Anandamide (BioDeep_00000002570)

 

Secondary id: BioDeep_00001871795

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


(5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)-5,8,11,14-eicosatetraenamide

化学式: C22H37NO2 (347.2824)
中文名称: 花生四烯酸乙醇胺, 花生四烯酰乙醇胺
谱图信息: 最多检出来源 Homo sapiens(blood) 27.88%

分子结构信息

SMILES: C(NCCO)(=O)CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC
InChI: InChI=1S/C22H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22(25)23-20-21-24/h6-7,9-10,12-13,15-16,24H,2-5,8,11,14,17-21H2,1H3,(H,23,25)/b7-6-,10-9-,13-12-,16-15-

描述信息

Anandamide, also known as arachidonoylethanolamide (AEA), is a highly potent endogenous agonist of the cannabinoid CB1 and CB2 receptors. CB1 receptors are predominantly found in the central nervous system (CNS) where they mainly mediate the psychotropic effects of tetrahydrocannabinol (THC) and endocannabinoids, whereas the expression of the CB2 receptor is thought to be restricted to cells of the immune system. It was suggested that AEA might inhibit tumour cell proliferation or induce apoptosis independently of CB1 and CB2 receptors, via interaction with the type 1 vanilloid receptor (VR1). VR1 is an ion channel expressed almost exclusively by sensory neurons, activated by pH, noxious heat (> 48-degree centigrade), and plant toxins and is thought to play an important role in nociception. Cervical cancer cells are sensitive to AEA-induced apoptosis via VR1 that is aberrantly expressed in vitro and in vivo while CB1 and CB2 receptors play a protective role. (PMID: 15047233). Novel prostaglandins (prostaglandin glycerol esters and prostaglandin ethanolamides) are COX-2 oxidative metabolites of endogenous cannabinoids (such as anandamide). Recent evidence suggests that these new types of prostaglandins are likely novel signalling mediators involved in synaptic transmission and plasticity (PMID: 16957004).
Anandamide is a highly potent endogenous agonist of the cannabinoid CB1 and CB2 receptors. CB1 receptors are predominantly found in the central nervous system (CNS) where they mainly mediate the psychotropic effects of Tetrahydrocannabinol (THC) and endocannabinoids, whereas the expression of the CB2 receptor is thought to be restricted to cells of the immune system. It was suggested that AEA might inhibit tumor cell proliferation or induce apoptosis independently of CB1 and CB2 receptors, via interaction with the type 1 vanilloid receptor (VR1). VR1 is an ion channel expressed almost exclusively by sensory neurons, activated by pH, noxious heat (>48 degree centigrade) and plant toxins and is thought to play an important role in nociception. Cervical cancer cells are sensitive to AEA-induced apoptosis via VR1 that is aberrantly expressed in vitro and in vivo while CB1 and CB2 receptors play a protective role. (PMID 15047233)
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D063385 - Cannabinoid Receptor Modulators
D018377 - Neurotransmitter Agents > D063385 - Cannabinoid Receptor Modulators > D063386 - Cannabinoid Receptor Agonists
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D000077264 - Calcium-Regulating Hormones and Agents
CONFIDENCE standard compound; INTERNAL_ID 41
D049990 - Membrane Transport Modulators

同义名列表

35 个代谢物同义名

(5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)-5,8,11,14-eicosatetraenamide; (5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide; N-(2-Hydroxyethyl)-5,8,11,14-eicosatetraenamide (all-Z); (all-Z)-N-(2-Hydroxyethyl)-5,8,11,14-eicosatetraenamide; N-(2-hydroxyethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide; N-(5Z,8Z,11Z,14Z-Eicosatetraenoyl) ethanolamine; N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine; N-(5Z,8Z,11Z,14Z-Icosatetraenoyl)-ethanolamide; Arachidonic acid N-(hydroxyethyl)amide; 5,8,11,14-Eicosatetraenoylethanolamide; N-(2-Hydroxyethyl)arachidonylamide; N-Arachidonoyl-2-hydroxyethylamide; Arachidonate N-(hydroxyethyl)amide; N-(2-Hydroxyethyl)anachidonamide; N-(2-Hydroxyethyl)arachidonamide; N-arachidonoyl ethanolamine; N-Arachidonoylethanolamine; N-Arachidonoylethanolamide; N-Arachidonylethanolamide; Arachidonoyl ethanolamide; N-Arachidonylethanolamine; arachidonoylethanolamide; Arachidonylethanolamide; Anandamide (20:4, n-6); Anandamide (20.4, N-6); Anandamide (20.4,N-6); Anandamide(20:4, n-6); Anandamide - d4; Arachidonoyl-EA; Anandamide; NAE 20:4; AEA; Anandamide; Anandamide; Anandamide



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(0)

PlantCyc(0)

代谢反应

55 个相关的代谢反应过程信息。

Reactome(48)

BioCyc(6)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 AKT1, CA1, CA3, FABP5, PPARG, PTGS1, PTGS2
Peripheral membrane protein 3 MGLL, PTGS1, PTGS2
Endoplasmic reticulum membrane 3 MGLL, PTGS1, PTGS2
Nucleus 5 AKT1, FABP5, PLCZ1, PPARA, PPARG
cytosol 9 AKT1, CA1, CA3, FABP5, LEP, MGLL, PLCZ1, PPARG, PRKCQ
nucleoplasm 6 AKT1, DAGLB, FABP5, PLCZ1, PPARA, PPARG
RNA polymerase II transcription regulator complex 1 PPARG
Cell membrane 4 AKT1, DAGLB, GPR55, GPRC5A
lamellipodium 1 AKT1
Multi-pass membrane protein 6 CACNA1I, CATSPER3, DAGLB, GPR55, GPRC5A, KCNA3
Synapse 2 FABP5, TAC1
cell cortex 1 AKT1
glutamatergic synapse 3 AKT1, FABP5, KCNA3
Golgi apparatus 1 PTGS1
Golgi membrane 1 INS
lysosomal membrane 1 DAGLB
neuronal cell body 1 TAC1
postsynapse 1 AKT1
presynaptic membrane 1 KCNA3
Cytoplasm, cytosol 1 MGLL
acrosomal vesicle 1 CATSPER3
plasma membrane 10 AKT1, CACNA1I, CATSPER3, DAGLB, FABP5, GPR55, GPRC5A, KCNA3, MGLL, PRKCQ
Membrane 6 AKT1, CACNA1I, DAGLB, GPR55, KCNA3, MGLL
axon 2 KCNA3, TAC1
caveola 1 PTGS2
extracellular exosome 4 CA1, FABP5, GPRC5A, PTGS1
endoplasmic reticulum 2 CATSPER3, PTGS2
extracellular space 4 FABP5, INS, LEP, TAC1
perinuclear region of cytoplasm 3 KCNA3, PLCZ1, PPARG
protein-containing complex 2 AKT1, PTGS2
intracellular membrane-bounded organelle 3 GPRC5A, PPARG, PTGS1
Microsome membrane 2 PTGS1, PTGS2
postsynaptic density 1 FABP5
pronucleus 1 PLCZ1
Secreted 3 FABP5, INS, LEP
extracellular region 4 FABP5, INS, LEP, TAC1
centriolar satellite 1 PRKCQ
motile cilium 1 CATSPER3
photoreceptor outer segment 1 PTGS1
microtubule cytoskeleton 1 AKT1
nucleolus 2 GPRC5A, PLCZ1
cell-cell junction 1 AKT1
vesicle 2 AKT1, GPRC5A
postsynaptic membrane 1 KCNA3
Cytoplasm, perinuclear region 1 PLCZ1
Membrane raft 1 KCNA3
spindle 1 AKT1
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 2 GPRC5A, PPARG
neuron projection 2 PTGS1, PTGS2
ciliary basal body 1 AKT1
chromatin 2 PPARA, PPARG
postsynaptic density, intracellular component 1 FABP5
[Isoform 2]: Cell membrane 1 KCNA3
Endomembrane system 1 PTGS1
endosome lumen 1 INS
Cell projection, cilium, flagellum membrane 1 CATSPER3
Cytoplasmic vesicle membrane 1 GPRC5A
voltage-gated potassium channel complex 1 KCNA3
secretory granule lumen 1 INS
secretory granule membrane 1 FABP5
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 INS, PTGS2
voltage-gated calcium channel complex 1 CACNA1I
transport vesicle 1 INS
azurophil granule lumen 1 FABP5
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
calyx of Held 1 KCNA3
[Isoform 1]: Cell membrane 1 KCNA3
postsynaptic cytosol 1 FABP5
sperm head 1 PLCZ1
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3
CatSper complex 1 CATSPER3


文献列表

  • Matthew P O'Donohue, Khalisa Amir Hamzah, David Nichols, Luke J Ney. Trauma film viewing and intrusive memories: Relationship between salivary alpha amylase, endocannabinoids, and cortisol. Psychoneuroendocrinology. 2024 Jun; 164(?):107007. doi: 10.1016/j.psyneuen.2024.107007. [PMID: 38503195]
  • Oscar David Lopez-Cortes, Francisco Trujillo-Sánchez, Erika Sierra-Ruelas, Erika Martinez-Lopez, Vincenzo Di Marzo, Barbara Vizmanos. Association between the FAAH C385A variant (rs324420) and obesity-related traits: a systematic review. International journal of obesity (2005). 2024 Feb; 48(2):188-201. doi: 10.1038/s41366-023-01428-9. [PMID: 38114812]
  • Katarzyna Stachowicz. Deciphering the mechanisms of reciprocal regulation or interdependence at the cannabinoid CB1 receptors and cyclooxygenase-2 level: Effects on mood, cognitive implications, and synaptic signaling. Neuroscience and biobehavioral reviews. 2023 Oct; ?(?):105439. doi: 10.1016/j.neubiorev.2023.105439. [PMID: 37898448]
  • Besma Boubertakh, Olivier Courtemanche, David Marsolais, Vincenzo Di Marzo, Cristoforo Silvestri. New role for the anandamide metabolite prostaglandin F2α ethanolamide: Rolling preadipocyte proliferation. Journal of lipid research. 2023 Sep; ?(?):100444. doi: 10.1016/j.jlr.2023.100444. [PMID: 37730163]
  • Jessica Schwerdtfeger, Helga Sauerwein, Elke Albrecht, Gemma Mazzuoli-Weber, Dirk von Soosten, Sven Dänicke, Björn Kuhla. The effect of N-arachidonoylethanolamide administration on energy and fat metabolism of early lactating dairy cows. Scientific reports. 2023 09; 13(1):14665. doi: 10.1038/s41598-023-41938-0. [PMID: 37673919]
  • Emmanuel Bäckryd, Andreas Themistocleous, Niclas Stensson, Andrew S C Rice, Solomon Tesfaye, David L Bennett, Björn Gerdle, Bijar Ghafouri. Serum levels of endocannabinoids and related lipids in painful vs painless diabetic neuropathy: results from the Pain in Neuropathy Study. Pain. 2023 Aug; ?(?):. doi: 10.1097/j.pain.0000000000003015. [PMID: 37578507]
  • Adrien Paquot, Juan Bestard-Escalas, Giulio G Muccioli. Set up and validation of a sensitive method to quantify prostaglandins, prostaglandin-glycerol esters and prostaglandin-ethanolamides, as well as their respective precursors. Prostaglandins & other lipid mediators. 2023 Jun; ?(?):106763. doi: 10.1016/j.prostaglandins.2023.106763. [PMID: 37391027]
  • Guanghui Tang, Ying-Jie Lim, Wei Wang, Zi Ye, Chong-Jing Zhang, Shao Q Yao. Orthogonal Strategies for Profiling Potential Cellular Targets of Anandamide and Cannabidiol. Chemistry (Weinheim an der Bergstrasse, Germany). 2023 Jun; ?(?):e202300682. doi: 10.1002/chem.202300682. [PMID: 37265377]
  • Mauro Maccarrone, Vincenzo Di Marzo, Juerg Gertsch, Uwe Grether, Allyn C Howlett, Tian Hua, Alexandros Makriyannis, Daniele Piomelli, Natsuo Ueda, Mario van der Stelt. Goods and bads of endocannabinoid system as a therapeutic target: Lessons learned after 30 years. Pharmacological reviews. 2023 May; ?(?):. doi: 10.1124/pharmrev.122.000600. [PMID: 37164640]
  • Anastasia Levichev, Serge Faumont, Rachel Z Berner, Zhifeng Purcell, Amanda M White, Kathy Chicas-Cruz, Shawn R Lockery. The conserved endocannabinoid anandamide modulates olfactory sensitivity to induce hedonic feeding in C. elegans. Current biology : CB. 2023 Apr; ?(?):. doi: 10.1016/j.cub.2023.03.013. [PMID: 37084730]
  • Goldie Wolfson, Ronit Vogt Sionov, Reem Smoum, Maya Korem, Itzhack Polacheck, Doron Steinberg. Anti-Bacterial and Anti-Biofilm Activities of Anandamide against the Cariogenic Streptococcus mutans. International journal of molecular sciences. 2023 Mar; 24(7):. doi: 10.3390/ijms24076177. [PMID: 37047147]
  • Nuha Anajirih, Saoirse E O'Sullivan, Stephen Ph Alexander. Endocannabinoid hydrolases differentially distribute in platelets and red blood cells and are differentially released by thrombin. Prostaglandins & other lipid mediators. 2023 Feb; 164(?):106692. doi: 10.1016/j.prostaglandins.2022.106692. [PMID: 36372184]
  • Qian Yang, Shan Kong, Jiajia Yu, Yanhua Xu, Mei Tao, Shuo Ma, Chenxue Tang, Xianjuan Shen, Zhiyuan Tang, Shaoqing Ju. MicroRNA miR-1275 coordinately regulates AEA/LPA signals via targeting FAAH in lipid metabolism reprogramming of gastric cancer. Cell death & disease. 2023 01; 14(1):62. doi: 10.1038/s41419-023-05584-8. [PMID: 36702852]
  • Raphael Mechoulam. A Delightful Trip Along the Pathway of Cannabinoid and Endocannabinoid Chemistry and Pharmacology. Annual review of pharmacology and toxicology. 2023 Jan; 63(?):1-13. doi: 10.1146/annurev-pharmtox-051921-083709. [PMID: 35850522]
  • Alzbeta Svobodova, Vladimir Vrkoslav, Ingrida Smeringaiova, Katerina Jirsova. Distribution of an analgesic palmitoylethanolamide and other N-acylethanolamines in human placental membranes. PloS one. 2023; 18(1):e0279863. doi: 10.1371/journal.pone.0279863. [PMID: 36638082]
  • Elliot D Mock, Berend Gagestein, Mario van der Stelt. Anandamide and other N-acylethanolamines: A class of signaling lipids with therapeutic opportunities. Progress in lipid research. 2023 01; 89(?):101194. doi: 10.1016/j.plipres.2022.101194. [PMID: 36150527]
  • Faizy Ahmed, Alexa Torrens, Stephen V Mahler, Francesca Ferlenghi, Marilyn A Huestis, Daniele Piomelli. A Sensitive Ultrahigh-Performance Liquid Chromatography/Tandem Mass Spectrometry Method for the Simultaneous Analysis of Phytocannabinoids and Endocannabinoids in Plasma and Brain. Cannabis and cannabinoid research. 2022 Nov; ?(?):. doi: 10.1089/can.2022.0216. [PMID: 36367975]
  • Wahid Zada, Jonathan W VanRyzin, Miguel Perez-Pouchoulen, Samantha L Baglot, Matthew N Hill, Ghulam Abbas, Sarah M Clark, Umer Rashid, Margaret M McCarthy, Abdul Mannan. Fatty acid amide hydrolase inhibition and N-arachidonoylethanolamine modulation by isoflavonoids: A novel target for upcoming antidepressants. Pharmacology research & perspectives. 2022 10; 10(5):e00999. doi: 10.1002/prp2.999. [PMID: 36029006]
  • Berend Gagestein, Anna F Stevens, Domenico Fazio, Bogdan I Florea, Tom van der Wel, Alexander T Bakker, Filomena Fezza, Hans den Dulk, Herman S Overkleeft, Mauro Maccarrone, Mario van der Stelt. Chemical Proteomics Reveals Off-Targets of the Anandamide Reuptake Inhibitor WOBE437. ACS chemical biology. 2022 05; 17(5):1174-1183. doi: 10.1021/acschembio.2c00122. [PMID: 35482948]
  • Sepideh Khaksar, Mona Salimi, Hadi Zeinoddini, Nima Naderi. The Role of the Possible Receptors and Intracellular Pathways in Protective Effect of Exogenous Anandamide in Kindling Model of Epilepsy. Neurochemical research. 2022 May; 47(5):1226-1242. doi: 10.1007/s11064-021-03517-5. [PMID: 35112235]
  • Patricia Rivera, Santiago Guerra-Cantera, Antonio Vargas, Francisca Díaz, Rocío García-Úbeda, Rubén Tovar, María Teresa Ramírez-López, Jesús Argente, Fernando Rodríguez de Fonseca, Juan Suárez, Julie A Chowen. Maternal hypercaloric diet affects factors involved in lipid metabolism and the endogenous cannabinoid systems in the hypothalamus of adult offspring: sex-specific response of astrocytes to palmitic acid and anandamide. Nutritional neuroscience. 2022 May; 25(5):931-944. doi: 10.1080/1028415x.2020.1821519. [PMID: 32954972]
  • Sherif S Abdel Mageed, Ramy M Ammar, Noha N Nassar, Helmy Moawad, Ahmed S Kamel. Role of PI3K/Akt axis in mitigating hippocampal ischemia-reperfusion injury via CB1 receptor stimulation by paracetamol and FAAH inhibitor in rat. Neuropharmacology. 2022 04; 207(?):108935. doi: 10.1016/j.neuropharm.2021.108935. [PMID: 34968475]
  • Stacey Herriage, Guangping Chen, Carey Pope. Concentration-dependent effects of chlorpyrifos oxon on peroxisome proliferator-activated receptor signaling in MCF-7 cells. Toxicology in vitro : an international journal published in association with BIBRA. 2022 Feb; 78(?):105268. doi: 10.1016/j.tiv.2021.105268. [PMID: 34756920]
  • Chanté Muller, Diane L Lynch, Dow P Hurst, Patricia H Reggio. TRPV1 Activation by Anandamide via a Unique Lipid Pathway. Journal of chemical information and modeling. 2021 12; 61(12):5742-5746. doi: 10.1021/acs.jcim.1c00893. [PMID: 34780173]
  • Ahmed Ramadan, Asmaa R Khalaf, Ahmed El Ray, Yasmin Saad. Serum anandamide level as a potential indicator for nonalcoholic fatty liver disease severity. European journal of gastroenterology & hepatology. 2021 12; 33(1S Suppl 1):e363-e367. doi: 10.1097/meg.0000000000002092. [PMID: 33731590]
  • Isabel van Ackern, Angela Kuhla, Björn Kuhla. A Role for Peripheral Anandamide and 2-Arachidonoylglycerol in Short-Term Food Intake and Orexigenic Hypothalamic Responses in a Species with Continuous Nutrient Delivery. Nutrients. 2021 Oct; 13(10):. doi: 10.3390/nu13103587. [PMID: 34684588]
  • Kunming Tao, Jiao Zhu, Kai Wei, Xiaoyan Meng, Mei Zhu, Yong Tao, Zhijie Lu, Weifeng Yu. Cannabinoid Receptor-2 Activation in Keratinocytes Contributes to Elevated Peripheral β-Endorphin Levels in Patients With Obstructive Jaundice. Anesthesia and analgesia. 2021 07; 133(1):251-262. doi: 10.1213/ane.0000000000005405. [PMID: 33560661]
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  • Karla Johanna Ruth Hoyer-Allo, Martin Richard Späth, Ruth Hanssen, Marc Johnsen, Susanne Brodesser, Kathrin Kaufmann, Katharina Kiefer, Felix Carlo Koehler, Heike Göbel, Torsten Kubacki, Franziska Grundmann, Bernhard Schermer, Jens Brüning, Thomas Benzing, Volker Burst, Roman-Ulrich Müller. Modulation of Endocannabinoids by Caloric Restriction Is Conserved in Mice but Is Not Required for Protection from Acute Kidney Injury. International journal of molecular sciences. 2021 May; 22(11):. doi: 10.3390/ijms22115485. [PMID: 34067475]
  • Carolin Redlich, Andrea Dlugos, Matthew Nicholas Hill, Sachin Patel, Dominika Korn, Verena Enneking, Katharina Foerster, Volker Arolt, Katharina Domschke, Udo Dannlowski, Ronny Redlich. The endocannabinoid system in humans: significant associations between anandamide, brain function during reward feedback and a personality measure of reward dependence. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2021 04; 46(5):1020-1027. doi: 10.1038/s41386-020-00870-x. [PMID: 33007775]
  • Virna Margarita Martín Giménez, Feres José Mocayar Marón, Sebastián García, Luciana Mazzei, Manuel Guevara, Roberto Yunes, Walter Manucha. Central nervous system, peripheral and hemodynamic effects of nanoformulated anandamide in hypertension. Advances in medical sciences. 2021 Mar; 66(1):72-80. doi: 10.1016/j.advms.2020.12.003. [PMID: 33388673]
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  • Simone Grasso, Marco Santonico, Giorgio Pennazza, Alessandro Zompanti, Alessandra Piccoli, Tiziana Bisogno, Mauro Maccarrone. BIONOTE as an Innovative Biosensor for Measuring Endocannabinoid Levels. Sensors (Basel, Switzerland). 2021 Jan; 21(2):. doi: 10.3390/s21020489. [PMID: 33445599]
  • Gregory T Carter, Ryan J McLaughlin, Carrie Cuttler, Garrett J Sauber, Douglas L Weeks, Cecilia J Hillard, Michael D Weiss. Endocannabinoids and related lipids in serum from patients with amyotrophic lateral sclerosis. Muscle & nerve. 2021 01; 63(1):120-126. doi: 10.1002/mus.27096. [PMID: 33094490]
  • Joseph K Ritter, Ashfaq Ahmad, Shobha Mummalaneni, Zdravka Daneva, Sara K Dempsey, Ningjun Li, Pin-Lan Li, Vijay Lyall. Mechanism of Diuresis and Natriuresis by Cannabinoids: Evidence for Inhibition of Na+-K+-ATPase in Mouse Kidney Thick Ascending Limb Tubules. The Journal of pharmacology and experimental therapeutics. 2021 01; 376(1):1-11. doi: 10.1124/jpet.120.000163. [PMID: 33087396]
  • Mohammad Bashashati, Emma Leishman, Heather Bradshaw, Solmaz Sigaroodi, Eric Tatro, Tamis Bright, Richard McCallum, Irene Sarosiek. Plasma endocannabinoids and cannabimimetic fatty acid derivatives are altered in gastroparesis: A sex- and subtype-dependent observation. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 2021 01; 33(1):e13961. doi: 10.1111/nmo.13961. [PMID: 32779297]
  • Karl Kevala, Michel Lagarde, Arthur A Spector, Hee-Yong Kim. Biosynthesis of N-Docosahexanoylethanolamine from Unesterified Docosahexaenoic Acid and Docosahexaenoyl-Lysophosphatidylcholine in Neuronal Cells. International journal of molecular sciences. 2020 Nov; 21(22):. doi: 10.3390/ijms21228768. [PMID: 33233525]
  • Elisabeth J Harfmann, Timothy L McAuliffe, Eric R Larson, Stacy A Claesges, Garrett Sauber, Cecilia J Hillard, Joseph S Goveas. Circulating endocannabinoid concentrations in grieving adults. Psychoneuroendocrinology. 2020 10; 120(?):104801. doi: 10.1016/j.psyneuen.2020.104801. [PMID: 32682172]
  • Katharina Klatt-Schreiner, Lucie Valek, Jun-Suk Kang, Alexander Khlebtovsky, Sandra Trautmann, Lisa Hahnefeld, Yannick Schreiber, Robert Gurke, Dominique Thomas, Annett Wilken-Schmitz, Sabine Wicker, Georg Auburger, Gerd Geisslinger, Jörn Lötsch, Waltraud Pfeilschifter, Ruth Djaldetti, Irmgard Tegeder. High Glucosylceramides and Low Anandamide Contribute to Sensory Loss and Pain in Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. 2020 10; 35(10):1822-1833. doi: 10.1002/mds.28186. [PMID: 32652698]
  • Sophie Castonguay-Paradis, Sébastien Lacroix, Gabrielle Rochefort, Lydiane Parent, Julie Perron, Cyril Martin, Benoît Lamarche, Frédéric Raymond, Nicolas Flamand, Vincenzo Di Marzo, Alain Veilleux. Dietary fatty acid intake and gut microbiota determine circulating endocannabinoidome signaling beyond the effect of body fat. Scientific reports. 2020 09; 10(1):15975. doi: 10.1038/s41598-020-72861-3. [PMID: 32994521]
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