Phosphohydroxypyruvic acid (BioDeep_00000005146)
Secondary id: BioDeep_00001869275
human metabolite PANOMIX_OTCML-2023 Endogenous
代谢物信息卡片
2-oxo-3-(Phosphonooxy)-propanoic acid
化学式: C3H5O7P (183.9773)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(plant) 13.13%
分子结构信息
SMILES: C(=O)(C(=O)COP(=O)(O)O)O
InChI: InChI=1S/C3H5O7P/c4-2(3(5)6)1-10-11(7,8)9/h1H2,(H,5,6)(H2,7,8,9)
描述信息
Phosphohydroxypyruvic acid is a prduct of both enzyme phosphoglycerate dehydrogenase [EC 1.1.1.95] and phosphoserine transaminase [EC 2.6.1.52] in glycine, serine and threonine metabolism pathway (KEGG). This compound belongs to the family of Organophosphate Esters. These are organic compounds containing phosphoric acid ester functional group.
Phosphohydroxypyruvic acid is a prduct of both enzyme phosphoglycerate dehydrogenase [EC 1.1.1.95] and phosphoserine transaminase [EC 2.6.1.52] in glycine, serine and threonine metabolism pathway (KEGG). [HMDB]
同义名列表
17 个代谢物同义名
2-oxo-3-(Phosphonooxy)-propanoic acid; 2-Oxo-3-(phosphonooxy)propanoic acid; 2-Oxo-3-(phosphonooxy)propionic acid; Hydroxypyruvic acid phosphoric acid; 2-oxo-3-(Phosphonooxy)-propanoate; Hydroxypyruvic acid phosphate; 3-Phosphohydroxypyruvic acid; Phosphohydroxypyruvic acid; 3-Phosphonooxypyruvic acid; Hydroxypyruvate phosphate; 3-Phosphonatooxypyruvate; 3-Phosphooxypyruvic acid; 3-Phosphohydroxypyruvate; Phosphohydroxypyruvate; 3-Phosphonooxypyruvate; 3-Phosphooxypyruvate; 3-Phosphonooxypyruvate
数据库引用编号
22 个数据库交叉引用编号
- ChEBI: CHEBI:30933
- KEGG: C03232
- PubChem: 105
- HMDB: HMDB0001024
- Metlin: METLIN484
- Wikipedia: Phosphohydroxypyruvic acid
- MetaCyc: 3-P-HYDROXYPYRUVATE
- KNApSAcK: C00019657
- foodb: FDB022377
- chemspider: 103
- CAS: 114887-36-4
- CAS: 3913-50-6
- PMhub: MS000017859
- ChEBI: CHEBI:18110
- PubChem: 6103
- PDB-CCD: HPV
- 3DMET: B00565
- NIKKAJI: J2.180.747H
- RefMet: Phosphohydroxypyruvic acid
- KNApSAcK: 18110
- LOTUS: LTS0245342
- wikidata: Q4353545
分类词条
相关代谢途径
Reactome(4)
BioCyc(0)
PlantCyc(0)
代谢反应
106 个相关的代谢反应过程信息。
Reactome(68)
- Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid synthesis and interconversion (transamination):
ATP + H2O + L-Asp + L-Gln ⟶ AMP + L-Asn + L-Glu + PPi - Serine biosynthesis:
Ser ⟶ H2O + PYR + ammonia - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid synthesis and interconversion (transamination):
H2O + NAA ⟶ CH3COO- + L-Asp - Serine biosynthesis:
Ser ⟶ H2O + PYR + ammonia - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid synthesis and interconversion (transamination):
H2O + L-Asn ⟶ L-Asp + ammonia - Serine biosynthesis:
Ser ⟶ H2O + PYR + ammonia - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid synthesis and interconversion (transamination):
H2O + NAA ⟶ CH3COO- + L-Asp - Serine biosynthesis:
3POPA + L-Glu ⟶ 2OG + O-P-Ser - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid synthesis and interconversion (transamination):
H2O + NAA ⟶ CH3COO- + L-Asp - Serine biosynthesis:
3POPA + L-Glu ⟶ 2OG + O-P-Ser - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid synthesis and interconversion (transamination):
ATP + H2O + L-Asp + L-Gln ⟶ AMP + L-Asn + L-Glu + PPi - Serine biosynthesis:
Ser ⟶ H2O + PYR + ammonia - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid synthesis and interconversion (transamination):
H2O + L-Asn ⟶ L-Asp + ammonia - Serine biosynthesis:
3POPA + L-Glu ⟶ 2OG + O-P-Ser - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid synthesis and interconversion (transamination):
H2O + NAA ⟶ CH3COO- + L-Asp - Serine biosynthesis:
Ser ⟶ H2O + PYR + ammonia - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid synthesis and interconversion (transamination):
H2O + NAA ⟶ CH3COO- + L-Asp - Serine biosynthesis:
Ser ⟶ H2O + PYR + ammonia - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid synthesis and interconversion (transamination):
H2O + NAA ⟶ CH3COO- + L-Asp - Serine biosynthesis:
Ser ⟶ H2O + PYR + ammonia - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid synthesis and interconversion (transamination):
ATP + H2O + L-Asp + L-Gln ⟶ AMP + L-Asn + L-Glu + PPi - Serine biosynthesis:
Ser ⟶ H2O + PYR + ammonia - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid synthesis and interconversion (transamination):
H2O + NAA ⟶ CH3COO- + L-Asp - Serine biosynthesis:
Ser ⟶ H2O + PYR + ammonia - Metabolism:
CAR + propionyl CoA ⟶ CoA-SH + Propionylcarnitine - Amino acid and derivative metabolism:
GAA + SAM ⟶ CRET + H+ + SAH - Amino acid synthesis and interconversion (transamination):
ATP + H2O + L-Asp + L-Gln ⟶ AMP + L-Asn + L-Glu + PPi - Serine biosynthesis:
Ser ⟶ H2O + PYR + ammonia - Metabolism:
GAA + SAM ⟶ CRET + H+ + SAH - Amino acid and derivative metabolism:
GAA + SAM ⟶ CRET + H+ + SAH - Amino acid synthesis and interconversion (transamination):
ATP + H2O + L-Asp + L-Gln ⟶ AMP + L-Asn + L-Glu + PPi - Serine biosynthesis:
Ser ⟶ H2O + PYR + ammonia - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid synthesis and interconversion (transamination):
H2O + NAA ⟶ CH3COO- + L-Asp - Serine biosynthesis:
3POPA + L-Glu ⟶ 2OG + O-P-Ser - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid synthesis and interconversion (transamination):
H2O + NAA ⟶ CH3COO- + L-Asp - Serine biosynthesis:
Ser ⟶ H2O + PYR + ammonia - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid synthesis and interconversion (transamination):
H2O + NAA ⟶ CH3COO- + L-Asp - Serine biosynthesis:
Ser ⟶ H2O + PYR + ammonia
BioCyc(0)
Plant Reactome(0)
INOH(3)
- Glycine and Serine metabolism ( Glycine and Serine metabolism ):
Guanidino-acetic acid + S-Adenosyl-L-methionine ⟶ Creatine + S-Adenosyl-L-homocysteine - 2-Oxo-glutaric acid + L-O-Phospho-serine = L-Glutamic acid + 3-Phospho-hydroxy-pyruvic acid ( Glycine and Serine metabolism ):
3-Phospho-hydroxy-pyruvic acid + L-Glutamic acid ⟶ 2-Oxo-glutaric acid + L-O-Phospho-serine - NAD+ + D-Glycerate 3-phosphate = NADH + 3-Phospho-hydroxy-pyruvic acid ( Glycine and Serine metabolism ):
D-Glycerate 3-phosphate + NAD+ ⟶ 3-Phospho-hydroxy-pyruvic acid + NADH
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(34)
- Glycine and Serine Metabolism:
Guanidoacetic acid + S-Adenosylhomocysteine ⟶ Creatine + S-Adenosylmethionine - Dimethylglycine Dehydrogenase Deficiency:
Guanidoacetic acid + S-Adenosylhomocysteine ⟶ Creatine + S-Adenosylmethionine - Dihydropyrimidine Dehydrogenase Deficiency (DHPD):
Guanidoacetic acid + S-Adenosylhomocysteine ⟶ Creatine + S-Adenosylmethionine - Sarcosinemia:
Guanidoacetic acid + S-Adenosylhomocysteine ⟶ Creatine + S-Adenosylmethionine - Non-Ketotic Hyperglycinemia:
Guanidoacetic acid + S-Adenosylhomocysteine ⟶ Creatine + S-Adenosylmethionine - Dimethylglycine Dehydrogenase Deficiency:
Guanidoacetic acid + S-Adenosylhomocysteine ⟶ Creatine + S-Adenosylmethionine - Hyperglycinemia, Non-Ketotic:
Guanidoacetic acid + S-Adenosylhomocysteine ⟶ Creatine + S-Adenosylmethionine - 3-Phosphoglycerate Dehydrogenase Deficiency:
Guanidoacetic acid + S-Adenosylhomocysteine ⟶ Creatine + S-Adenosylmethionine - Cysteine Biosynthesis:
Hydrogen sulfide + O-Acetylserine ⟶ Acetic acid + Hydrogen Ion + L-Cysteine - Serine Biosynthesis and Metabolism:
DL-O-Phosphoserine + Water ⟶ L-Serine + Phosphate - Secondary Metabolites: Cysteine Biosynthesis from Serine:
Hydrogen sulfide + O-Acetylserine ⟶ Acetic acid + Hydrogen Ion + L-Cysteine - Glycine Metabolism:
DL-O-Phosphoserine + Water ⟶ L-Serine + Phosphate - Serine Metabolism:
DL-O-Phosphoserine + Water ⟶ L-Serine + Phosphate - Glycine Metabolism:
L-Serine + Tetrahydrofolic acid ⟶ 5,10-Methylene-THF + Glycine + Water - Serine Metabolism:
L-Serine + Tetrahydrofolic acid ⟶ 5,10-Methylene-THF + Glycine + Water - Glycine and Serine Metabolism:
Guanidoacetic acid + S-Adenosylhomocysteine ⟶ Creatine + S-Adenosylmethionine - 3-Phosphoglycerate Dehydrogenase Deficiency:
Guanidoacetic acid + S-Adenosylhomocysteine ⟶ Creatine + S-Adenosylmethionine - Dihydropyrimidine Dehydrogenase Deficiency (DHPD):
Guanidoacetic acid + S-Adenosylhomocysteine ⟶ Creatine + S-Adenosylmethionine - Dimethylglycine Dehydrogenase Deficiency:
Guanidoacetic acid + S-Adenosylhomocysteine ⟶ Creatine + S-Adenosylmethionine - Sarcosinemia:
Guanidoacetic acid + S-Adenosylhomocysteine ⟶ Creatine + S-Adenosylmethionine - Non-Ketotic Hyperglycinemia:
Guanidoacetic acid + S-Adenosylhomocysteine ⟶ Creatine + S-Adenosylmethionine - Hyperglycinemia, Non-Ketotic:
Guanidoacetic acid + S-Adenosylhomocysteine ⟶ Creatine + S-Adenosylmethionine - 3-Phosphoglycerate Dehydrogenase Deficiency:
Guanidoacetic acid + S-Adenosylhomocysteine ⟶ Creatine + S-Adenosylmethionine - Glycine and Serine Metabolism:
Guanidoacetic acid + S-Adenosylhomocysteine ⟶ Creatine + S-Adenosylmethionine - Glycine and Serine Metabolism:
Guanidoacetic acid + S-Adenosylhomocysteine ⟶ Creatine + S-Adenosylmethionine - Glycine and Serine Metabolism:
Guanidoacetic acid + S-Adenosylhomocysteine ⟶ Creatine + S-Adenosylmethionine - Glycine and Serine Metabolism:
Guanidoacetic acid + S-Adenosylhomocysteine ⟶ Creatine + S-Adenosylmethionine - Dihydropyrimidine Dehydrogenase Deficiency (DHPD):
Guanidoacetic acid + S-Adenosylhomocysteine ⟶ Creatine + S-Adenosylmethionine - Dimethylglycine Dehydrogenase Deficiency:
Guanidoacetic acid + S-Adenosylhomocysteine ⟶ Creatine + S-Adenosylmethionine - Sarcosinemia:
Guanidoacetic acid + S-Adenosylhomocysteine ⟶ Creatine + S-Adenosylmethionine - Non-Ketotic Hyperglycinemia:
Guanidoacetic acid + S-Adenosylhomocysteine ⟶ Creatine + S-Adenosylmethionine - Hyperglycinemia, Non-Ketotic:
Guanidoacetic acid + S-Adenosylhomocysteine ⟶ Creatine + S-Adenosylmethionine - Cysteine Biosynthesis:
Hydrogen sulfide + O-Acetylserine ⟶ Acetic acid + Hydrogen Ion + L-Cysteine - Secondary Metabolites: Cysteine Biosynthesis from Serine:
Hydrogen sulfide + O-Acetylserine ⟶ Acetic acid + Hydrogen Ion + L-Cysteine
PharmGKB(0)
3 个相关的物种来源信息
- 3039 - Euglena gracilis: 10.3389/FBIOE.2021.662655
- 9606 - Homo sapiens: -
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Feng Xue, Haiyan Dong, Jinyu Wu, Zuowei Wu, Weilin Hu, Aihua Sun, Bryan Troxell, X Frank Yang, Jie Yan. Transcriptional responses of Leptospira interrogans to host innate immunity: significant changes in metabolism, oxygen tolerance, and outer membrane.
PLoS neglected tropical diseases.
2010 Oct; 4(10):e857. doi:
10.1371/journal.pntd.0000857. [PMID: 21049008] - Ricardo Nilo, Carlos Saffie, Kathryn Lilley, Ricardo Baeza-Yates, Verónica Cambiazo, Reinaldo Campos-Vargas, Mauricio González, Lee A Meisel, Julio Retamales, Herman Silva, Ariel Orellana. Proteomic analysis of peach fruit mesocarp softening and chilling injury using difference gel electrophoresis (DIGE).
BMC genomics.
2010 Jan; 11(?):43. doi:
10.1186/1471-2164-11-43. [PMID: 20082721] - Paul Francis Morris, Laura Rose Schlosser, Katherine Diane Onasch, Tom Wittenschlaeger, Ryan Austin, Nicholas Provart. Multiple horizontal gene transfer events and domain fusions have created novel regulatory and metabolic networks in the oomycete genome.
PloS one.
2009 Jul; 4(7):e6133. doi:
10.1371/journal.pone.0006133. [PMID: 19582169] - M Leduc, C Tikhomiroff, M Cloutier, M Perrier, M Jolicoeur. Development of a kinetic metabolic model: application to Catharanthus roseus hairy root.
Bioprocess and biosystems engineering.
2006 Apr; 28(5):295-313. doi:
10.1007/s00449-005-0034-z. [PMID: 16453114] - Y Achouri, M H Rider, E V Schaftingen, M Robbi. Cloning, sequencing and expression of rat liver 3-phosphoglycerate dehydrogenase.
The Biochemical journal.
1997 Apr; 323 ( Pt 2)(?):365-70. doi:
10.1042/bj3230365. [PMID: 9163325]
