L-Targinine (BioDeep_00000003180)
Secondary id: BioDeep_00001868765
human metabolite Endogenous
代谢物信息卡片
(2S)-2-amino-5-(3-methylcarbamimidamido)pentanoic acid
化学式: C7H16N4O2 (188.1273)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(feces) 47.3%
分子结构信息
SMILES: CN=C(N)NCCCC(C(=O)O)N
InChI: InChI=1S/C7H16N4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11)
描述信息
L-Targinine is found in pulses. L-Targinine is isolated from broad bean seed L-Targinine has been identified in the human placenta (PMID: 32033212).
C471 - Enzyme Inhibitor > C29574 - Nitric Oxide Synthase Inhibitor
D004791 - Enzyme Inhibitors
同义名列表
41 个代谢物同义名
(2S)-2-amino-5-(3-methylcarbamimidamido)pentanoic acid; Acide (2S)-2-amino-5-(3-methylguanidino)pentanoique; N(5)-[Imino(methylamino)methyl]-L-ornithine; N5-[imino(methylamino)methyl]-L-ornithine; N(5)-(N-Methylcarbamimidoyl)-L-ornithine; N5-(N-Methylcarbamimidoyl)-L-ornithine; N(5)-(Methylamidino)-L-ornithine; N(Omega)-monomethyl-L-arginine; N(5)-(Metilamidino)-L-ornitina; N-Omega-monomethyl-L-arginine; Ngamma-monomethyl-L-arginine; Omega-N-monomethylarginine; N(g)-Monomethyl-L-arginine; N(g)-Monomethyl-D-arginine; N(Omega)-methyl-L-arginine; Arginine, L-NG-monomethyl; N-Omega-methyl-L-arginine; L NG Monomethyl arginine; L-NG-Monomethyl arginine; NG-Monomethyl-L-arginine; NG Monomethyl L arginine; N-Monomethyl-L-arginine; N(g)-Monomethylarginine; NG-Monomethyl-L-argine; Omega-N-methylarginine; Omega N methylarginine; Ng-METHYL-L-ARGININE; L-Monomethylarginine; L Monomethylarginine; N-Methyl-L-arginine; N(g)-Methylarginine; Methylarginine; Tilargininum; L-Targinine; Tilarginina; Tilarginine; Targininum; Targinine; Targinina; D-NMMA; L-NMMA
数据库引用编号
21 个数据库交叉引用编号
- ChEBI: CHEBI:124959
- ChEBI: CHEBI:28229
- KEGG: C03884
- PubChem: 132862
- PubChem: 4366
- HMDB: HMDB0029416
- Metlin: METLIN44311
- DrugBank: DB11815
- ChEMBL: CHEMBL1835117
- ChEMBL: CHEMBL312870
- ChEMBL: CHEMBL256147
- Wikipedia: Methylarginine
- MeSH: omega-N-Methylarginine
- foodb: FDB000510
- chemspider: 117259
- PMhub: MS000008407
- PubChem: 6617
- PDB-CCD: NMM
- NIKKAJI: J264.000G
- LOTUS: LTS0058526
- wikidata: Q99615184
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tuling Li, Bo Bao, Yixian Hao, Jinpeng Liu, Hongsheng Bi, Dadong Guo. Suppressive effect of nitric oxide synthase (NOS) inhibitor L-NMMA acetate on choroidal fibrosis in experimental myopic guinea pigs through the nitric oxide signaling pathway.
European journal of pharmacology.
2023 Oct; 960(?):176111. doi:
10.1016/j.ejphar.2023.176111. [PMID: 37863413] - Volkan Şengül, Zeliha Güney, Şivge Kurgan, Canan Önder, Muhittin A Serdar, Meral Günhan. Evaluation of salivary and serum methylated arginine metabolites and nitric oxide synthase in advanced periodontitis patients.
Clinical oral investigations.
2022 Jul; 26(7):5061-5070. doi:
10.1007/s00784-022-04479-w. [PMID: 35426000] - Su-Juan Wang, Min Yu, Hua Li, Gui-Jie Zhang. Structures and Biological Activities of Polyacylated ent-Kaurane Diterpenoid Glycosides from the Aerial Parts of Inula hupehensis.
Journal of natural products.
2022 01; 85(1):185-195. doi:
10.1021/acs.jnatprod.1c00947. [PMID: 34964626] - Ozgur Oztan, Vugar A Turksoy, Serdar Deniz, Servet B Iritas, Engin Tutkun. The Relationship of Methylated Arginines with Urine Cadmium Levels.
Clinical laboratory.
2022 Jan; 68(1):. doi:
10.7754/clin.lab.2021.210504. [PMID: 35023667] - Kai-Nan Song, You-Jia Lu, Cheng-Jiao Chu, Yan-Ni Wu, Hui-Lian Huang, Bo-Yi Fan, Guang-Tong Chen. Biotransformation of Betulonic Acid by the Fungus Rhizopus arrhizus CGMCC 3.868 and Antineuroinflammatory Activity of the Biotransformation Products.
Journal of natural products.
2021 10; 84(10):2664-2674. doi:
10.1021/acs.jnatprod.1c00480. [PMID: 34546050] - InWha Park, Hee Sun Byun, Gang Min Hur, MinKyun Na. Tulipiferamide A, an Alkamide from Liriodendron tulipifera, Exhibits an Anti-Inflammatory Effect via Targeting IKKβ Phosphorylation.
Journal of natural products.
2021 05; 84(5):1598-1606. doi:
10.1021/acs.jnatprod.1c00146. [PMID: 33939429] - Thae Thae San, Yue-Hu Wang, Dong-Bao Hu, Jun Yang, Dong-Dong Zhang, Meng-Yuan Xia, Xue-Fei Yang, Yong-Ping Yang. A new sesquineolignan and four new neolignans isolated from the leaves of Piper betle, a traditional medicinal plant in Myanmar.
Bioorganic & medicinal chemistry letters.
2021 01; 31(?):127682. doi:
10.1016/j.bmcl.2020.127682. [PMID: 33207281] - Hawley E Kunz, Jessica M Dorschner, Taylor E Berent, Thomas Meyer, Xuewei Wang, Aminah Jatoi, Rajiv Kumar, Ian R Lanza. Methylarginine metabolites are associated with attenuated muscle protein synthesis in cancer-associated muscle wasting.
The Journal of biological chemistry.
2020 12; 295(51):17441-17459. doi:
10.1074/jbc.ra120.014884. [PMID: 33453990] - Ryan L Hoiland, Hannah G Caldwell, Connor A Howe, Daniela Nowak-Flück, Benjamin S Stacey, Damian M Bailey, Julian F R Paton, Daniel J Green, Mypinder S Sekhon, David B Macleod, Philip N Ainslie. Nitric oxide is fundamental to neurovascular coupling in humans.
The Journal of physiology.
2020 11; 598(21):4927-4939. doi:
10.1113/jp280162. [PMID: 32785972] - Kyoung Jin Park, Zahra Khan, Lalita Subedi, Sun Yeou Kim, Kang Ro Lee. Antineurodegenerative Labdane Diterpenoid Glycosides from the Twigs of Pinus koraiensis.
Journal of natural products.
2020 06; 83(6):1794-1803. doi:
10.1021/acs.jnatprod.9b01158. [PMID: 32520551] - Min Kim, Jun Yin, In Hyeok Hwang, Dong Hui Park, Eun Kyeong Lee, Min Ji Kim, Min Won Lee. Anti-Acne Vulgaris Effects of Pedunculagin from the Leaves of Quercus mongolica by Anti-Inflammatory Activity and 5α-Reductase Inhibition.
Molecules (Basel, Switzerland).
2020 May; 25(9):. doi:
10.3390/molecules25092154. [PMID: 32380665] - Muserref Hosaf, Sedat Abusoglu, Ahmet Avci, Kenan Demir, Ali Unlu, Duygu Eryavuz, Gulsum Abusoglu. Total methylated arginine load as a risk parameter in subjects with masked hypertension.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2020; 42(2):126-130. doi:
10.1080/10641963.2019.1583246. [PMID: 30795691] - Tae Hyun Lee, Zahra Khan, Sun Yeou Kim, Kang Ro Lee. Thiohydantoin and Hydantoin Derivatives from the Roots of Armoracia rusticana and Their Neurotrophic and Anti-neuroinflammatory Activities.
Journal of natural products.
2019 11; 82(11):3020-3024. doi:
10.1021/acs.jnatprod.9b00527. [PMID: 31625742] - Marcel H A Muskiet, Anna L Emanuel, Mark M Smits, Lennart Tonneijck, Rick I Meijer, Jaap A Joles, Erik H Serné, Daniël H van Raalte. Assessment of real-time and quantitative changes in renal hemodynamics in healthy overweight males: Contrast-enhanced ultrasonography vs para-aminohippuric acid clearance.
Microcirculation (New York, N.Y. : 1994).
2019 10; 26(7):e12580. doi:
10.1111/micc.12580. [PMID: 31313410] - Kyoung Jin Park, Chung Sub Kim, Zahra Khan, Joonseok Oh, Sun Yeou Kim, Sang Un Choi, Kang Ro Lee. Securinega Alkaloids from the Twigs of Securinega suffruticosa and Their Biological Activities.
Journal of natural products.
2019 05; 82(5):1345-1353. doi:
10.1021/acs.jnatprod.9b00142. [PMID: 31082231] - Edward Yu, Miguel Ruiz-Canela, Cristina Razquin, Marta Guasch-Ferré, Estefania Toledo, Dong D Wang, Christopher Papandreou, Courtney Dennis, Clary Clish, Liming Liang, Monica Bullo, Dolores Corella, Montserrat Fitó, Mario Gutiérrez-Bedmar, José Lapetra, Ramón Estruch, Emilio Ros, Montserrat Cofán, Fernando Arós, Dora Romaguera, Lluis Serra-Majem, Jose V Sorlí, Jordi Salas-Salvadó, Frank B Hu, Miguel A Martínez-González. Changes in arginine are inversely associated with type 2 diabetes: A case-cohort study in the PREDIMED trial.
Diabetes, obesity & metabolism.
2019 02; 21(2):397-401. doi:
10.1111/dom.13514. [PMID: 30146690] - Yang Tang, Zhen-Zhu Zhao, Jian-Neng Yao, Tao Feng, Zheng-Hui Li, He-Ping Chen, Ji-Kai Liu. Irpeksins A-E, 1,10- seco-Eburicane-Type Triterpenoids from the Medicinal Fungus Irpex lacteus and Their Anti-NO Activity.
Journal of natural products.
2018 10; 81(10):2163-2168. doi:
10.1021/acs.jnatprod.7b00845. [PMID: 30296083] - Chung Sub Kim, Joonseok Oh, Lalita Subedi, Sun Yeou Kim, Sang Un Choi, Kang Ro Lee. Rare Thioglycosides from the Roots of Wasabia japonica.
Journal of natural products.
2018 09; 81(9):2129-2133. doi:
10.1021/acs.jnatprod.8b00570. [PMID: 30232882] - Hong Zheng, Kenichi Katsurada, Xuefei Liu, Mark M Knuepfer, Kaushik P Patel. Specific Afferent Renal Denervation Prevents Reduction in Neuronal Nitric Oxide Synthase Within the Paraventricular Nucleus in Rats With Chronic Heart Failure.
Hypertension (Dallas, Tex. : 1979).
2018 09; 72(3):667-675. doi:
10.1161/hypertensionaha.118.11071. [PMID: 30012866] - Xiaohong Liu, Xin Xu, Ruru Shang, Yingjie Chen. Asymmetric dimethylarginine (ADMA) as an important risk factor for the increased cardiovascular diseases and heart failure in chronic kidney disease.
Nitric oxide : biology and chemistry.
2018 08; 78(?):113-120. doi:
10.1016/j.niox.2018.06.004. [PMID: 29928990] - Kongara Damodar, Jeong Tae Lee, Jin-Kyung Kim, Jong-Gab Jun. Synthesis and in vitro evaluation of homoisoflavonoids as potent inhibitors of nitric oxide production in RAW-264.7 cells.
Bioorganic & medicinal chemistry letters.
2018 06; 28(11):2098-2102. doi:
10.1016/j.bmcl.2018.04.037. [PMID: 29685654] - Barbara Tóth, Judit Hohmann, Andrea Vasas. Phenanthrenes: A Promising Group of Plant Secondary Metabolites.
Journal of natural products.
2018 03; 81(3):661-678. doi:
10.1021/acs.jnatprod.7b00619. [PMID: 29280630] - Insa E Emrich, Adam M Zawada, Jens Martens-Lobenhoffer, Danilo Fliser, Stefan Wagenpfeil, Gunnar H Heine, Stefanie M Bode-Böger. Symmetric dimethylarginine (SDMA) outperforms asymmetric dimethylarginine (ADMA) and other methylarginines as predictor of renal and cardiovascular outcome in non-dialysis chronic kidney disease.
Clinical research in cardiology : official journal of the German Cardiac Society.
2018 Mar; 107(3):201-213. doi:
10.1007/s00392-017-1172-4. [PMID: 29101459] - Gui-Min Xue, Xiao-Qing Li, Chen Chen, Kang Chen, Xiao-Bing Wang, Yu-Cheng Gu, Jian-Guang Luo, Ling-Yi Kong. Highly Oxidized Guaianolide Sesquiterpenoids with Potential Anti-inflammatory Activity from Chrysanthemum indicum.
Journal of natural products.
2018 02; 81(2):378-386. doi:
10.1021/acs.jnatprod.7b00867. [PMID: 29400471] - You-Lin Tain, Chien-Ning Hsu, Pei-Chen Lu. Early short-term treatment with exogenous hydrogen sulfide postpones the transition from prehypertension to hypertension in spontaneously hypertensive rat.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2018; 40(1):58-64. doi:
10.1080/10641963.2017.1313847. [PMID: 29072501] - Ryan M Broxterman, Joel D Trinity, Jayson R Gifford, Oh Sung Kwon, Andrew C Kithas, Jay R Hydren, Ashley D Nelson, David E Morgan, Jacob E Jessop, Amber D Bledsoe, Russell S Richardson. Single passive leg movement assessment of vascular function: contribution of nitric oxide.
Journal of applied physiology (Bethesda, Md. : 1985).
2017 12; 123(6):1468-1476. doi:
10.1152/japplphysiol.00533.2017. [PMID: 28860173] - Nicole Lüneburg, Patricia Siques, Julio Brito, Juan José De La Cruz, Fabiola León-Velarde, Juliane Hannemann, Cristian Ibanez, Rainer H Böger. Long-Term Intermittent Exposure to High Altitude Elevates Asymmetric Dimethylarginine in First Exposed Young Adults.
High altitude medicine & biology.
2017 Sep; 18(3):226-233. doi:
10.1089/ham.2016.0123. [PMID: 28453332] - Ji-Qin Hou, Cui Guo, Jian-Juan Zhao, Yang-Yang Dong, Xiao-Long Hu, Qi-Wei He, Bao-Bao Zhang, Ming Yan, Hao Wang. Anti-inflammatory Meroterpenoids from Baeckea frutescens.
Journal of natural products.
2017 08; 80(8):2204-2214. doi:
10.1021/acs.jnatprod.7b00042. [PMID: 28753309] - Xing Tan, Ji-Kui Li, Jia-Cen Sun, Pei-Lei Jiao, Yang-Kai Wang, Zhao-Tang Wu, Bing Liu, Wei-Zhong Wang. The asymmetric dimethylarginine-mediated inhibition of nitric oxide in the rostral ventrolateral medulla contributes to regulation of blood pressure in hypertensive rats.
Nitric oxide : biology and chemistry.
2017 Jul; 67(?):58-67. doi:
10.1016/j.niox.2017.04.002. [PMID: 28392446] - Gearoid M McMahon, Shih-Jen Hwang, Clary B Clish, Adrienne Tin, Qiong Yang, Martin G Larson, Eugene P Rhee, Man Li, Daniel Levy, Christopher J O'Donnell, Josef Coresh, J Hunter Young, Robert E Gerszten, Caroline S Fox. Urinary metabolites along with common and rare genetic variations are associated with incident chronic kidney disease.
Kidney international.
2017 06; 91(6):1426-1435. doi:
10.1016/j.kint.2017.01.007. [PMID: 28302371] - Edward Yu, Miguel Ruiz-Canela, Frank B Hu, Clary B Clish, Dolores Corella, Jordi Salas-Salvadó, Adela Hruby, Montserrat Fitó, Liming Liang, Estefanía Toledo, Emilio Ros, Ramón Estruch, Enrique Gómez-Gracia, José Lapetra, Fernando Arós, Dora Romaguera, Lluís Serra-Majem, Marta Guasch-Ferré, Dong D Wang, Miguel A Martínez-González. Plasma Arginine/Asymmetric Dimethylarginine Ratio and Incidence of Cardiovascular Events: A Case-Cohort Study.
The Journal of clinical endocrinology and metabolism.
2017 06; 102(6):1879-1888. doi:
10.1210/jc.2016-3569. [PMID: 28323949] - Francesca Schinzari, Augusto Veneziani, Nadia Mores, Angela Barini, Nicola Di Daniele, Carmine Cardillo, Manfredi Tesauro. Vascular Effects of Obestatin in Lean and Obese Subjects.
Diabetes.
2017 05; 66(5):1214-1221. doi:
10.2337/db16-1067. [PMID: 28174289] - Chung Sub Kim, Lalita Subedi, Joonseok Oh, Sun Yeou Kim, Sang Un Choi, Kang Ro Lee. Bioactive Triterpenoids from the Twigs of Chaenomeles sinensis.
Journal of natural products.
2017 04; 80(4):1134-1140. doi:
10.1021/acs.jnatprod.7b00111. [PMID: 28358502] - Safa Al Therwani, Jeppe Bakkestrøm Rosenbæk, Frank Holden Mose, Jesper Nørgaard Bech, Erling Bjerregaard Pedersen. Effect of tolvaptan on renal water and sodium excretion and blood pressure during nitric oxide inhibition: a dose-response study in healthy subjects.
BMC nephrology.
2017 Mar; 18(1):86. doi:
10.1186/s12882-017-0501-1. [PMID: 28288570] - Abel Tesfai, Niall MacCallum, Nicholas S Kirkby, Hime Gashaw, Nicola Gray, Elizabeth Want, Gregory J Quinlan, Sharon Mumby, James M Leiper, Mark Paul-Clark, Blerina Ahmetaj-Shala, Jane A Mitchell. Metabolomic profiling of amines in sepsis predicts changes in NOS canonical pathways.
PloS one.
2017; 12(8):e0183025. doi:
10.1371/journal.pone.0183025. [PMID: 28813479] - Chung Sub Kim, Lalita Subedi, Oh Wook Kwon, Hyun Bong Park, Sun Yeou Kim, Sang Un Choi, Kang Ro Lee. Wasabisides A-E, Lignan Glycosides from the Roots of Wasabia japonica.
Journal of natural products.
2016 10; 79(10):2652-2657. doi:
10.1021/acs.jnatprod.6b00582. [PMID: 27700070] - Wen-Jun Xu, Rui-Jun Li, Olga Quasie, Ming-Hua Yang, Ling-Yi Kong, Jun Luo. Polyprenylated Tetraoxygenated Xanthones from the Roots of Hypericum monogynum and Their Neuroprotective Activities.
Journal of natural products.
2016 08; 79(8):1971-81. doi:
10.1021/acs.jnatprod.6b00251. [PMID: 27525351] - Mayuramas Sang-Ngern, Ui Joung Youn, Eun-Jung Park, Tamara P Kondratyuk, Charles J Simmons, Marisa M Wall, Michael Ruf, Sam E Lorch, Ethyn Leong, John M Pezzuto, Leng Chee Chang. Withanolides derived from Physalis peruviana (Poha) with potential anti-inflammatory activity.
Bioorganic & medicinal chemistry letters.
2016 Jun; 26(12):2755-2759. doi:
10.1016/j.bmcl.2016.04.077. [PMID: 27210437] - Guang-Lei Ma, Juan Xiong, Guo-Xun Yang, Li-Long Pan, Chang-Ling Hu, Wei Wang, Hui Fan, Qiu-Hua Zhao, Hai-Yan Zhang, Jin-Feng Hu. Biginkgosides A-I, Unexpected Minor Dimeric Flavonol Diglycosidic Truxinate and Truxillate Esters from Ginkgo biloba Leaves and Their Antineuroinflammatory and Neuroprotective Activities.
Journal of natural products.
2016 05; 79(5):1354-64. doi:
10.1021/acs.jnatprod.6b00061. [PMID: 27140807] - Satoko Nonaka-Hashida, Masae Sekine, Yuji Ozeki, Kumiko Fujii, Kazufumi Akiyama, Kazutaka Shimoda, Makoto Tsunoda, Masumi Katane, Yasuaki Saitoh, Tetsuya Miyamoto, Hiroshi Homma. Plasma concentrations of three methylated arginines, endogenous nitric oxide synthase inhibitors, in schizophrenic patients undergoing antipsychotic drug treatment.
Psychiatry research.
2016 Apr; 238(?):203-210. doi:
10.1016/j.psychres.2016.02.029. [PMID: 27086234] - Won Se Suh, Lalita Subedi, Sun Yeou Kim, Sang Un Choi, Kang Ro Lee. Bioactive lignan constituents from the twigs of Sambucus williamsii.
Bioorganic & medicinal chemistry letters.
2016 Apr; 26(8):1877-80. doi:
10.1016/j.bmcl.2016.03.023. [PMID: 26988298] - Xiaoyu Liu, Lei Hou, Dachun Xu, Angela Chen, Liuqing Yang, Yan Zhuang, Yawei Xu, John T Fassett, Yingjie Chen. Effect of asymmetric dimethylarginine (ADMA) on heart failure development.
Nitric oxide : biology and chemistry.
2016 Apr; 54(?):73-81. doi:
10.1016/j.niox.2016.02.006. [PMID: 26923818] - Yongqing Hou, Shengdi Hu, Sichao Jia, Gayan Nawaratna, Dongsheng Che, Fenglai Wang, Fuller W Bazer, Guoyao Wu. Whole-body synthesis of L-homoarginine in pigs and rats supplemented with L-arginine.
Amino acids.
2016 Apr; 48(4):993-1001. doi:
10.1007/s00726-015-2145-4. [PMID: 26676627] - Chung Sub Kim, Lalita Subedi, Sun Yeou Kim, Sang Un Choi, Ki Hyun Kim, Kang Ro Lee. Diterpenes from the Trunk of Abies holophylla and Their Potential Neuroprotective and Anti-inflammatory Activities.
Journal of natural products.
2016 Feb; 79(2):387-94. doi:
10.1021/acs.jnatprod.5b01053. [PMID: 26812172] - Kyeong Wan Woo, Won Se Suh, Lalita Subedi, Sun Yeou Kim, Aejung Kim, Kang Ro Lee. Bioactive lignan derivatives from the stems of Firmiana simplex.
Bioorganic & medicinal chemistry letters.
2016 Feb; 26(3):730-733. doi:
10.1016/j.bmcl.2016.01.008. [PMID: 26774654] - M H A Muskiet, L Tonneijck, M M Smits, M H H Kramer, M Diamant, J A Joles, D H van Raalte. Acute renal haemodynamic effects of glucagon-like peptide-1 receptor agonist exenatide in healthy overweight men.
Diabetes, obesity & metabolism.
2016 Feb; 18(2):178-85. doi:
10.1111/dom.12601. [PMID: 26636423] - Bing-Yuan Yang, Ling-Yi Kong, Xiao-Bing Wang, Yang-Mei Zhang, Rui-Jun Li, Ming-Hua Yang, Jian-Guang Luo. Nitric Oxide Inhibitory Activity and Absolute Configurations of Arylalkenyl α,β-Unsaturated δ/γ-Lactones from Cryptocarya concinna.
Journal of natural products.
2016 Jan; 79(1):196-203. doi:
10.1021/acs.jnatprod.5b00839. [PMID: 26741483] - Jens Martens-Lobenhoffer, Stefanie M Bode-Böger, Bernd Clement. First detection and quantification of N(δ)-monomethylarginine, a structural isomer of N(G)-monomethylarginine, in humans using MS(3).
Analytical biochemistry.
2016 Jan; 493(?):14-20. doi:
10.1016/j.ab.2015.10.001. [PMID: 26464121] - SeonJu Park, Nguyen Xuan Nhiem, Taek Hwan Lee, Nanyoung Kim, Sun Yeou Kim, Han-Jung Chae, Seung Hyun Kim. Isolation of two new bioactive sesquiterpene lactone glycosides from the roots of Ixeris dentata.
Bioorganic & medicinal chemistry letters.
2015 Oct; 25(20):4562-6. doi:
10.1016/j.bmcl.2015.08.061. [PMID: 26341134] - M A Halim, L Gillberg, S Boghus, M Sundbom, U Karlbom, D-L Webb, P M Hellström. Nitric oxide regulation of migrating motor complex: randomized trial of N(G)-monomethyl-L-arginine effects in relation to muscarinic and serotonergic receptor blockade.
Acta physiologica (Oxford, England).
2015 Oct; 215(2):105-18. doi:
10.1111/apha.12554. [PMID: 26176347] - Frank H Mose, Janni M Jensen, Safa Therwani, Jesper Mortensen, Annebirthe B Hansen, Jesper N Bech, Erling B Pedersen. Effect of nebivolol on renal nitric oxide availability and tubular function in patients with essential hypertension.
British journal of clinical pharmacology.
2015 Sep; 80(3):425-35. doi:
10.1111/bcp.12627. [PMID: 25778445] - Li-Jun Wang, Juan Xiong, Shu-Ting Liu, Li-Long Pan, Guo-Xun Yang, Jin-Feng Hu. ent-Abietane-Type and Related Seco-/Nor-diterpenoids from the Rare Chloranthaceae Plant Chloranthus sessilifolius and Their Antineuroinflammatory Activities.
Journal of natural products.
2015 Jul; 78(7):1635-46. doi:
10.1021/acs.jnatprod.5b00195. [PMID: 26126961] - Ahmed H Abdelazeem, Shabana I Khan, Stephen W White, Kenneth J Sufka, Christopher R McCurdy. Design, synthesis and biological evaluation of bivalent benzoxazolone and benzothiazolone ligands as potential anti-inflammatory/analgesic agents.
Bioorganic & medicinal chemistry.
2015 Jul; 23(13):3248-59. doi:
10.1016/j.bmc.2015.04.057. [PMID: 25975638] - Chuan-Pu Shen, Jian-Guang Luo, Ming-Hua Yang, Ling-Yi Kong. Cafestol-Type Diterpenoids from the Twigs of Tricalysia fruticosa with Potential Anti-inflammatory Activity.
Journal of natural products.
2015 Jun; 78(6):1322-9. doi:
10.1021/acs.jnatprod.5b00165. [PMID: 26052978] - Wen-Jun Xu, Meng-Di Zhu, Xiao-Bing Wang, Ming-Hua Yang, Jun Luo, Ling-Yi Kong. Hypermongones A-J, Rare Methylated Polycyclic Polyprenylated Acylphloroglucinols from the Flowers of Hypericum monogynum.
Journal of natural products.
2015 May; 78(5):1093-100. doi:
10.1021/acs.jnatprod.5b00066. [PMID: 25924023] - Chung Sub Kim, Lalita Subedi, Sun Yeou Kim, Sang Un Choi, Ki Hyun Kim, Kang Ro Lee. Lignan Glycosides from the Twigs of Chaenomeles sinensis and Their Biological Activities.
Journal of natural products.
2015 May; 78(5):1174-8. doi:
10.1021/acs.jnatprod.5b00090. [PMID: 25894905] - Rita S Patarrão, W Wayne Lautt, M Paula Macedo. Acute glucagon induces postprandial peripheral insulin resistance.
PloS one.
2015; 10(5):e0127221. doi:
10.1371/journal.pone.0127221. [PMID: 25961284] - Ki Hyun Kim, Chung Sub Kim, Yong Joo Park, Eunjung Moon, Sang Un Choi, Jei Hyun Lee, Sun Yeou Kim, Kang Ro Lee. Anti-inflammatory and antitumor phenylpropanoid sucrosides from the seeds of Raphanus sativus.
Bioorganic & medicinal chemistry letters.
2015 Jan; 25(1):96-9. doi:
10.1016/j.bmcl.2014.11.001. [PMID: 25466198] - Gemma Vilahur, Laura Casani, Guiomar Mendieta, Rosa M Lamuela-Raventos, Ramon Estruch, Lina Badimon. Beer elicits vasculoprotective effects through Akt/eNOS activation.
European journal of clinical investigation.
2014 Dec; 44(12):1177-88. doi:
10.1111/eci.12352. [PMID: 25323945] - Frank Holden Mose, Thomas Larsen, Janni Majgaard Jensen, Annebirthe Bo Hansen, Jesper Nørgaard Bech, Erling Bjerregaard Pedersen. Effects of atorvastatin on systemic and renal NO dependency in patients with non-diabetic stage II-III chronic kidney disease.
British journal of clinical pharmacology.
2014 Oct; 78(4):789-99. doi:
10.1111/bcp.12390. [PMID: 24697877] - Alfredo Gamboa, Luis E Okamoto, Amy C Arnold, Rocio A Figueroa, André Diedrich, Satish R Raj, Sachin Y Paranjape, Ginnie Farley, Naji Abumrad, Italo Biaggioni. Autonomic blockade improves insulin sensitivity in obese subjects.
Hypertension (Dallas, Tex. : 1979).
2014 Oct; 64(4):867-74. doi:
10.1161/hypertensionaha.114.03738. [PMID: 25001269] - Chung Sub Kim, Oh Wook Kwon, Sun Yeou Kim, Sang Un Choi, Jae Yoon Kim, Ji Young Han, Soo Im Choi, Jong Gil Choi, Ki Hyun Kim, Kang Ro Lee. Phenolic Glycosides from the Twigs of Salix glandulosa.
Journal of natural products.
2014 Aug; 77(8):1955-61. doi:
10.1021/np500488v. [PMID: 25098650] - Satoko Nonaka, Masae Sekine, Makoto Tsunoda, Yuji Ozeki, Kumiko Fujii, Kazufumi Akiyama, Kazutaka Shimoda, Takemitsu Furuchi, Masumi Katane, Yasuaki Saitoh, Hiroshi Homma. Simultaneous determination of N(G)-monomethyl-L-arginine, N(G),N(G)-dimethyl-L-arginine, N(G),N(G')-dimethyl-L-arginine, and L-arginine using monolithic silica disk-packed spin columns and a monolithic silica column.
Journal of separation science.
2014 Aug; 37(16):2087-94. doi:
10.1002/jssc.201400240. [PMID: 24895248] - Safa Al Therwani, Frank Holden Mose, Janni Majgaard Jensen, Jesper Nørgaard Bech, Erling Bjerregaard Pedersen. Effect of vasopressin antagonism on renal handling of sodium and water and central and brachial blood pressure during inhibition of the nitric oxide system in healthy subjects.
BMC nephrology.
2014 Jun; 15(?):100. doi:
10.1186/1471-2369-15-100. [PMID: 24965902] - Jesper N Bech, Niels K Aagaard, Robert S Pedersen, Tina B Sorensen, Hendrik Vilstrup, Erling B Pedersen. Renal effects of NO-inhibition in patients with cirrhosis vs. healthy controls: a randomized placebo-controlled crossover study.
Liver international : official journal of the International Association for the Study of the Liver.
2014 Feb; 34(2):211-9. doi:
10.1111/liv.12233. [PMID: 23809512] - Frank H Mose, Thomas Larsen, Janni M Jensen, Annebirthe B Hansen, Jesper N Bech, Erling B Pedersen. Effect of atorvastatin on renal NO availability and tubular function in patients with stage II-III chronic kidney disease and type 2 diabetes.
Scandinavian journal of clinical and laboratory investigation.
2014 Jan; 74(1):8-19. doi:
10.3109/00365513.2013.855942. [PMID: 24256611] - Manh Heun Kim, Jun Hye Jang, Myeong Hwan Oh, Jun Hyeok Heo, Min Won Lee. The comparison of DPPH-scavenging capacity and anti-inflammatory effects of phenolic compounds isolated from the stems of Stewartia koreana Nakai.
Natural product research.
2014; 28(17):1409-12. doi:
10.1080/14786419.2014.905560. [PMID: 24749670] - J N Bech, J Starklint, H Bentzen, O Nyvad, E B Pedersen. Renal and hormonal effects of systemic nitric oxide inhibition in patients with congestive heart failure and in healthy control subjects.
Journal of cardiac failure.
2013 Nov; 19(11):776-85. doi:
10.1016/j.cardfail.2013.10.001. [PMID: 24263123] - Sofie Brouwers, Ilse Smolders, Ann Massie, Alain G Dupont. Angiotensin II type 2 receptor-mediated and nitric oxide-dependent renal vasodilator response to compound 21 unmasked by angiotensin-converting enzyme inhibition in spontaneously hypertensive rats in vivo.
Hypertension (Dallas, Tex. : 1979).
2013 Nov; 62(5):920-6. doi:
10.1161/hypertensionaha.112.00762. [PMID: 24041944] - Jiao Jiao, Benguo Zhou, Xiaoping Zhu, Zhengliang Gao, Yuancun Liang. Fusaric acid induction of programmed cell death modulated through nitric oxide signalling in tobacco suspension cells.
Planta.
2013 Oct; 238(4):727-37. doi:
10.1007/s00425-013-1928-7. [PMID: 23838885] - Carla S Jung, B Lange, M Zimmermann, Volker Seifert. Role of endogenous monomethylated L-arginine (L-NMMA) after subarachnoid hemorrhage.
Neurological research.
2013 Sep; 35(7):709-12. doi:
10.1179/1743132813y.0000000194. [PMID: 23582621] - Péter Tamás, József Bódis, Endre Sulyok, Gábor L Kovács, Eszter Hantosi, Gábor Molnár, Jens Martens-Lobenhoffer, Stefanie M Bode-Böger. L-arginine metabolism in early-onset and late-onset pre-eclamptic pregnancies.
Scandinavian journal of clinical and laboratory investigation.
2013 Aug; 73(5):436-43. doi:
10.3109/00365513.2013.803230. [PMID: 23777299] - K S Cho, C W Park, C K Kim, H Y Jeon, W G Kim, S J Lee, Y M Kim, J Y Lee, Y D Choi. Effects of Korean ginseng berry extract (GB0710) on penile erection: evidence from in vitro and in vivo studies.
Asian journal of andrology.
2013 Jul; 15(4):503-7. doi:
10.1038/aja.2013.49. [PMID: 23708462] - Thomas H Linz, Susan M Lunte. Heat-assisted extraction for the determination of methylarginines in serum by CE.
Electrophoresis.
2013 Jun; 34(11):1693-700. doi:
10.1002/elps.201200567. [PMID: 23417924] - David Z I Cherney, James W Scholey, Etienne B Sochett. Sex differences in renal responses to hyperglycemia, L-arginine, and L-NMMA in humans with uncomplicated type 1 diabetes.
Diabetes care.
2013 May; 36(5):1290-6. doi:
10.2337/dc12-1305. [PMID: 23250800] - Seung Young Lee, Eunjung Moon, Sun Yeou Kim, Kang Ro Lee. Quinic acid derivatives from Pimpinella brachycarpa exert anti-neuroinflammatory activity in lipopolysaccharide-induced microglia.
Bioorganic & medicinal chemistry letters.
2013 Apr; 23(7):2140-4. doi:
10.1016/j.bmcl.2013.01.115. [PMID: 23462643] - Rou-Mu Hu, Bi-Hua Tan, Kate M Orland, Carmen R Valdivia, Amber Peterson, Jielin Pu, Jonathan C Makielski. Digenic inheritance novel mutations in SCN5a and SNTA1 increase late I(Na) contributing to LQT syndrome.
American journal of physiology. Heart and circulatory physiology.
2013 Apr; 304(7):H994-H1001. doi:
10.1152/ajpheart.00705.2012. [PMID: 23376825] - Chung Sub Kim, Sun Yeou Kim, Eunjung Moon, Mi Kyeong Lee, Kang Ro Lee. Steroidal constituents from the leaves of Hosta longipes and their inhibitory effects on nitric oxide production.
Bioorganic & medicinal chemistry letters.
2013 Mar; 23(6):1771-5. doi:
10.1016/j.bmcl.2013.01.050. [PMID: 23411079] - V S Sprung, D J Cuthbertson, C J A Pugh, C Daousi, G Atkinson, N F Aziz, G J Kemp, D J Green, N T Cable, H Jones. Nitric oxide-mediated cutaneous microvascular function is impaired in polycystic ovary sydrome but can be improved by exercise training.
The Journal of physiology.
2013 Mar; 591(6):1475-87. doi:
10.1113/jphysiol.2012.246918. [PMID: 23318877] - Francesca Schinzari, Manfredi Tesauro, Valentina Rovella, Nicola Di Daniele, Nadia Mores, Augusto Veneziani, Carmine Cardillo. Leptin stimulates both endothelin-1 and nitric oxide activity in lean subjects but not in patients with obesity-related metabolic syndrome.
The Journal of clinical endocrinology and metabolism.
2013 Mar; 98(3):1235-41. doi:
10.1210/jc.2012-3424. [PMID: 23372172] - Hong Yin, Jian-Guang Luo, Ling-Yi Kong. Tetracyclic diterpenoids with isomerized isospongian skeleton and labdane diterpenoids from the fruits of Amomum kravanh.
Journal of natural products.
2013 Feb; 76(2):237-42. doi:
10.1021/np3007217. [PMID: 23394284] - Jordi Ribera, Montse Pauta, Pedro Melgar-Lesmes, Sònia Tugues, Guillermo Fernández-Varo, Kara F Held, Guadalupe Soria, Raúl Tudela, Anna M Planas, Carlos Fernández-Hernando, Vicente Arroyo, Wladimiro Jiménez, Manuel Morales-Ruiz. Increased nitric oxide production in lymphatic endothelial cells causes impairment of lymphatic drainage in cirrhotic rats.
Gut.
2013 Jan; 62(1):138-45. doi:
10.1136/gutjnl-2011-300703. [PMID: 22267600] - Francesco Addabbo, Qiuying Chen, Dhara P Patel, May Rabadi, Brian Ratliff, Frank Zhang, Jean-Francois Jasmin, Michael Wolin, Michael Lisanti, Steven S Gross, Michael S Goligorsky. Glutamine supplementation alleviates vasculopathy and corrects metabolic profile in an in vivo model of endothelial cell dysfunction.
PloS one.
2013; 8(6):e65458. doi:
10.1371/journal.pone.0065458. [PMID: 23776484] - Kyeong Wan Woo, Eunjung Moon, So Young Park, Sun Yeou Kim, Kang Ro Lee. Flavonoid glycosides from the leaves of Allium victorialis var. platyphyllum and their anti-neuroinflammatory effects.
Bioorganic & medicinal chemistry letters.
2012 Dec; 22(24):7465-70. doi:
10.1016/j.bmcl.2012.10.043. [PMID: 23149227] - Jeremy Bellien, Isabelle Remy-Jouet, Michele Iacob, Etienne Blot, Alain Mercier, Daniele Lucas, Yvonne Dreano, Laurence Gutierrez, Nathalie Donnadieu, Christian Thuillez, Robinson Joannides. Impaired role of epoxyeicosatrienoic acids in the regulation of basal conduit artery diameter during essential hypertension.
Hypertension (Dallas, Tex. : 1979).
2012 Dec; 60(6):1415-21. doi:
10.1161/hypertensionaha.112.201087. [PMID: 23090775] - Xiaoyu Huang, Yijun Zhou, Jiying Ma, Ning Wang, Zhen Zhang, Jiajia Ji, Qing Ding, Guoyuan Chen. Nitric oxide mediated effects on reproductive toxicity caused by carbon disulfide in male rats.
Environmental toxicology and pharmacology.
2012 Nov; 34(3):679-87. doi:
10.1016/j.etap.2012.10.001. [PMID: 23146592] - David Z I Cherney, Heather N Reich, Shan Jiang, Ronnie Har, Rania Nasrallah, Richard L Hébert, Vesta Lai, James W Scholey, Etienne B Sochett. Hyperfiltration and effect of nitric oxide inhibition on renal and endothelial function in humans with uncomplicated type 1 diabetes mellitus.
American journal of physiology. Regulatory, integrative and comparative physiology.
2012 Oct; 303(7):R710-8. doi:
10.1152/ajpregu.00286.2012. [PMID: 22855276] - Stefan P Mortensen, Christopher D Askew, Meegan Walker, Michael Nyberg, Ylva Hellsten. The hyperaemic response to passive leg movement is dependent on nitric oxide: a new tool to evaluate endothelial nitric oxide function.
The Journal of physiology.
2012 Sep; 590(17):4391-400. doi:
10.1113/jphysiol.2012.235952. [PMID: 22733658] - Robert A Beard, David J Anderson, Jennifer L Bufford, Gary Tallman. Heat reduces nitric oxide production required for auxin-mediated gene expression and fate determination in tree tobacco guard cell protoplasts.
Plant physiology.
2012 Aug; 159(4):1608-23. doi:
10.1104/pp.112.200089. [PMID: 22730424] - Robert C Hickner, Gabor Kemeny, Paige D Clark, Vaughna B Galvin, Kerry L McIver, Chris A Evans, Michael J Carper, Joseph P Garry. In vivo nitric oxide suppression of lipolysis in subcutaneous abdominal adipose tissue is greater in obese than lean women.
Obesity (Silver Spring, Md.).
2012 Jun; 20(6):1174-8. doi:
10.1038/oby.2011.91. [PMID: 21494230] - Megan R Sutherland, Bradley A Yoder, Donald McCurnin, Steven Seidner, Lina Gubhaju, Ronald I Clyman, M Jane Black. Effects of ibuprofen treatment on the developing preterm baboon kidney.
American journal of physiology. Renal physiology.
2012 May; 302(10):F1286-92. doi:
10.1152/ajprenal.00216.2011. [PMID: 22357916] - Laura H R Leite, Hong Zheng, Cândido C Coimbra, Kaushik P Patel. Contribution of the paraventricular nucleus in autonomic adjustments to heat stress.
Experimental biology and medicine (Maywood, N.J.).
2012 May; 237(5):570-7. doi:
10.1258/ebm.2011.011286. [PMID: 22619372] - Rémy Chenevard, David Hürlimann, Lukas Spieker, Markus Béchir, Frank Enseleit, Matthias Hermann, Andreas J Flammer, Isabella Sudano, Roberto Corti, Thomas F Lüscher, Georg Noll, Frank Ruschitzka. Reconstituted HDL in acute coronary syndromes.
Cardiovascular therapeutics.
2012 Apr; 30(2):e51-7. doi:
10.1111/j.1755-5922.2010.00221.x. [PMID: 20840194] - Joel D Trinity, H Jonathan Groot, Gwenael Layec, Matthew J Rossman, Stephen J Ives, Sean Runnels, Ben Gmelch, Amber Bledsoe, Russell S Richardson. Nitric oxide and passive limb movement: a new approach to assess vascular function.
The Journal of physiology.
2012 Mar; 590(6):1413-25. doi:
10.1113/jphysiol.2011.224741. [PMID: 22310310] - Jeremy Bellien, Michele Iacob, Isabelle Remy-Jouet, Daniele Lucas, Christelle Monteil, Laurence Gutierrez, Cathy Vendeville, Yvonne Dreano, Alain Mercier, Christian Thuillez, Robinson Joannides. Epoxyeicosatrienoic acids contribute with altered nitric oxide and endothelin-1 pathways to conduit artery endothelial dysfunction in essential hypertension.
Circulation.
2012 Mar; 125(10):1266-75. doi:
10.1161/circulationaha.111.070680. [PMID: 22412088] - Luis Aldámiz-Echevarría, Fernando Andrade. Asymmetric dimethylarginine, endothelial dysfunction and renal disease.
International journal of molecular sciences.
2012; 13(9):11288-11311. doi:
10.3390/ijms130911288. [PMID: 23109853] - Guanghui Wang, Chenfang Wang, Rui Hou, Xiaoying Zhou, Guotian Li, Shijie Zhang, Jin-Rong Xu. The AMT1 arginine methyltransferase gene is important for plant infection and normal hyphal growth in Fusarium graminearum.
PloS one.
2012; 7(5):e38324. doi:
10.1371/journal.pone.0038324. [PMID: 22693618] - Joon Lee, Rishi Kothari, Joseph A Ladapo, Daniel J Scott, Leo A Celi. Interrogating a clinical database to study treatment of hypotension in the critically ill.
BMJ open.
2012; 2(3):. doi:
10.1136/bmjopen-2012-000916. [PMID: 22685222] - Neeru M Sharma, Hong Zheng, Parmender P Mehta, Yi-Fan Li, Kaushik P Patel. Decreased nNOS in the PVN leads to increased sympathoexcitation in chronic heart failure: role for CAPON and Ang II.
Cardiovascular research.
2011 Nov; 92(2):348-57. doi:
10.1093/cvr/cvr217. [PMID: 21831995]
