Losartan (BioDeep_00000002449)

 

Secondary id: BioDeep_00000404787

human metabolite blood metabolite


代谢物信息卡片


[2-butyl-4-chloro-1-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-imidazol-5-yl]methanol

化学式: C22H23ClN6O (422.1622)
中文名称: 氯沙坦
谱图信息: 最多检出来源 Homo sapiens(blood) 18.75%

分子结构信息

SMILES: CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl
InChI: InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)

描述信息

Losartan is an angiotensin-receptor blocker (ARB) that may be used alone or with other agents to treat hypertension. Losartan and its longer acting metabolite, E-3174, lower blood pressure by antagonizing the renin-angiotensin-aldosterone system (RAAS); they compete with angiotensin II for binding to the type-1 angiotensin II receptor (AT1) subtype and prevents the blood pressure increasing effects of angiotensin II. Unlike angiotensin-converting enzyme (ACE) inhibitors, ARBs do not have the adverse effect of dry cough. Losartan may be used to treat hypertension, isolated systolic hypertension, left ventricular hypertrophy and diabetic nephropathy. It may also be used as an alternative agent for the treatment of systolic dysfunction, myocardial infarction, coronary artery disease, and heart failure.
C - Cardiovascular system > C09 - Agents acting on the renin-angiotensin system > C09C - Angiotensin ii receptor blockers (arbs), plain > C09CA - Angiotensin ii receptor blockers (arbs), plain
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C66930 - Angiotensin II Receptor Antagonist
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials, COVID-19 Disease Map
D057911 - Angiotensin Receptor Antagonists > D047228 - Angiotensin II Type 1 Receptor Blockers
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
CONFIDENCE standard compound; EAWAG_UCHEM_ID 2794
CONFIDENCE standard compound; INTERNAL_ID 8189
CONFIDENCE standard compound; INTERNAL_ID 8607
CONFIDENCE standard compound; INTERNAL_ID 2280
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.

同义名列表

17 个代谢物同义名

[2-butyl-4-chloro-1-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-imidazol-5-yl]methanol; 2-Butyl-4-chloro-1-((2-(1H-etrazol-5-yl) (1,1-biphenyl)-4-yl)methyl)-1H-imidazole-5-methanol; 2-N-Butyl-4-chloro-5-hydroxymethyl-1-[(2-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole; (2-Butyl-4-chloro-1-{[2-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol; Salt, losartan monopotassium; Monopotassium salt, losartan; Losartan monopotassium salt; Potassium, losartan; Losartan potassium; Losartic; losartan; DuP 753; DuP-753; Cozaar; DUP 89; Losartan; Losartan



数据库引用编号

52 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 APOE, CAT, NOS1, NOS2, NOX4, NPPA, NR3C2, TGFB1
Peripheral membrane protein 2 CYP1B1, NOS1
Endoplasmic reticulum membrane 3 CYP1B1, NOX4, NR3C2
Nucleus 8 APOE, FOS, NOS1, NOS2, NOX4, NR3C2, PLCZ1, TGFB1
cytosol 8 AVP, CAT, FOS, LEP, NOS1, NOS2, NR3C2, PLCZ1
dendrite 2 APOE, AVP
nucleoplasm 5 FOS, NOS1, NOS2, NR3C2, PLCZ1
RNA polymerase II transcription regulator complex 1 FOS
Cell membrane 1 NOX4
Multi-pass membrane protein 2 CACNA1I, NOX4
Synapse 1 NOS1
cell surface 2 EPO, TGFB1
glutamatergic synapse 1 APOE
Golgi apparatus 1 APOE
Golgi membrane 1 INS
neuronal cell body 2 APOE, TGFB1
sarcolemma 1 NOS1
Cytoplasm, cytosol 1 NOS2
plasma membrane 7 APOE, CACNA1I, KNG1, NOS1, NOS2, NOX4, TGFB1
Membrane 5 APOE, CACNA1I, CAT, CYP1B1, NOX4
axon 1 TGFB1
extracellular exosome 5 AGT, APOE, CAT, EPO, KNG1
endoplasmic reticulum 3 APOE, FOS, NOX4
extracellular space 11 AGT, APOE, AVP, CRP, EPO, FBN1, INS, KNG1, LEP, NPPA, TGFB1
perinuclear region of cytoplasm 4 NOS1, NOS2, NOX4, PLCZ1
mitochondrion 4 CAT, CYP1B1, NOS1, NOX4
protein-containing complex 3 CAT, NOS1, NPPA
intracellular membrane-bounded organelle 2 CAT, CYP1B1
Microsome membrane 1 CYP1B1
postsynaptic density 1 NOS1
pronucleus 1 PLCZ1
Secreted 10 AGT, APOE, AVP, CRP, EPO, FBN1, INS, LEP, NPPA, TGFB1
extracellular region 12 AGT, APOE, AVP, CAT, CRP, EPO, FBN1, INS, KNG1, LEP, NPPA, TGFB1
mitochondrial matrix 1 CAT
photoreceptor inner segment 1 NOS1
Endosome, multivesicular body 1 APOE
Extracellular vesicle 1 APOE
Secreted, extracellular space, extracellular matrix 3 APOE, FBN1, TGFB1
chylomicron 1 APOE
high-density lipoprotein particle 1 APOE
low-density lipoprotein particle 1 APOE
multivesicular body 1 APOE
very-low-density lipoprotein particle 1 APOE
dendritic spine 1 NOS1
perikaryon 1 NPPA
nucleolus 2 NOX4, PLCZ1
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
Early endosome 1 APOE
Cell membrane, sarcolemma 1 NOS1
Cytoplasm, perinuclear region 4 NOS1, NOS2, NOX4, PLCZ1
Membrane raft 1 NOS1
Cell junction, focal adhesion 1 NOX4
focal adhesion 2 CAT, NOX4
extracellular matrix 3 APOE, FBN1, TGFB1
Peroxisome 2 CAT, NOS2
basement membrane 1 FBN1
sarcoplasmic reticulum 1 NOS1
Peroxisome matrix 1 CAT
peroxisomal matrix 2 CAT, NOS2
peroxisomal membrane 1 CAT
Cell projection, dendritic spine 1 NOS1
collagen-containing extracellular matrix 6 AGT, APOE, FBN1, KNG1, NPPA, TGFB1
secretory granule 2 AVP, TGFB1
receptor complex 1 NR3C2
chromatin 2 FOS, NR3C2
cell projection 1 NPPA
cell periphery 1 NOS1
cytoskeleton 1 NOS1
[Isoform 5]: Cytoplasm 1 NOX4
Secreted, extracellular space 2 APOE, KNG1
Nucleus, nucleolus 1 NOX4
blood microparticle 4 AGT, APOE, KNG1, TGFB1
endosome lumen 1 INS
Melanosome 1 APOE
cell body 1 EPO
[Isoform 3]: Cytoplasm 1 NOX4
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 3 CAT, EPO, INS
Golgi lumen 2 INS, TGFB1
endoplasmic reticulum lumen 4 APOE, FBN1, INS, KNG1
nuclear matrix 1 FOS
platelet alpha granule lumen 2 KNG1, TGFB1
voltage-gated calcium channel complex 1 CACNA1I
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
neuronal dense core vesicle 1 AVP
perinuclear endoplasmic reticulum 1 NOX4
clathrin-coated endocytic vesicle membrane 2 APOE, AVP
synaptic cleft 1 APOE
protein-DNA complex 1 FOS
[Isoform 4]: Nucleus 1 NOX4
discoidal high-density lipoprotein particle 1 APOE
microfibril 1 FBN1
endocytic vesicle lumen 1 APOE
transcription factor AP-1 complex 1 FOS
[Latency-associated peptide]: Secreted, extracellular space, extracellular matrix 1 TGFB1
[Transforming growth factor beta-1]: Secreted 1 TGFB1
[Long-acting natriuretic peptide]: Secreted 1 NPPA
[Vessel dilator]: Secreted 1 NPPA
[Kaliuretic peptide]: Secreted 1 NPPA
[Urodilatin]: Secreted 1 NPPA
[Atrial natriuretic peptide]: Secreted 1 NPPA
[Atriopeptin-3]: Secreted 1 NPPA
chylomicron remnant 1 APOE
intermediate-density lipoprotein particle 1 APOE
lipoprotein particle 1 APOE
multivesicular body, internal vesicle 1 APOE
cortical cytoskeleton 1 NOS2
catalase complex 1 CAT
sperm head 1 PLCZ1
NADPH oxidase complex 1 NOX4
[Isoform 6]: Cytoplasm 1 NOX4
[Fibrillin-1]: Secreted, extracellular space, extracellular matrix 1 FBN1
[Asprosin]: Secreted 1 FBN1


文献列表

  • Yangyang Yin, Yuqi Yang, Yongqiang Zhang, Yu Shang, Qian Li, Jing Yuan. MiR-132-3p suppresses peritoneal fibrosis induced by peritoneal dialysis via targeting TGF-β1/Smad2/3 signaling pathway. PloS one. 2024; 19(4):e0301540. doi: 10.1371/journal.pone.0301540. [PMID: 38603722]
  • Fu-Ping Wang, Lei Zhang, Jian Lyu, Yi Liu, Yan-Ming Xie. [Efficacy, safety, and mechanism of Huangkui Capsules in treating chronic kidney disease: Meta-analysis and integrative bioinformatics]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Aug; 48(16):4493-4507. doi: 10.19540/j.cnki.cjcmm.20230515.502. [PMID: 37802876]
  • Jing-Kui Wu, Dong-Ping Chen, Chao-Yang Ye. [Notoginsenoside R_1 interferes with renal oxidative stress and Nrf2/HO-1 signaling pathway to alleviate kidney injury in mice with IgA nephropathy and its mechanism]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Jul; 48(14):3839-3847. doi: 10.19540/j.cnki.cjcmm.20230213.401. [PMID: 37475075]
  • Sumit Bansal, C Austin Zamarripa, Tory R Spindle, Elise M Weerts, Kenneth E Thummel, Ryan Vandrey, Mary F Paine, Jashvant D Unadkat. Evaluation of Cytochrome P450-Mediated Cannabinoid-Drug Interactions in Healthy Adult Participants. Clinical pharmacology and therapeutics. 2023 Jun; ?(?):. doi: 10.1002/cpt.2973. [PMID: 37313955]
  • Le Bo, Lun Wei, Linling Shi, Chao Luo, Shasha Gao, Anwen Zhou, Caiping Mao. Altered local RAS in the liver increased the risk of NAFLD in male mouse offspring produced by in vitro fertilization. BMC pregnancy and childbirth. 2023 May; 23(1):345. doi: 10.1186/s12884-023-05681-8. [PMID: 37173649]
  • Mahyar Khazaeli, Ane C F Nunes, Yitong Zhao, Mahziar Khazaali, John Prudente, Nosratola D Vaziri, Bhupinder Singh, Wei Ling Lau. Tetrahydrocurcumin Add-On therapy to losartan in a rat model of diabetic nephropathy decreases blood pressure and markers of kidney injury. Pharmacology research & perspectives. 2023 Apr; 11(2):e01079. doi: 10.1002/prp2.1079. [PMID: 36971089]
  • Bingran Liu, Xina Jie, Jiankun Deng, Simeng Zhang, Fuhua Lu, Xusheng Liu, Difei Zhang. Bupi Yishen formula may prevent kidney fibrosis by modulating fatty acid metabolism in renal tubules. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Mar; 114(?):154767. doi: 10.1016/j.phymed.2023.154767. [PMID: 37001297]
  • Lei Luo, Si-Si Ning, Shao-Zheng Yang, Jia-Hui Jin, Wan-Ting Wang, Yi-Fei Zhong, Yi Li. [Effect of electroacupuncture on transforming growth factor-β1 and renal tubular epithelial mesenchymal transformation in renal tissue of spontaneously hypertensive rats]. Zhen ci yan jiu = Acupuncture research. 2023 Feb; 48(2):172-9. doi: 10.13702/j.1000-0607.20220281. [PMID: 36858414]
  • Qi Liu, Shuai Dong, Xue Zhou, Yubo Zhao, Bin Dong, Jing Shen, Kang Yang, Linsen Li, Dan Zhu. Effects of Long-Term Intervention with Losartan, Aspirin and Atorvastatin on Vascular Remodeling in Juvenile Spontaneously Hypertensive Rats. Molecules (Basel, Switzerland). 2023 Feb; 28(4):. doi: 10.3390/molecules28041844. [PMID: 36838830]
  • Rui Li, Chuanzhou Liang, Sif B Svendsen, Vaidotas Kisielius, Kai Bester. Sartan blood pressure regulators in classical and biofilm wastewater treatment - Concentrations and metabolism. Water research. 2023 Feb; 229(?):119352. doi: 10.1016/j.watres.2022.119352. [PMID: 36450176]
  • Ronghua Feng, Jinjie Wan, Yongsheng He, Hui Gong, Zeqin Xu, Jiugeng Feng. Angiotensin-receptor blocker losartan alleviates atrial fibrillation in rats by downregulating frizzled 8 and inhibiting the activation of WNT-5A pathway. Clinical and experimental pharmacology & physiology. 2023 01; 50(1):19-27. doi: 10.1111/1440-1681.13715. [PMID: 36047789]
  • Rosmayanti S Siregar, Oke Rina Ramayani, Delyuzar Haris, Aznan Lelo, Nelva Karmila Jusuf, Putri Chairani Eyanoer, Muhammad Rusda, Mustafa Mahmud Amin. Comparison of Gambier Extract (Uncaria Gambier Robx) and Angiotensin Receptor Blocker on Proteinuria Reduction and Antioxidants - Enhancement in Nephrotic Rat Models. Medical archives (Sarajevo, Bosnia and Herzegovina). 2023; 77(6):422-427. doi: 10.5455/medarh.2023.77.422-427. [PMID: 38313113]
  • Bao Trong Nguyen, Eun-Joo Shin, Ji Hoon Jeong, Naveen Sharma, Seung Yeol Nah, Sung Kwon Ko, Jae Kyung Byun, Yi Lee, Xin Gen Lei, Dae-Joong Kim, Toshitaka Nabeshima, Hyoung-Chun Kim. Ginsenoside Re attenuates memory impairments in aged Klotho deficient mice via interactive modulations of angiotensin II AT1 receptor, Nrf2 and GPx-1 gene. Free radical biology & medicine. 2022 08; 189(?):2-19. doi: 10.1016/j.freeradbiomed.2022.07.003. [PMID: 35840016]
  • Jie Sheng, Ziyue Zu, Yugang Zhang, Haitao Zhu, Jianchen Qi, Tao Zheng, Ying Tian, Longjiang Zhang. Targeted therapy of atherosclerosis by zeolitic imidazolate framework-8 nanoparticles loaded with losartan potassium via simultaneous lipid-scavenging and anti-inflammation. Journal of materials chemistry. B. 2022 08; 10(31):5925-5937. doi: 10.1039/d2tb00686c. [PMID: 35639392]
  • Miriam B Vos, Mark L Van Natta, Niviann M Blondet, Srinivasan Dasarathy, Mark Fishbein, Paula Hertel, Ajay K Jain, Saul J Karpen, Joel E Lavine, Saeed Mohammad, Laura A Miriel, Jean P Molleston, Marialena Mouzaki, Arun Sanyal, Emily P Sharkey, Jeffrey B Schwimmer, James Tonascia, Laura A Wilson, Stavra A Xanthakos. Randomized placebo-controlled trial of losartan for pediatric NAFLD. Hepatology (Baltimore, Md.). 2022 Aug; 76(2):429-444. doi: 10.1002/hep.32403. [PMID: 35133671]
  • Chung-Hao Lin, Po-Cheng Chang, Pao-Hsien Chu, Yi-Fang Chuang, Rong-Chi Huang, Chiao-Nan Chen. Effects of losartan and exercise on muscle mass and exercise endurance of old mice. Experimental gerontology. 2022 Aug; 165(?):111869. doi: 10.1016/j.exger.2022.111869. [PMID: 35710057]
  • Selina Tisler, Nikolina Engler, Mathias B Jørgensen, Kristoffer Kilpinen, Giorgio Tomasi, Jan H Christensen. From data to reliable conclusions: Identification and comparison of persistent micropollutants and transformation products in 37 wastewater samples by non-target screening prioritization. Water research. 2022 Jul; 219(?):118599. doi: 10.1016/j.watres.2022.118599. [PMID: 35598471]
  • Taha Umair Wani, Abdul Aala Fazli, Syed Naiem Raza, Nisar Ahmad Khan, Faheem A Sheikh. Formulation and Pharmacokinetic Evaluation of Ethyl Cellulose/HPMC-Based Oral Expandable Sustained Release Dosage of Losartan Potassium. AAPS PharmSciTech. 2022 Jun; 23(5):160. doi: 10.1208/s12249-022-02295-9. [PMID: 35676602]
  • Ayesha Tanveer, Khalid Hussain, Hirra Tasneem, Iqra Arif, Memoona Rashid, Nasir Abbas, Rahat Shamim, Pervaiz A Shah, Nadeem Irfan Bukhari. Prediction of CYP-mediated silybin A-losartan pharmacokinetic interactions using physiological based pharmacokinetic modeling. Journal of pharmacokinetics and pharmacodynamics. 2022 06; 49(3):311-323. doi: 10.1007/s10928-022-09804-0. [PMID: 35061161]
  • Shogo Shimizu, Yoshiki Nagao, Atsushi Kurabayashi, Takahiro Shimizu, Youichirou Higashi, Takashi Karashima, Motoaki Saito. Effects of losartan on bladder dysfunction due to aging-related severe hypertension in rats. European journal of pharmacology. 2022 May; 922(?):174911. doi: 10.1016/j.ejphar.2022.174911. [PMID: 35337813]
  • Hiromasa Ito, Ryuji Okamoto, Yusuf Ali, Ye Zhe, Kan Katayama, Masaaki Ito, Kaoru Dohi. Cardiorenal protective effects of sodium-glucose cotransporter 2 inhibition in combination with angiotensin II type 1 receptor blockade in salt-sensitive Dahl rats. Journal of hypertension. 2022 05; 40(5):956-968. doi: 10.1097/hjh.0000000000003099. [PMID: 35285452]
  • Satoshi Shimada, Chun Yang, Theresa Kurth, Allen W Cowley. Divergent roles of angiotensin II upon the immediate and sustained increases of renal blood flow following unilateral nephrectomy. American journal of physiology. Renal physiology. 2022 05; 322(5):F473-F485. doi: 10.1152/ajprenal.00376.2021. [PMID: 35224992]
  • M Maekawa, T Maekawa, T Sasase, K Takagi, S Takeuchi, M Kitamoto, T Nakagawa, K Toyoda, N Konishi, T Ohta, T Yamada. Pathophysiological analysis of uninephrectomized db/db mice as a model of severe diabetic kidney disease. Physiological research. 2022 04; 71(2):209-217. doi: 10.33549/physiolres.934784. [PMID: 35344670]
  • Lars Erichsen, Chantelle Thimm, Martina Bohndorf, Md Shaifur Rahman, Wasco Wruck, James Adjaye. Activation of the Renin-Angiotensin System Disrupts the Cytoskeletal Architecture of Human Urine-Derived Podocytes. Cells. 2022 03; 11(7):. doi: 10.3390/cells11071095. [PMID: 35406662]
  • Mohammadreza Mirjalili, Moslem Taheri Soodejani, Mehdi Raadabadi, Ali Dehghani, Fateme Salemi. Does Losartan reduce the severity of COVID-19 in hypertensive patients?. BMC cardiovascular disorders. 2022 03; 22(1):116. doi: 10.1186/s12872-022-02548-2. [PMID: 35305551]
  • Michael A Puskarich, Nicholas E Ingraham, Lisa H Merck, Brian E Driver, David A Wacker, Lauren Page Black, Alan E Jones, Courtney V Fletcher, Andrew M South, Thomas A Murray, Christopher Lewandowski, Joseph Farhat, Justin L Benoit, Michelle H Biros, Kartik Cherabuddi, Jeffrey G Chipman, Timothy W Schacker, Faheem W Guirgis, Helen T Voelker, Joseph S Koopmeiners, Christopher J Tignanelli. Efficacy of Losartan in Hospitalized Patients With COVID-19-Induced Lung Injury: A Randomized Clinical Trial. JAMA network open. 2022 03; 5(3):e222735. doi: 10.1001/jamanetworkopen.2022.2735. [PMID: 35294537]
  • Xinxing Lai, Zhenyu Dong, Shengxian Wu, Xiaohua Zhou, Genming Zhang, Shangquan Xiong, Wei Wu, Rui Cao, Xiaolong Wang, Qi Hua, Jinhang Du, Jinying Fan, Jingyuan Mao, Weimin Jiang, Huishu Yuan, Yushan Chen, Yong Xu, Zhanquan Li, Jun Zhang, Guiying Dong, Hui Zhen, Ru Ding, Zonggui Wu, Ying Gao. Efficacy and Safety of Chinese Herbal Medicine Compared With Losartan for Mild Essential Hypertension: A Randomized, Multicenter, Double-Blind, Noninferiority Trial. Circulation. Cardiovascular quality and outcomes. 2022 03; 15(3):e007923. doi: 10.1161/circoutcomes.121.007923. [PMID: 35105177]
  • Naoki Onoda, Ayako Kawabata, Kumi Hasegawa, Megumi Sakakura, Itaru Urakawa, Masahide Seki, Junko Zenkoh, Ayako Suzuki, Yutaka Suzuki. Spatial and single-cell transcriptome analysis reveals changes in gene expression in response to drug perturbation in rat kidney. DNA research : an international journal for rapid publication of reports on genes and genomes. 2022 Feb; 29(2):. doi: 10.1093/dnares/dsac007. [PMID: 35325072]
  • Frederik Husum Mårup, Christian Daugaard Peters, Jeppe Hagstrup Christensen, Henrik Birn. Can patiromer allow for intensified renin-angiotensin-aldosterone system blockade with losartan and spironolactone leading to decreased albuminuria in patients with chronic kidney disease, albuminuria and hyperkalaemia? An open-label randomised controlled trial: MorphCKD. BMJ open. 2022 Feb; 12(2):e057503. doi: 10.1136/bmjopen-2021-057503. [PMID: 35190442]
  • Daniel P Regan, Lyndah Chow, Sunetra Das, Laurel Haines, Eric Palmer, Jade N Kurihara, Jonathan W Coy, Alissa Mathias, Douglas H Thamm, Daniel L Gustafson, Steven W Dow. Losartan Blocks Osteosarcoma-Elicited Monocyte Recruitment, and Combined With the Kinase Inhibitor Toceranib, Exerts Significant Clinical Benefit in Canine Metastatic Osteosarcoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2022 02; 28(4):662-676. doi: 10.1158/1078-0432.ccr-21-2105. [PMID: 34580111]
  • David M MacDonald, Gary Collins, Chris H Wendt, Julian Wolfson, Russell P Tracy, Frank Rhame, Steven Deeks, Stacey A Rizza, Zelalem Temesgen, Caryn Morse, Angelike P Liappis, Irini Sereti, Jason V Baker, Ken M Kunisaki. Short Communication: A Pilot Study of the Effects of Losartan Versus Placebo on Pneumoproteins in HIV: A Secondary Analysis of a Randomized Double Blind Study. AIDS research and human retroviruses. 2022 02; 38(2):127-130. doi: 10.1089/aid.2020.0285. [PMID: 33749317]
  • Midori Awazu, Mamiko Yamada, Nariaki Asada, Akinori Hashiguchi, Kenjiro Kosaki, Kazuya Matsumura. A girl with a mutation of the ciliary gene CC2D2A presenting with FSGS and nephronophthisis. CEN case reports. 2022 02; 11(1):116-119. doi: 10.1007/s13730-021-00640-8. [PMID: 34435324]
  • Hiroe Toba, Mitsushi J Ikemoto, Miyuki Kobara, Tetsuo Nakata. Secreted protein acidic and rich in cysteine (SPARC) and a disintegrin and metalloproteinase with thrombospondin type 1 motif (ADAMTS1) increments by the renin-angiotensin system induce renal fibrosis in deoxycorticosterone acetate-salt hypertensive rats. European journal of pharmacology. 2022 Jan; 914(?):174681. doi: 10.1016/j.ejphar.2021.174681. [PMID: 34871556]
  • Inseung Jeon, Seol Ju Moon, Sang-In Park, Yewon Choi, Jina Jung, Kyung-Sang Yu, Jae-Yong Chung. Pharmacokinetics of a Fixed-Dose Combination of Amlodipine/Losartan and Chlorthalidone Compared to Concurrent Administration of the Separate Components. Clinical pharmacology in drug development. 2022 01; 11(1):91-99. doi: 10.1002/cpdd.963. [PMID: 34159751]
  • Valeria R Martínez, Evelina G Ferrer, Patricia Am Williams. Candesartan, losartan and valsartan Zn(II) complexes interactions with bovine serum albumin. Future medicinal chemistry. 2022 01; 14(1):9-16. doi: 10.4155/fmc-2021-0216. [PMID: 34730021]
  • Amaury Pereira-Acácio, João P M Veloso-Santos, Luiz F Nossar, Gloria Costa-Sarmento, Humberto Muzi-Filho, Adalberto Vieyra. Angiotensin-(3-4) normalizes the elevated arterial blood pressure and abnormal Na+/energy handling associated with chronic undernutrition by counteracting the effects mediated by type 1 angiotensin II receptors. PloS one. 2022; 17(8):e0273385. doi: 10.1371/journal.pone.0273385. [PMID: 35984814]
  • Jorge Andrade-Sierra, Mónica Lizbeth Morales-Guillén, Andrés García-Sánchez, Elodia Nataly Díaz-de la Cruz, José Ignacio Cerrillos-Gutiérrez, Enrique Rojas-Campos, Alejandra Guillermina Miranda-Díaz. The Effect of Enalapril, Losartan, or Not Antihypertensive on the Oxidative Status in Renal Transplant Recipients. Oxidative medicine and cellular longevity. 2022; 2022(?):5622626. doi: 10.1155/2022/5622626. [PMID: 35308174]
  • Diego A Duarte, Lucas T Parreiras-E-Silva, Eduardo B Oliveira, Michel Bouvier, Claudio M Costa-Neto. Angiotensin II Type 1 Receptor Tachyphylaxis Is Defined by Agonist Residence Time. Hypertension (Dallas, Tex. : 1979). 2022 01; 79(1):115-125. doi: 10.1161/hypertensionaha.121.17977. [PMID: 34739768]
  • Majid Askaripour, Hamid Najafipour, Shadan Saberi, Elham Jafari, Soodeh Rajabi. Daidzein Mitigates Oxidative Stress and Inflammation in the Injured Kidney of Ovariectomized Rats: AT1 and Mas Receptor Functions. Iranian journal of kidney diseases. 2022 Jan; 1(1):32-43. doi: . [PMID: 35271498]
  • Dan Gao, Pei Yu, Sanhui Jing, Chengcheng Yan, Dandan Ding, Yingjin Qiao, Ge Wu. miR-193a as a potential mediator of WT-1/synaptopodin in the renoprotective effect of Losartan on diabetic kidney. Canadian journal of physiology and pharmacology. 2022 Jan; 100(1):26-34. doi: 10.1139/cjpp-2021-0150. [PMID: 34411489]
  • Javeria Zaheer, Hyeongi Kim, Jin Su Kim. Correlation of ACE2 with RAS components after Losartan treatment in light of COVID-19. Scientific reports. 2021 12; 11(1):24397. doi: 10.1038/s41598-021-03921-5. [PMID: 34937861]
  • Efraím A Serna-Galvis, John F Guateque-Londoño, Javier Silva-Agredo, Jazmín Porras, Yenny Ávila-Torres, Ricardo A Torres-Palma. Superior selectivity of high-frequency ultrasound toward chorine containing-pharmaceuticals elimination in urine: A comparative study with other oxidation processes through the elucidation of the degradation pathways. Ultrasonics sonochemistry. 2021 Dec; 80(?):105814. doi: 10.1016/j.ultsonch.2021.105814. [PMID: 34763213]
  • Cristina Almengló, Marinela Couselo-Seijas, Rosa M Agra, Alfonso Varela-Román, José M García-Acuña, Mercedes González-Peteiro, José R González-Juanatey, Sonia Eiras, Ezequiel Álvarez. Soluble angiotensin-converting enzyme levels in heart failure or acute coronary syndrome: revisiting its modulation and prognosis value. Journal of molecular medicine (Berlin, Germany). 2021 12; 99(12):1741-1753. doi: 10.1007/s00109-021-02129-4. [PMID: 34529122]
  • Gwenolé Loas, Pascal Le Corre. Comment on 'Comparison of losartan and amlodipine effects on the outcomes of patient with COVID-19 and primary hypertension: A randomised clinical trial'. International journal of clinical practice. 2021 12; 75(12):e14957. doi: 10.1111/ijcp.14957. [PMID: 34965651]
  • Bibi S van Thiel, Janette van der Linden, Yanto Ridwan, Ingrid M Garrelds, Marcel Vermeij, Marian C Clahsen-van Groningen, Fatimunnisa Qadri, Natalia Alenina, Michael Bader, Anton J M Roks, A H Jan Danser, Jeroen Essers, Ingrid van der Pluijm. In Vivo Renin Activity Imaging in the Kidney of Progeroid Ercc1 Mutant Mice. International journal of molecular sciences. 2021 Nov; 22(22):. doi: 10.3390/ijms222212433. [PMID: 34830315]
  • Valeria Victoria Costantino, Andrea Fernanda Gil Lorenzo, Victoria Bocanegra, Patricia G Vallés. Molecular Mechanisms of Hypertensive Nephropathy: Renoprotective Effect of Losartan through Hsp70. Cells. 2021 11; 10(11):. doi: 10.3390/cells10113146. [PMID: 34831368]
  • Beere Nagaraju, K V Anilkumar. Pharmacodynamic and pharmacokinetic interaction of losartan with glimepiride-metformin combination in rats and rabbits. Indian journal of pharmacology. 2021 Nov; 53(6):465-470. doi: 10.4103/ijp.ijp_845_19. [PMID: 34975134]
  • Hsuan-Miao Liu, Cheng-Hui Wang, Zi-Yu Chang, Tse-Hung Huang, Tzung-Yan Lee. Losartan Attenuates Insulin Resistance and Regulates Browning Phenomenon of White Adipose Tissue in ob/ob Mice. Current issues in molecular biology. 2021 Oct; 43(3):1828-1843. doi: 10.3390/cimb43030128. [PMID: 34889901]
  • Jessika Iwanski, Sobhi G Kazmouz, Shuaizhi Li, Ben Stansfield, Tori T Salem, Samantha Perez-Miller, Toshinobu Kazui, Lipsa Jena, Jennifer L Uhrlaub, Scott Lick, Janko Nikolich-Žugich, John P Konhilas, Carol C Gregorio, May Khanna, Samuel K Campos, Jared M Churko. Antihypertensive drug treatment and susceptibility to SARS-CoV-2 infection in human PSC-derived cardiomyocytes and primary endothelial cells. Stem cell reports. 2021 10; 16(10):2459-2472. doi: 10.1016/j.stemcr.2021.08.018. [PMID: 34525378]
  • Liting Wu, Yingchao Fan, Yuan Wang, Zhumeng Li, Delong Mao, Wenfang Zhuang. The impact of an URAT1 polymorphism on the losartan treatment of hypertension and hyperuricemia. Journal of clinical laboratory analysis. 2021 Oct; 35(10):e23949. doi: 10.1002/jcla.23949. [PMID: 34498315]
  • Charlotte E Bryant, Azita Rajai, Nicholas J A Webb, Ronald J Hogg. Effects of losartan and enalapril on serum uric acid and GFR in children with proteinuria. Pediatric nephrology (Berlin, Germany). 2021 10; 36(10):3211-3219. doi: 10.1007/s00467-021-05045-4. [PMID: 33881639]
  • Tamer I M Ragab, Naglaa A Ali, Abdel Nasser G El Gendy, Safaa H Mohamed, Aziza B Shalby, Abdel-Razik H Farrag, Al Shimaa Gamal Shalaby. Renoprotective and therapeutic effects of newly water, ethanol, and butanol ginseng fractions in hypertensive and chronic kidney disease with L-NAME. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Oct; 142(?):111978. doi: 10.1016/j.biopha.2021.111978. [PMID: 34411920]
  • Masayo Koide, Osama F Harraz, Fabrice Dabertrand, Thomas A Longden, Hannah R Ferris, George C Wellman, David C Hill-Eubanks, Adam S Greenstein, Mark T Nelson. Differential restoration of functional hyperemia by antihypertensive drug classes in hypertension-related cerebral small vessel disease. The Journal of clinical investigation. 2021 09; 131(18):. doi: 10.1172/jci149029. [PMID: 34351870]
  • Zsuzsanna Z A Kovács, Gergő Szűcs, Marah Freiwan, Mónika G Kovács, Fanni M Márványkövi, Hoa Dinh, Andrea Siska, Katalin Farkas, Ferenc Kovács, András Kriston, Péter Horváth, Bence Kővári, Bálint Gábor Cserni, Gábor Cserni, Imre Földesi, Tamás Csont, Márta Sárközy. Comparison of the antiremodeling effects of losartan and mirabegron in a rat model of uremic cardiomyopathy. Scientific reports. 2021 09; 11(1):17495. doi: 10.1038/s41598-021-96815-5. [PMID: 34471171]
  • Diogo B Peruchetti, Paulo F R Barahuna-Filho, Rodrigo P Silva-Aguiar, Thiago P Abreu, Christina M Takiya, Jie Cheng, Ana Acacia S Pinheiro, Liudmila Cebotaru, William B Guggino, Celso Caruso-Neves. Megalin-mediated albumin endocytosis in renal proximal tubules is involved in the antiproteinuric effect of angiotensin II type 1 receptor blocker in a subclinical acute kidney injury animal model. Biochimica et biophysica acta. General subjects. 2021 09; 1865(9):129950. doi: 10.1016/j.bbagen.2021.129950. [PMID: 34144121]
  • João Pedro Ferreira, Marvin A Konstam, John J V McMurray, Javed Butler, Nicolas Girerd, Patrick Rossignol, Abhinav Sharma, Adriaan A Voors, Carolyn S P Lam, Milton Packer, Faiez Zannad. Dosing of losartan in men versus women with heart failure with reduced ejection fraction: the HEAAL trial. European journal of heart failure. 2021 09; 23(9):1477-1484. doi: 10.1002/ejhf.2255. [PMID: 34050594]
  • Carla Patrícia Carlos, Enzo Prandi de Carvalho, Euradir Vitório Angeli Junior, Glayber Falcão Garcia Filho, João Pedro Lot Doná, Rodrigo Piloto de Oliveira Batanero, Rafael de Oliveira Guena, Camila Agren, Maria Alice Sperto Ferreira Baptista, Thaís Santana Gastardelo Bizotto, Patricia Maluf Cury, Agnaldo Bruno Chies. Angiotensin involvement in kidney injury induced by rheumatoid arthritis in rat. Clinical and experimental pharmacology & physiology. 2021 09; 48(9):1271-1279. doi: 10.1111/1440-1681.13527. [PMID: 34037987]
  • Ana Paula Oliveira Leite, Xiao C Li, Rumana Hassan, Xiaowen Zheng, Barbara Alexander, Dulce Elena Casarini, Jia L Zhuo. Sex differences in angiotensin II-induced hypertension and kidney injury: role of AT1a receptors in the proximal tubule of the kidney. Clinical science (London, England : 1979). 2021 08; 135(15):1825-1843. doi: 10.1042/cs20201574. [PMID: 34282828]
  • Fangfang Zhao, Yun Zou, Hui Li, Yaheng Zhang, Xuele Liu, Xuehao Zhao, Xinyi Wu, Wenyi Fei, Ziling Xu, Xuejun Yang. Decreased angiotensin receptor 1 expression in ± AT1 Knockout mice testis results in male infertility and GnRH reduction. Reproductive biology and endocrinology : RB&E. 2021 Aug; 19(1):120. doi: 10.1186/s12958-021-00805-1. [PMID: 34344365]
  • Cheng-Hui Wang, Hsuan-Miao Liu, Zi-Yu Chang, Tse-Hung Huang, Tzung-Yan Lee. Losartan Prevents Hepatic Steatosis and Macrophage Polarization by Inhibiting HIF-1α in a Murine Model of NAFLD. International journal of molecular sciences. 2021 Jul; 22(15):. doi: 10.3390/ijms22157841. [PMID: 34360607]
  • Malik Nadeem Azam, Khalid Mehmood Raja, Abdur Rehman Arshad, Faryal Riaz Khan, Abdul Wahab Mir, Taleah Tahir, Batool Butt, Anum Khan. The Comparison Of Efficacy Between Losartan And Diltiazem As Antiproteinuric Agent In Non-Diabetic Renal Diseases. Journal of Ayub Medical College, Abbottabad : JAMC. 2021 Jul; 33(3):492-495. doi: NULL. [PMID: 34487664]
  • Stephanie Franzén, Erik Näslund, Helen Wang, Robert Frithiof. Prevention of hemorrhage-induced renal vasoconstriction and hypoxia by angiotensin II type 1 receptor antagonism in pigs. American journal of physiology. Regulatory, integrative and comparative physiology. 2021 07; 321(1):R12-R20. doi: 10.1152/ajpregu.00073.2021. [PMID: 34009032]
  • Michael Marshall. COVID and the brain: researchers zero in on how damage occurs. Nature. 2021 07; 595(7868):484-485. doi: 10.1038/d41586-021-01693-6. [PMID: 34234323]
  • Terumasa Hashimoto, Keita Shibata, Kazuo Honda, Koji Nobe. Acetic acid treatment causes renal inflammation and chronic kidney disease in mice. Journal of pharmacological sciences. 2021 Jul; 146(3):160-168. doi: 10.1016/j.jphs.2021.04.002. [PMID: 34030798]
  • Masoud Nouri-Vaskeh, Niusha Kalami, Ramin Zand, Zahra Soroureddin, Mojtaba Varshochi, Khalil Ansarin, Haleh Rezaee, Ali Taghizadieh, Armin Sadeghi, Masoud Ahangari Maleki, Azam Esmailnajad, Parviz Saleh, Mehdi Haghdoost, Mehdi Maleki, Akbar Sharifi. Comparison of losartan and amlodipine effects on the outcomes of patient with COVID-19 and primary hypertension: A randomised clinical trial. International journal of clinical practice. 2021 Jun; 75(6):e14124. doi: 10.1111/ijcp.14124. [PMID: 33650197]
  • Hui Gao, Wen-Yan Du, Jing Lin, Shi-Liang Han, Yun-Jing Zhang, Xi-Feng Sun. Losartan Protects Podocytes against High Glucose-induced Injury by Inhibiting B7-1 Expression. Current medical science. 2021 Jun; 41(3):505-512. doi: 10.1007/s11596-021-2367-5. [PMID: 34129205]
  • Dominique M Bovée, Liwei Ren, Estrellita Uijl, Marian C Clahsen-van Groningen, Richard van Veghel, Ingrid M Garrelds, Oliver Domenig, Marko Poglitsch, Ivan Zlatev, Jae B Kim, Stephen Huang, Lauren Melton, Xifeng Lu, Ewout J Hoorn, Don Foster, A H Jan Danser. Renoprotective Effects of Small Interfering RNA Targeting Liver Angiotensinogen in Experimental Chronic Kidney Disease. Hypertension (Dallas, Tex. : 1979). 2021 05; 77(5):1600-1612. doi: 10.1161/hypertensionaha.120.16876. [PMID: 33719507]
  • Seyedeh Mahsa Poormoosavi, Mohammad Amin Behmanesh, Hamed Abeyat, Ehsan Sangtarash. Evaluation of the Effect of Captopril and Losartan on Tacrolimus-induced Nephrotoxicity in Rats. Drug research. 2021 May; 71(5):243-249. doi: 10.1055/a-1369-8651. [PMID: 33711846]
  • Aida M Abreu Diaz, Gergana O Drumeva, Philippe Laporte, Luis M Alonso Martinez, Daniil R Petrenyov, Jean-François Carrier, Jean N DaSilva. Evaluation of the high affinity [18F]fluoropyridine-candesartan in rats for PET imaging of renal AT1 receptors. Nuclear medicine and biology. 2021 May; 96-97(?):41-49. doi: 10.1016/j.nucmedbio.2021.03.003. [PMID: 33798796]
  • Eleni Karatza, Vangelis Karalis. Investigating the Impact of Gastric Emptying on Pharmacokinetic Parameters Using Delay Differential Equations and Principal Component Analysis. European journal of drug metabolism and pharmacokinetics. 2021 May; 46(3):451-458. doi: 10.1007/s13318-021-00683-3. [PMID: 33768449]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Mehrnoush Taherzadeh Ghahfarrokhi, Shakiba Zeinali, Habib Bagheri. Preparation of amine-modified lignin and its applicability toward online micro-solid phase extraction of valsartan and losartan in urine samples. Journal of chromatography. A. 2021 Apr; 1643(?):462081. doi: 10.1016/j.chroma.2021.462081. [PMID: 33780883]
  • Daniel Fernandes, Letícia Kramer Pacheco, Regina Sordi, Karin Scheschowitsch, Gustavo Campos Ramos, Jamil Assreuy. Angiotensin II receptor type 1 blockade improves hyporesponsiveness to vasopressors in septic shock. European journal of pharmacology. 2021 Apr; 897(?):173953. doi: 10.1016/j.ejphar.2021.173953. [PMID: 33617825]
  • Wende Li, Sen Li, Ivy X Chen, Yujiao Liu, Rakesh R Ramjiawan, Chi-Ho Leung, Leo E Gerweck, Dai Fukumura, Jay S Loeffler, Rakesh K Jain, Dan G Duda, Peigen Huang. Combining losartan with radiotherapy increases tumor control and inhibits lung metastases from a HER2/neu-positive orthotopic breast cancer model. Radiation oncology (London, England). 2021 Mar; 16(1):48. doi: 10.1186/s13014-021-01775-9. [PMID: 33663521]
  • Shuai Hu, Runhong Han, Long Chen, Weisong Qin, Xiaodong Xu, Jingsong Shi, Xiaodong Zhu, Mingchao Zhang, Caihong Zeng, Zheng Tang, Hao Bao, Zhihong Liu. Upregulated LRRC55 promotes BK channel activation and aggravates cell injury in podocytes. The Journal of experimental medicine. 2021 03; 218(3):. doi: 10.1084/jem.20192373. [PMID: 33346797]
  • John P Delamere, Susie B Bradwell, Christopher T Lewis, Alex Clarke, Arthur R Bradwell. Losartan Has No Effect on High Altitude Diuresis or Acute Mountain Sickness in Well-Acclimatizing Individuals. High altitude medicine & biology. 2021 03; 22(1):96-101. doi: 10.1089/ham.2020.0156. [PMID: 33783237]
  • Yu Wang, Hikari Takeshita, Koichi Yamamoto, Yibin Huang, Cheng Wang, Tsuneo Nakajima, Yoichi Nozato, Taku Fujimoto, Serina Yokoyama, Kazuhiro Hongyo, Futoshi Nakagami, Hiroshi Akasaka, Yoichi Takami, Yasushi Takeya, Ken Sugimoto, Hiromi Rakugi. A pressor dose of angiotensin II has no influence on the angiotensin-converting enzyme 2 and other molecules associated with SARS-CoV-2 infection in mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2021 03; 35(3):e21419. doi: 10.1096/fj.202100016r. [PMID: 33566370]
  • Prachi B Walke, Sneha B Bansode, Nikita P More, Arvindkumar H Chaurasiya, Rakesh S Joshi, Mahesh J Kulkarni. Molecular investigation of glycated insulin-induced insulin resistance via insulin signaling and AGE-RAGE axis. Biochimica et biophysica acta. Molecular basis of disease. 2021 02; 1867(2):166029. doi: 10.1016/j.bbadis.2020.166029. [PMID: 33248275]
  • Lei Zhang, Baoli Zhang, Ying Yu, Jingfeng Wang, Jian Wu, Yangang Su, Hong Jiang, Yunzeng Zou, Junbo Ge. Angiotensin II Increases HMGB1 Expression in the Myocardium Through AT1 and AT2 Receptors When Under Pressure Overload. International heart journal. 2021 Jan; 62(1):162-170. doi: 10.1536/ihj.20-384. [PMID: 33455985]
  • Zizheng Suo, Yanzhi Liu, Yueyi Li, Cong Xu, Yuhan Liu, Mingming Gao, Jinghui Dong. Calcitriol inhibits COX-1 and COX-2 expressions of renal vasculature in hypertension: Reactive oxygen species involved?. Clinical and experimental hypertension (New York, N.Y. : 1993). 2021 Jan; 43(1):91-100. doi: 10.1080/10641963.2020.1817473. [PMID: 32909857]
  • Daniel E Leisman, Tiago D Fernandes, Vanesa Bijol, Mabel N Abraham, Jake R Lehman, Matthew D Taylor, Christine Capone, Omar Yaipan, Rinaldo Bellomo, Clifford S Deutschman. Impaired angiotensin II type 1 receptor signaling contributes to sepsis-induced acute kidney injury. Kidney international. 2021 01; 99(1):148-160. doi: 10.1016/j.kint.2020.07.047. [PMID: 32882263]
  • Reza Mohebbati, Yasamin Kamkar-Del, Mohammad N Shafei. The Possible Regulatory Mechanisms of Aqueous, Ethyl Acetate and NHexane Fractions of the Ribes khorassanicum Extract on Acute Hypertension in Rats. Endocrine, metabolic & immune disorders drug targets. 2021; 21(9):1620-1626. doi: 10.2174/1871530320666201104114609. [PMID: 33148161]
  • Anna Masajtis-Zagajewska, Jacek Majer, Michał Nowicki. Losartan and Eprosartan Induce a Similar Effect on the Acute Rise in Serum Uric Acid Concentration after an Oral Fructose Load in Patients with Metabolic Syndrome. Journal of the renin-angiotensin-aldosterone system : JRAAS. 2021; 2021(?):2214978. doi: 10.1155/2021/2214978. [PMID: 34527078]
  • Yu L He, Jian G Wen, Qing S Pu, Yi B Wen, Rong Q Zhai, Yan Chen, Yuan Ma, Er P Liu, Dong Xing, Feng P Ji, Xing H Yang, Qing W Wang, Yan Wang, Stuart B Bauer. Losartan prevents bladder fibrosis and protects renal function in rat with neurogenic paralysis bladder. Neurourology and urodynamics. 2021 01; 40(1):137-146. doi: 10.1002/nau.24567. [PMID: 33606304]
  • Daniela Volonte, Morgan Sedorovitz, Victoria E Cespedes, Maria L Beecher, Ferruccio Galbiati. Cell autonomous angiotensin II signaling controls the pleiotropic functions of oncogenic K-Ras. The Journal of biological chemistry. 2021 Jan; 296(?):100242. doi: 10.1074/jbc.ra120.015188. [PMID: 33380422]
  • Motoyasu Miura, Shimako Tanaka, Shinya Uchida, Chiaki Kamiya, Naoki Katayama, Akio Hakamata, Keiichi Odagiri, Naoki Inui, Junichi Kawakami, Hiroshi Watanabe, Noriyuki Namiki. Prediction of the Area under the Curve Using Limited-Point Blood Sampling in a Cocktail Study to Assess Multiple CYP Activities. Biological & pharmaceutical bulletin. 2021; 44(6):762-770. doi: 10.1248/bpb.b20-00691. [PMID: 34078808]
  • Songling Jiang, Dal-Seok Oh, Debra Dorotea, Eunjung Son, Dong-Seon Kim, Hunjoo Ha. Dojuksan ameliorates tubulointerstitial fibrosis through irisin-mediated muscle-kidney crosstalk. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Jan; 80(?):153393. doi: 10.1016/j.phymed.2020.153393. [PMID: 33120292]
  • Reza Nejat, Ahmad Shahir Sadr, Branden Freitas, Jackelyn Crabttree, Scott D Pegan, Ralph A Tripp, David Najafi. Losartan Inhibits SARS-CoV-2 Replication in Vitro. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. 2021; 24(?):390-399. doi: 10.18433/jpps31931. [PMID: 34319871]
  • Mohamed M Elseweidy, Gehad M Elnagar, Marwa M Elsawy, Abdelmoneim A Ali, Nabila Zein. Losartan and azelastine either alone or in combination as modulators for endothelial dysfunction and platelets activation in diabetic hyperlipidemic rats. The Journal of pharmacy and pharmacology. 2020 Dec; 72(12):1812-1821. doi: 10.1111/jphp.13363. [PMID: 32880967]
  • Elizabeth M Sutton Burke, Tessa C Kelly, Lindsey A Shoales, Angela K Nagel. Angiotensin Receptor Blockers Effect on Serum Uric Acid-A Class Effect?. Journal of pharmacy practice. 2020 Dec; 33(6):874-881. doi: 10.1177/0897190019866315. [PMID: 31390929]
  • Abdulaziz M S AlSaad, Fawaz Alasmari, Hatem M Abuohashish, Mohamed Mohany, Mohammed M Ahmed, Salim S Al-Rejaie. Renin angiotensin system blockage by losartan neutralize hypercholesterolemia-induced inflammatory and oxidative injuries. Redox report : communications in free radical research. 2020 Dec; 25(1):51-58. doi: 10.1080/13510002.2020.1763714. [PMID: 32396454]
  • Sherif Elkappany, Abdelwahab Hashem, Ahmed Elkarta, Hussein Sheashaa, Yasser Osman, Ahmed A Shokeir. Effect of losartan on the recoverability of renal function in anuric and oliguric patients with a solitary obstructed kidney: a double-blind randomized placebo-controlled trial. BJU international. 2020 12; 126(6):715-721. doi: 10.1111/bju.15168. [PMID: 32648662]
  • Abdolhamid Esmaeeli, Fatemeh Ebrahimi, Kaveh Tanha, Majid Assadi, Mohammad Seyedabadi. Low-dose angiotensin AT1 receptor β-arrestin-biased ligand, TRV027, protects against cisplatin-induced nephrotoxicity. Pharmacological reports : PR. 2020 Dec; 72(6):1676-1684. doi: 10.1007/s43440-020-00172-5. [PMID: 33090352]
  • Jin Seong Hyeon, Youngae Jung, Gayoung Lee, Hunjoo Ha, Geum-Sook Hwang. Urinary Metabolomic Profiling in Streptozotocin-Induced Diabetic Mice after Treatment with Losartan. International journal of molecular sciences. 2020 Nov; 21(23):. doi: 10.3390/ijms21238969. [PMID: 33255934]
  • Rui Wu, Fan Wei, Lianlian Qu, Litao Bai, Jun Li, Fei Li, Weitian Yan, Qiuhong Wang, Junping Wei. Effects of Keluoxin capsule combined with losartan potassium on diabetic kidney disease: study protocol for a randomized double-blind placebo-controlled multicenter clinical trial. Trials. 2020 Nov; 21(1):951. doi: 10.1186/s13063-020-04852-8. [PMID: 33228726]
  • Fen Zheng, Chao Ye, Guo-Wei Wan, Bing Zhou, Ying Tong, Jian-Zhen Lei, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu. Interleukin-1β in hypothalamic paraventricular nucleus mediates excitatory renal reflex. Pflugers Archiv : European journal of physiology. 2020 11; 472(11):1577-1586. doi: 10.1007/s00424-020-02461-7. [PMID: 32915316]
  • Ismet Hortu, Orkun Ilgen, Cagdas Sahin, Ali Akdemir, Gurkan Yigitturk, Oytun Erbas. Losartan ameliorates ovarian ischaemia/reperfusion injury in rats: an experimental study. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. 2020 Nov; 40(8):1148-1154. doi: 10.1080/01443615.2019.1701639. [PMID: 31955629]
  • Nuha I Abou Obaid, Fahad I Al-Jenoobi, Mohamed A Ibrahim, Mohd A Alam. Losartan potassium sustained release pellets with improved in vitro and in vivo performance. Pharmaceutical development and technology. 2020 Nov; 25(9):1031-1042. doi: 10.1080/10837450.2020.1782934. [PMID: 32538215]
  • Hyo-Bin Shin, Eui Hyun Jung, Pureum Kang, Chang Woo Lim, Kyung-Yul Oh, Chang-Keun Cho, Yun Jeong Lee, Chang-Ik Choi, Choon-Gon Jang, Seok-Yong Lee, Jung-Woo Bae. ABCB1 c.2677G>T/c.3435C>T diplotype increases the early-phase oral absorption of losartan. Archives of pharmacal research. 2020 Nov; 43(11):1187-1196. doi: 10.1007/s12272-020-01294-3. [PMID: 33249530]