Loxapine (BioDeep_00000002019)

 

Secondary id: BioDeep_00000405887

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


13-chloro-10-(4-methylpiperazin-1-yl)-2-oxa-9-azatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3,5,7,9,12,14-heptaene

化学式: C18H18ClN3O (327.1138)
中文名称: 洛沙平
谱图信息: 最多检出来源 Homo sapiens(blood) 13.99%

分子结构信息

SMILES: CN1CCN(C2=NC3=CC=CC=C3OC4=CC=C(Cl)C=C24)CC1
InChI: InChI=1S/C18H18ClN3O/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3

描述信息

Loxapine is only found in individuals that have used or taken this drug. It is an antipsychotic agent used in schizophrenia. [PubChem]Loxapine is a dopamine antagonist, and also a serotonin 5-HT2 blocker. The exact mode of action of Loxapine has not been established, however changes in the level of excitability of subcortical inhibitory areas have been observed in several animal species in association with such manifestations of tranquilization as calming effects and suppression of aggressive behavior.
N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AH - Diazepines, oxazepines, thiazepines and oxepines
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent
Loxapine is an orally active dopamine inhibitor, 5-HT receptor antagonist and also a dibenzoxazepine anti-psychotic agent[1][4].

同义名列表

20 个代谢物同义名

13-chloro-10-(4-methylpiperazin-1-yl)-2-oxa-9-azatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3,5,7,9,12,14-heptaene; 2-Chloro-11-(4-methyl-1-piperazinyl)-dibenz(b,F)(1,4)oxazepine; 2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,F][1,4]oxazepine; Loxapine monohydrochloride; Hydrochloride, loxapine; Loxapine hydrochloride; Succinate, loxapine; Loxipine succinate; Loxapine succinate; Maleate, loxipine; Loxipine maleate; Loxapinsuccinate; Cloxazepine; Loxapinum; Oxilapine; Loxitane; loxapine; Loxapina; Adasuve; Loxapine



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 BDNF, CA1, CYP2D6, CYP3A4, HTR4, TH
Peripheral membrane protein 1 CYP1B1
Endosome membrane 1 HTR4
Endoplasmic reticulum membrane 5 CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1
Nucleus 2 DRD1, TH
cytosol 2 CA1, TH
dendrite 9 BDNF, DRD2, HTR1A, HTR2A, HTR2C, HTR4, HTR6, HTR7, TH
Cell membrane 9 DRD1, DRD2, HTR1A, HTR2A, HTR2C, HTR4, HTR6, HTR7, KCNT1
Cell projection, axon 2 HTR2A, TH
Multi-pass membrane protein 11 DRD1, DRD2, HTR1A, HTR2A, HTR2C, HTR4, HTR6, HTR7, KCNA3, KCNT1, NNT
Golgi apparatus membrane 1 DRD2
Synapse 6 DRD2, HTR1A, HTR2C, HTR4, HTR6, HTR7
dendritic shaft 1 HTR2A
glutamatergic synapse 5 DRD1, DRD2, HTR2A, HTR4, KCNA3
Golgi membrane 1 DRD2
lysosomal membrane 1 GAA
mitochondrial inner membrane 1 NNT
neuronal cell body 1 HTR2A
postsynapse 1 HTR4
presynaptic membrane 4 DRD1, DRD2, HTR2A, KCNA3
smooth endoplasmic reticulum 1 TH
synaptic vesicle 2 BDNF, TH
Lysosome 1 GAA
Presynapse 1 HTR2A
acrosomal vesicle 1 DRD2
endosome 1 HTR4
plasma membrane 11 DRD1, DRD2, GAA, HTR1A, HTR2A, HTR2C, HTR4, HTR6, HTR7, KCNA3, KCNT1
synaptic vesicle membrane 1 DRD2
terminal bouton 1 TH
Membrane 9 BDNF, CYP1B1, CYP2D6, CYP3A4, GAA, HTR4, KCNA3, KCNT1, NNT
axon 5 BDNF, DRD2, HTR2A, KCNA3, TH
caveola 1 HTR2A
extracellular exosome 2 CA1, GAA
Lysosome membrane 1 GAA
endoplasmic reticulum 1 CYP2D6
extracellular space 2 BDNF, IL2
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 3 BDNF, KCNA3, TH
mitochondrion 4 CYP1B1, CYP2D6, NNT, TH
intracellular membrane-bounded organelle 5 CYP1A2, CYP1B1, CYP2D6, CYP3A4, GAA
Microsome membrane 4 CYP1A2, CYP1B1, CYP2D6, CYP3A4
Secreted 3 BDNF, GAA, IL2
extracellular region 3 BDNF, GAA, IL2
cytoplasmic side of plasma membrane 1 TH
Single-pass membrane protein 1 CYP2D6
ciliary membrane 2 DRD1, DRD2
dendritic spine 2 DRD1, DRD2
perikaryon 2 DRD2, TH
cytoplasmic vesicle 2 HTR2A, TH
Melanosome membrane 1 TH
postsynaptic membrane 4 DRD1, DRD2, HTR2A, KCNA3
Cytoplasm, perinuclear region 1 TH
Mitochondrion inner membrane 1 NNT
Matrix side 1 NNT
Membrane raft 1 KCNA3
GABA-ergic synapse 2 DRD1, DRD2
Cell projection, dendritic spine 1 DRD1
lateral plasma membrane 1 DRD2
neuron projection 1 TH
cilium 3 DRD1, DRD2, HTR6
non-motile cilium 2 DRD1, DRD2
[Isoform 2]: Cell membrane 1 KCNA3
sperm flagellum 1 DRD2
Membrane, caveola 1 HTR2A
cell body fiber 1 HTR2A
Cell projection, dendrite 3 DRD1, HTR1A, HTR2A
tertiary granule membrane 1 GAA
respiratory chain complex 1 NNT
voltage-gated potassium channel complex 1 KCNA3
trans-Golgi network membrane 1 HTR7
endoplasmic reticulum lumen 1 BDNF
axon terminus 1 DRD2
endocytic vesicle 1 DRD2
azurophil granule membrane 1 GAA
neurofilament 1 HTR2A
calyx of Held 1 KCNA3
ficolin-1-rich granule membrane 1 GAA
[Isoform 1]: Cell membrane 1 KCNA3
dopaminergic synapse 1 DRD2
Cell projection, cilium membrane 1 DRD1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle 1 TH
autolysosome lumen 1 GAA
G protein-coupled receptor complex 2 DRD1, DRD2
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
G protein-coupled serotonin receptor complex 2 HTR2A, HTR2C


文献列表

  • Tyler Ruch, Sharon Nuss, Rajashekar Reddy Yeruva, Yonglin Gao, Gulay Tegin, Christina Terrell, Rif S El-Mallakh. Inhaled loxapine for acute agitation in a psychiatric emergency service. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists. 2021 08; 33(3):162-167. doi: 10.12788/acp.0032. [PMID: 34398731]
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  • Sally Selim, Robert Riesenberg, James Cassella, Jeevan Kunta, Edward Hellriegel, Mark A Smith, Alexander A Vinks, Laura Rabinovich-Guilatt. Pharmacokinetics and Safety of Single-Dose Inhaled Loxapine in Children and Adolescents. Journal of clinical pharmacology. 2017 10; 57(10):1244-1257. doi: 10.1002/jcph.932. [PMID: 28510296]
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