Tolterodine (BioDeep_00000003184)
Secondary id: BioDeep_00000406043
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
2-[(1R)-3-[bis(propan-2-yl)amino]-1-phenylpropyl]-4-methylphenol
化学式: C22H31NO (325.2406)
中文名称: 2-[3-(二异丙胺基)-1-苯丙基l]-4-甲基苯酚, 托特罗定
谱图信息:
最多检出来源 Mentha canadensis(blood) 16.27%
分子结构信息
SMILES: CC(C)N(C(C)C)CC[C@H](C1=CC=CC=C1)C2=C(O)C=CC(C)=C2
InChI: InChI=1S/C22H31NO/c1-16(2)23(17(3)4)14-13-20(19-9-7-6-8-10-19)21-15-18(5)11-12-22(21)24/h6-12,15-17,20,24H,13-14H2,1-5H3
描述信息
Tolterodine is only found in individuals that have used or taken this drug. It is an antimuscarinic drug that is used to treat urinary incontinence. Tolterodine acts on M2 and M3 subtypes of muscarinic receptors.Both tolterodine and its active metabolite, 5-hydroxymethyltolterodine, act as competitive antagonists at muscarinic receptors. This antagonism results in inhibition of bladder contraction, decrease in detrusor pressure, and an incomplete emptying of the bladder.
G - Genito urinary system and sex hormones > G04 - Urologicals > G04B - Urologicals > G04BD - Drugs for urinary frequency and incontinence
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
D000089162 - Genitourinary Agents > D064804 - Urological Agents
Tolterodine(PNU-200583) is a potent muscarinic receptor antagonists that show selectivity for the urinary bladder over salivary glands in vivo. IC50 Value: Target: mAChR in vitro: Carbachol-induced contractions of isolated guinea pig bladder were effectively inhibited by tolterodine (IC50 14 nM) and 5-HM (IC50 5.7 nM). The IC50 values were in the microM range and the antimuscarinic potency of tolterodine was 27, 200 and 370-485 times higher, respectively, than its potency in blocking histamine receptors, alpha-adrenoceptors and calcium channels. The active metabolite, 5-HM, was >900 times less potent at these sites than at bladder muscarinic receptors [1]. in vivo: Tolterodine was extensively metabolized in vivo [2]. In the passive-avoidance test, tolterodine at 1 or 3 mg/kg had no effect on memory; the latency to cross and percentage of animals crossing were comparable to controls. In contrast, scopolamine induced a memory deficit; the latency to cross was decreased, and the number of animals crossing was increased [3].
同义名列表
26 个代谢物同义名
2-[(1R)-3-[bis(propan-2-yl)amino]-1-phenylpropyl]-4-methylphenol; 2-[3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-methylphenol; (+)-(R)-2-(alpha-(2-(Diisopropylamino)ethyl)benzyl)-p-cresol; (+)-(R)-2-(Α-(2-(diisopropylamino)ethyl)benzyl)-p-cresol; (+)-(R)-2-(a-(2-(Diisopropylamino)ethyl)benzyl)-p-cresol; 2-(3-(Diisopropylamino)-1-phenylpropyl)-4-methylphenol; Tolterodine extended release capsules; Tolterodine L-tartrate; Tolterodine-L-tartrate; Tartrate, tolterodine; Tolterondine tartrate; Tolterodine tartrate; (+)-Tolterodine; Tolterodinum; Tolterodina; Tolterodine; LA, detrol; Detrusitol; Detrol la; Urotrol; Detrol; Unidet; (R)-(+)-Tolterodine; (R)-Tolterodine; PNU-200583; Tolterodine
数据库引用编号
21 个数据库交叉引用编号
- ChEBI: CHEBI:9622
- KEGG: C07750
- KEGGdrug: D00646
- PubChem: 443879
- PubChem: 5512
- HMDB: HMDB0015170
- Metlin: METLIN43895
- DrugBank: DB01036
- ChEMBL: CHEMBL319757
- ChEMBL: CHEMBL1382
- Wikipedia: Tolterodine
- MeSH: Tolterodine Tartrate
- chemspider: 391967
- CAS: 124937-51-5
- CAS: 124936-74-9
- PMhub: MS000008423
- PubChem: 9952
- NIKKAJI: J561.859B
- RefMet: Tolterodine
- medchemexpress: HY-A0024
- KNApSAcK: 9622
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xiangyang Wang, Tongyu Ji, Zhaoqiang Jiang, Jianan Wang, Xiang Su, Lei Shan. Tolterodine ameliorates inflammatory response and ferroptosis against LPS in human bladder epithelial cells.
Journal of biochemical and molecular toxicology.
2023 Sep; ?(?):e23517. doi:
10.1002/jbt.23517. [PMID: 37702107] - Kasım Ertaş, Hanifi Yıldız, Murat Demir, Rahmi Aslan, Recep Eryılmaz, Şevder Kırmızıtoprak, Kerem Taken. Effect of combined use of tolterodine and continuous positive airway pressure vs continuous positive airway pressure only treatment on overactive bladder symptoms in women with moderate-to-severe obstructive sleep apnea syndrome: a randomized clinical trial.
International urogynecology journal.
2022 07; 33(7):2031-2036. doi:
10.1007/s00192-022-05206-5. [PMID: 35445808] - Frank Donath, Larissa Hoffmann, Marina Todorova-Sanjari, Ralph-Steven Wedemeyer, André Warnke, Klaus Nickisch. Intravaginal Tolterodine Formulation Intended for Overactive Bladder Treatment-Results of a Pharmacokinetic Phase I Pilot Study in Healthy, Postmenopausal Women.
Clinical pharmacology in drug development.
2022 01; 11(1):80-90. doi:
10.1002/cpdd.968. [PMID: 34101369] - Bhavik Patel, Fernando Perez, Patrik Aronsson, Ranya Alothmani, Thomas Carlsson, Michael Winder. Combination drug therapy against OAB normalizes micturition parameters and increases the release of nitric oxide during chemically induced cystitis.
Pharmacology research & perspectives.
2020 02; 8(1):e00564. doi:
10.1002/prp2.564. [PMID: 32030913] - Christopher R Chapple, Francisco Cruz, Linda Cardozo, David Staskin, Sender Herschorn, Nurul Choudhury, Matthias Stoelzel, John Heesakkers, Emad Siddiqui. Safety and Efficacy of Mirabegron: Analysis of a Large Integrated Clinical Trial Database of Patients with Overactive Bladder Receiving Mirabegron, Antimuscarinics, or Placebo.
European urology.
2020 01; 77(1):119-128. doi:
10.1016/j.eururo.2019.09.024. [PMID: 31635815] - Martina S Burczyk, Martin D Burkhalter, Teresa Casar Tena, Laurel A Grisanti, Michael Kauk, Sabrina Matysik, Cornelia Donow, Monika Kustermann, Melanie Rothe, Yinghong Cui, Farah Raad, Svenja Laue, Allessandra Moretti, Wolfram-H Zimmermann, Jürgen Wess, Michael Kühl, Carsten Hoffmann, Douglas G Tilley, Melanie Philipp. Muscarinic receptors promote pacemaker fate at the expense of secondary conduction system tissue in zebrafish.
JCI insight.
2019 10; 4(20):. doi:
10.1172/jci.insight.121971. [PMID: 31619590] - Ji-Yeong Byeon, Choong-Min Lee, Yea-Jin Lee, Young-Hoon Kim, Se-Hyung Kim, Eui Hyun Jung, Won Ki Chae, Yun Jeong Lee, Choon-Gon Jang, Seok-Yong Lee. Influence of CYP2D6 genetic polymorphism on pharmacokinetics of active moiety of tolterodine.
Archives of pharmacal research.
2019 Feb; 42(2):182-190. doi:
10.1007/s12272-018-1099-y. [PMID: 30542809] - Yu A Kupriyanov, G R Kasyan, D Yu Pushkar. [A role of fesoterodine in treatment of overactive bladder].
Urologiia (Moscow, Russia : 1999).
2018 Dec; ?(6):155-162. doi:
10.18565/urology.2018.6.155-162. [PMID: 30742396] - Sheng-Mou Hsiao, Ting-Chen Chang, Chi-Hau Chen, Wen-Yih Wu, Ho-Hsiung Lin. Comparisons of the Clinical Outcomes and Urodynamic Effects of Mirabegron versus Tolterodine Treatment for Female Overactive Bladder Syndrome: A Subgroup Analysis of a Controlled, Randomised, Prospective Study.
Lower urinary tract symptoms.
2018 Sep; 10(3):215-220. doi:
10.1111/luts.12167. [PMID: 28436145] - Eric S Rovner, Kyle Raymond, Eugene Andruczyk, Kristian V Juul. Low-dose Desmopressin and Tolterodine Combination Therapy for Treating Nocturia in Women with Overactive Bladder: A Double-blind, Randomized, Controlled Study.
Lower urinary tract symptoms.
2018 Sep; 10(3):221-230. doi:
10.1111/luts.12169. [PMID: 28560762] - Nikunjkumar Patel, Barbara Wisniowska, Sebastian Polak. Virtual Thorough QT (TQT) Trial-Extrapolation of In Vitro Cardiac Safety Data to In Vivo Situation Using Multi-Scale Physiologically Based Ventricular Cell-wall Model Exemplified with Tolterodine and Fesoterodine.
The AAPS journal.
2018 07; 20(5):83. doi:
10.1208/s12248-018-0244-3. [PMID: 29995258] - Young Seok Ji, In Sook Kim, Tae Kon Kim, Hye Hyun Yoo. Plasma concentration profile of tolterodine and 5-hydroxymethyl tolterodine following transdermal administration of tolterodine in rats.
Die Pharmazie.
2018 07; 73(7):375-378. doi:
10.1691/ph.2018.8033. [PMID: 30001770] - Shuhei Kawamura, Yoshihiko Ito, Takatsugu Hirokawa, Eriko Hikiyama, Shizuo Yamada, Satoshi Shuto. Ligand-Phospholipid Conjugation: A Versatile Strategy for Developing Long-Acting Ligands That Bind to Membrane Proteins by Restricting the Subcellular Localization of the Ligand.
Journal of medicinal chemistry.
2018 05; 61(9):4020-4029. doi:
10.1021/acs.jmedchem.8b00041. [PMID: 29652494] - Robab Maghsoudi, Saeed Farhadi-Niaki, Masoud Etemadian, Amir H Kashi, Pejman Shadpour, Asemaneh Shirani, Rana Samadinezhad-Khoshbaf-Sorkhabi, Meghdad Tabatabaei. Comparing the Efficacy of Tolterodine and Gabapentin Versus Placebo in Catheter Related Bladder Discomfort After Percutaneous Nephrolithotomy: A Randomized Clinical Trial.
Journal of endourology.
2018 02; 32(2):168-174. doi:
10.1089/end.2017.0563. [PMID: 29278929] - Young-Hoon Kim, Ji-Yeong Byeon, Se-Hyung Kim, Choong-Min Lee, Eui Hyun Jung, Won Ki Chae, Choon-Gon Jang, Seok-Yong Lee, Yun Jeong Lee. Simultaneous determination of tolterodine and its two metabolites, 5-hydroxymethyltolterodine and N-dealkyltolterodine in human plasma using LC-MS/MS and its application to a pharmacokinetic study.
Archives of pharmacal research.
2017 Nov; 40(11):1287-1295. doi:
10.1007/s12272-017-0981-3. [PMID: 29128914] - Jian-Liang Cai, Da Chen, Yu-Feng Song, Jing-Chao Han, Jing-Tian Xiao, Ning-Chen Li, Ming Xia, Yan-Qun Na. [A dosage regimen of M-receptor blocker after TURP for severe BPH with predominant urine storage symptoms].
Zhonghua nan ke xue = National journal of andrology.
2017 Sep; 23(9):793-797. doi:
NULL. [PMID: 29726659] - Abdullah K Alhwiesh, Husain Alsharani, Eman Fathi Ibrahim, Zaid Alanazi, Bushra Ahmed AlGhamdi, Nadia Alaudah, Feras Alzahrani, Adnan Alsarawi, Ashwaqu Almohaws, Ibraheem Saeed Abdurrahman. Recurrent syndrome of inappropriate antidiuretic hormone secretion due to tolterodine in an elderly male patient.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia.
2017 May; 28(3):625-628. doi:
10.4103/1319-2442.206471. [PMID: 28540903] - Nicolas Monjotin, Martine Farrié, Nathalie Vergnolle, Bruno Le Grand, James Gillespie, Didier Junquero. Bladder telemetry: A new approach to evaluate micturition behavior under physiological and inflammatory conditions.
Neurourology and urodynamics.
2017 02; 36(2):308-315. doi:
10.1002/nau.22970. [PMID: 26879122] - Jing Leng, Limin Liao, Ben Wan, Chuanjun Du, Wei Li, Keji Xie, Zhoujun Shen, Zhuoqun Xu, Shiliang Wu, Zujun Fang, Lulin Ma, Shaomei Han, Cornelia Feustel, Yong Yang, Helmut Madersbacher. Results of a randomized, double-blind, active-controlled clinical trial with propiverine extended release 30 mg in patients with overactive bladder.
BJU international.
2017 Jan; 119(1):148-157. doi:
10.1111/bju.13500. [PMID: 27087507] - Dong-Dong Xiao, Jian-Wei Lv, Xin Xie, Xing-Wei Jin, Mu-Jun Lu, Yuan Shao. The combination of herbal medicine Weng-li-tong with Tolterodine may be better than Tolterodine alone in the treatment of overactive bladder in women: a randomized placebo-controlled prospective trial.
BMC urology.
2016 Aug; 16(1):49. doi:
10.1186/s12894-016-0167-1. [PMID: 27503124] - N Idkaidek, N Najib, I I Salem, O Najib. Saliva versus Plasma Relative Bioavailability of Tolterodine in Humans: Validation of Class III Drugs of the Salivary Excretion Classification System.
Drug research.
2016 Jun; 66(6):312-5. doi:
10.1055/s-0035-1569442. [PMID: 27011385] - Sri Sivalingam, Necole M Streeper, Priyanka D Sehgal, Brian C Sninsky, Sara L Best, Stephen Y Nakada. Does Combination Therapy with Tamsulosin and Tolterodine Improve Ureteral Stent Discomfort Compared with Tamsulosin Alone? A Double-Blind, Randomized, Controlled Trial.
The Journal of urology.
2016 Feb; 195(2):385-90. doi:
10.1016/j.juro.2015.08.104. [PMID: 26393904] - Hua Tang, Jian Chen, Yongfu Wang, Ting Yu, Changping Guo, Xiaoqi Liao. Combination of sacral neuromodulation and tolterodine for treatment of idiopathic overactive bladder in women: a clinical trial.
Urology journal.
2014 Sep; 11(4):1800-5. doi:
. [PMID: 25194079] - Ximing Liu, Lu Fu, Wenwen Dai, Wei Liu, Jinlong Zhao, Yi Wu, Lengsheng Teng, Fengying Sun, Youxin Li. Design of transparent film-forming hydrogels of tolterodine and their effects on stratum corneum.
International journal of pharmaceutics.
2014 Aug; 471(1-2):322-31. doi:
10.1016/j.ijpharm.2014.05.051. [PMID: 24882035] - Osamu Yamaguchi, Eiji Marui, Hidehiro Kakizaki, Yukio Homma, Yasuhiko Igawa, Masayuki Takeda, Osamu Nishizawa, Momokazu Gotoh, Masaki Yoshida, Osamu Yokoyama, Narihito Seki, Yasushi Ikeda, Sumito Ohkawa. Phase III, randomised, double-blind, placebo-controlled study of the β3-adrenoceptor agonist mirabegron, 50 mg once daily, in Japanese patients with overactive bladder.
BJU international.
2014 Jun; 113(6):951-60. doi:
10.1111/bju.12649. [PMID: 24471907] - Chunlan Jin, Xinyao Zhou, Ran Pang. Effect of electroacupuncture combined with tolterodine on treating female mixed urinary incontinence.
Journal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy and Continence Nurses Society.
2014 May; 41(3):268-72. doi:
10.1097/won.0000000000000025. [PMID: 24805179] - Tahereh Eftekhar, Nastaran Teimoory, Elahe Miri, Abolghasem Nikfallah, Mahsa Naeimi, Mahsa Ghajarzadeh. Posterior tibial nerve stimulation for treating neurologic bladder in women: a randomized clinical trial.
Acta medica Iranica.
2014; 52(11):816-21. doi:
NULL. [PMID: 25415813] - Yang-Yun Wang, Guo-Wei Shi, Jia-Yang He, Yan-Bin Zhang. [Cardura monotherapy versus combination therapy of cardura and tolterodine L-tartrate tablets for II° ? benign prostatic hyperplasia with overactive bladder].
Zhonghua nan ke xue = National journal of andrology.
2013 Dec; 19(12):1099-102. doi:
NULL. [PMID: 24432622] - Fengying Sun, Cheng Sui, Yulin Zhou, Ximing Liu, Yanan Shi, Yi Wu, Youxin Li. Preparation, characterization and pharmacological evaluation of tolterodine hydrogels for the treatment of overactive bladder.
International journal of pharmaceutics.
2013 Sep; 454(1):532-8. doi:
10.1016/j.ijpharm.2013.07.041. [PMID: 23891744] - Chiu-Lin Wang, Chin-Hu Wu, Cheng-Min Liu, Ching-Ju Shen, Kun-Ling Lin, Cheng-Yu Long. Clinical and urodynamic effects of tolterodine in women with an overactive bladder.
Taiwanese journal of obstetrics & gynecology.
2013 Sep; 52(3):381-4. doi:
10.1016/j.tjog.2012.06.001. [PMID: 24075377] - Abdurrahman Karaman, Emine Samdancı, Sadegül Sayın, Ismail Karabulut, Ersin Fadıllıoglu. Effects of tolterodine and trospium chloride on renal damage induced by partial upper urinary tract obstruction.
Urology.
2013 Jul; 82(1):194-200. doi:
10.1016/j.urology.2013.01.030. [PMID: 23453648] - Chun-Hou Liao, Yu-Chen Kuo, Hann-Chorng Kuo. Predictors of successful first-line antimuscarinic monotherapy in men with enlarged prostate and predominant storage symptoms.
Urology.
2013 May; 81(5):1030-3. doi:
10.1016/j.urology.2013.01.018. [PMID: 23506731] - Cho-Ming Loi, Dennis A Smith, Deepak Dalvie. Which metabolites circulate?.
Drug metabolism and disposition: the biological fate of chemicals.
2013 May; 41(5):933-51. doi:
10.1124/dmd.112.050278. [PMID: 23454828] - Hsin-Tzu Liu, Yuan-Hong Jiang, Hann-Chorng Kuo. Increased serum adipokines implicate chronic inflammation in the pathogenesis of overactive bladder syndrome refractory to antimuscarinic therapy.
PloS one.
2013; 8(10):e76706. doi:
10.1371/journal.pone.0076706. [PMID: 24098552] - Toshiki Hatanaka, Masashi Ukai, Mai Watanabe, Akiyoshi Someya, Akiyoshi Ohtake, Masanori Suzuki, Koji Ueshima, Shuichi Sato, Seiji Kaku. Effect of mirabegron, a novel β3-adrenoceptor agonist, on bladder function during storage phase in rats.
Naunyn-Schmiedeberg's archives of pharmacology.
2013 Jan; 386(1):71-8. doi:
10.1007/s00210-012-0814-3. [PMID: 23224420] - Nasir Idkaidek, Tawfiq Arafat. Saliva versus plasma pharmacokinetics: theory and application of a salivary excretion classification system.
Molecular pharmaceutics.
2012 Aug; 9(8):2358-63. doi:
10.1021/mp300250r. [PMID: 22784220] - Jie Liu, Zhongyan Wang, Chao Liu, Honglei Xi, Chunmei Li, Yang Chen, Lin Sun, Liwei Mu, Liang Fang. Silicone adhesive, a better matrix for tolterodine patches-a research based on in vitro/in vivo studies.
Drug development and industrial pharmacy.
2012 Aug; 38(8):1008-14. doi:
10.3109/03639045.2011.637049. [PMID: 22126709] - Marwa M Sakr, Rasha M El Nashar. Potentiometric determination of tolterodine in batch and flow injection conditions.
Talanta.
2012 Jul; 96(?):153-60. doi:
10.1016/j.talanta.2012.02.018. [PMID: 22817943] - Yi-Liang' Chen, Wei-Ju Feng, Xiao-Li Zhang. [Parkinson's disease combined with overactive bladder syndrome treated with acupuncture and medication].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion.
2012 Mar; 32(3):215-8. doi:
NULL. [PMID: 22471132] - Ramesh Yanamandra, Chandra Sekhar Vadla, Umamaheshwar Puppala, Balaram Patro, Yellajyosula L N Murthy, Parimi Atchuta Ramaiah. A New Rapid and Sensitive Stability-Indicating UPLC Assay Method for Tolterodine Tartrate: Application in Pharmaceuticals, Human Plasma and Urine Samples.
Scientia pharmaceutica.
2012 Jan; 80(1):101-14. doi:
10.3797/scipharm.1110-14. [PMID: 22396907] - Itaru Maruyama, Saori Yonekubo, Satoshi Tatemichi, Kazuyasu Maruyama, Yuji Hoyano, Yoshinobu Yamazaki, Hiroshi Kusama. Effects of ritobegron (KUC-7483), a novel β3-adrenoceptor agonist, on both rat bladder function following partial bladder outlet obstruction and on rat salivary secretion: a comparison with the effects of tolterodine.
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.
2012; 48(5-6):115-24. doi:
10.1540/jsmr.48.115. [PMID: 23538508] - Sun-Ouck Kim, Eu Chang Hwang, Kyung Jin Oh, Dongdeuk Kwon, Kwangsung Park, Soo Bang Ryu. Efficacy and safety of combined therapy with tamsulosin and tolterodine in female patients with a maximal flow rate less than 12 ml/s.
International urogynecology journal.
2011 Oct; 22(10):1287-91. doi:
10.1007/s00192-011-1453-9. [PMID: 21617983] - Ernesto Callegari, Bimal Malhotra, Peter J Bungay, Rob Webster, Katherine S Fenner, Sarah Kempshall, Jennifer L LaPerle, Martin C Michel, Gary G Kay. A comprehensive non-clinical evaluation of the CNS penetration potential of antimuscarinic agents for the treatment of overactive bladder.
British journal of clinical pharmacology.
2011 Aug; 72(2):235-46. doi:
10.1111/j.1365-2125.2011.03961.x. [PMID: 21392072] - Ji Hyun Jeong, Dong Kyun Kim, Hye Young Ji, Sei Ryang Oh, Hyung-Kyu Lee, Hye Suk Lee. Liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry for the simultaneous determination of dimethoxyaschantin, dimethylliroresinol, dimethylpinoresinol, epimagnolin A, fargesin and magnolin in rat plasma.
Biomedical chromatography : BMC.
2011 Aug; 25(8):879-89. doi:
10.1002/bmc.1538. [PMID: 21058411] - Tryggve Nevéus. Nocturnal enuresis-theoretic background and practical guidelines.
Pediatric nephrology (Berlin, Germany).
2011 Aug; 26(8):1207-14. doi:
10.1007/s00467-011-1762-8. [PMID: 21267599] - Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
Journal of medicinal chemistry.
2011 Jul; 54(13):4548-58. doi:
10.1021/jm2001629. [PMID: 21599003] - Hiroshi Nagabukuro, Katherine L Villa, L Alexandra Wickham, Alison A Kulick, Loise Gichuru, Marcie J Donnelly, Gregory O Voronin, Tony Pereira, Xinchun Tong, Andrew Nichols, Stephen E Alves, Gary P O'Neill, Christopher V Johnson, Emily J Hickey. Comparative analysis of the effects of antimuscarinic agents on bladder functions in both nonhuman primates and rodents.
The Journal of pharmacology and experimental therapeutics.
2011 Jul; 338(1):220-7. doi:
10.1124/jpet.111.179747. [PMID: 21459965] - Wen-Yih Wu, Sheng-Mou Hsiao, Ting-Chen Chang, Ho-Hsiung Lin. Changes in urodynamic parameters after tolterodine treatment for female overactive bladder syndrome with or without voiding dysfunction.
The journal of obstetrics and gynaecology research.
2011 May; 37(5):436-41. doi:
10.1111/j.1447-0756.2010.01370.x. [PMID: 21272154] - Yue Guan, Yun Tian, Yan Li, Zhifu Yang, Yanyan Jia, Taijun Hang, Aidong Wen. Application of a liquid chromatographic/tandem mass spectrometric method to a kinetic study of derivative glucosamine in healthy human urine.
Journal of pharmaceutical and biomedical analysis.
2011 Apr; 55(1):181-6. doi:
10.1016/j.jpba.2011.01.012. [PMID: 21310576] - Wei Gan, Shao-Feng Zhang, Hong-Tao Jia, Sheng Xie, Mao-Hua Luo, Yun-Fei Li. [Tolterodine tartrate combined with alpha-receptor blocker for benign prostatic hyperplasia with detrusor overactivity].
Zhonghua nan ke xue = National journal of andrology.
2011 Apr; 17(4):348-50. doi:
. [PMID: 21548214] - Stine Mjåvatn Jakobsen, Hege Kersten, Espen Molden. Evaluation of brain anticholinergic activities of urinary spasmolytic drugs using a high-throughput radio receptor bioassay.
Journal of the American Geriatrics Society.
2011 Mar; 59(3):501-5. doi:
10.1111/j.1532-5415.2010.03307.x. [PMID: 21391941] - Howard B Goldman, Jon D Morrow, Jason Gong, Li-Jung Tseng, Tim Schneider. Early onset of fesoterodine efficacy in subjects with overactive bladder.
BJU international.
2011 Feb; 107(4):598-602. doi:
10.1111/j.1464-410x.2010.09586.x. [PMID: 20868387] - Naoya Masumori, Shintaro Miyamoto, Taiji Tsukamoto, Seiji Furuya, Akihiko Iwasawa, Takashi Sato, Naoki Itoh, Akihiko Shibuya, Toshiro Oda. The efficacy and safety of propiverine hydrochloride in patients with overactive bladder symptoms who poorly responded to previous anticholinergic agents.
Advances in urology.
2011; 2011(?):714978. doi:
10.1155/2011/714978. [PMID: 21747845] - Deok Ha Seo, Sung Chul Kam, Jae Seog Hyun. Impact of lower urinary tract symptoms/benign prostatic hyperplasia treatment with tamsulosin and solifenacin combination therapy on erectile function.
Korean journal of urology.
2011 Jan; 52(1):49-54. doi:
10.4111/kju.2011.52.1.49. [PMID: 21344031] - He Xiao, Han-Zhong Li, Zhong-Ming Huang, Yong-Qiang Li. [Clinical effectiveness and safety of combined therapy with an alpha-blocker and an anticholinergic drug for patients with benign prostatic hyperplasia].
Zhonghua wai ke za zhi [Chinese journal of surgery].
2010 Dec; 48(23):1771-3. doi:
NULL. [PMID: 21211380] - Ki Hong Kim, Young Sig Kim. Correlation of male overactive bladder with intravesical prostatic protrusion.
Korean journal of urology.
2010 Dec; 51(12):843-6. doi:
10.4111/kju.2010.51.12.843. [PMID: 21221204] - Christopher R Chapple, Sender Herschorn, Paul Abrams, Joseph T Wang, Marina Brodsky, Zhonghong Guan. Efficacy and safety of tolterodine extended-release in men with overactive bladder symptoms treated with an α-blocker: effect of baseline prostate-specific antigen concentration.
BJU international.
2010 Nov; 106(9):1332-8. doi:
10.1111/j.1464-410x.2010.09359.x. [PMID: 20497416] - Stéphane Bolduc, Katherine Moore, Geneviève Nadeau, Sylvie Lebel, Pascale Lamontagne, Micheline Hamel. Prospective open label study of solifenacin for overactive bladder in children.
The Journal of urology.
2010 Oct; 184(4 Suppl):1668-73. doi:
10.1016/j.juro.2010.03.124. [PMID: 20728124] - Manoj K Poonia, Ginpreet Kaur, Meena Chintamaneni, Ilesh Changela. New insights into molecular targets for urinary incontinence.
Indian journal of pharmacology.
2010 Oct; 42(5):261-6. doi:
10.4103/0253-7613.69980. [PMID: 21206614] - Fengying Sun, Cheng Sui, Lesheng Teng, Ximing Liu, Lirong Teng, Qingfan Meng, Youxin Li. Studies on the preparation, characterization and pharmacological evaluation of tolterodine PLGA microspheres.
International journal of pharmaceutics.
2010 Sep; 397(1-2):44-9. doi:
10.1016/j.ijpharm.2010.06.042. [PMID: 20600717] - Linda Cardozo, Vik Khullar, Ahmed El-Tahtawy, Zhonghong Guan, Bimal Malhotra, David Staskin. Modeling dose-response relationships of the effects of fesoterodine in patients with overactive bladder.
BMC urology.
2010 Aug; 10(?):14. doi:
10.1186/1471-2490-10-14. [PMID: 20723260] - Daniel A Shoskes, J Curtis Nickel, Michael W Kattan. Phenotypically directed multimodal therapy for chronic prostatitis/chronic pelvic pain syndrome: a prospective study using UPOINT.
Urology.
2010 Jun; 75(6):1249-53. doi:
10.1016/j.urology.2010.01.021. [PMID: 20363491] - Philippe Zimmern, Heather J Litman, Elizabeth Mueller, Peggy Norton, Patricia Goode. Effect of fluid management on fluid intake and urge incontinence in a trial for overactive bladder in women.
BJU international.
2010 Jun; 105(12):1680-5. doi:
10.1111/j.1464-410x.2009.09055.x. [PMID: 19912207] - Ulrich Mehnert, André Reitz, Sumaya Abo Youssef, Brigitte Schurch. Proof of principle: The effect of antimuscarinics on bladder filling sensations in healthy subjects--a placebo controlled double blind investigation using 4 and 8 mg tolterodine extended release.
Neurourology and urodynamics.
2010 Mar; 29(3):464-9. doi:
10.1002/nau.20743. [PMID: 19637377] - Jean-Jacques Wyndaele. Pediatrics: combining antimuscarinics shows promise for overactive bladder.
Nature reviews. Urology.
2010 Feb; 7(2):66-8. doi:
10.1038/nrurol.2010.1. [PMID: 20145662] - Naoya Masumori, Taiji Tsukamoto, Masahiro Yanase, Hiroki Horita, Masaharu Aoki. The add-on effect of solifenacin for patients with remaining overactive bladder after treatment with tamsulosin for lower urinary tract symptoms suggestive of benign prostatic obstruction.
Advances in urology.
2010; ?(?):205251. doi:
10.1155/2010/205251. [PMID: 20981257] - Therése Andersson, Kotryna Simonyte, Ruth Andrew, Magnus Strand, Jonas Burén, Brian R Walker, Cecilia Mattsson, Tommy Olsson. Tissue-specific increases in 11beta-hydroxysteroid dehydrogenase type 1 in normal weight postmenopausal women.
PloS one.
2009 Dec; 4(12):e8475. doi:
10.1371/journal.pone.0008475. [PMID: 20041117] - Akira Tsujimura, Tetsuya Takao, Kinya Uchida, Keisuke Yamamoto, Shinichiro Fukuhara, Jiro Nakayama, Tomohiro Ueda, Toshiaki Hirai, Hiroshi Kiuchi, Yasushi Miyagawa, Toru Takahashi, Yasuyuki Kojimaan, Akihiko Okuyama. [Clinical efficacy of tolterodine for patients with overactive bladder after insufficient efficacy by monotherapy with alpha1-adrenoceptor antagonist].
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology.
2009 Nov; 100(7):686-92. doi:
10.5980/jpnjurol.100.686. [PMID: 19999133] - Stéphane Bolduc, Katherine Moore, Sylvie Lebel, Pascale Lamontagne, Micheline Hamel. Double anticholinergic therapy for refractory overactive bladder.
The Journal of urology.
2009 Oct; 182(4 Suppl):2033-8. doi:
10.1016/j.juro.2009.05.099. [PMID: 19695628] - Nam Jin Kim, Sei-Ryang Oh, Hyung Kyu Lee, Hye Suk Lee. Simultaneous determination of magnolin and epimagnolin A in rat plasma by liquid chromatography with tandem mass spectrometry: Application to pharmacokinetic study of a purified extract of the dried flower buds of Magnolia fargesii, NDC-052 in rats.
Journal of pharmaceutical and biomedical analysis.
2009 Aug; 50(1):53-7. doi:
10.1016/j.jpba.2009.03.036. [PMID: 19409747] - Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
10.1021/jm900403j. [PMID: 19445515] - Subramanian Vaidyanathan, Bakul M Soni, Peter L Hughes, Gurpreet Singh. Use of open-ended Foley catheter to treat profuse urine leakage around suprapubic catheter in a female patient with spina bifida who had undergone closure of urethra and suprapubic cystostomy: a case report.
Cases journal.
2009 Jun; 2(?):6851. doi:
10.4076/1757-1626-2-6851. [PMID: 19829871] - Ligang Zhao, Yan Li, Liang Fang, Zhonggui He, Xuntao Liu, Lin Wang, Yongnan Xu, Changshu Ren. Transdermal delivery of tolterodine by O-acylmenthol: In vitro/in vivo correlation.
International journal of pharmaceutics.
2009 Jun; 374(1-2):73-81. doi:
10.1016/j.ijpharm.2009.03.005. [PMID: 19446762] - Hsin-Tzu Liu, Michael B Chancellor, Hann-Chorng Kuo. Decrease of urinary nerve growth factor levels after antimuscarinic therapy in patients with overactive bladder.
BJU international.
2009 Jun; 103(12):1668-72. doi:
10.1111/j.1464-410x.2009.08380.x. [PMID: 19220267] - Jan Macek, Pavel Ptácek, Josef Klíma. Determination of tolterodine and its 5-hydroxymethyl metabolite in human plasma by hydrophilic interaction liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Apr; 877(10):968-74. doi:
10.1016/j.jchromb.2009.02.036. [PMID: 19269904] - Saori Nishijima, Kimio Sugaya, Katsumi Kadekawa, Hidekatsu Naka, Minoru Miyazato. Comparison of the effect of anti-muscarinic agents on bladder activity, urinary ATP level, and autonomic nervous system in rats.
Biomedical research (Tokyo, Japan).
2009 Apr; 30(2):107-12. doi:
10.2220/biomedres.30.107. [PMID: 19420734] - Hans-Uwe Simon, Bimal Malhotra. The pharmacokinetic profile of fesoterodine: similarities and differences to tolterodine.
Swiss medical weekly.
2009 Mar; 139(9-10):146-51. doi:
smw-12542. [PMID: 19145494] - Oxana Doroshyenko, Uwe Fuhr. Clinical pharmacokinetics and pharmacodynamics of solifenacin.
Clinical pharmacokinetics.
2009; 48(5):281-302. doi:
10.2165/00003088-200948050-00001. [PMID: 19566112] - Lambertus P W Witte, Wilhemina M C Mulder, Jean J M C H de la Rosette, Martin C Michel. Muscarinic receptor antagonists for overactive bladder treatment: does one fit all?.
Current opinion in urology.
2009 Jan; 19(1):13-9. doi:
10.1097/mou.0b013e32831a6ff3. [PMID: 19057211] - Claus G Roehrborn, Steven A Kaplan, Stephen R Kraus, Joseph T Wang, Tamara Bavendam, Zhonghong Guan. Effects of serum PSA on efficacy of tolterodine extended release with or without tamsulosin in men with LUTS, including OAB.
Urology.
2008 Nov; 72(5):1061-7; discussion 1067. doi:
10.1016/j.urology.2008.06.067. [PMID: 18817961] - Christopher R Chapple, Philip E Van Kerrebroeck, Klaus-Peter Jünemann, Joseph T Wang, Marina Brodsky. Comparison of fesoterodine and tolterodine in patients with overactive bladder.
BJU international.
2008 Nov; 102(9):1128-32. doi:
10.1111/j.1464-410x.2008.07907.x. [PMID: 18647298] - Yao-Chi Chuang, Catherine A Thomas, Shachi Tyagi, Naoki Yoshimura, Pradeep Tyagi, Michael B Chancellor. Human urine with solifenacin intake but not tolterodine or darifenacin intake blocks detrusor overactivity.
International urogynecology journal and pelvic floor dysfunction.
2008 Oct; 19(10):1353-7. doi:
10.1007/s00192-008-0650-7. [PMID: 18504514] - Christine Thomas, Ute Hestermann, Juergen Kopitz, Konstanze Plaschke, Peter Oster, Martin Driessen, Christoph Mundt, Matthias Weisbrod. Serum anticholinergic activity and cerebral cholinergic dysfunction: an EEG study in frail elderly with and without delirium.
BMC neuroscience.
2008 Sep; 9(?):86. doi:
10.1186/1471-2202-9-86. [PMID: 18793418] - Subramanian Vaidyanathan, Peter L Hughes, Paul Mansour, Bakul M Soni. Burrowing of urinary bladder wall by the tip of a size 22 Fr silicone foley catheter in an adult male patient with multiple sclerosis and suprapubic cystostomy: should caution be exercised in using a size 22 Fr silicone foley catheter for long-term drainage of neuropathic bladder?.
Cases journal.
2008 Jul; 1(1):25. doi:
10.1186/1757-1626-1-25. [PMID: 18611260] - Marci L Chew, Benoit H Mulsant, Bruce G Pollock, Mark E Lehman, Andrew Greenspan, Ramy A Mahmoud, Margaret A Kirshner, Denise A Sorisio, Robert R Bies, Georges Gharabawi. Anticholinergic activity of 107 medications commonly used by older adults.
Journal of the American Geriatrics Society.
2008 Jul; 56(7):1333-41. doi:
10.1111/j.1532-5415.2008.01737.x. [PMID: 18510583] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Myeong Heon Jin, Du Geon Moon. Practical management of nocturia in urology.
Indian journal of urology : IJU : journal of the Urological Society of India.
2008 Jul; 24(3):289-94. doi:
10.4103/0970-1591.42607. [PMID: 19468456] - Dermot F McGinnity, Nigel J Waters, James Tucker, Robert J Riley. Integrated in vitro analysis for the in vivo prediction of cytochrome P450-mediated drug-drug interactions.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jun; 36(6):1126-34. doi:
10.1124/dmd.108.020446. [PMID: 18356267] - Kim A Madewell, Phil Kuo. Hyponatremia associated with tolterodine therapy.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2008 Jun; 65(11):1054-6. doi:
10.2146/ajhp070535. [PMID: 18499879] - Jean-Jacques Wyndaele, Stefan De Wachter. Urgency in overactive bladder: translating experimental data into clinical practice.
Drugs of today (Barcelona, Spain : 1998).
2008 May; 44(5):381-9. doi:
10.1358/dot.2008.44.5.1215723. [PMID: 18548139] - Kinkar Mahanta, Bikas Medhi, Balpinder Kaur, Kannan Laksmi Narasimhan. Comparative efficacy and safety of extended-release and instant-release tolterodine in children with neural tube defects having cystometric abnormalities.
Journal of pediatric urology.
2008 Apr; 4(2):118-23. doi:
10.1016/j.jpurol.2007.10.011. [PMID: 18631906] - Sönke Boy, Brigitte Schurch, Ulrich Mehnert, Gudrun Mehring, Gilles Karsenty, André Reitz. The effects of tolterodine on bladder-filling sensations and perception thresholds to intravesical electrical stimulation: method and initial results.
BJU international.
2007 Sep; 100(3):574-8. doi:
10.1111/j.1464-410x.2007.06903.x. [PMID: 17669142] - Jeffrey P Weiss, Jerry G Blaivas, Mark Jones, Joseph T Wang, Zhonghong Guan. Age related pathogenesis of nocturia in patients with overactive bladder.
The Journal of urology.
2007 Aug; 178(2):548-51; discussion 551. doi:
10.1016/j.juro.2007.03.117. [PMID: 17570424] - Kristen Hesch. Agents for treatment of overactive bladder: a therapeutic class review.
Proceedings (Baylor University. Medical Center).
2007 Jul; 20(3):307-14. doi:
10.1080/08998280.2007.11928310. [PMID: 17637888] - He Xiao, Han-Zhong Li, Yong Yang, Zhong-Ming Huang, Yong-Qiang Li, Xiao-Feng Zhao. [Clinical effectiveness and safety study of combined therapy with an alpha-blocker and an anticholinergic for patients with LUT/BPH].
Zhonghua yi xue za zhi.
2007 Jun; 87(23):1590-3. doi:
NULL. [PMID: 17803845] - Scott A MacDiarmid. Maximizing anticholinergic therapy for overactive bladder: has the ceiling been reached?.
BJU international.
2007 Jun; 99 Suppl 3(?):8-12. doi:
10.1111/j.1464-410x.2007.06881.x. [PMID: 17488367] - M Goepel, K-C Steinwachs. [How do medications used to treat urinary incontinence affect the cerebral function of the elderly?].
Der Urologe. Ausg. A.
2007 Apr; 46(4):387-8, 390. doi:
10.1007/s00120-007-1326-5. [PMID: 17377763] - Yong Yang, Xiao-feng Zhao, Han-zhong Li, Wei Wang, Yong Zhang, He Xiao, Xin Zhang. Efficacy and safety of combined therapy with terazosin and tolteradine for patients with lower urinary tract symptoms associated with benign prostatic hyperplasia: a prospective study.
Chinese medical journal.
2007 Mar; 120(5):370-4. doi:
. [PMID: 17376305] - Siva Narayanan, Annamaria Cerulli, Kristijan H Kahler, Joseph G Ouslander. Is drug therapy for urinary incontinence used optimally in long-term care facilities?.
Journal of the American Medical Directors Association.
2007 Feb; 8(2):98-104. doi:
10.1016/j.jamda.2006.07.004. [PMID: 17289539]
