Tripelennamine (BioDeep_00000002300)

human metabolite blood metabolite Chemicals and Drugs

代谢物信息卡片

N-benzyl-N-[2-(dimethylamino)ethyl]pyridin-2-amine

化学式: C16H21N3 (255.1735386)
中文名称: 曲吡那敏
谱图信息: 最多检出来源 Homo sapiens(blood) 63.49%

分子结构信息

SMILES: CN(C)CCN(CC1=CC=CC=C1)C1=CC=CC=N1
InChI: InChI=1S/C16H21N3/c1-18(2)12-13-19(16-10-6-7-11-17-16)14-15-8-4-3-5-9-15/h3-11H,12-14H2,1-2H3

描述信息

Tripelennamine is only found in individuals that have used or taken this drug. It is a histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. [PubChem]Tripelennamine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
D - Dermatologicals > D04 - Antipruritics, incl. antihistamines, anesthetics, etc. > D04A - Antipruritics, incl. antihistamines, anesthetics, etc. > D04AA - Antihistamines for topical use
R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use > R06AC - Substituted ethylene diamines
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D018926 - Anti-Allergic Agents

同义名列表

17 个代谢物同义名

N-benzyl-N-[2-(dimethylamino)ethyl]pyridin-2-amine; Asid bonz brand OF tripelennamine hydrochloride; Parnell brand OF tripelennamine hydrochloride; Tripelennamine monohydrochloride; Chefaro brand OF tripelennamine; Tripelennamine hydrochloride; Tripelennamine maleate (1:1); Tripelennamine citrate (1:1); Tripelennamine maleate; Tripelennamine citrate; tripelennamine; Pyribenzamine; Vetibenzamin; Histantin; PBZ-SR; Azaron; PBZ

数据库引用编号

17 个数据库交叉引用编号

ChEBI: CHEBI:9741
KEGG: C07180
KEGGdrug: D08645
PubChem: 5587
HMDB: HMDB0014930
Metlin: METLIN44153
DrugBank: DB00792
ChEMBL: CHEMBL1241
Wikipedia: Tripelennamine
MeSH: Tripelennamine
chemspider: 5385
CAS: 6138-56-3
CAS: 91-81-6
PMhub: MS000002309
PubChem: 9389
NIKKAJI: J4.349D
RefMet: Tripelennamine

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Silvia Tardioli, Joost Buijs, Cees Gooijer, Gert van der Zwan. pH-dependent complexation of histamine H1 receptor antagonists and human serum albumin studied by UV resonance Raman spectroscopy. The journal of physical chemistry. B. 2012 Mar; 116(12):3808-15. doi: 10.1021/jp206409d. [PMID: 22372713]
Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. Journal of medicinal chemistry. 2011 Jul; 54(13):4548-58. doi: 10.1021/jm2001629. [PMID: 21599003]
James P Scarth, Holly A Spencer, Sarah E Timbers, Simon C Hudson, Lynn L Hillyer. The use of in vitro technologies coupled with high resolution accurate mass LC-MS for studying drug metabolism in equine drug surveillance. Drug testing and analysis. 2010 Jan; 2(1):1-10. doi: 10.1002/dta.88. [PMID: 20878880]
M A Martínez-Gómez, M M Carril-Avilés, S Sagrado, R M Villanueva-Camañas, M J Medina-Hernández. Characterization of antihistamine-human serum protein interactions by capillary electrophoresis. Journal of chromatography. A. 2007 Apr; 1147(2):261-9. doi: 10.1016/j.chroma.2007.02.054. [PMID: 17339039]
G Viola, E Galbiati. Mast cell--pituitary interaction: modulation by serine phospholipids. Die Pharmazie. 2004 Dec; 59(12):948-51. doi: . [PMID: 15638084]
J A Hasrat, L Pieters, A J Vlietinck. Medicinal plants in Suriname: hypotensive effect of Gossypium barbadense. The Journal of pharmacy and pharmacology. 2004 Mar; 56(3):381-7. doi: 10.1211/0022357022917. [PMID: 15025864]
Nu He, Wen-Qi Zhang, Dolores Shockley, Timi Edeki. Inhibitory effects of H1-antihistamines on CYP2D6- and CYP2C9-mediated drug metabolic reactions in human liver microsomes. European journal of clinical pharmacology. 2002 Feb; 57(12):847-51. doi: 10.1007/s00228-001-0399-0. [PMID: 11936702]
F G de Miranda, J C Vilar, I A Alves, S C Cavalcanti, A R Antoniolli. Antinociceptive and antiedematogenic properties and acute toxicity of Tabebuia avellanedae Lor. ex Griseb. inner bark aqueous extract. BMC pharmacology. 2001; 1(?):6. doi: 10.1186/1471-2210-1-6. [PMID: 11574048]
I A Wasfi, A A Abdel Hadi, M Elghazali, N S Boni, N A Alkatheeri, I M Barezaig, A M Al Muharami, A M Hamid. Comparative disposition of tripelennamine in horses and camels after intravenous administration. Journal of veterinary pharmacology and therapeutics. 2000 Jun; 23(3):145-52. doi: 10.1046/j.1365-2885.2000.00261.x. [PMID: 11110101]
Y Ohta, T Kobayashi, I Ishiguro. Role of endogenous serotonin and histamine in the pathogenesis of gastric mucosal lesions in unanaesthetised rats with a single treatment of compound 48/80, a mast cell degranulator. Pharmacological research. 1999 Apr; 39(4):261-7. doi: 10.1006/phrs.1998.0403. [PMID: 10208755]
S Y Yeh. Metabolic profile of tripelennamine in humans. Journal of pharmaceutical sciences. 1991 Sep; 80(9):815-9. doi: 10.1002/jps.2600800902. [PMID: 1800700]
S Y Yeh, F L Hsu. Quantitative metabolic profile of tripelennamine and pyrilamine in the rat. Drug metabolism and disposition: the biological fate of chemicals. 1988 May; 16(3):499-502. doi: NULL. [PMID: 2900747]
I Haye-Legrand, X Norel, C Labat, J Benveniste, C Brink. Antigenic contraction of guinea pig tracheal preparations passively sensitized with monoclonal IgE: pharmacological modulation. International archives of allergy and applied immunology. 1988; 87(4):342-8. doi: 10.1159/000234699. [PMID: 3229856]
D Dadgar, A Power. Applications of column-switching techniques in biopharmaceutical analysis. II. High-performance liquid chromatographic determination of tripelennamine in bovine plasma and milk. Journal of chromatography. 1987 Oct; 421(1):216-22. doi: 10.1016/0378-4347(87)80401-2. [PMID: 3429571]
S Y Yeh. N-debenzylation of pyrilamine and tripelennamine in the rat. A new metabolic pathway. Drug metabolism and disposition: the biological fate of chemicals. 1987 Jul; 15(4):466-72. doi: . [PMID: 2888618]
D C May, J H Helderman, E H Eigenbrodt, F G Silva. Chronic sclerosing glomerulopathy (heroin-associated nephropathy) in intravenous T's and Blues abusers. American journal of kidney diseases : the official journal of the National Kidney Foundation. 1986 Dec; 8(6):404-9. doi: 10.1016/s0272-6386(86)80166-4. [PMID: 3812469]
S Y Yeh, G D Todd, R E Johnson, C W Gorodetzky, W R Lange. The pharmacokinetics of pentazocine and tripelennamine. Clinical pharmacology and therapeutics. 1986 Jun; 39(6):669-76. doi: 10.1038/clpt.1986.117. [PMID: 3709032]
K J Radke, L R Willis, G W Zimmerman, M H Weinberger, E E Selkurt. Effects of histamine-receptor antagonists on histamine-stimulated renin secretion. European journal of pharmacology. 1986 Apr; 123(3):421-6. doi: 10.1016/0014-2999(86)90718-1. [PMID: 3522250]
K Takeuchi, H Ohtsuki, S Okabe. Pathogenesis of compound 48/80-induced gastric lesions in rats. Digestive diseases and sciences. 1986 Apr; 31(4):392-400. doi: 10.1007/bf01311675. [PMID: 3956335]
S Y Yeh. Potentiation of pentazocine antinociception by tripelennamine in the rat. The Journal of pharmacology and experimental therapeutics. 1985 Dec; 235(3):683-9. doi: . [PMID: 4078730]
C Jackson, A Hart, M D Robinson. Fatal intracranial hemorrhage associated with phenylpropanolamine, pentazocine, and tripelennamine overdose. The Journal of emergency medicine. 1985; 3(2):127-32. doi: 10.1016/0736-4679(85)90044-7. [PMID: 4093565]
K J Radke, E E Selkurt, L R Willis. The role of histamine H1 and H2 receptors in the canine kidney. Renal physiology. 1985; 8(2):100-11. doi: 10.1159/000173041. [PMID: 3991981]
C W Gorodetzky, E J Cone, R E Johnson, M E Risner, T P Su, S Y Yeh. Progress report from the NIDA Addiction Research Center (preclinical laboratory), Lexington, Kentucky. NIDA research monograph. 1984 Mar; 49(?):63-8. doi: NULL. [PMID: 6148696]
N L Vadlamani, R B Pontani, A L Misra. Increased brain uptake of morphine in the presence of the antihistamine tripelennamine. The Journal of pharmacy and pharmacology. 1984 Jan; 36(1):61-3. doi: 10.1111/j.2042-7158.1984.tb02992.x. [PMID: 6141270]
N W Robie, L A Barker. Evaluation of presynaptic histamine receptors in the canine renal vascular bed. The Journal of pharmacology and experimental therapeutics. 1983 Sep; 226(3):712-9. doi: NULL. [PMID: 6136599]
R E Bluhm, M A Evans, E K Zsigmond. Analgesic potentiation and the distribution of morphine in the presence of triplennamine in mice. Life sciences. 1983; 33 Suppl 1(?):673-6. doi: 10.1016/0024-3205(83)90592-1. [PMID: 6664243]
J R Monforte, R Gault, J Smialek, T Goodin. Toxicological and pathological findings in fatalities involving pentazocine and tripelennamine. Journal of forensic sciences. 1983 Jan; 28(1):90-101. doi: NULL. [PMID: 6680755]
R W Reid, C M Gerbeck. Detection of pentazocine and tripelennamine in urine. Clinical chemistry. 1981 Jan; 27(1):10-3. doi: 10.1093/clinchem/27.1.10. [PMID: 7449089]
H W Lahmeyer, R G Steingold. Medical and psychiatric complications of pentazocine and tripelennamine abuse. The Journal of clinical psychiatry. 1980 Aug; 41(8):275-8. doi: . [PMID: 7400105]
K H Meador, Z Sharon, E J Lewis. Renal amyloidosis and subcutaneous drug abuse. Annals of internal medicine. 1979 Oct; 91(4):565-7. doi: 10.7326/0003-4819-91-4-565. [PMID: 484955]
R O Banks, J D Fondacaro, M M Schwaiger, E D Jacobson. Renal histamine H1 and H2 receptors: characterization and functional significance. The American journal of physiology. 1978 Dec; 235(6):F570-5. doi: 10.1152/ajprenal.1978.235.6.f570. [PMID: 736141]
K K Kaistha, R Tadrus. Thin-layer detection of pentazocine, tripelennamine, phencyclidine and propoxyphene alone or in combination with opiates in drug abuse urine screening programs. Journal of chromatography. 1978 Aug; 155(1):214-7. doi: 10.1016/s0021-9673(00)83956-4. [PMID: 28334]
N K Chaudhuri, O A Servando, M J Manniello, R C Luders, D K Chao, M F Bartlett. Metabolism of tripelennamine in man. Drug metabolism and disposition: the biological fate of chemicals. 1976 Jul; 4(4):372-8. doi: . [PMID: 8293]
G S Rao, G Krishna, J R Gillette. Metabolism, tissue distribution and covalent binding of tripelennamine and its N-nitroso derivative in the rat. The Journal of pharmacology and experimental therapeutics. 1975 Dec; 195(3):433-40. doi: . [PMID: 1195130]
G S Rao, G Krishna, J R Gillette. Drug-nitrite interactions: the lack of toxicity of a N-nitroso derivative of tripelennamine formed in the rat. Toxicology and applied pharmacology. 1975 Nov; 34(2):264-70. doi: 10.1016/0041-008x(75)90031-9. [PMID: 1209624]
S F Vatner. Effects of hemorrhage on regional blood flow distribution in dogs and primates. The Journal of clinical investigation. 1974 Aug; 54(2):225-35. doi: 10.1172/jci107757. [PMID: 4211160]
M D McCracken, W W Carlton, J Tuite. Penicillium viridicatum mycotoxicosis in the rat. IV. Attempts to modify the tissue responses. Food and cosmetics toxicology. 1974 Jun; 12(3):331-40. doi: 10.1016/0015-6264(74)90005-4. [PMID: 4155396]
D Clément. Reflex regulation of blood pressure and peripheral vascular tone during muscular contraction in the dog. Archives internationales de physiologie et de biochimie. 1974; 82(2):406-8. doi: NULL. [PMID: 4135895]
W M Pedersoli. Effects of acute anaphylactic shock on arterial blood pressure of anesthetized chickens. American journal of veterinary research. 1973 Jul; 34(7):881-5. doi: NULL. [PMID: 4720674]
C R Barton, W M Allen. Possible paralytic myoglobinuria of unknown aetiology in young cattle. The Veterinary record. 1973 Mar; 92(11):288-90. doi: 10.1136/vr.92.11.288. [PMID: 4718144]
V R Grund, N D Goldberg, D B Hunninghake. Effect of histamine of lipolysis and adenosine 3',5'-monophosphate levels in canine adipose tissue. Biochemical pharmacology. 1973 Mar; 22(6):769-72. doi: 10.1016/0006-2952(73)90409-7. [PMID: 4348314]
K L Melmon, H R Bourne, J Weinstein, M Sela. Receptors for histamine can be detected on the surface of selected leukocytes. Science (New York, N.Y.). 1972 Aug; 177(4050):707-9. doi: 10.1126/science.177.4050.707. [PMID: 4403369]
K P O'Brien, H E Williamson. The natriuretic action of histamine. European journal of pharmacology. 1971 Nov; 16(3):385-90. doi: 10.1016/0014-2999(71)90043-4. [PMID: 5132567]
F M Dietrich, A Komarek, C Pericin. Hypersensitivity in mice. II. The effect of chemical compounds on systemic active anaphylaxis and on anaphylaxis-like reactions in normal and B. pertussis-pretreated mice. International archives of allergy and applied immunology. 1971; 40(4-5):495-506. doi: NULL. [PMID: 4102842]
A Agren, R Elofsson, U Meresaar, S O Nilsson. Complex formation between macromolecules and drugs. 3. A study of the influence of ionic strength and pH. Binding between Aptin, nortriptyline, sulfamethizole or tripelenamine and serum albumin, poly-arginine, poly-lysine, poly-ornithine, protamine or dextran sulfate. Acta pharmaceutica Suecica. 1970 Apr; 7(2):105-12. doi: NULL. [PMID: 5421619]
P Cambon, R Chambon-Mougenot. [Research on metabolites with N-oxide function. Experimental study on the tripelennamine hydrochloride (pyribenzamine)]. Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles. 1969 Jan; 268(3):596-8. doi: NULL. [PMID: 4977784]
J A Levin, J D Bartlett, L Beck. Active reflex vasodilatation induced by intravenous epinephrine or norepinephrine in primates. The Journal of pharmacology and experimental therapeutics. 1968 Jun; 161(2):262-70. doi: NULL. [PMID: 4967783]
N Sato, I Himuro, A Shioya. A photoelectric method for estimating inflammatory intensity in mice and its application to the anti-inflammatory evaluation of glucuronic acid derivatives. Japanese journal of pharmacology. 1967 Dec; 17(4):557-71. doi: 10.1254/jjp.17.557. [PMID: 5301347]
P C Matchette, R W Hughes, H J Bozivich. Effect of intravenous administration of histamine on the packed cell volume and the plasma levels of calcium and potassium in sheep. American journal of veterinary research. 1967 Nov; 28(127):1897-901. doi: NULL. [PMID: 6076575]
K J Netter, K Bodenschatz. Inhibition of histamine-N-methylation by some antihistamines. Biochemical pharmacology. 1967 Aug; 16(8):1627-31. doi: 10.1016/0006-2952(67)90141-4. [PMID: 4383052]
W NETZER, W VOGT. [ANAPHYLATOXIN FORMATION CAUSED BY PYROGENIC LIPOPOLYSACCHARIDE]. Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie. 1964 May; 248(?):261-8. doi: NULL. [PMID: 14230239]
J H MOYER, J BURGESS, R V FORD. Pyribenzamine (tripelennamine): effects on renal hemodynamics and the excretion of water and electrolytes. American heart journal. 1957 Nov; 54(5):643-50. doi: 10.1016/0002-8703(57)90419-2. [PMID: 13469733]
R M SUSSMAN, N WALD. Tripelennamine dysuria in chronic nephritic uremia. The New England journal of medicine. 1952 May; 246(19):735-7. doi: 10.1056/nejm195205082461904. [PMID: 14929309]
B DICKSTEIN. The effect of substitution of antistine (phenyl-benzyl-amino-methyl-imidazoline) for benadryl or pyribenzamine during the height of the ragweed pollen season. Annals of allergy. 1949 Mar; 7(2):250-3. doi: ". [PMID: 18114850]
T H McGAVACK, I J DREKTER. Levels for pyribenzamine and benadryl in blood and urine following a single orally administered dose. The Journal of allergy. 1948 Jul; 19(4):251-5. doi: 10.1016/0021-8707(48)90062-8. [PMID: 18871142]
J G CONIGLIO. Changes in plasma inorganic phosphorus of dogs under postural restraint. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1947 Dec; 66(3):534-7. doi: 10.3181/00379727-66-16148. [PMID: 18900016]
R H DREISBACH. Failure of benadryl and pyribenzamine in experimental skin sensitization to penicillin and horse serum. The Journal of allergy. 1947 Nov; 18(6):397-401. doi: 10.1016/0021-8707(47)90091-9. [PMID: 20270599]