Dehydroepiandrosterone sulfate (BioDeep_00000003221)

 

Secondary id: BioDeep_00000404705

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite natural product


代谢物信息卡片


[(1S,2R,5S,10R,11S,15S)-2,15-dimethyl-14-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-5-yl]oxidanesulfonic acid

化学式: C19H28O5S (368.1657)
中文名称: 脱氢表雄酮硫酸
谱图信息: 最多检出来源 Homo sapiens(blood) 26.99%

Reviewed

Last reviewed on 2024-09-13.

Cite this Page

Dehydroepiandrosterone sulfate. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/dehydroepiandrosterone_sulfate (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000003221). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC12CCC3C(C1CCC2=O)CC=C4C3(CCC(C4)OS(=O)(=O)O)C
InChI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)

描述信息

Dehydroepiandrosterone sulfate or DHEA-S is the sulfated form of dehydroepiandrosterone (DHEA). This sulfation is reversibly catalyzed by sulfotransferase 2A1 (SULT2A1) primarily in the adrenals, the liver, and small intestine. In the blood, most DHEA is found as DHEA-S with levels that are about 300 times higher than those of free DHEA. Orally-ingested DHEA is converted into its sulfate when passing through the intestines and liver. Whereas DHEA levels naturally reach their peak in the early morning hours, DHEAS levels show no diurnal variation. From a practical point of view, measurement of DHEA-S is preferable to DHEA since levels are more stable. DHEA (from which DHEA-S comes from) is a natural steroid prohormone produced from cholesterol by the adrenal glands, the gonads, adipose tissue, brain, and in the skin (by an autocrine mechanism). DHEA is the precursor of androstenedione, which can undergo further conversion to produce the androgen testosterone and the estrogens estrone and estradiol. DHEA is also a potent sigma-1 agonist. Serum dehydroepiandrosterone sulfate is a classic marker for adrenarche, and subsequently for the individual hormonal milieu (PMID: 10599744). Dehydroepiandrosterone sulfate is an endogenously produced sex steroid that has been hypothesized to have anti-aging effects (PMID: 16960027). It also has been inversely associated with the development of atherosclerosis (PMID: 8956025).
DHEAS or Dehydroepiandrosterone sulfate is the sulfated form of DHEA. This sulfation is reversibly catalyzed by sulfotransferase (SULT2A1) primarily in the adrenals, the liver, and small intestine. In the blood, most DHEA is found as DHEAS with levels that are about 300 times higher than those of free DHEA. Orally-ingested DHEA is converted to its sulfate when passing through intestines and liver. Whereas DHEA levels naturally reach their peak in the early morning hours, DHEAS levels show no diurnal variation. From a practical point of view, measurement of DHEAS is preferable to DHEA, as levels are more stable. DHEA (from which DHEAS comes from) is a natural steroid prohormone produced from cholesterol by the adrenal glands, the gonads, adipose tissue, brain and in the skin (by an autocrine mechanism). DHEA is the precursor of androstenedione, which can undergo further conversion to produce the androgen testosterone and the estrogens estrone and estradiol. DHEA is also a potent sigma-1 agonist. DHEAS can serve as a precursor for testosterone; androstenedione; estradiol; and estrone. [HMDB]
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

同义名列表

110 个代谢物同义名

[(1S,2R,5S,10R,11S,15S)-2,15-dimethyl-14-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-5-yl]oxidanesulfonic acid; 17-Oxoandrost-5-en-3beta-yl hydrogen sulphuric acid; 3beta-Hydroxy-androst-5-en-17-one hydrogen sulphate; 17-Oxoandrost-5-en-3beta-yl hydrogen sulfuric acid; 3beta-Hydroxy-androst-5-en-17-one hydrogen sulfate; 3beta-Hydroxyandrost-5-en-17-one 3-sulphuric acid; 17-Oxoandrost-5-en-3b-yl hydrogen sulphuric acid; 3beta-Hydroxyandrost-5-en-17-one 3-sulfuric acid; 17-Oxoandrost-5-en-3β-yl hydrogen sulphuric acid; 3b-Hydroxy-androst-5-en-17-one hydrogen sulphate; 17-Oxoandrost-5-en-3β-yl hydrogen sulfuric acid; 3b-Hydroxy-androst-5-en-17-one hydrogen sulfate; 17-Oxoandrost-5-en-3b-yl hydrogen sulfuric acid; 3Β-hydroxyandrost-5-en-17-one 3-sulphuric acid; 3b-Hydroxyandrost-5-en-17-one 3-sulphuric acid; 3Β-hydroxyandrost-5-en-17-one 3-sulfuric acid; 17-Oxoandrost-5-en-3beta-yl hydrogen sulphate; 3b-Hydroxyandrost-5-en-17-one 3-sulfuric acid; 3-beta-Hydroxyandrost-5-en-17-one 3-sulphate; 17-Oxoandrost-5-en-3beta-yl hydrogen sulfate; 3-beta-Hydroxyandrost-5-en-17-one 3-sulfate; 3beta-Hydroxyandrost-5-en-17-one 3-sulphate; 17-Ketoandrost-5-en-3beta-yl sulphuric acid; 17-Oxoandrost-5-en-3b-yl hydrogen sulphate; Androst-5-en-17-on-3beta-yl sulphuric acid; 17-Ketoandrost-5-en-3beta-yl sulfuric acid; 17-Oxoandrost-5-en-3β-yl hydrogen sulphate; 3beta-Hydroxyandrost-5-en-17-one 3-sulfate; (3-beta)-3-(Sulphooxy)androst-5-en-17-one; 17-Oxoandrost-5-en-3-yl hydrogen sulphate; Androst-5-en-17-on-3beta-yl sulfuric acid; 17-Oxoandrost-5-en-3b-yl hydrogen sulfate; 17-Oxoandrost-5-en-3β-yl hydrogen sulfate; 3-b-Hydroxyandrost-5-en-17-one 3-sulphate; Dehydroepiandrosterone monosulphuric acid; 17-Ketoandrost-5-en-3β-yl sulphuric acid; 3-b-Hydroxyandrost-5-en-17-one 3-sulfate; (3beta)-3-(Sulfooxy)-androst-5-en-17-one; 3b-Hydroxyandrost-5-en-17-one 3-sulphate; 17-Ketoandrost-5-en-3b-yl sulphuric acid; Dehydroepiandrosterone monosulfuric acid; 3Β-hydroxyandrost-5-en-17-one 3-sulphate; (3-beta)-3-(Sulfooxy)androst-5-en-17-one; 17-Oxoandrost-5-en-3-yl hydrogen sulfate; Androst-5-en-17-on-3β-yl sulphuric acid; 17-Ketoandrost-5-en-3b-yl sulfuric acid; 3b-Hydroxyandrost-5-en-17-one 3-sulfate; 3Β-hydroxyandrost-5-en-17-one 3-sulfate; Dehydroisoandrosterone-3-sulphuric acid; 17-Ketoandrost-5-en-3β-yl sulfuric acid; Dehydroepiandrosterone 3-sulphuric acid; Androst-5-en-17-on-3b-yl sulphuric acid; (3-b)-3-(Sulphooxy)androst-5-en-17-one; Androst-5-en-17-on-3b-yl sulfuric acid; Androst-5-en-17-on-3β-yl sulfuric acid; Dehydroisoandrosterone-3-sulfuric acid; (3-Β)-3-(sulphooxy)androst-5-en-17-one; Dehydroepiandrosterone 3-sulfuric acid; (3-b)-3-(Sulfooxy)androst-5-en-17-one; 17-Ketoandrost-5-en-3beta-yl sulphate; Dehydroisoandrosterone sulphuric acid; (3-Β)-3-(sulfooxy)androst-5-en-17-one; Dehydroepiandrosterone sulphuric acid; Androst-5-en-17-on-3beta-yl sulphate; Dehydroisoandrosterone sulfuric acid; Dehydroepiandrosterone sulfuric acid; 17-Ketoandrost-5-en-3beta-yl sulfate; Androst-5-en-17-on-3beta-yl sulfate; Dehydroepiandrosterone monosulphate; 17-Ketoandrost-5-en-3b-yl sulphate; 17-Ketoandrost-5-en-3β-yl sulphate; Dehydroepiandrosterone monosulfate; Dehydroepiandrosterone 3-sulphate; 17-Ketoandrost-5-en-3β-yl sulfate; Dehydroepiandrosterone-3-sulphate; Androst-5-en-17-on-3b-yl sulphate; Dehydroisoandrosterone-3-sulphate; 17-Ketoandrost-5-en-3b-yl sulfate; Androst-5-en-17-on-3β-yl sulphate; 3-O-Sulphodehydroepiandrosterone; Dehydroepiandrosterone-3-sulfate; Androst-5-en-17-on-3b-yl sulfate; Androst-5-en-17-on-3β-yl sulfate; Dehydroisoandrosterone-3-sulfate; Dehydroepiandrosterone 3-sulfate; Dehydroepiandrosterone sulphate; Sulfate, dehydroepiandrosterone; Sulfate, dehydroisoandrosterone; 3-O-Sulfodehydroepiandrosterone; Dehydroisoandrosterone sulphate; Dehydroisoandrosterone sulfate; Dehydroepiandrosterone sulfate; Prasterone sulphuric acid; Prasterone sulfuric acid; Formylisoglutamic acid; Prasterone-3-sulphate; Prasterone-3-sulfate; Prasterone sulphate; DHEA sulphuric acid; Sulfate, prasterone; DHEA sulfuric acid; Prasterone sulfate; Sulfate, dhea; DHEA sulphate; Sulfate, dha; DHEA sulfate; DHA sulfate; DHEA-S; DHEAS; Dehydroepiandrosterone sulfate



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

20 个相关的代谢反应过程信息。

Reactome(7)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(12)

PharmGKB(0)

16 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ALB, AR, BDNF, BGLAP, PGR, PRL
Peripheral membrane protein 1 CYP11A1
Endoplasmic reticulum membrane 4 CD4, CYP17A1, CYP19A1, STS
Mitochondrion membrane 1 CYP11A1
Nucleus 4 ALB, AR, PGR, PRL
cytosol 4 ALB, AR, LEP, PGR
dendrite 2 BDNF, BGLAP
centrosome 1 ALB
nucleoplasm 3 AR, PGR, PRL
RNA polymerase II transcription regulator complex 1 PRL
Cell membrane 2 CD4, TNF
Multi-pass membrane protein 1 CYP19A1
cell surface 2 ADIPOQ, TNF
Golgi apparatus 2 ALB, STS
mitochondrial inner membrane 1 CYP11A1
neuronal cell body 2 CYP17A1, TNF
synaptic vesicle 1 BDNF
Lysosome 1 STS
endosome 1 STS
plasma membrane 6 AR, CD4, PGR, REN, STS, TNF
Membrane 6 AR, BDNF, CYP11A1, CYP19A1, REN, STS
axon 2 BDNF, CYP17A1
extracellular exosome 2 ALB, SHBG
endoplasmic reticulum 5 ADIPOQ, ALB, CYP17A1, CYP19A1, STS
extracellular space 12 ADIPOQ, ALB, AMH, BDNF, BGLAP, GNRH1, IGF1, IL10, LEP, PRL, REN, TNF
perinuclear region of cytoplasm 1 BDNF
mitochondrion 1 CYP11A1
protein-containing complex 2 ALB, AR
intracellular membrane-bounded organelle 1 STS
Microsome membrane 2 CYP17A1, CYP19A1
Single-pass type I membrane protein 1 CD4
Secreted 11 ADIPOQ, ALB, AMH, BDNF, BGLAP, IGF1, IL10, LEP, PRL, REN, SHBG
extracellular region 13 ADIPOQ, ALB, AMH, BDNF, BGLAP, GNRH1, IGF1, IL10, LEP, PRL, REN, SHBG, TNF
mitochondrial outer membrane 1 PGR
mitochondrial matrix 1 CYP11A1
anchoring junction 1 ALB
external side of plasma membrane 2 CD4, TNF
perikaryon 1 BGLAP
Early endosome 1 CD4
apical part of cell 1 REN
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 BGLAP
Mitochondrion inner membrane 1 CYP11A1
Membrane raft 2 CD4, TNF
collagen trimer 1 ADIPOQ
collagen-containing extracellular matrix 1 ADIPOQ
nuclear speck 1 AR
ciliary basal body 1 ALB
chromatin 3 AR, PGR, PRL
phagocytic cup 1 TNF
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
endosome lumen 1 PRL
exocytic vesicle 1 IGF1
Golgi lumen 1 BGLAP
endoplasmic reticulum lumen 5 ALB, BDNF, BGLAP, CD4, STS
platelet alpha granule lumen 2 ALB, IGF1
clathrin-coated endocytic vesicle membrane 1 CD4
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 1 CD4
alphav-beta3 integrin-IGF-1-IGF1R complex 1 IGF1
insulin-like growth factor binding protein complex 1 IGF1
insulin-like growth factor ternary complex 1 IGF1
[Isoform 4]: Mitochondrion outer membrane 1 PGR
Cytoplasmic vesicle, secretory vesicle, microneme membrane 1 STS
microneme membrane 1 STS
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Qiaoran Wang, Xuebao Wang, Beibei Liu, Shuai Ma, Feng Zhang, Shuhui Sun, Yaobin Jing, Yanling Fan, Yingjie Ding, Muzhao Xiong, Jiaming Li, Qiaocheng Zhai, Yandong Zheng, Chengyu Liu, Gang Xu, Jiayin Yang, Si Wang, Jinlin Ye, Juan Carlos Izpisua Belmonte, Jing Qu, Guang-Hui Liu, Weiqi Zhang. Aging induces region-specific dysregulation of hormone synthesis in the primate adrenal gland. Nature aging. 2024 Mar; 4(3):396-413. doi: 10.1038/s43587-024-00588-1. [PMID: 38503993]
  • Kexin Zhang, Yanyan Liu, Lingyun Liu, Baoling Bai, Lin Shi, Qin Zhang. Untargeted Metabolomics Analysis Using UHPLC-Q-TOF/MS Reveals Metabolic Changes Associated with Hypertension in Children. Nutrients. 2023 Feb; 15(4):. doi: 10.3390/nu15040836. [PMID: 36839194]
  • Guijiao Zhang, Huan Yu, Shengxu Yu, Xiaoping Luo, Yan Liang, Ling Hou, Wei Wu. Association of size for gestational age and dehydroepiandrosterone sulfate with cardiometabolic risk in central precocious puberty girls. Frontiers in endocrinology. 2023; 14(?):1131438. doi: 10.3389/fendo.2023.1131438. [PMID: 37293501]
  • Shanshan Chen, Shuo Li, Xinxin Zhang, Yuxin Fan, Ming Liu. Low serum dehydroepiandrosterone is associated with diabetic dyslipidemia risk in males with type 2 diabetes. Frontiers in endocrinology. 2023; 14(?):1272797. doi: 10.3389/fendo.2023.1272797. [PMID: 38075062]
  • Soumita Mandal, Pradip Mukhopadhyay, Sujoy Ghosh. DHEA on Sexual Function in Sheehan Syndrome: A Randomized Double-Blind Placebo-Controlled Crossover Trial. The Journal of clinical endocrinology and metabolism. 2022 07; 107(8):e3395-e3402. doi: 10.1210/clinem/dgac260. [PMID: 35481572]
  • Sabina A Guler, Carlos Machahua, Thomas K Geiser, Gregor Kocher, Thomas M Marti, Benjamin Tan, Verdiana Trappetti, Christopher J Ryerson, Manuela Funke-Chambour. Dehydroepiandrosterone in fibrotic interstitial lung disease: a translational study. Respiratory research. 2022 Jun; 23(1):149. doi: 10.1186/s12931-022-02076-9. [PMID: 35676709]
  • Rita Santos-Silva, Manuel Fontoura, João T Guimarães, Henrique Barros, Ana Cristina Santos. Association of dehydroepiandrosterone sulfate, birth size, adiposity and cardiometabolic risk factors in 7-year-old children. Pediatric research. 2022 06; 91(7):1897-1905. doi: 10.1038/s41390-021-01706-0. [PMID: 34417562]
  • Zoja Babinkostova, Nensi Manuseva, Snezana Markovic. Correlation Between the Different Types of Antipsychotics and Serum Cortisol, Dehidroepiandrosterone Sulfat and their Ratio in Schizophrenia. Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki). 2022 Apr; 43(1):29-39. doi: 10.2478/prilozi-2022-0003. [PMID: 35451297]
  • Meng-Si Liu, Yuan Lou, Huan Chen, Yi-Jie Wang, Zi-Wei Zhang, Ping Li, Da-Long Zhu. Performance of DHEAS as a Screening Test for Autonomous Cortisol Secretion in Adrenal Incidentalomas: A Prospective Study. The Journal of clinical endocrinology and metabolism. 2022 04; 107(5):e1789-e1796. doi: 10.1210/clinem/dgac072. [PMID: 35137142]
  • Johan Quester, Maria Nethander, Anna Eriksson, Claes Ohlsson. Endogenous DHEAS Is Causally Linked With Lumbar Spine Bone Mineral Density and Forearm Fractures in Women. The Journal of clinical endocrinology and metabolism. 2022 04; 107(5):e2080-e2086. doi: 10.1210/clinem/dgab915. [PMID: 34935937]
  • José Patricio Miranda, María Cecilia Lardone, Fernando Rodríguez, Gordon B Cutler, José Luis Santos, Camila Corvalán, Ana Pereira, Verónica Mericq. Genome-Wide Association Study and Polygenic Risk Scores of Serum DHEAS Levels in a Chilean Children Cohort. The Journal of clinical endocrinology and metabolism. 2022 03; 107(4):e1727-e1738. doi: 10.1210/clinem/dgab814. [PMID: 34748635]
  • Robert T Chatterton. Functions of dehydroepiandrosterone in relation to breast cancer. Steroids. 2022 03; 179(?):108970. doi: 10.1016/j.steroids.2022.108970. [PMID: 35122788]
  • Maryam Karamali, Masoumeh Gholizadeh. The effects of coenzyme Q10 supplementation on metabolic profiles and parameters of mental health in women with polycystic ovary syndrome. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2022 Jan; 38(1):45-49. doi: 10.1080/09513590.2021.1991910. [PMID: 34664527]
  • Shunsuke Fujimura, Takenori Ito, Shoujiro Ogawa, Takayuki Ishige, Shoichi Nishimoto-Kusunose, Tatsuya Higashi. An LC/MS/MS method for quantifying testosterone and dehydroepiandrosterone sulfate in four different serum samples during a single run. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2022 Jan; 38(1):167-173. doi: 10.2116/analsci.21p268. [PMID: 35287219]
  • Xinxin Zhang, Jinfeng Xiao, Tong Liu, Qing He, Jingqiu Cui, Shaofang Tang, Xin Li, Ming Liu. Low Serum Dehydroepiandrosterone and Dehydroepiandrosterone Sulfate Are Associated With Coronary Heart Disease in Men With Type 2 Diabetes Mellitus. Frontiers in endocrinology. 2022; 13(?):890029. doi: 10.3389/fendo.2022.890029. [PMID: 35832423]
  • Aarthi Sundararajan, Kranti Vora, Shahin Saiyed, Senthilkumar Natesan. Comparative profiling of prenatal cortisol and DHEA-S among pregnant women with poor birth outcome and pregnant women with normal birth outcome. Clinical endocrinology. 2021 12; 95(6):863-872. doi: 10.1111/cen.14569. [PMID: 34370329]
  • Cecilia Rustichelli, Emanuela Monari, Rossella Avallone, Elisa Bellei, Stefania Bergamini, Aldo Tomasi, Anna Ferrari. Dehydroepiandrosterone sulfate, dehydroepiandrosterone, 5α-dihydroprogesterone and pregnenolone in women with migraine: Analysis of serum levels and correlation with age, migraine years and frequency. Journal of pharmaceutical and biomedical analysis. 2021 Nov; 206(?):114388. doi: 10.1016/j.jpba.2021.114388. [PMID: 34597839]
  • Naoki Edo, Koji Morita, Chisato Ishiwata, Rina Nakajima, Yohei Sayama, Takashi Suzuki, Miki Sakamoto, Kaori Okamoto, Takuya Uchino, Yuki Ozawa, Kiyoko Uno, Kenji Uno, Kazuhisa Tsukamoto, Toshio Ishikawa. Diagnostic value of standard deviation score of log-transformed serum dehydroepiandrosterone sulfate in patients with hypothalamic-pituitary-adrenal axis insufficiency. Endocrine journal. 2021 Nov; 68(11):1337-1345. doi: 10.1507/endocrj.ej21-0140. [PMID: 34162776]
  • Takako Kawakita, Toshiyuki Yasui, Kanako Yoshida, Sumika Matsui, Takeshi Iwasa. Correlations of androstenediol with reproductive hormones and cortisol according to stages during the menopausal transition in Japanese women. The Journal of steroid biochemistry and molecular biology. 2021 11; 214(?):106009. doi: 10.1016/j.jsbmb.2021.106009. [PMID: 34571175]
  • M Probo, T Peric, J Fusi, A Prandi, M Faustini, M C Veronesi. Hair cortisol and dehydroepiandrosterone sulfate concentrations in healthy beef calves from birth to 6 months of age. Theriogenology. 2021 Nov; 175(?):89-94. doi: 10.1016/j.theriogenology.2021.08.037. [PMID: 34517287]
  • Ciro Salzano, Giovanna Saracino, Giuseppe Cardillo. Possible Adrenal Involvement in Long COVID Syndrome. Medicina (Kaunas, Lithuania). 2021 Oct; 57(10):. doi: 10.3390/medicina57101087. [PMID: 34684123]
  • Karolina M Wronka, Ewa Wunsch, Katarzyna Kozłowska-Petriczko, Maciej Wójcicki, Beata Kruk, Piotr Milkiewicz. Dehydroepiandrosterone sulfate indicates decreased sulfation capacity and impaired quality of life in patients with primary sclerosing cholangitis. Polish archives of internal medicine. 2021 09; 131(9):790-796. doi: 10.20452/pamw.16030. [PMID: 34132084]
  • Sojit Tomo, Mithu Banerjee, Praveen Sharma, Mahendra Garg. Does dehydroepiandrosterone sulfate have a role in COVID-19 prognosis and treatment?. Endocrine regulations. 2021 Sep; 55(3):174-181. doi: 10.2478/enr-2021-0019. [PMID: 34523302]
  • Felwah S Al-Zaid, Abdel Fattah A Alhader, Laila Y Al-Ayadhi. A potential role for the adrenal gland in autism. Scientific reports. 2021 09; 11(1):17743. doi: 10.1038/s41598-021-97266-8. [PMID: 34493761]
  • Johanna Ruhnau, Stephanie Hübner, Donna Sunny, Till Ittermann, Michaela F Hartmann, Jan De Lafollie, Stefan A Wudy, Matthias Heckmann. Impact of Gestational and Postmenstrual Age on Excretion of Fetal Zone Steroids in Preterm Infants Determined by Gas Chromatography-Mass Spectrometry. The Journal of clinical endocrinology and metabolism. 2021 08; 106(9):e3725-e3738. doi: 10.1210/clinem/dgab194. [PMID: 33822093]
  • Anouk E de Wit, Erik J Giltay, Marrit K de Boer, Willem A Nolen, Fokko J Bosker, Brenda W J H Penninx, Robert A Schoevers. Plasma androgens and the presence and course of depression in a large cohort of men. Psychoneuroendocrinology. 2021 08; 130(?):105278. doi: 10.1016/j.psyneuen.2021.105278. [PMID: 34049017]
  • Tianling Wang, Lei Tang, Ruili Lin, Dian He, Yanqing Wu, Yang Zhang, Pingrong Yang, Junquan He. Individual variability in human urinary metabolites identifies age-related, body mass index-related, and sex-related biomarkers. Molecular genetics & genomic medicine. 2021 08; 9(8):e1738. doi: 10.1002/mgg3.1738. [PMID: 34293245]
  • Conor Bentley, Claire Potter, Kamal Makram Yakoub, Kristian Brock, Victoria Homer, Emma Toman, Angela E Taylor, Fozia Shaheen, Lorna C Gilligan, Amrita Athwal, Darren Barton, Ronald Carrera, Katie Young, Amisha Desai, Kirsty McGee, Christos Ermogenous, Gurneet Sur, Carolyn A Greig, Jon Hazeldine, Wiebke Arlt, Janet M Lord, Mark A Foster. A prospective, phase II, single-centre, cross-sectional, randomised study investigating Dehydroepiandrosterone supplementation and its Profile in Trauma: ADaPT. BMJ open. 2021 07; 11(7):e040823. doi: 10.1136/bmjopen-2020-040823. [PMID: 34312190]
  • Heesung Chae, Hyun Su Lee, Joo Hyung Lee, Minheon Kim, Sang Yoo Park, Young Joon Seo. Usefulness of stress-related hormones as predictors and prognostic factors for idiopathic sudden sensorineural hearing loss. Acta oto-laryngologica. 2021 Jul; 141(7):695-701. doi: 10.1080/00016489.2021.1936165. [PMID: 34191673]
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