARK2
[Isoform 5]: Cytoplasmic vesicle 1 SCN8A


文献列表

  • Chengyu Dong, Ningning Lu, Ying Liu. Binding of methacycline to human serum albumin at subdomain IIA using multispectroscopic and molecular modeling methods. Luminescence : the journal of biological and chemical luminescence. 2013 Nov; 28(6):933-41. doi: 10.1002/bio.2462. [PMID: 23233363]
  • Na Zhang, Jin-Kai Liu, Chong-Qiu Jiang. Lysozyme-enhanced europium(III)-metacycline luminescence and its application to the determination of metacycline. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2005 May; 21(5):541-4. doi: 10.2116/analsci.21.541. [PMID: 15913144]
  • M C Mahedero, D Bohoyo, F Salinas, T Ardila, D Airado, B Roldán. Improvements in europium sensitized fluorimetric determination of demeclocycline and methacycline. Journal of pharmaceutical and biomedical analysis. 2005 Apr; 37(5):1101-4. doi: 10.1016/j.jpba.2004.10.040. [PMID: 15862691]
  • A Takadate, M Irikura, Y Ohkubo, S Goya, M Otagiri, K Uekama. Interaction between methacycline and human serum albumin. Chemical & pharmaceutical bulletin. 1984 May; 32(5):1898-903. doi: 10.1248/cpb.32.1898. [PMID: 6467471]
  • J Brodie. Antibiotics and the Aberdeen typhoid outbreak in 1964. The Journal of hygiene. 1976 Apr; 76(2):191-203. doi: 10.1017/s0022172400055091. [PMID: 1063214]
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