1,2-Dihydronaphthalene-1,2-diol (BioDeep_00000003194)

 

Secondary id: BioDeep_00000014793, BioDeep_00001869595


代谢物信息卡片


(1R,2S)-cis-1,2-Dihydro-1,2-naphthalenediol

化学式: C10H10O2 (162.0681)
中文名称: (+)-顺式-1(r),2(s)-1,2-二羟基-1,2-二氢萘
谱图信息: 最多检出来源 Homo sapiens(plant) 5.03%

分子结构信息

SMILES: C1=CC=C2C(C(C=CC2=C1)O)O
InChI: InChI=1S/C10H10O2/c11-9-6-5-7-3-1-2-4-8(7)10(9)12/h1-6,9-12H

描述信息

A member of the class of naphthalenediols that is 1,2-dihydronaphthalene substituted by hydroxy groups at positions 1 and 2 respectively.

同义名列表

3 个代谢物同义名

1,2-Dihydronaphthalene-1,2-diol; (1R,2S)-cis-1,2-Dihydro-1,2-naphthalenediol; (1R,2S)-1,2-Dihydronaphthalene-1,2-diol



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

6 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(6)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 AKR1B1, CAT, CYP1A1, HELB, NQO1, THNSL1, TYR, XDH
Peripheral membrane protein 1 CYP1A1
Endoplasmic reticulum membrane 1 CYP1A1
Nucleus 3 HELB, HEMGN, NQO1
cytosol 6 AKR1A1, AKR1B1, CAT, HELB, NQO1, XDH
dendrite 1 NQO1
nuclear body 1 HELB
nucleoplasm 4 AKR1B1, ATP2B1, HELB, HEMGN
Cell membrane 1 ATP2B1
Multi-pass membrane protein 1 ATP2B1
Synapse 3 AKR1A1, ATP2B1, NQO1
glutamatergic synapse 1 ATP2B1
mitochondrial inner membrane 1 CYP1A1
neuronal cell body 1 NQO1
presynaptic membrane 1 ATP2B1
Cytoplasm, cytosol 2 AKR1A1, NQO1
Lysosome 1 TYR
plasma membrane 1 ATP2B1
synaptic vesicle membrane 1 ATP2B1
Membrane 3 ATP2B1, CAT, NQO1
apical plasma membrane 1 AKR1A1
basolateral plasma membrane 1 ATP2B1
extracellular exosome 4 AKR1A1, AKR1B1, ATP2B1, CAT
extracellular space 3 AKR1A1, AKR1B1, XDH
perinuclear region of cytoplasm 1 TYR
mitochondrion 5 AKR1B1, CAT, CYP1A1, HELB, THNSL1
protein-containing complex 1 CAT
intracellular membrane-bounded organelle 4 ATP2B1, CAT, CYP1A1, TYR
Microsome membrane 1 CYP1A1
Single-pass type I membrane protein 1 TYR
extracellular region 1 CAT
mitochondrial matrix 1 CAT
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
Melanosome membrane 1 TYR
Golgi-associated vesicle 1 TYR
Apical cell membrane 1 AKR1A1
Mitochondrion inner membrane 1 CYP1A1
focal adhesion 1 CAT
Peroxisome 2 CAT, XDH
sarcoplasmic reticulum 1 XDH
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
lateral plasma membrane 1 ATP2B1
cell projection 1 ATP2B1
Chromosome 1 HELB
Basolateral cell membrane 1 ATP2B1
site of double-strand break 1 HELB
Melanosome 1 TYR
Presynaptic cell membrane 1 ATP2B1
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
immunological synapse 1 ATP2B1
catalase complex 1 CAT
photoreceptor ribbon synapse 1 ATP2B1


文献列表

  • Maria Chatzopoulou, Tim D W Claridge, Kay E Davies, Stephen G Davies, David J Elsey, Enrico Emer, Ai M Fletcher, Shawn Harriman, Neil Robinson, Jessica A Rowley, Angela J Russell, Jonathon M Tinsley, Richard Weaver, Isabel V L Wilkinson, Nicky J Willis, Francis X Wilson, Graham M Wynne. Isolation, Structural Identification, Synthesis, and Pharmacological Profiling of 1,2-trans-Dihydro-1,2-diol Metabolites of the Utrophin Modulator Ezutromid. Journal of medicinal chemistry. 2020 03; 63(5):2547-2556. doi: 10.1021/acs.jmedchem.9b01547. [PMID: 31599580]